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Effects of insulin and pathway inhibitors on the PI3K-Akt- mTOR phosphorylation profile in acute myeloid leukemia cells

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Signal Transduction and Targeted Therapy 2019年第1期4卷 504-515页

作者： Ina Nepstad Kimberley Joanne Hatfield Ida Sofie Grønningsæter Elise Aasebø Maria Hernandez-Valladares Karen Marie Hagen Kristin Paulsen Rye Frode SBerven Frode Selheim Håkon Reikvam Øystein Bruserud Section for Hematology Department of Clinical ScienceUniversity of BergenBergenNorway Department of Immunology and Transfusion Medicine Haukeland University HospitalBergenNorway Department of Biomedicine Faculty of Medicine and DentistryUniversity of BergenJonas Lies vei 915009 BergenNorway Section for Hematology Department of MedicineHaukeland University HospitalBergenNorway

The phosphatidylinositol 3-kinase(PI3K)-Akt-mechanistic target of rapamycin(mTOR)pathway is constitutively activated in human acute myeloid leukemia(AML)cells and is regarded as a possible therapeutic *** is an agonist of this pathway and a growth factor for AML *** characterized the effect of insulin on the phosphorylation of 10 mediators in the main track of the PI3K-Akt-mTOR pathway in AML cells from 76 consecutive *** overall results showed that insulin significantly increased the phosphorylation of all investigated ***,insulin effects on the pathway activation profile varied among patients,and increased phosphorylation in all mediators was observed only in a minority of patients;in other patients,insulin had divergent *** gene expression profiling and proteomic/phosphoproteomic comparisons suggested that AML cells from these two patient subsets differed with regard to AML cell differentiation,transcriptional regulation,RNA metabolism,and cellular *** insulin-induced phosphorylation was associated with weakened antiproliferative effects of metabolic ***3K,Akt,and mTOR inhibitors also caused divergent effects on the overall pathway phosphorylation profile in the presence of insulin,although PI3K and Akt inhibition caused a general reduction in Akt pT308 and 4EBP1 pT36/pT45 *** Akt inhibition,the phosphorylation of upstream mediators was generally increased or *** contrast,mTOR inhibition reduced mTOR pS2448 and S6 pS244 phosphorylation but increased Akt pT308 *** conclusion,the effects of both insulin and PI3K-Akt-mTOR inhibitors differ between AML patient subsets,and differences in insulin responsiveness are associated with differential susceptibility to metabolic targeting.

关键词： metabolism myeloid mTOR

Multiple-patterning colloidal lithography-implemented scalable manufacturing of heat-tolerant titanium nitride broadband absorbers in the visible to near-infrared

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Microsystems & Nanoengineering 2021年第2期7卷 51-58页

作者： Dasol Lee Myeongcheol Go Minkyung Kim Junho Jang Chungryong Choi Jin kon Kim Junsuk Rho Department of Mechanical Engineering Pohang University of Science and Technology(POSTECH)Pohang37673Republic of Korea Department of Chemical Engineering Pohang University of Science and Technology(POSTECH)Pohang37673Republic of Korea National Institute of Nanomaterials Technology(NINT) Pohang37673Republic of Korea

Broadband perfect absorbers have been intensively researched for decades because of their near-perfect absorption optical property that can be applied to diverse applications. Unfortunately, achieving large-scale and heat-tolerant absorbers has been remained challenging work because of costly and time-consuming lithography methods and thermolability of materials, respectively. Here, we demonstrate a thermally robust titanium nitride broadband absorber with >95% absorption efficiency in the visible and near-infrared region (400–900 nm). A relatively large-scale (2.5 cm × 2.5 cm) absorber device is fabricated by using a fabrication technique of multiple-patterning colloidal lithography. The optical properties of the absorber are still maintained even after heating at the temperatures >600 ∘C. Such a large-scale, heat-tolerant, and broadband near-perfect absorber will provide further useful applications in solar thermophotovoltaics, stealth, and absorption controlling in high-temperature conditions.

关键词： absorber titanium absorption

神性与人性的对话——藏族和古希腊关于人类起源神话之比较

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西藏研究 2006年第3期 63-66页

作者：贡觉西藏大学文学院西藏拉萨850000

藏族和古希腊关于人类起源神话都反映了“神造人”的世界性母题,体现了早期先民们对自身起源之谜的大胆探索,充满了神奇瑰丽的想象和创造精神;另外,二者都揭示了劳动与人类产生之间的密切关系,透露出强烈的人本主义色彩。作为不同文化... 详细信息

藏族和古希腊关于人类起源神话都反映了“神造人”的世界性母题,体现了早期先民们对自身起源之谜的大胆探索,充满了神奇瑰丽的想象和创造精神;另外,二者都揭示了劳动与人类产生之间的密切关系,透露出强烈的人本主义色彩。作为不同文化的产物,藏族人类起源神话带有最素朴的唯物色彩,但已有后期佛教思想明显改造的痕迹,其“善”与“恶”对立统一的二元论思想构成了藏族文化哲学思维的基础;古希腊人类起源神话带有强烈的抗争精神,其精髓是西方“渎神”精神、悲剧精神的具体体现和升华。

关键词：人类起源神话人本主义二元论 “渎神”意识悲剧精神

Giant Aneurysmal Bone Cyst of the Right Femur about a Case

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Open Journal of Radiology 2023年第3期13卷 139-145页

作者： Cheick oumar Keïta Aboudramane konaté Yacouba Drissa Traoré Youssouf koné Abdoulaye koné Issa Diarra Ilias Guindo salia Coulibaly Mahamadou Diallo Siaka Sidibé Radiology Department Mohammed VI Perinatal Clinic Bamako Mali Radiology Department County Hospital of Sikasso Sikasso Mali Radiology Department CNAM Bamako Mali Radiology Department Jacques Boutard Hospital Center Saint Yrieix La Perche France Medical Imaging Department University Hospital of Point G Bamako Mali Medical Imaging Department University Hospital of Kati Kati Mali Medical Imaging Department Gabriel Touré University Hospital Bamako Mali

Aneurysmal bone cyst (ABC) is a rare bone tumor accounting for 1% - 4% of benign bone tumors. Its etiopathogenesis remains unknown. The main site is the metaphysis of the long bones. ABC occurs almost exclusively in young people, with a slight female predominance. We report an exceptional case of ABC of the femur with involvement of the right hip in a 16-year-old girl in the Medical Imaging Department of Pr Bocar Sidy sall Hospital of Kati (Mali). We will discuss the clinical and radiological aspects of this pathology. Observation: Mrs N C., aged 16, was referred to the orthopaedic-traumatology department for an X-ray of the right thigh, indicated as having a large, disabling thigh. Clinical examination revealed a large thigh measuring 890 mm in circumference, compared with 300 mm on the contralateral side. Radiographically, the femur showed a blown appearance, with the cortex thinned and broken in places. Exceptionally, the lesion affected the entire femur. On CT scan, we found a voluminous fluid collection occupying the entire right femur, including the right femoral head and homolateral ischium. The cortex was interrupted in places, and the adjacent soft tissues were thinned or laminated, but not infiltrated. Histology revealed haemorrhagic and inflammatory elements compatible with the diagnosis of ABC. Conclusion: ABC is a tumor entity that is often difficult to diagnose. Medical imaging, topographical distribution and histology form an indissociable whole to establish a diagnosis of certainty.

关键词： Aneurysmal Bone Cyst Medical Imaging Femur

Ear Cholesteatoma Surgery in South sahara: Our Experience in Bamako

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Severe Hepatic Sinusoidal Obstruction Syndrome during the Induction Chemotherapy of Burkitt’s Lymphoma

International Journal of Otolaryngology and Head & Neck Surgery（耳鼻喉） 2024年第4期 293页

作者： Kassim Diarra Oumou Coulibaly Yaya Dembele Nfaly konaté Sidibe Youssouf saydi Ag Mohamed Harouna sanogo Abraham Diarra Ibrahim Fofana Moussa Bourama Keita Youssouf Traore fatogoma Issa koné Boubacary Guindo Siaka Soumaoro Doumbia Kadidiatou Singare Mohamed Amadou Keita

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Open Journal of Blood Diseases 2018年第1期8卷 10-16页

作者： Line Couitchere Yao Nicaise Atiméré Daouda koné Delphine Lagou Paediatric Ward of University and Teaching Hospital of Treichville Abidjan C&ocirc te d’Ivoire Hematology Ward of University and Teaching Hospital of Treichville Abidjan C&ocirc te d’Ivoire Nephrology Ward of University and Teaching Hospital of Yopougon Abidjan C&ocirc te d’Ivoire

The Hepatic sinusoidal obstruction syndrome (HSOS), also known as veno-occlusive disease (VOD), is a well-known complication of haematopoietic stem cell transplantation, of the treatment of Wilms tumor and rhabdomyosarcoma and maintenance therapy of acute lymphoblastic leukemias. Its occurrence is rare in other cancers of the child. We report the observation of a 7-year-old girl with Burkitt’s lymphoma who developed a severe HSOS during her second induction treatment with dexamethasone, cisplatin, cytosine arabinoside. The evolution was fatal. This observation shows that the diagnosis of HSOS should not be excluded in the absence of the risk factors usually described.

关键词： Lymphoma Treatment Veno-Occlusive Disease Multi Organ failure

Study of a Kit of GSM Radio Operator Site for Event-Driven Movable Coverage: Application to the Deployment of a Site of the Orange Operator in Ivory Coast

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International Journal of Communications, Network and System Sciences 2011年第11期4卷 744-755页

作者： Sié Ouattara Georges Laussane Loum koné Adama Alain Clément 不详

The mobile communication is nowadays one of the basic needs of humanity. It is essential to the flourishing of human beings. Considering this reality, the need to use its mobile phone is become more important and diversified. The subscribers of the various mobile telephone operators are increasingly demanding. This situation poses the problems of the cover mobile network to the operators and leads them to opt for several solutions and investments. The mobile operators in order to satisfy their customers use a policy of pushing the limits of network coverage in time and space for festive moments in targeted zones. Thus, we have conducted a study on the topic: study of a kit of GSM radio site for event-driven movable coverage. This work is applied to GSM (Global system mobile) network of the operator Orange-Ci, leader of mobile telephony in Ivory Coast. We thus proceeded under investigation initially of the various aspects of the ordinary sites (motionless radio site) which are already deployed with Orange-Ci in order to impregnate us infrastructures and equipment used. This study revealed us that a radio site comprises 4 parts: infrastructures, installations and energy equipments, installations and radio equipments, and installations and equipment of transmission. After the first analysis, we made a study of the movable site. The study of the movable site enabled us to see the various possible solutions to fulfill the basic functions of a movable radio site. After analysis we retained that our radio site will be built on a truck on which a mast of 25 m maximum length for the antennas will be embarked, it will be fed by a generator also embarked on the truck and the solution of transmission selected is the transmission by satellite more precisely technology VsaT. We choose the various equipments (radio, transmission, energy) according to features which we defined to constitute the kit of movable radio site.

关键词： Movable GSM Radio Site Deployment Kit Movable Coverage Even-Driven Generator Battery

Traumatic Perforation of the Small Intestine in General Surgery of the CHU Gabriel Touré

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Surgical Science 2017年第9期8卷 414-421页

作者： Alhassane Traoré Bakary Tientigui Dembélé Ibrahima Diakité Adégné Togo Lassana Kanté Amadou Traoré Madiassa konaté Boubacar Karembé Abdoulaye Diarra Amadou Bah Boubacar Sidibé Tany koné Astan koné Nouténé koné Djibo Mahamane Diango Gangaly Diallo Department of General Surgery CHU Gabriel Touré Bamako Mali Department of Anesthesia and Intensive Care CHU Gabriel Touré Bamako Mali

Goal: To determine hospital frequency, to describe the clinical and therapeutic aspects and to determine the prognosis. Patients and Methods: This was a retrospective and prospective study carried out in the General Surgery Department from 1 January 1999 to 31 December 2015. Inclusion criteria: 1) open or closed trauma of the abdomen with perforation of the small bowel;2) clinical examination (abdominal pain, vomiting, fever, abdominal contracture, evisceration, intraoperative findings);3) paraclinical examinations: pneumoperitoneum on the abdominal X-ray without preparation (ASP) and CT scan. Exclusion Criteria: Abdominal trauma without perforation of the small bowel. We selected 128 patients operated for traumatic perforation of the small bowel. The data was entered and analyzed using Word, Excel 2007 and Statistical Package and Social Science Windows 16.0. The statistical analysis consisted in the calculation of the different frequencies of the variables studied. We used the Khi2 test with significance level P Results: We recorded 119 men versus 9 women and the sex ratio was 13.22. The mean age was 25 years with extremes varying between 15 and 70 years. The majority of patients 57.7% (74 cases) came from the capital, 46.1% (59 cases) were workers, 26.6% (34 cases) of the students. The average time to admission was 29 hours. The main etiologies were road traffic accidents 36.7% (47 cases), stabbing 21.9% (28 cases), firearm 14.8% (19 cases), and sports accidents 10.1% (13 cases). The main clinical signs were abdominal pain 48.44% (62 cases), abdominal contracture 60% (76 cases), disappearance of pre-liver dullness 66.36% (84 cases), and Douglas painful 74.4% (94 cases). The abdominal X-ray without preparation (A.S.P) allowed to objectify a pneumoperitoneum in 45.31% and the scanner a liquid effusion in 45.31% with the associated lesions in 37.5% (48 cases). The surgical treatment consisted of 60.15% suture excision (77 cases), 25% anastomosis resection (32 cases)

关键词： Abdominal Trauma Small Perforation Surgery Mali

Valorisation of Auriferous Indices: Case of the Siribaya Deposit, Western Mali

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Open Journal of Geology 2021年第10期11卷 457-470页

作者： Fodé Tounkara Jianguo Chen Mory Sidibe oumar Soumare Adama Youssouf koné Université de Ségou Ségou Mali State Key Laboratory of Geological Processes and Mineral Resources China University of Geosciences Wuhan China Ecole Nationale d’Ingènieurs Abderhamane Baba Touré Bamako Mali Laboratoire de Cartographie Département de Géologie Faculté des Sciences et Techniques (FST) Université des Sciences des Techniques et des Technologiques de Bamako (USTTB) Bamako Mali

The purpose of this paper is to understand the valorization of gold showings in the Seribaya deposit, western Mali. samples taken from Air Core (AC) boreholes were subjected respectively to the magnetic susceptibility test and the X-ray fluorescence analysis. These results lead to the development of a simple methodology, based on signatures/indicators geochemical to identify lithology or to locate mineralization. We note that, compared to other chemical elements, Arsenic remains the most correlated with gold in the study area. Since this correlation remains weak (r = 0.16), it shows that Arsenic does not always accompany gold. There would be a generation of Arsenic related to mineralization, and other generations that would not be. The observation of the strip logs led to the identification of the lithologies (focusing on the immobile elements, Ti, V, Cr, Y, Zr) and the establishment of the alteration profile. Highly altered levels (saprolite ± saprock) are characterized by the disappearance of most mobile elements. A medium to strong correlation between gold mineralization and magnetic susceptibility measurements has been observed, in some places, and at depths. These mineralized intervals typically consist of quartz veins, suggesting that they have structural control over the mineralization. Gold mineralization is believed to be related to quartz veins. In addition, gold would be in paragenesis with a generation of Arsenic hosted in coarse sediments.

关键词： Valorization Gold Index Strip Logs Magnetic Susceptibility