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Computational Chemistry 2022年第4期10卷 186-202页

作者： Yafigui Traoré Jean Missa Ehouman Mamadou Guy-Richard koné Donourou diabaté Nahossé Ziao Laboratory of Thermodynamics and Environmental Physico-Chemistry Nangui Abrogoua University Abidjan Ivory Coast Training and Research Unit Biological Sciences University Peleforo Gon Coulibaly Korhogo Ivory Coast Ivorian Research Group in Disease Modeling (GIR2M) Abidjan Ivory Coast

Anti-inflammatory activity of a series of tri-substituted pyrimidine derivatives was predicted using two Quantitative Structure-Activity Relationship models. These relationships were developed from molecular descriptors calculated using the DFT quantum chemistry method using the B3LYP/6-31G(d,p) level of theory and molecular lipophilicity. Thus, the four descriptors which are the dipole moment μD, the energy of the highest occupied molecular orbital EHOMO, the isotropic polarizability α and the ACD/logP lipophilicity were selected for this purpose. The Multiple Linear Regression (MLR) and Artificial Neural Network (ANN) models are respectively accredited with the following statistical indicators: R2=91.28%, R2aj=89.11%, RMCE = 0.2831, R2ext=86.50% and R2=98.22%, R2aj=97.75%, RMCE = 0.1131, R2ext=98.54%. The results obtained with the artificial neural network are better than those of the multiple linear regression. However, these results show that the two models developed have very good predictive performance of anti-inflammatory activity. These two models can therefore be used to predict anti-inflammatory activity of new similar pyrimidine derivatives.

关键词： Anti-Inflammatory Activity Multiple Linear Regression Artificial Neural Network QSAR

Primary Cerebral Lymphoma: About 22 Cases with Literature Review

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Journal of Cancer Therapy 2016年第7期7卷 500-504页

作者： Adama Diakité Aphou Salle koné Idrissa Mama Diarra koniba diabaté Tayeb Kebdani Noureddine Benjaafar Pole de Radiothérapie Institut National d’Oncologie CHU Ibn Sina Rabat Maroc

Primitive cerebral lymphoma (PCL) is a rare entity often poorly known. They are defined as extra nodal tumor interesting the CNS, brain and eye, and this in the absence of systemic lymphoma disease and brain metastases. The favoring factor is established immunosuppression which is explained by an increase in the incidence related to HIV. The basis of treatment is chemotherapy with consolidation radiotherapy. We report the experience of the National Institute of Oncology in Rabat in management of this disease.

关键词： Primitive Cerebral Lymphoma Chemotherapy Radiotherapy

Routine Screening for Cervical Cancer

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Open Journal of Obstetrics and Gynecology 2021年第7期11卷 922-928页

作者： Alassane Traoré Aphou Sallé koné Sima Mamadou Amadou Bocoum Mamadou Bakary Coulibaly kon.nba diabaté Adama Diakité Kanté Ibrahim Seydou Mariko Idrissa Mama Diarra Service de gynécologie H&ocirc pital du Mali Bamako Mali Service de radiothérapie H&ocirc pital du Mali Bamako Mali Service de gynécologie-obstétrique Centre hospitalier et universitaire du Point G Bamako Mali Service de gynécologie-obstétrique Centre hospitalier et universitaire Gabriel Touré Bamako Mali

Objective: To describe the screening for uterine cancer by visual methods. Method: We conducted a prospective and descriptive study over a period of 12 months from January to December 2020. Direct observation of providers and interview of patients were performed for data collection. Results: Out of 3400 patients, 1024 were enrolled for the study, or 30.11%. The average age of the patients was 41 years with the extremes of 17 to 87 years. Women aged 40 to 45 were the most represented with 58.78%, (n = 602). Housewives 85.83% (n = 879), they had a primary education level in 71.09% of cases (n = 728), the vast majority were married 92.28% (n = 945). Multiparous represented 58.78% (n = 602) of the sample, nulliparous 18.26% (n = 187), women living in rural areas 30.17% (n = 309), in urban areas 69.82% (n = 715). The test was positive in 43 patients (4.19%) but squamocylindrical junction was not visible in 17% of cases. The preparation of acetic acid and lugol: good preparation in 100% of cases;

Hypofractionated Radiation Therapy for the Treatment of Breast Cancer: Experience of National Institute of Oncology, Rabat, Morocco

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Journal of Cancer Therapy 2016年第10期7卷 773-783页

作者： A. S. koné A. Diakité S. Ahid I. M. Diarra K. diabaté R. Abouqal Y. Cherrah N. Benjaafar Service de Radiothérapie Institut National d’Oncologie de Rabat Rabat Morocco Laboratoire de Pharmacologie & Toxicologie Faculté de Médecine et de pharmacie de Rabat Rabat Morocco Laboratoire de Biostatistique de Recherche Clinique et d’Epidémiologie Faculté de Médecine et de pharmacie de Rabat Rabat Morocco

Hypofractionated radiation therapy has proven effective on locoregional control and tolerance in the adjuvant treatment of breast cancer. The aim of this study is to compare the results of hypofractionated radiation therapy versus conventional radiation therapy in terms of local control and tolerance. It was a retrospective study of patients observations collected from January 2007 to December 2008 in Department of Radiation Therapy in Institut National d’Oncologie de Rabat. The treatment results were evaluated by the rate of locoregional recurrence, distant recurrence and research of late toxicities. Radiotherapy was delivered using the same technique in both groups, by gamma photons of cobalt 60 with an energy of 1.25 MeV. They were 2 groups: the first group treated with standard dose rate and the second group treated by hypofractionated radiation therapy. The mean age of the patients was 42.8 ± 6.9 years old in the standard group and 43.22 ± 7.2 years old in the hypofractionation group. We noted a predominance of infiltrating ductal carcinoma. The majority of patients were pT2, pN0 and pN1. The majority of patients had radical surgery and chemotherapy with anthracyclines in both groups. We noted a statistically significant difference in the irradiation of chest wall between the standard (89.2%) and hypofractionated group (70.3%), with p = 0.043. The median duration of radiation therapy was statistically different in both groups: 39 days in the standard and 23 days in the hypofractionated group (p 0.001). The local recurrences were statistically identical to 12 and 24 months (p = 0.999). Concerning toxicities, the frequency of adverse event was similar in both groups. Hypofractionated radiation therapy with a total dose of 42 Gy at 2.8 Gy per fraction in 5 fractions weekly is comparable to standard radiotherapy in terms of local control and tolerance and is therefore a very good alternative to standard treatment.

关键词： Hypofractionated Radiation Therapy Breast Cancer Local Control Tolerance

Epidemiological and Clinical Profile of Cervix Cancer at Bamako Radiotherapy Center

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Open Journal of Obstetrics and Gynecology 2019年第1期9卷 92-97页

作者： A. Diakité A. S. koné Y. L. Diallo K. diabaté I. M. Diarra M. Ndiaye M. A. Camara M. M. Traoré A. Traoré F. M. Sidibé S. Sidibé Radiotherapy Center H&ocirc pital du Mali Bamako Mali Service of Medicine and Endocrinology H&ocirc pital du Mali Bamako Mali Infirmary Hospital of Bamako Bamako Mali Service of Radiology H&ocirc pital du Mali Bamako Mali Service of Gynecology H&ocirc pital du Mali Bamako Mali Service of Hemato-Oncology CHU du Point G Bamako Mali Service of Radiology CHU du Point G Bamako Mali

Cervical cancer remains a major public health problem in Africa, particularly in Mali. The goal of this work was to investigate the epidemiological and clinical aspects of cervix cancer seen at the radiation therapy center. This was a descriptive study on the retrospective collection of data on patients found in the Radiation Therapy Centre of Bamako, for invasive cervical cancer be-tween April 2014 and April 2017. The average age of our population was 52 ± 12.5 years with extremes ranges from 18 to 95 years. The most represented age group was [50 - 65 years] with 44.2%. The predominant histological type was squamous carcinoma (CE) with 94.2%. Bleeding were found in almost all patients, most often associated with foul smelling hydrorrhea;80.3% of our patients were stage III and 12.9% of stage IV according to the IFGO classifi-cation. Cervix cancer remains a major public health problem in Mali. The di-agnosis is often late, therefore, resulting in late care and unfavorable progno-sis. Sensitization, vulgarization of vaccination and systematization of screen-ing could be helpful in the fight against this cancer.

关键词： Epidemiology Clinic Cervix Cancer