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2008北京国际生理科学学术大会

作者： kondo fumio KOIDE Tatsuro ISHIKAWA Naohisa Department of Pharmacology Aichi Medical University School of MedicineNagakuteAichi-gunAichi-PrefectureJapan Health Reserch Center Aichi Gakuin UniversityNagoyaAichi-PrefectureJapan

＜正＞Naofen（GenBank ID:EF613262）,a novel WD40-repeat-domain（WRD）containing protein,has recently been cloned from cDNA library of rat’s brain/spinal cord using anti-shigatoxin 2（STX2）*** containing proteins have a wide variety of functions including signal transductions,apoptosis,cell proliferation,and many are involved in coordinating protein-protein interactions in large multiprotein *** STX2 induces apoptosis in *** the present study,we evaluated the participation of naofen in apoptosis of HEK293 cells and further the roles of naofen in tumor necrosis factor alpha（TNF-α）-induced *** results showed that:（1）Naofen is ubiquitously distributed throughout the body of rat,with a maximal concentration in testis.（2） The transfection with an empty plasmid as control did not alter the caspase activities,whereas full-length naofen transfection increased them:Caspase-8 and -9 activities increased at 12 h after naofen transfection,reached maximum at 36 h and then ***-3 activities also increased from 24 h and continued till 72 h.（3）Clones of HEK293,which stably expressed naofen,also continuously elicited high caspase-3 activities.（4）Treatment with TNF-αor dexomethasone,both apoptosis inducers,significantly increased naofen mRNA expressions in a concentration -dependent manner.（5）In the clones,TNF-αincreased the caspase-3 activities to a much greater *** addition,higher susceptibility to cells was demonstrated with a flowcytometry utilizing the fluorescent labeled annexin V as a *** conclude that naofen is an important cytosolic protein,playing a principal role in cell apoptosis via promoting the caspase-3 activities,and that naofen may mediate the caspase-activation in the TNF-α-induced apoptosis.

关键词： naofen caspase-3 apoptosis TNF-α

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Determination of bisphenol A and 4-nonylphenol in media samples for <i>in vitro</i>fertilization by high-performance liquid chromatography with tandem mass spectrometry

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Natural Science 2013年第5期5卷 541-548页

作者： Rie Ishii Satoshi Takatori Kazuhiko Akutsu fumio kondo Hiroyuki Nakazawa Tsunehisa Makino Department of Analytical Chemistry Hoshi University Tokyo Japan Division of Food Chemistry Osaka Prefectural Institute of Public Health Osaka Japan Division of Pharmacology Aichi Medical University Aichi Japan Division of Water and Food Saitama Prefectural Institute of Public Health Saitama Japan Tobu Hospital Shizuoka Japan *Corresponding Author

In vitro fertilization (IVF) is an important treatment for infertility, and in recent years, the delivery rate in IVF has increased markedly with the progress of reproductive medicine. However, chemical contaminants in IVF media have not been fully studied. A simple method using highperformance liquid chromatography coupled with tandem mass spectrometry was therefore investigated for quantitation of bisphenol A (BPA), 4nonylphenol (NP) and 4-n-nonylphenol (n-NP) in IVF media. Media samples were processed using the solid-phase extraction method. The quantitation limits of BPA, NP, and n-NP were 0.5, 5 and 0.5 ng·ml-1, respectively, and the recoveries for BPA, NP and n-NP added to the media samples were above 90%. Commercially available media samples for IVF including 15 media for incubation of ova, 9 sperm washing media (SWM), 4 human serum albumin (HSA) samples and 2 substitute serum (SS) samples were examined, with 2 lots for each sample. NP was detected in 3 media for incubation of ova, 12 SWM, 7 HSA samples and 4 SS samples, in ranges of 6.3 14.5, 5.3 21.7, 5.5 164.0 and 9.0 19.0 ng·ml-1, respectively. BPA and n-NP were not detected in any of the samples.

关键词： Nonylphenol Bisphenol A Media for in vitro Fertilization LC-MS/MS Human Serum

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电动机驱动装置中采用微机的速度最优控制系统

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现代雷达 1983年第6期 131-138页

作者：申彭建

本文介绍电动机驱动装置中一种采用微处理机的时间最优的速度控制系统。推荐了两种补偿微处理机数据处理时间的控制方法,这是用状态量反馈技术实现最少拍特性所必须的。对这两种方法都做了实验和数字模拟。文中还讨论了系统的稳定性和... 详细信息

本文介绍电动机驱动装置中一种采用微处理机的时间最优的速度控制系统。推荐了两种补偿微处理机数据处理时间的控制方法,这是用状态量反馈技术实现最少拍特性所必须的。对这两种方法都做了实验和数字模拟。文中还讨论了系统的稳定性和精度。

关键词：观察器微处理机方框图速度检测电动机驱动装置直流电动机直流电机增益常数阶跃响应采样周期采样间隔

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通过测量电力输入预测磨料/工件界面的条件变化(英文)

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材料与冶金学报 2011年第1期10卷 70-75页

作者：山本和近藤康雄上原一刚小幡文雄日本鸟取大学 Tottori University Tottori 680-8552Japan

A monitoring system is proposed in order to detect the condition changes at abrasive/workpiece interface in abrasive cutoff *** system can detect the condition changes from the electric power change consumed by the driving motor of lapping *** electric power is strongly related with the abrasive *** the abrasive effectiveness has been kept a normal state,the electric power also has been kept a constant *** bodily removal of abrasive leads to reduce the electric power *** piling up of cutting chips leads to a peculiar electric power change;the electric power increased gradually at the beginning and then began to fluctuate *** severe adhesion of cutting chips to the cutting edges leads to the loss of nominal function in the cutting edges and the electric power input was thus descended suddenly at an early stage of lapping.

关键词： flat lapping condition change abrasive/worlpiece interface electric power AISI304 A5052 Inconel713

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An Earth-mass planet in a time of COVID-19:KMT-2020-BLG-0414Lb

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Research in Astronomy and Astrophysics 2021年第9期21卷 243-261页

作者： Weicheng Zang Cheongho Han Iona kondo Jennifer C.Yee Chung-Uk Lee Andrew Gould Shude Mao Leandro de Almeida Yossi Shvartzvald Xiangyu Zhang Michael D.Albrow Sun-Ju Chung Kyu-Ha Hwang Youn Kil Jung Yoon-Hyun Ryu In-Gu Shin Sang-Mok Cha Dong-Jin Kim Hyoun-Woo Kim Seung-Lee Kim Dong-Joo Lee Yongseok Lee Byeong-Gon Park Richard W.Pogge John Drummond Thiam-Guan Tan JoséDias do Nascimento Júnior Dan Maoz Matthew T.Penny Wei Zhu Ian A.Bond fumio Abe Richard Barry David P.Bennett Aparna Bhattacharya Martin Donachie Hirosane Fujii Akihiko Fukui Yuki Hirao Yoshitaka Itow Rintaro Kirikawa Naoki Koshimoto Man Cheung Alex Li Yutaka Matsubara Yasushi Muraki Shota Miyazaki Greg Olmschenk Clément Ranc Nicholas J.Rattenbury Yuki Satoh Hikaru Shoji Stela Ishitani Silva Takahiro Sumi Daisuke Suzuki Yuzuru Tanaka Paul J.Tristram Tsubasa Yamawaki Atsunori Yonehara Andreea Petric Todd Burdullis Pascal Fouqué Department of Astronomy Tsinghua UniversityBeijing 100084China Department of Physics Chungbuk National UniversityCheongju 28644Republic of Korea Department of Earth and Space Science Graduate School of ScienceOsaka UniversityToyonakaOsaka 560-0043Japan Center for Astrophysics j Harvard&Smithsonian 60 Garden St.CambridgeMA 02138USA Korea Astronomy and Space Science Institute Daejon 34055Republic of Korea University of Science and Technology Korea(UST)217 Gajeong-ro Yuseong-guDaejeon 34113Republic of Korea Max-Planck-Institute for Astronomy Königstuhl 1769117 HeidelbergGermany Department of Astronomy Ohio State University140 W.18th Ave.ColumbusOH 43210USA National Astronomical Observatories Chinese Academy of SciencesBeijing 100101China Universidade Federal do Rio Grande do Norte(UFRN) Departamento de F´1sica59078-970NatalRNBrazil Department of Particle Physics and Astrophysics Weizmann Institute of ScienceRehovot 76100Israel University of Canterbury Department of Physics and AstronomyPrivate Bag 4800Christchurch 8020New Zealand School of Space Research Kyung Hee UniversityYonginKyeonggi 17104Republic of Korea Possum Observatory PatutahiGisbourneNew Zealand Perth Exoplanet Survey Telescope PerthAustralia School of Physics and Astronomy Tel-Aviv UniversityTel-Aviv 6997801Israel Department of Physics and Astronomy Louisiana State UniversityBaton RougeLA 70803 USA Canadian Institute for Theoretical Astrophysics University of Toronto60 St George StreetTorontoON M5S 3H8Canada Institute of Natural and Mathematical Sciences Massey UniversityAuckland 0745New Zealand Institute for Space-Earth Environmental Research Nagoya UniversityNagoya 464-8601Japan Code 667 NASA Goddard Space Flight CenterGreenbeltMD 20771USA Department of Astronomy University of MarylandCollege ParkMD 20742USA Department of Physics University of AucklandPrivate Bag 92019AucklandNew Zealand Department of Earth and Planetary Science Graduate School of ScienceThe University of Tokyo7-3-1 Hongo

We report the discovery of KMT-2020-BLG-0414 Lb,with a planet-to-host mass ratio q2=0.9-1.2×10-5=3-4 q⊕at 1σ,which is the lowest mass-ratio microlensing planet to *** with two other recent discoveries(4?q/q⊕?6),it fills out the previous empty sector at the bottom of the triangular(log s,log q)diagram,where s is the planet-host separation in units of the angular Einstein radiusθ***,these discoveries call into question the existence,or at least the strength,of the break in the mass-ratio function that was previously suggested to account for the paucity of very low-q *** to the extreme magnification of the event,Amax~1450 for the underlying single-lens event,its light curve revealed a second companion with q3~0.05 and|log s3|~1,i.e.,a factor~10 closer to or farther from the host in *** measurements of the microlens parallaxπE and the angular Einstein radiusθE allow estimates of the host,planet and second companion masses,(M1,M2,M3)~(0.3 M⊙,1.0 M⊕,17 MJ),the planet and second companion projected separations,(a⊥,2,a⊥,3)~(1.5,0.15 or 15)au,and system distance DL~1 *** lens could account for most or all of the blended light(I~19.3)and so can be studied immediately with high-resolution photometric and spectroscopic observations that can further clarify the nature of the *** planet was found as part of a new program of high-cadence follow-up observations of high-magnification *** detection of this planet,despite the considerable difficulties imposed by COVID-19(two KMT sites and OGLE were shut down),illustrates the potential utility of this program.

关键词： gravitational lensing:micro

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