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Frequency of the C677T Polymorphism of MTHFR, G20210A of Prothrombin and R506Q of factor V Leiden in Type 2 Diabetics in Abidjan

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Open Journal of Genetics 2024年第1期14卷 13-25页

作者： N’Guessan-Blao Rebecca Yapo Vincent Yayo-Ayé Mireille Adjambri Eusèbe koné-koné fa.ouma.a.sa.a.ogo duni Hematology and General Biology Unit Faculty of Pharmaceutical and Biological Sciences Department of Biological Sciences Felix Houphouet-Boigny University Abidjan Ivory Coast Laboratory of Biology and Medical Research National Institute of Public Health (INSP) Abidjan Ivory Coast Molecular Biology Unit Center for Diagnosis and Research on AIDS and Other Infectious Diseases (CeDReS) Treichville University Hospital (CHU) Abidjan Ivory Coast

In Africa, the prevalence of diabetes is escalating and remains a concern due to the numerous complications it causes. Vascular damage associated with diabetes leads to a prothrombotic state observed in diabetic individuals. Diabetes is a complex and multifactorial disease involving genetic components. With the aim of preventing complications and contributing to an efficient management of diabetes, we investigated genes likely to lead to a risk of thrombosis, in particular the C677T of MTHFR, G20210A of prothrombin, and R506Q of factor V Leiden in type 2 diabetics in Abidjan receiving ambulatory care. A descriptive cross-sectional study was carried out on consenting type 2 diabetic patients. Mutation detection was carried out using the PCR-RFLP method employing restriction enzymes. Hemostasis tests (fibrinogen, D-dimers, fibrin monomers, and von Willebrand factor) were performed using citrate tubes on the Stage? Star Max automated system. Plasminogen activator inhibitor was assayed by ELIsa method, and biochemical parameters were determined using the COBAS C311. The study population consisted of 45 diabetic patients, 51.1% of whom presented vascular complications, mainly neuropathy. Disturbances in hemostasis parameters were observed, with 15.5% of patients showing an increase in fibrin monomers. Mutation analysis revealed an absence of factor V mutation (factor V Leiden) and of G20210A mutation of the prothrombin gene. However, 15.6% of subjects had a heterozygous C677T mutation of MTHFR, with 57% of them being anemic. The exploration of biological and genetic factors associated with thrombotic risk is of significant interest in the optimal management of African type 2 diabetics.

关键词： Type 2 Diabetes C677T of MTHFR G20210A factor V Leiden Thrombosis

Theoretical Study of Benzothiazole and Its Derivatives: Molecular Structure, Spectroscopic Properties, NBO, MEP and TD-DFT Analyses

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Journal of Materials Science and Chemical Engineering 2024年第3期12卷 31-50页

作者： konaté Abdoulaye Bédé Affoué Lucie Ouattara Lamoussa koné Soleymane Bamba Kafoumba Laboratory of Constitution and Reaction of Matter University Félix Houphou&#235t-Boigny Abidjan Ivory Coast Department of Marine Sciences University of San-Pedro San-Pedro Ivory Coast Laboratory of Thermodynamics and Physico-Chemistry of Environment University Nangui Abrogoua Abidjan Ivory Coast

Benzothiazole (BTH) and its derivatives are organic molecules with biologic actions. Because of their many applications, they are produced on a massive scale and used in a number of environmental compartments. Their discharge into water produces environmental problems, exposing our environment to public health problems. A solution that can contribute to their deterioration is becoming a necessity. For this reason, a conceptual analysis of the reactivity of benzothiazole and four of its compounds was undertaken in order to investigate certain aspects of their biodegradability. A theoretical investigations of the compounds studied were conducted in the gas and water phases with the most widely used density functional theory method, Becke-3-Parameter-Lee-Yang-Parr (B3LYP) with 6-31G+ (d, p) basis. Reactivity study calculated global indices of reactivity revealed that 2-SCH3_BTH is the most reactive. Dipole moment values analysis reveals that 2-NH2_BTH is the most soluble in water, while the lipophilicity shows that 2-NH2_BTH is the most hydrophilic compound. Thermodynamic parameters values reflect that reactions are respectively exothermic and spontaneous. By analyzing an Electrostatic Molecular Potential (EMP) map, researchers can pinpoint reactive sites on a molecule and anticipate its reactivity. This assessment is further enhanced by incorporating global and local reactivity descriptors. Additionally, an exploration of frontier molecular orbitals offers valuable insights into the molecule’s charge transfer characteristics. Moreover, a combined examination of internal and external molecular interactions unveils hyperconjugative interactions arising from charge delocalization, as elucidated through natural bond orbital (NBO) analysis.

关键词： Benzothiazole Reactivity DFT/B3LYP Stability TD-DFT

Habits on Social Networks at Workplace: A Survey of Motivations and Behaviour

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Open Journal of Applied Sciences 2024年第8期14卷 2154-2168页

作者： Thomas Kakou Kouassi Douatia koné Aliou Bamba Aladji Kamagaté Olivier Asseu Yvon Kermarrec Laboratoire des Sciences et Technologies de lInformation et de la Communication (LASTIC) Ecole Superieure Africaine des TIC (ESATIC) Abidjan Cte dIvoire Institut National Polytechnique Houphout Boigny (INPHB) Yamoussoukro Cte dIvoire Departement de Mathematiques Physique et Chimie Universit Plforo Gon Coulibaly (UPGC) Korhogo Cte dIvoire Agence Nationale de la Recherche (ANR) Paris France Laboratoire des Sciences et Techniques de linformation de la Communication et de la Connaissance (Lab-STICC) IMT Atlantique Brest France

This article explores the use of social networks by workers in Abidjan, Côte d’Ivoire, with particular emphasis on a descriptive or quantitative analysis aimed at understanding motivations and methods of use. More than five hundred and fifty questionnaires were distributed, highlighting workers’ preferred digital channels and platforms. The results indicate that the majority use social media through their mobile phones, with Whatsapp being the most popular app, followed by facebook and LinkedIn. The study reveals that workers use social media for entertainment purposes and to develop professional and social relationships, with 55% unable to live without social media at work for recreational activities. In addition, 35% spend on average 1 to 2 hours on social networks, mainly between 12 p.m. and 2 p.m. It also appears that 46% believe that social networks moderately improve their productivity. These findings can guide marketing strategies, training, technology development and government policies related to the use of social media in the workplace.

关键词： Social Network Social Media Applications Poisson’s Law Statistics Digital Supports Workers Productivity

Effect of Biofertilizers on the Agromorphological Parameters of Three Okra Cultivars in Southern Côte d’Ivoire

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Agricultural Sciences 2024年第4期15卷 408-422页

作者： Guinagui N’doua Bertrand Nomel Meless Patrice sanogo Souleymane Kouassi N’dri Pacôme Kouadio Edouard Yves Gilchrist Dao Jonas Patrick koné Dapah sara fatim koné Daouda fatogoma Sorho Plant Physiology and Pathology Teaching and Research Unit UFR Biosciences F&#233lix Houphou&#235t-Boigny University Abidjan C&#244te d&#8217Ivoire WASCAL Center/African Center of Excellence on Climate Change Biodiversity and Sustainable Agriculture (WASCAL/CEA-CCBAD) Abidjan C&#244te d&#8217Ivoire

Okra (Abelmoschus esculentus L.) is an herbaceous plant of the Malvaceae family. In Côte d’Ivoire, okra production is estimated to be over 193,000 tons. This low production is largely due to poor soils and hardly covers the needs of the population. To remedy this, growers systematically use mineral fertilizers. However, these fertilizers pollute the environment. To find an alternative to chemical fertilization and increase production, the effect of biofertilizers (Spaawet, Retone, Super Gro) compared with NPK mineral fertilizer was evaluated on Divo, Teriman, and Djonan F1 cultivars. The trial was set up in a factorial block design with three replications. Plant height, number of functional leaves, and crown diameter were assessed at 60 days after sowing (DAS). The time to 50% flowering, production time, and fruit yield were calculated. The results showed that the biofertilizer Retone induced the highest heights and number of functional leaves, with averages of 61.89 cm and 29.88 leaves, respectively. The diameter at the crown (17.77 mm) was highest with the NPK mineral fertilizer, and the shortest 50% flowering time, with an average of 47.61 days, was also obtained with the biofertilizer Retone. The NPK mineral fertilizer produced the longest production time, with an average of 35.25 days. The highest yields were obtained using Retone (11.07 t/ha) and NPK (9.52 t/ha) fertilizers. The “Divo*Retone” interaction produced the highest yield with an average of 12.19 t/ha. The biofertilizer Retone could therefore be used as an alternative fertilizer to chemical fertilization in okra crops, given its effect on the parameters assessed.

关键词： Biofertilizer Retone Mineral Fertilizer Okra Yield Côte d’Ivoire

Distribution, Mobility, and Health Risks Assessment of Trace Metals in River Sediments from Intense Agricultural Activity Areas in West Africa

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Journal of Materials Science and Chemical Engineering 2024年第8期12卷 12-42页

作者： Ahbeauriet Ahmed Ouattara Maley-Pacôme Soro Albert Brou Kouadio Horo koné Albert Trokourey Dpartment des Sciences et Technique Universit Alassane Ouattara Bouak Cte dIvoire Laboratoire de Thermodynamique et de Physico-Chimie du Milieu Universit Nangui Abrogoua Abidjan Cte dIvoire Laboratoire de Chimie Physique Universit Flix Houphout Boigny Abidjan Cte dIvoire

The economy of West African countries is mainly based on agriculture. However, the trace metal(loid)s contamination status in rivers is relatively unknown in the region. In this work, 45 surface sediments collected from the Bandama, Comoé, and Bia Rivers in south and south eastern Côte d’Ivoire (West Africa), were analyzed for total metal concentrations and chemical speciation. The results showed that the river sediments were considerably contaminated by Cd and moderately contaminated by As, Cu, Pb, and Zn. Significant spatial variations were observed among the stations but not between the rivers. Metals Cd and Cu were likely to cause more ecological risks. The speciation analysis unravelled that the metal(loid)s partitioned mainly in the residual fraction, with the potential mobile fraction varying from 14% to 28%. The study calls for establishment of strict policies relative to the application of fertilizers and agrochemicals and mining activities to protect the environment and human health risks.

关键词： River Sediment Trace Metal (Loid)s Multivariate Analysis Potential Ecological Risk Assessments Sequential Extraction Geochemical Indices

Duplication of the Urethra in Boys: A Case Report

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Open Journal of Urology 2024年第6期14卷 353-358页

作者： Mamadou Tidiani Coulibaly falaye Sissoko Moumine Diarra Adama Toutou Diallo Issa Amadou Amadou Berthé Sory koné CHU Gabriel Tour Urology Department Bamako University of Science Technology and Engineering Bamako Mali Lafiabougou Reference Health Center Bamako University of Science Technology and Engineering Bamako Mali CHU Gabriel Tour Pediatric Surgery Bamako University of Science Technology and Engineering Bamako Mali Korofina Reference Health Center Bamako University of Science Technology and Engineering Bamako Mali Segou Regional Hospital Bamako University of Science Technology and Engineering Bamako Mali

Supernumerary urethra in boys is a very rare anatomical entity. sagittal urethral duplications are classified into four groups: epispadias, hypospadias, fusiform and Y-shaped urethra. The most widely used classification is that of Effmann and Lebowitz, which describes 6 types, one of the rarest being the ‘Y’ subtype IIA2, which corresponds to a duplicated urethral path from the vesical neck to an ectopic perineal or anal outlet. We report here the case of a 4-year-old child presenting with subtype IIA2 with a perineal orifice and no other urinary disorders.

关键词： Duplicity Ureter Malformation

Frequency of the C677T Polymorphism of MTHFR, G20210A of Prothrombin and R506Q of factor V Leiden in Type 2 Diabetics in Abidjan

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Improvement of Rice Plant Root by Kaolin Application in Iron Toxicity Condition at Zoukougbeu (Central-West of Côte d’Ivoire)

Open Journal of Genetics（遗传学期刊） 2024年第1期 13页

作者： N’Guessan-Blao Rebecca Yapo Vincent Yayo-Ayé Mireille Adjambri Eusèbe koné-koné fa.ouma.a.sa.a.ogo duni

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Open Journal of Soil Science 2024年第5期14卷 308-318页

作者： Sehi Zokagon Sylvain konan Kouassi Urbain Adechina Olayossimi Ouattara Amidou Kouamé Firmin Bongoua Jeanne Devisme Cherif Mamadou Brahima koné Dé partement des Sciences et Techniques Universit&#233 Alassane Ouattara Bouak&#233 C&#244te d&#8217Ivoire Centre d’ Excellence Africain sur le Changement Climatique la Bidiversit&#233 et l&#8217Agriculture DurableUniversit&#233 F&#233lix Houphouet Boigny Abidjan C&#244te d&#8217Ivoire Dé partement Agriculture et Technologie Nouvelle Universit&#233 de San-Pedro San-Pedro C&#244te d'Ivoire Unité de Formation et de Recherche en Agroforesterie D&#233partement des Sciences de la Terre Universit&#233 Jean Lorougnon Gu&#233d&#233 de Daloa Daloa C&#244te d&#8217Ivoire Dé partement de Physiologie V&#233g&#233tale Universit&#233 Felix Houphouet Boigny Abidjan C&#244te d&#8217Ivoire Dé patartement des Sciences du sol Universit&#233 Felix Houphouet Boigny Abidjan C&#244te d&#8217Ivoire

In the tropics, lowland rice cultivation is often confronted with the problem of iron toxicity. The solution proposed by research in general is the use of industrial silicon. However, the high cost of industrial silicon limits its adoption by farmers. A study was carried out in Zakogbeu;Center-West of Côte d’Ivoire, to assess the potential of kaolin to mitigate the effect of this soil constraint on the root of the rice plant. Five kaolin-based treatments were analyzed (T0 = 0 kg kaolin ha−1, T1 = 366 kg kaolin ha−1, T2 = 736 kg kaolin ha−1, T3 = 1097 kg kaolin ha−1 and T4 = 1465 kg kaolin ha−1 are 0, 200, 400, 600 and 800 kg SiO2 ha−1) in a device in complete random blocks, with 5 repetitions. The results obtained show that kaolin supply increases the length of the root tissue as well as the number of branching of the root of the rice plant. Root tissue increased from 10 cm with T0 treatment to more than 15 cm with treatment T4. The microscopic observation of the roots shows that in the treatment T0, the roots present only primary ramifications and the tertiary and quaternary ramifications are observed with the treatments T3 and T4. The contribution of kaolin is an alternative to inhibit the effect of iron toxicity on the rice plant root development in iron toxicity condition.

关键词： Iron Toxicity Kaolin Root Rice Cote d’Ivoire

Therapeutic Profile and Prognostic factors of Patients Suffering from Upper Digestive Bleeding at Sikasso Regional Hospital

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Open Journal of Gastroenterology 2024年第9期14卷 300-312页

作者： oumar Traoré Abdoul salam Diarra Dramane Touré Tawfiq Abu Amadou Boubeye Maïga Kadiatou Cissé saïdon Touré Mohomedine Touré Aboudou Dolo Youana koné Madou Traoré Mamadou Togo Kalba Péliaba Mamadou samaké Hamadoun sangho Service of Internal Medicine Regional Hospital Sikasso Mali National Center for Scientific and Technological Research Bamako Mali Department of Pediatric Health Referral Center of Kalaban Coro Koulikoro Mali Private Practice for family and Emergency Medicine Casablanca Morocco Service of Nephrology Regional Hospital Sikasso Mali Department of Infectious Disease Regional Hospital Sikasso Mali Service de Mdecine Interne CHU Gabriel Tour Bamako Mali Service dHpato-Gastro-Entrologie CHU Gabriel Tour Bamako Mali Department of Public Health Faculty of Medicine and Odontostomatology University of Sciences Techniques and Technologies of Bamako Bamako Mali

Introduction: Upper digestive hemorrhage is one of the main digestive emergencies and remains a major cause of morbidity and mortality in Mali. The aim of this study was to describe the therapeutic profile and outcome of patients suffering from upper digestive haemorrhage. Methodology: This was a prospective study carried out in the internal medicine department of the Sikasso Regional Hospital from August 2022 to July 2023. All adult patients presenting with upper digestive haemorrhage and having given their consent, were included. Data were analyzed using SPSS version 21 software. Results: Sixty-three patients were enrolled. The mean age was 49.7 ± 18.99 years, with a male-female sex ratio of 2.2. Ruptured esophageal varices (37.5%) and peptic ulcer (25%) were the main etiologies. Pharmacological treatment was dominated by proton pump inhibitors (85.7%). Hemostasis endoscopy accounted for 3.17%. The evolution was marked by hemorrhagic arrest (69.84%), recurrence of hemorrhage (11.11%) and death (19.04%), the main cause of which was hemorrhagic shock (58.3%). We found no statistically significant relationship between prognosis and etiologies (P = 0.11), and length of hospital stay (P = 0.18). Conclusion: Hemostasis endoscopy remains a challenge for Sikasso Hospital. A holistic strategy of communication and community awareness-raising, combined with adequate technical facilities, will help to improve patient care and outcomes.

关键词： Digestive Hemorrhage Digestive Endoscopy Treatment Outcome