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The expanding functional diversity of plasma cells in immunity and inflammation

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Cellular & Molecular Immunology 2020年第4期17卷 421-422页

作者： kongyang ma Xiaohui Wang Xiaofei Shi Xiang Lin Fan Xiao Xin ma Dongzhou Liu Liwei Lu Department of Rheumatology and Immunology Second Clinical Medical College of Jinan UniversityShenzhen People’s HospitalShenzhenChina Department of Pathology and Shenzhen Institute of Research and Innovation The University of Hong KongHong KongChina Department of Rheumatology The First Affiliated Hospital and College of Clinical MedicineHenan University of Science and TechnologyLuoyangChina

The generation and function of plasma cells have been well recognized as the central events in humoral immunity.In particular,long-lived plasma cells,characterized by a long lifespan and the lack of cell division,persistently secrete high-affinity antibodies to maintain serum antibody titers in the immune response and autoimmune inflammation.Although the significant expansion of plasma cells is observed during the aging process,autoimmune diseases and chronic infections,the expanding functional diversity and underlying mechanisms of plasma cells remain incompletely understood.Here,we describe recent advances in revealing new functional subsets and phenotypic features of plasma cells in aging and autoimmunity.

关键词： immunity inflammation autoimmune

B1-cell-produced anti-phosphatidylserine antibodies contribute to lupus nephritis development via TLR-mediated Syk activation

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Cellular & Molecular Immunology 2023年第8期20卷 881-894页

作者： kongyang ma Wenhan Du Shiyun Wang Fan Xiao Jingyi Li Jie Tian Yida Xing Xiaodan Kong Ke Rui Rencai Qin Xiaoxia Zhu Jing Wang Cainan Luo Haijing Wu Yun Zhang Chengping Wen Lan He Dongzhou Liu Hejian Zou Qianjin Lu Lijun Wu Liwei Lu Centre for Infection and Immunity Studies School of MedicineThe Sun Yat-sen UniversityShenzhen518107GuangdongChina Department of Pathology and Shenzhen Institute of Research and Innovation The University of Hong KongHong Kong999077China Department of Rheumatology Shenzhen People’s HospitalThe Second Clinical Medical CollegeJinan UniversityShenzhenChina Chongqing International Institute for Immunology Chongqing400038China Department of Rheumatology and Immunology Southwest HospitalThe First Hospital Affiliated to Army Medical UniversityChongqing400038China Department of Laboratory Medicine Affiliated Hospital and Institute of Medical ImmunologyJiangsu UniversityZhenjiangChina Department of Rheumatology The Second Affiliated Hospital of Dalian Medical UniversityDalianChina Department of Rheumatology Huashan HospitalFudan UniversityShanghaiChina Department of Rheumatology and Immunology The First Affiliated Hospital of Xi’an Jiaotong UniversityXi’an710061ShaanxiChina Department of Rheumatology and Immunology People’s Hospital of Xinjiang Uygur Autonomous RegionUrumqiChina Department of Dermatology Hunan Key Laboratory of Medical EpigenomicsSecond Xiangya HospitalCentral South UniversityChangshaHunanChina Key Laboratory of Chinese Medicine Rheumatology of Zhejiang Province Institute of Basic Research in Clinical MedicineCollege of Basic Medical ScienceZhejiang Chinese Medical UniversityHangzhou310053China Centre for Oncology and Immunology Hong Kong Science ParkHong KongChina

Autoantibodies produced by B cells play a pivotal role in the pathogenesis of systemic lupus erythematosus (SLE). However, both the cellular source of antiphospholipid antibodies and their contributions to the development of lupus nephritis (LN) remain largely unclear. Here, we report a pathogenic role of anti-phosphatidylserine (PS) autoantibodies in the development of LN. Elevated serum PS-specific IgG levels were measured in model mice and SLE patients, especially in those with LN. PS-specific IgG accumulation was found in the kidney biopsies of LN patients. Both transfer of SLE PS-specific IgG and PS immunization triggered lupus-like glomerular immune complex deposition in recipient mice. ELISPOT analysis identified B1a cells as the main cell type that secretes PS-specific IgG in both lupus model mice and patients. Adoptive transfer of PS-specific B1a cells accelerated the PS-specific autoimmune response and renal damage in recipient lupus model mice, whereas depletion of B1a cells attenuated lupus progression. In culture, PS-specific B1a cells were significantly expanded upon treatment with chromatin components, while blockade of TLR signal cascades by DNase I digestion and inhibitory ODN 2088 or R406 treatment profoundly abrogated chromatin-induced PS-specific IgG secretion by lupus B1a cells. Thus, our study has demonstrated that the anti-PS autoantibodies produced by B1 cells contribute to lupus nephritis development. Our findings that blockade of the TLR/Syk signaling cascade inhibits PS-specific B1-cell expansion provide new insights into lupus pathogenesis and may facilitate the development of novel therapeutic targets for the treatment of LN in SLE.

关键词： B1 cell Anti-phosphatidylserine antibodies Lupus nephritis TLR Syk

Epigenetic regulation in B-cell maturation and its dysregulation in autoimmunity

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Cellular & Molecular Immunology 2018年第7期15卷 676-684页

作者： Haijing Wu Yaxiong Deng Yu Feng Di Long kongyang ma Xiaohui Wang Ming Zhao Liwei Lu Qianjin Lu Department of Dermatology Second Xiangya HospitalCentral South UniversityHunan Key Laboratory of Medical EpigenomicsChangshaHunan 410011China Department of Pathology and Shenzhen Institute of Research and Innovation The University of Hong KongHong KongChina

B cells have a critical role in the initiation and acceleration of autoimmune diseases, especially those mediated byautoantibodies. In the peripheral lymphoid system, mature B cells are activated by self or/and foreign antigens andsignals from helper T cells for differentiating into either memory B cells or antibody-producing plasma cells.Accumulating evidence has shown that epigenetic regulations modulate somatic hypermutation and class switchDNA recombination during B-cell activation and differentiation. Any abnormalities in these complex regulatoryprocesses may contribute to aberrant antibody production, resulting in autoimmune pathogenesis such as systemiclupus erythematosus. Newly generated knowledge from advanced modern technologies such as next-generationsequencing, single-cell sequencing and DNA methylation sequencing has enabled us to better understand B-cellbiology and its role in autoimmune development. Thus this review aims to summarize current research progress inepigenetic modifications contributing to B-cell activation and differentiation, especially under autoimmuneconditions such as lupus, rheumatoid arthritis and type 1 diabetes.

关键词： autoimmunity B cell DNA methylation histone modification microRNA

New insights into the significance of the BCR repertoire in B-1 cell development and function

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Cellular & Molecular Immunology 2019年第9期16卷 772-773页

作者： Xiaohui Wang Cong Ye Xiang Lin kongyang ma Fan Xiao Lingli Dong Liwei Lu Department of Pathology and Shenzhen Institute of Research and Innovation The University of Hong KongHong KongChina Department of Rheumatology and Immunology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubeiChina

As an important player of innate immunity,B-1 cells have been characterized by natural antibody production and rapid immune response.Based on their expression or lack of CD5,B-1 cells are further separated into B-1a and B-1b subsets.1 Although extensive studies have demonstrated a pivotal role of conventional B cells in adaptive immunity,there is increasing evidence indicating the close associations of B-1a cells with self-reactivity,autoimmunity,infection,and even leukemia.2–4 Here,we describe recent advances that lead to a clearer understanding of B-1 cell development with a focus on new insights into the significance of the B-cell receptor(BCR)repertoire in B-1a cell biology and discuss the potential strategies for specific targeting of B-1a cells under pathological settings.

关键词： immunity insight function

IL-10-producing regulatory B cells restrain the T follicular helper cell response in primary Sjögren’s syndrome

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Cellular & Molecular Immunology 2019年第12期16卷 921-931页

作者： Xiang Lin Xiaohui Wang Fan Xiao kongyang ma Lixiong Liu Xiaoqi Wang Dong Xu Fei Wang Xiaofei Shi Dongzhou Liu Yan Zhao Liwei Lu Department of Pathology and Shenzhen Institute of Research and Innovation The University of Hong KongHong KongChina Department of Rheumatology and Immunology Second Clinical Medical College of Jinan UniversityShenzhen People’s HospitalShenzhenChina Department of Rheumatology Peking Union Medical College HospitalBeijingChina Department of Rheumatology The First Affiliated Hospital and College of Clinical MedicineHenan University of Science and TechnologyLuoyangChina

Increased numbers of T follicular helper(Tfh)cells have been implicated in the development of autoimmune diseases including primary Sjögren’s syndrome(pSS),but how the Tfh cell response is regulated during autoimmune pathogenesis remains largely unclear.Here,we first found negative correlations between IL-10^(+)regulatory B(Breg)cell numbers and Tfh cell responses and disease activity in patients with pSS and mice with experimental Sjögren’s syndrome(ESS).Moreover,we detected high expression of IL-10 receptor on Tfh cells and their precursors in both humans and mice.In culture,IL-10 suppressed human and murine Tfh cell differentiation by promoting STAT5 phosphorylation.By using an adoptive transfer approach and two-photon live imaging,we found significantly increased numbers of Tfh cells with enhanced T cell homing into B cell follicles in the draining cervical lymph nodes of RAG-2−/−mice transferred with IL-10-deficient B cells during ESS development compared with those of RAG-2−/−mice transferred with wild-type B cells.In ESS mice,CD19^(+)CD1d^(hi)CD5^(+)Breg cells with decreased IL-10 production exhibited severely impaired suppressive effects on T cell proliferation.Consistently,CD19^(+)CD24^(+)CD38^(hi) Breg cells from pSS patients showed significantly reduced IL-10 production with defective inhibitory function in the suppression of autologous Tfh cell expansion.Furthermore,the adoptive transfer of IL-10-producing Breg cells markedly suppressed the Tfh cell response and ameliorated ESS progression in ESS mice.Together,these findings demonstrate a critical role for IL-10-producing Breg cells in restraining the effector Tfh cell response during pSS development.

关键词： Primary Sjögren’s syndrome T follicular helper cells Breg cells

基于海量遥感影像的高铁沿线建筑物隐患在线检测系统研究

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测绘与空间地理信息 2024年第1期47卷 50-53页

作者：马娇赵孔阳慎利西南交通大学高速铁路运营安全空间信息技术国家地方联合工程实验室四川成都611756

高速铁路沿线建筑物隐患检测对高铁运营安全至关重要。针对当前隐患排查作业中存在的检测周期长、检测效率低、检测结果共享性差等问题,本文基于海量遥感影像设计并研发了高铁沿线建筑物隐患在线检测系统。该系统首先基于GeoTrellis构... 详细信息

高速铁路沿线建筑物隐患检测对高铁运营安全至关重要。针对当前隐患排查作业中存在的检测周期长、检测效率低、检测结果共享性差等问题,本文基于海量遥感影像设计并研发了高铁沿线建筑物隐患在线检测系统。该系统首先基于GeoTrellis构建高铁沿线遥感影像与金字塔瓦片混合存储方案,实现对高铁沿线多尺度遥感影像分片式存储;其次在服务端嵌入基于ResNet101的深度学习算法搭建高铁沿线建筑物隐患智能检测服务,并为提高海量影像数据检测效率采用Spark多服务节点并行的计算策略加速模型预测;最后利用WebGL技术实时渲染高铁沿线大跨度复杂场景以及建筑物隐患检测结果。该系统实现了高铁沿线场景可视化与建筑物隐患在线检测交互一体化作业,对以建筑物隐患检测为重要内容的高铁安全监管工作具有重要参考意义。

关键词：高铁场景建筑隐患海量影像在线检测深度学习

IL-17 sustains the plasma cell response via p38-mediated Bcl-xL RNA stability in lupus pathogenesis

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Cellular & Molecular Immunology 2021年第7期18卷 1739-1750页

作者： kongyang ma Wenhan Du Fan Xiao man Han Enyu Huang Na Peng Yuan Tang Chong Deng Lixiong Liu Yulan Chen Jingjing Li Shiwen Yuan Qin Huang Xiaoping Hong Dajun Hu Xiaoyan Cai Quan Jiang Dongzhou Liu Liwei Lu Department of Pathology and Shenzhen Institute of Research and Innovation The University of Hong KongChongqing International Institute for ImmunologyHong KongChina Department of Rheumatology and Immunology Second Clinical Medical College of Jinan UniversityShenzhen People’s HospitalShenzhenChina Division of Rheumatology Guang’anmen HospitalChina Academy of Chinese Medical SciencesBeijingChina Department of Rheumatology and Nephrology the Second People’s HospitalChina Three Gorges UniversityYichangChina Department of Rheumatology Guangzhou First People’s HospitalSchool of MedicineSouth China University of TechnologyGuangzhouChina

Recent studies have demonstrated a central role for plasma cells in the development of autoimmune diseases,such as systemic lupus erythematosus(SLE).Currently,both the phenotypic features and functional regulation of autoreactive plasma cells during SLE pathogenesis remain largely unclear.In this study,we first found that a major subset of IL-17 receptor-expressing plasma cells potently produced anti-dsDNA IgG upon IL-17A(IL-17)stimulation in SLE patients and lupus mice.Using a humanized lupus mouse model,we showed that the transfer of Th17 cell-depleted PBMCs from lupus patients resulted in a significantly reduced plasma cell response and attenuated renal damage in recipient mice compared to the transfer of total SLE PBMCs.Moreover,long-term BrdU incorporation in lupus mice detected highly enriched long-lived BrdU+subsets among IL-17 receptor-expressing plasma cells.Lupus mice deficient in IL-17 or IL-17 receptor C(IL-17RC)exhibited a diminished plasma cell response and reduced autoantibody production with attenuated renal damage,while the adoptive transfer of Th17 cells triggered the plasma cell response and renal damage in IL-17-deficient lupus mice.In reconstituted chimeric mice,IL-17RC deficiency resulted in severely impaired plasma cell generation but showed no obvious effect on germinal center B cells.Further mechanistic studies revealed that IL-17 significantly promoted plasma cell survival via p38-mediated Bcl-xL transcript stabilization.Together,our findings identified a novel function of IL-17 in enhancing plasma cell survival for autoantibody production in lupus pathogenesis,which may provide new therapeutic strategies for the treatment of SLE.

关键词： Systemic lupus erythematosus(SLE) Plasma cell(PC) Autoantibody Interleukin-17A(IL-17)

内蒙古达茂旗东北部比旗格淖复式岩体的形成年龄、地球化学特征及成因

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地质论评 2024年第1期70卷 207-227页

作者：张建超朱孔阳杨波苏美霞许立权周飞董传万沈忠悦吴艳君孟晓玲佘琳琳浙江大学地球科学学院浙江省地学大数据与地球深部资源重点实验室杭州310058 内蒙古自治区地质调查研究院呼和浩特010020

达茂旗东北部比旗格淖复式岩体位于内蒙古中部,该岩体由两期侵入体组成,岩性分别为花岗闪长岩和二长花岗岩,前者为岩体主体岩性。主体花岗闪长岩主要由斜长石(An=14~30)、石英、钾长石和普通角闪石组成,内部发育暗色微粒包体;补体二长... 详细信息

达茂旗东北部比旗格淖复式岩体位于内蒙古中部,该岩体由两期侵入体组成,岩性分别为花岗闪长岩和二长花岗岩,前者为岩体主体岩性。主体花岗闪长岩主要由斜长石(An=14~30)、石英、钾长石和普通角闪石组成,内部发育暗色微粒包体;补体二长花岗岩主要由石英、钾长石和斜长石(An=12~23)组成。LA-ICPMS锆石U-Pb定年显示岩体形成于晚二叠世,形成年龄为259±2 ma。主体花岗闪长岩SiO_(2)=66.37%-68.70%、为准铝质—弱过铝质(A/CNK=0.99~1.01),地球化学上显示出富集轻稀土、大离子亲石元素,亏损重稀土和高场强元素的特征,属于I型花岗岩;其中闪长质暗色微粒包体呈浑圆状或拉长扁平透镜状,年龄与寄主花岗闪长岩一致,为岩浆混合的产物;补体二长花岗岩,高硅(SiO_(2)=71.51%~73.09%)、富碱(Na_(2)O+K_(2)O=7.91%~8.61%),为弱过铝质—强过铝质(A/CNK=1.07~1.11),属分异I型花岗岩。比旗格淖复式岩体锆石εHf(t)分布范围为-3.0~3.4,对应的Hf同位素二阶段模式年龄为1473~1057 ma。具有相对较低的[n(87Sr)/n(86Sr)]i值(0.704829~0.705327),εNd(t)值为-5.85~-8.86,对应的Nd的二阶段模式年龄为1.69~1.45 Ga。结合区域研究资料,认为比旗格淖复式岩体为亏损地幔组分与受其诱发的部分熔融的古老地壳物质混合形成,属于后碰撞型花岗岩,这类岩体的形成标志了古亚洲洋在兴蒙造山带南缘的闭合,并发生造山后伸展作用。

关键词：兴蒙造山带达茂旗比旗格淖复式岩体锆石U-Pb定年锆石Hf同位素 Sr—Nd同位素后碰撞

浙北富阳地区新元古代骆家门组沉积时限的厘定

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岩石学报 2022年第4期38卷 1189-1201页

作者：姚卫华蔡小碧孙大亥龙香月朱孔阳李献华中山大学地球科学与工程学院广州510275 广东省地球动力作用与地质灾害重点实验室广州510275 浙江省地质调查院杭州311203 浙江大学地球科学学院杭州310027 中国科学院地质与地球物理研究所岩石圈演化国家重点实验室北京100029

中-新元古代四堡造山运动将扬子地块和华夏地块拼合成一个完整的华南板块。四堡造山运动结束后,位于华南板块东北部的浙北分区沉积了一套新元古代骆家门组地层,其底部以砾岩和砂质砾岩为特色,且以角度不整合直接覆盖于四堡造山单元双溪... 详细信息

中-新元古代四堡造山运动将扬子地块和华夏地块拼合成一个完整的华南板块。四堡造山运动结束后,位于华南板块东北部的浙北分区沉积了一套新元古代骆家门组地层,其底部以砾岩和砂质砾岩为特色,且以角度不整合直接覆盖于四堡造山单元双溪坞群之上。骆家门组地层的精确沉积时限对了解四堡造山结束后华南板块新一轮沉积盆地的形成和发展具有重要意义。本文对采自浙北富阳地区骆家门组底和顶部的两件沉凝灰岩样品进行SIMS锆石U-Pb定年工作,并据此分析骆家门组的起始沉积时间略早于845ma,终止沉积时间略晚于830ma。综合前人研究,我们认为浙北分区保存了华南板块新一轮沉积盆地(南华盆地)的早期沉积活动信息,骆家门组的初始沉积时限指示了南华盆地的开启时间略早于845ma。

关键词：浙北新元古代骆家门组沉凝灰岩锆石U-Pb年代学