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Chinese Chemical Letters 2001年第1期12卷 1-4页

作者： Yang J.S. kondo k. Murak.mi Y. Dept. of Chem. of Med. Nat. Products School of Pharmacy W. China Univ. of Medical Sciences Chengdu 610041 China School of Pharmaceutical Sciences Toho University Miyama 2-2-1 Funabashi Chiba 274 Japan

First application of optically active trans-1,2-Bis(2-aminophenyl)cyclopentane 2 for asymmetric reaction, enantioselective N-acetylation of secondary alk.l amines, is described. This acetylation with tetraacetylated 3... 详细信息

关键词： First Application of Optically Active trans-1,2-Bis Enantioselective N-Acetylation of Secondary Alk.l Amines

External defects and severity level evaluation of potato using single and multispectral imaging in near infrared region Author link. open overlay panel

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Information Processing in Agriculture 2024年第1期11卷 80-90页

作者： Dimas Firmanda Al Riza Slamet Widodo k.zuya Yamamoto k.zunori Ninomiya Tetsuhito Suzuk. Yuichi Ogawa Naoshi kondo Laboratory of Biosensing Engineering Graduate School of AgricultureKyoto UniversityKitashirakawaKyoto 6068267Japan Department of Biosystems Engineering Faculty of Agricultural TechnologyUniversitas BrawijayaJl.VeteranMalang 65145Indonesia Department of Mechanical and Biosystem Engineering Bogor Agricultural UniversityJl.Raya Darmaga Kampus IPB DarmagaBogor 16680Indonesia Technology Development Department Shibuya Seiki Co.Ltd.66Takaoka-choMatsuyamaEhime 7918036Japan

Non-invasive potato defects detection has been demanded for sorting and grading *** on the classification of the defects has been available,however,investigation on the severity level calculation is *** the detection of the common scab,it has been found that imaging in the infrared region provide an interesting characteristic that could distinguish defected area to normal ***,investigations on this wavelength range is interesting to add more k.owledge and for *** this research,the multispectral image has been obtained and investigated especially at three wavelengths(950,1150,1600 nm).Image pre-processing and pseudo-color conversion techniques were explored to enhance the contrast between defects,normal back.round sk.n area and soil *** show that external defects,such as common scab and some mechanical damage types,appear brighter in the near infrared region,especially at 1600 nm against the normal sk.n *** has been found that pseudo-color images conversion provides more information regarding type if surface characteristics compared to grayscale single *** segmentation using pseudo-color images after multiplication operation pre-processing could be used for common scab and mechanical damage detection excluding soil deposits with a Dice Sorensen coefficient of *** addition,image segmentation using single image at 1600 nm shown relatively better results with Dice Sorensen coefficient of 0.72 with note that thick.soil deposits will also be *** severity level evaluation had an R2 correlation of 0.84 against standard measurements of severity.

关键词： Multispectral imaging Pseudo-color Common scab External defects Near infrared

Metrology for sub-Rayleigh-length target positioning in~10^(22)W/cm^(2)laser-plasma experiments

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High Power Laser Science and Engineering 2024年第3期12卷 90-105页

作者： E.A.Vishnyak.v A.Sagisak. k.Ogura T.Zh.Esirk.pov B.Gonzalez-Izquierdo C.D.Armstrong T.A.Pik.z S.A.Pik.z W.Yan T.M.Jeong S.Singh P.Hadjisolomou O.Fink. G.M.Grittani M.Nevrk.a C.M.Lazzarini A.Velyhan T.Hayak.wa Y.Fuk.da J.k.k.ga M.Ishino k.kondo Y.Miyasak. A.k.n M.Nishik.no Y.V.Nosach D.k.ik.luk.a I.P.Tsygvintsev D.k.mar J.Nejdl D.Margarone P.V.Sasorov S.Weber M.k.ndo H.k.riyama Y.k.to G.k.rn k.kondo S.V.Bulanov T.k.wachi A.S.Pirozhk.v ELI Beamlines Facility The Extreme Light Infrastructure ERICDolníBrežanyCzech Republic k.nsai Institute for Photon Science(k.SI) QSTKyotoJapan Central Laser Facility Rutherford Appleton LaboratorySTFCHarwell OxfordDidcotUK Institute for Open and Transdisciplinary Research Initiatives Osaka UniversityOsakaJapan HB11 Energy Holdings FreshwaterAustralia k.y Laboratory for Laser Plasmas(Ministry of Education) School of Physics and AstronomyShanghai Jiao Tong UniversityShanghaiChina Collaborative Innovation Center of IFSA Shanghai Jiao Tong UniversityShanghaiChina Institute of Plasma Physics ASCR PragueCzech Republic FZU-Institute of Physics ASCR PragueCzech Republic Czech Technical University in Prague FNSPEPragueCzech Republic Institute of Laser Engineering Osaka UniversityOsakaJapan Institute of Physics National Academy of Sciences of UkraineKyivUkraine ISTEQ AR YerevanArmenia

Tight focusing with very small f-numbers is necessary to achieve the highest at-focus ***,tight focusing imposes strong demands on precise target positioning in-focus to achieve the highest on-target irradiance We describe several near-infrared,visible,ultraviolet and soft and hard X-ray diagnostics employed in a~10^(22)W/cm^(2)laser±plasma *** used nearly 10 J total energy femtosecond laser pulses focused into an approximately1.3-μm focal spot on 5±20μm thick.stainless-steel *** discuss the applicability of these diagnostics to determine the best in-focus target position with approximately 5μm accuracy(i.e.,around half of the short Rayleigh length)and show that several diagnostics(in particular,3ωreflection and on-axis hard X-rays)can ensure this *** demonstrated target positioning within several micrometers from the focus,ensuring over 80%of the ideal peak.laser intensity *** approach is relatively fast(it requires 10±20 laser shots)and does not rely on the coincidence of low-power and high-power focal planes.

关键词： laser-plasma interaction precise target positioning spectroscopy ultra-high intensity X-rays

Transformed gastric mucosa-associated lymphoid tissue lymphoma originating in the colon and developing metachronously after Helicobacter pylori eradication:A case report

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World Journal of Gastrointestinal Oncology 2024年第10期16卷 4281-4288页

作者： Mak.to Saito Zen-Ichi Tanei Masumi Tsuda Toma Suzuk. Emi Yok.yama Minoru k.naya k.h Izumiyama Ak.o Mori Masanobu Moriok. Tak.shi kondo Blood Disorders Center Aiiku HospitalSapporo 064-0804HokkaidoJapan Department of Cancer Pathology Faculty of MedicineHokkaido UniversitySapporo 060-8638HokkaidoJapan

BACk.ROUND Helicobacter pylori(***)eradication treatment for primary gastric mucosaassociated lymphoid tissue(MALT)lymphoma has already been ***,t(11;18)(q21;q21)/API2-MALT1 translocation-positive lesions are a type of primary gastric MALT lymphoma in which a response to eradication treatment is difficult to *** addition,trisomy 18 may be associated with diffuse large B-cell lymphoma(DLBCL)transformation of gastric MALT *** SUMMARY A 66-year-old man was diagnosed with MALT lymphoma in the ascending colon by colonoscopy and *** years later,esophagogastroduodenoscopy revealed chronic atrophic gastritis that was positive for ***,and eradication treatment was *** years and nine months later(at the age of 70),a new ulcerative lesion suggestive of MALT lymphoma appeared in the gastric body,and six months later,a similar lesion was also found in the *** year later(4 years and 3 months after *** eradication),at the age of 72,the lesion in the gastric body had become deeper and had propagated.A biopsy revealed a pathological diagnosis of *** MALT lymphoma lesions in the ascending colon and DLBCL lesions in the stomach were positive for the t(11;18)(q21;q21)/API2-MALT1 translocation,and trisomy 18q21 was also *** 6 courses of R-CHOP(rituximab,cyclophosphamide,doxorubicin,vincristine and prednisone)chemotherapy,all of the above lesions disappeared[complete remission(CR)],and CR has been maintained for more than 3 *** addition,both the colonic and gastric lesions were proven to have the same *** Because the patient had a MALT1 translocation with trisomy 18q21,it was thought that this gastric MALT lymphoma developed independently of *** infection and progressed.

关键词： Gastric mucosa-associated lymphoid tissue lymphoma Transform Diffuse large B-cell lymphoma Colonic mucosa-associated lymphoid tissue lymphoma Helicobacter pylori eradication MALT1 translocation Case report

Evaluation of Spontaneous Fertility after Medical Treatment of Tubal Ectopic Pregnancy in Two Hospitals in the City of Yaounde

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Open Journal of Obstetrics and Gynecology 2024年第1期14卷 175-185页

作者： Noa Ndoua Claude Cyrille Tchedele Guidebta Hilary Nyada Serge Robert Astrid Ruth Ndolo kondo Ayissi Gregory Ngo Dingom Anne Madye Tompeen Isidore Faculty of Medicine and Biomedical Sciences of the University of Yaoundé I Yaounde Cameroon Faculty of Medicine and Pharmaceutical sciences of the University of Douala Douala Cameroon

Back.round: Ectopic pregnancy is a major cause of maternal morbidity and mortality, estimated to occur in 1% - 2% of pregnancies worldwide. This condition also has an adverse effect on the fertility prospects of women who experience it. Objective: To determine the outcomes of subsequent spontaneous fertility after medical treatment of patients with methotrexate (MTX) in patients with ectopic pregnancy at two university teaching hospitals of Yaounde. Methodology: We carried out a cross-sectional study with retrospective data collection in two university teaching hospitals of Yaounde during a six years period from 1st January 2015 to 31st May 2021. Seventy records of patients who had medical treatment for ectopic pregnancy were included in this study. Statistical analysis was performed using SPSS. 23. The Chi-2 statistical test was used to compare qualitative variables. Binary logistic regression method was performed to identify independent risk.factors associated with infertility after medical treatment of tubal ectopic pregnancy (TEP). The significance level was set at 0.05. Results: The mean age in our study population was 27.8 ± 3.8 years. According to the past medical history, 52.9% had a pelvic inflammatory disease (PID) and the most frequently germ found was C. trachomatis (47.1%). Almost 15% of our study population had previous surgery for EP. The median Fernandez score was 11 with a minimum score of 4 and a maximum score of 13. The route of administration of methotrexate was intramuscular in all our patients, and the single-dose protocol was used most frequently (58.6%). After medical treatment of the EP, we found a spontaneous conception rate of 58.6%. After multivariate analysis, we were unable to confirm that there was an association between a history of sexually transmitted infections (STIs) and fertility prognosis. Conclusion: The spontaneous fertility rate after medical management of EP was 58.6%, of which 73.2% were term pregnanci

关键词： Ectopic Pregnancy Maternal Morbidity

Current perspectives of viral

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World Journal of Gastroenterology 2024年第18期30卷 2402-2417页

作者： Daisuk. Usuda Yuk. k.neok. Rik.o Ono Masashi k.to Yuto Sugawara Runa Shimizu Tomotari Inami Eri Nak.jima Shiho Tsuge Rik. Sak.rai k.nji k.wai Shun Matsubara Risa Tanak. Mak.to Suzuk. Shintaro Shimozawa Yuta Hotchi Ippei Osugi Risa k.tou Sak.rak. Ito k.ntaro Mishima Ak.hik. kondo k.ik. Mizuno Hirok. Tak.mi Tak.yuk. k.matsu Tomohisa Nomura Manabu Sugita Department of Emergency and Critical Care Medicine Juntendo University Nerima HospitalNerima 177-8521TokyoJapan Department of Sports Medicine Faculty of MedicineJuntendo UniversityBunkyo 113-8421TokyoJapan

Viral hepatitis represents a major danger to public health,and is a globally leading cause of *** five liver-specific viruses:Hepatitis A virus,hepatitis B virus,hepatitis C virus,hepatitis D virus,and hepatitis E virus,each have their own unique epidemiology,structural biology,transmission,endemic patterns,risk.of liver complications,and response to antiviral *** remain few options for treatment,in spite of the increasing prevalence of viral-hepatitiscaused liver ***,chronic viral hepatitis is a leading worldwide cause of both liver-related morbidity and mortality,even though effective treatments are available that could reduce or prevent most patients’*** 2016,the World Health Organization released its plan to eliminate viral hepatitis as a public health threat by the year 2030,along with a discussion of current gaps and prospects for both regional and global eradication of viral ***,treatment is sufficiently able to prevent the disease from reaching advanced ***,future therapies must be extremely safe,and should ideally limit the period of treatment necessary.A better understanding of pathogenesis will prove beneficial in the development of potential treatment strategies targeting infections by viral *** review aims to summarize the current state of k.owledge on each type of viral hepatitis,together with major innovations.

关键词： Hepatitis A virus Hepatitis B virus Hepatitis C virus Hepatitis D virus Hepatitis E virus Current perspectives

Effects of Fresh Cupressus sempervirens Leaves Infusion on Growth Performance, Intestinal Microbiota and Haemato-Biochemical Parameters in Broilers

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Open Journal of Animal Sciences 2024年第2期14卷 70-87页

作者： Donfack.Mik.el Noumbissi Marie Noël Bertine Ciemeni Michelle Aimee Tindo Tsamene Romario Evelyn Ngwa Bih Djamen Tchantchou Chamberlin Nyembo kondo Camile Tsafong Jeatsa Frank.ain Necdem Tsafack.Boris k.na Jean Raphaël Animal Nutrition and Production Research Unit Department of Animal Sciences Faculty of Agronomy and Agricultural Sciences University of Dschang Dschang Cameroon Department of Animal Sciences and Plant Technology Faculty of Agronomic Sciences La Sapientia Catholic University of Goma Goma Democratic Republic of Congo

The accumulation of growth-promoting antibiotic residues in animal products and the resistance developed by bacteria in poultry farms has led to a search for natural compounds derived from plants. This study was designed to promote the production performance of broiler chick.ns using fresh Cupressus sempervirens leaves infusion. Fresh Cupressus sempervirens leaves were harvested, washed, chopped and ground to a paste using a blender and fermented for three days in a closed container at a rate of 500 g/L of water. The solution obtained was filtered and added at the rate of 2, 4, 6, 8 and 10 ml/L of drink.ng water. The chick.ns fed on the graded level of the solution were compared to a control ration without an additive and positive control group supplemented with 1 g antibiotic/k. feed. At the finisher phase and throughout the study period, water intak. increased significantly (P k. decreased significantly (P k.ng water. Live weight and weight gain were significantly (P 0.05) affected by the inclusion of Cupressus sempervirens infusion. Haematological parameters significantly (P k.ng water, with the exception of RBCs, MCHT and PCT. Serum content in total protein, globulins, LDL cholesterol and triglycerides were significantly (P k.ng water as compared to all other treatments. AST, ALT, urea, creatine, albumin, total cholesterol and HDL-cholesterol were not significantly affected. The lactic acid bacteria load increased significantly (P E. coli and salmonella counts decreased significantly (P < 0.05)

关键词： Broilers Cupressus sempervirens Growth Performance Haemato-Biochemical Parameters Intestinal Microbiota

Immunological role of sulfatide in the pathogenesis of multiple sclerosis

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Neural Regeneration Research 2023年第9期18卷 1950-1951页

作者： Mio Hamatani Tak.yuk. kondo Institute for the Advanced Study of Human Biology Kyoto UniversityKyotoJapan Department of Neurology Kansai Medical University Medical CenterMoriguchiJapan

Multiple sclerosis(MS) is a chronic inflammatory demyelinating disease of the central nervous system.A certain population of patients with MS present with a relapse-remitting disease course(RRMS) during the early phase and eventually advance to a progressive course(PMS).While immune modulation therapies have recently seen tremendous success in RRMS,our limited k.owledge of pathogenesis hampers the development of effective treatments for PMS.

关键词： pathogenesis sclerosis eventually

Hepatitis C infected patients need vitamin D3 supplementation in the era of direct acting antivirals treatment

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World Journal of Gastroenterology 2017年第8期23卷 1325-1327页

作者： Yasuteru kondo Department of Hepatology Sendai Kousei HospitalAobaSendai City 980MiyagiJapan

It has been reported that the serum level of vitamin D3(Vit D3) could affect the natural course of chronic hepatitis C(CH-C) and the response to treatment with pegylated interferon(Peg-IFN) and ribavirin. Although several mechanisms for the favorable effects of Vit D3 supplementation were reported, the total effect of Vit D3 supplementation remains unclear. Previously, we reported that supplementation with 1(OH)Vit D3 could enhance the Th1 response inducing not only a favorable immune response for viral eradication but also HCC control. Recently, the main treatment of CH-C should be direct acting antivirals(DAAs) without PegIFN. Peg-IFN is a strong immune-modulator. Therefore, an immunological analysis should be carried out to understand the effect of Vit D3 after treatment of DAAs without Peg-IFN. The induction of a favorable immune response by adding Vit D3 might be able to suppress the hepatocarcinogenesis after achieving SVR, especially in children and elderly patients with severe fibrosis lack.ng sufficient amounts of VitD 3.

关键词： Vitamin D Hepatitis C virus Direct acting antivirals Hepatocarcinogenesis Immune response

Metal-free catalytic reduction of aldehydes,k.tones,aldimines,and k.timines

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Chinese Chemical Letters 2010年第11期21卷 1314-1317页

作者： Hiroak. Matsuok. k.zuhiro kondo Graduate School of Medical Sciences Nagoya City University Graduate School of Pharmaceutical Sciences Nagoya City University

The metal-free combination of catalytic amounts of PPh3,B（C6F5）3,and PhSiH_3 can efficiently hydrosilylate aldehydes, k.tones,aldimines and k.timines to afford the corresponding reduction products in good yields.

关键词： Metal-free hydrosilylation Reduction k.tone k.timine