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Nimotuzumab with Concurrent Chemoradiation in Inoperable Locally Advanced Squamous Cell Carcinoma of Head and Neck: An Indian Experience

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Journal of Cancer Therapy 2018年第1期9卷 89-100页

作者： Ankur Bahl komal Singh Pragati Choudhary A. K. Anand Amal Roy Chaoudhoory Harit Chaturvedi Biswajyoti Hazarika Dilip Pawar Medical Oncology Max Super Specialty Hospital Saket New Delhi India Radiation Oncology Max Super Specialty Hospital Saket New Delhi India Surgical Oncology Max Super Specialty Hospital Saket New Delhi India Medical Affairs & Clinical Development Biocon Banglore India

Background: The prognosis of patients with Epidermal Growth Factor Receptor (EGFR) overexpression in inoperable Locally Advanced Squamous Cell Carcinoma of Head and Neck (LASCCHN) remains poor. Nimotuzumab is an Anti EGFR humanized monoclonal antibody approved for treatment of LASCCHN, with concurrent chemoradiation. Objective: To assess the efficacy and safety of nimotuzumab with concurrent chemoradiation in inoperable LASCCHN patients. Methodology: This is a single-centre, single arm, retrospective study evaluating 35 patients with histologically confirmed inoperable LASCCHN (stages III-IV). The patients were administered IV cisplatin 50 mg/m2 and IV nimotuzumab 200 mg for 6 - 7 weeks, along with radiotherapy of 6600 - 7000 cGy over 35 fractions. Patients were evaluated over response evaluation criteria in solid tumors (RECIST) criteria 12 weeks after the last cycle of chemotherapy. They were also followed up for overall survival and relapse free survival. Results: The median duration of follow-up was 20 months. The most common site of cancer was oropharynx (68.6%). One patient was lost to follow up. Objective Response Rate (ORR) was observed in 97% of the patients with 17 patients (48.6%) achieving complete response (CR) and 17 patients (48.6%) achieving partial response (PR). The median overall survival was 22.7 months (95% CI: 21.30, 34.27). The median relapse free survival was 16.7 months (95% CI: 9.80, 24.50). Nimotuzumab was safe and well tolerated with few mild, self-limiting adverse events. Conclusion: Nimotuzumab with chemoradiation is a safe and efficacious option in patients with LASCCHN. Larger studies are needed to verify the same.

关键词： Epidermal Growth Factor Receptor Chemoradiation Locally Advanced Squamous Cell Carcinoma of Head and Neck Humanised Monoclonal Antibody Nimotuzumab

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Latin America Lessons for Euro zone to Avoid Lost Decade

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China's Foreign Trade 2011年第2期 23-23页

作者： komal Sri-Kumar

Despite a €110bn bail-out programme that the European Union and the International Monetary Fund arranged in early May, Greek debt yields remain elevated. Ten-year Greek debt yielded around 11.5 percent on December 13,

关键词：拉丁美洲国际货币基金组织欧洲联盟收益率希腊

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Dual color optogenetic control of neural populations using low-noise,multishank optoelectrodes

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Microsystems & Nanoengineering 2018年第1期4卷 309-324页

作者： komal Kampasi Daniel F.English John Seymour Eran Stark Sam McKenzie Mihály Vöröslakos György Buzsáki Kensall D.Wise Euisik Yoon Department of Biomedical Engineering University of MichiganAnn ArborMI 48105USA Center for Micro and Nanotechnology Lawrence Livermore National LaboratoryLivermoreCA 94550USA NYU Neuroscience Institute School of MedicineEast River Science ParkAlexandria Center450 East 29th St9th FloorNew YorkNY 10016USA Department of Electrical Engineering and Computer Science University of MichiganAnn ArborMI 48105USA Department of Physiology and Pharmacology Sackler Faculty of MedicineTel Aviv University69978 Tel AvivIsrael Sagol School of Neuroscience Tel Aviv University69978 Tel AvivIsrael

Optogenetics allows for optical manipulation of neuronal activity and has been increasingly combined with intracellular and extracellular electrophysiological ***-identified classes of neurons are optically manipulated,though the versatility of optogenetics would be increased if independent control of distinct neural populations could be achieved on a sufficient spatial and temporal *** report a scalable multisite optoelectrode design that allows simultaneous optogenetic control of two spatially intermingled neuronal populations in *** describe the design,fabrication,and assembly of low-noise,multisite/multicolor *** shank of the four-shank assembly is monolithically integrated with 8 recording sites and a dualcolor waveguide mixer with a 7×30μm cross-section,coupled to 405 nm and 635 nm injection laser diodes(ILDs)via gradient-index(GRIN)lenses to meet optical and thermal design *** better understand noise on the recording channels generated during diode-based activation,we developed a lumped-circuit modeling approach for EMI coupling mechanisms and used it to limit artifacts to amplitudes under 100μV upto an optical output power of 450μ*** implanted the packaged devices into the CA1 pyramidal layer of awake mice,expressing Channelrhodopsin-2 in pyramidal cells and ChrimsonR in paravalbumin-expressing interneurons,and achieved optical excitation of each cell type using sub-mW *** highlight the potential use of this technology for functional dissection of neural circuits.

关键词： waveguide mixer neural

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NLRP3炎性小体在人食管鳞癌组织和细胞中的表达及意义

NLRP3炎性小体在人食管鳞癌组织和细胞中的表达及意义

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中国药理学会分析药理学专业委员会成立大会、第三届全国分析药理学学术大会暨贵州省药学会药学青年专业委员会成立大会

作者：于爽尹俭俭韩圣娜黄宁 Sumra komal 张莉蓉郑州大学基础医学院药理学系

目的:研究NLRP3炎性小体在食管鳞癌中的表达及其与临床特征的相关性,并探索NLRP3炎性小体对人食管鳞癌细胞增殖、侵袭能力的影响。方法:利用qPCR法、Western blot法、ELISA法及免疫组化检测食管鳞癌组织及细胞中NLRP3、ASC、Caspase-1和... 详细信息

目的:研究NLRP3炎性小体在食管鳞癌中的表达及其与临床特征的相关性,并探索NLRP3炎性小体对人食管鳞癌细胞增殖、侵袭能力的影响。方法:利用qPCR法、Western blot法、ELISA法及免疫组化检测食管鳞癌组织及细胞中NLRP3、ASC、Caspase-1和IL-1β的mRNA和蛋白质的表达水平;CCK-8、划痕实验、Transwell实验观察siRNA干扰和转入外源性NLRP3基因后对细胞增殖、迁移和侵袭的影响。结果:(1)组织标本中食管癌组的各炎性因子的mRNA高于癌旁组(P<0.05);与癌旁组相比,westernblot与ELISA结果显示各炎性因子的蛋白表达水平在食管癌组中明显升高(P<0.05)。(2)组织芯片结果中,NLRP3及其相关炎性因子在食管癌组中的阳性表达率明显高于癌旁组(P<0.05),且与肿瘤分期和淋巴结转移存在相关性(P<0.05)。(3)细胞水平结果显示,转入外源性的NLRP3显著增加了细胞的增殖、侵袭能力;干扰其表达后显著降低细胞的增殖、侵袭能力。结论:NLRP3炎性小体影响食管鳞癌发生、发展的过程,可能成为未来食管鳞癌治疗的靶点。

关键词：食管鳞状细胞(ESCC) NLRP3 炎性因子

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Epidemiology of dengue virus infections in Nepal, 2006-2019

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Infectious Diseases of Poverty 2021年第2期10卷 89-89页

作者： komal Raj Rijal Bipin Adhikari Bindu Ghimire Binod Dhungel Uttam Raj Pyakurel Prakash Shah Anup Bastola Binod Lekhak Megha Raj Banjara Basu Dev Pandey Daniel MParker Prakash Ghimire Central Department of Microbiology Tribhuvan UniversityKirtipurKathmanduNepal 不详

Background:Dengue is one of the newest emerging diseases in Nepal with increasing burden and geographic spread over the *** main objective of this study was to explore the epidemiological patterns of dengue since its ... 详细信息

关键词： Dengue DENV Aedes aegypti Outbreak Nepal Spatial epidemiology

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基于肿瘤代谢靶标的抗脑胶质瘤海洋天然活性物质的发现和研究

基于肿瘤代谢靶标的抗脑胶质瘤海洋天然活性物质的发现和研究

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第十二届海洋药物学术年会

作者：梁英陈璐叶雪威陈磊 komal Anjum 宋腾飞王文玲颜世伦连晓媛张治针浙江大学海洋学院浙江大学药学院

胶质瘤是最恶性的脑肿瘤,过度糖酵解、旺盛的谷氨酰胺分解和脂类合成以满足细胞快速无限制增殖是其代谢的突出特征。本研究以与胶质瘤细胞过度糖酵解密切相关的生物小分子葡萄糖和乳酸为靶标,从300多种海洋生物中筛选获得了36种显著抑... 详细信息

胶质瘤是最恶性的脑肿瘤,过度糖酵解、旺盛的谷氨酰胺分解和脂类合成以满足细胞快速无限制增殖是其代谢的突出特征。本研究以与胶质瘤细胞过度糖酵解密切相关的生物小分子葡萄糖和乳酸为靶标,从300多种海洋生物中筛选获得了36种显著抑制胶质瘤细胞增殖和影响肿瘤细胞代谢的活性海洋生物样品,并从其中的8个样品中分离鉴定了20多个具有抗胶质瘤活性的新化合物,进一步研究发现,多个化合物的抗胶质瘤活性与肿瘤细胞代谢的多个特异关键酶有关。

关键词：胶质瘤肿瘤代谢生物小分子肿瘤代谢特异关键酶海洋生物新抗胶质瘤活性物质

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基于肿瘤代谢靶标的抗脑胶质瘤海洋天然活性物质的发现和研究

基于肿瘤代谢靶标的抗脑胶质瘤海洋天然活性物质的发现和研究

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第十二届海洋药物学术年会

作者：张治针梁英陈璐叶雪威陈磊 komal Anjum 宋腾飞王文玲颜世伦虞斯然连晓媛浙江大学海洋学院浙江大学药学院

胶质瘤是最常见和死亡率极高的恶性脑肿瘤,多累及脑的重要功能区,手术难度大且难将肿瘤全部切除,所以,药物对胶质瘤的治疗就显得更为重要。但目前替莫唑胺是为数极少可单独用于胶质瘤治疗的一线化疗药,更没有天然来源的抗胶质瘤新药物... 详细信息

胶质瘤是最常见和死亡率极高的恶性脑肿瘤,多累及脑的重要功能区,手术难度大且难将肿瘤全部切除,所以,药物对胶质瘤的治疗就显得更为重要。但目前替莫唑胺是为数极少可单独用于胶质瘤治疗的一线化疗药,更没有天然来源的抗胶质瘤新药物。肿瘤细胞代谢重编程是肿瘤细胞代谢的重要特征,近十年来,肿瘤代谢机制的研究异常活跃,为抗肿瘤新药的研发开辟了新途径。众所周知:在正常细胞中,葡萄糖绝大部分在糖酵解环节降解成丙酮酸后进入三羧酸循环（TCAC）,在线粒体内氧化磷酸化产生能量物质ATP,少部分进入磷酸戊糖旁路（PPP）产生5-磷酸核糖及谷胱甘肽。而肿瘤细胞表现出与正常细胞不同的代谢特征,既大量葡萄糖经过度糖酵解产生的丙酮酸并非进入三羧酸循环,而是转化为大量的中间产物和终产物乳酸。研究证明:己糖激酶HK2、磷酸果糖激酶PFKFB3、丙酮酸激酶PKM2和乳酸脱氢酶LDH5是肿瘤细胞过度糖酵解所偏爱依赖的重要代谢酶,抑制这些代谢特异调控酶的活性可抑制肿瘤细胞的增殖。葡萄糖高消耗和大量乳酸生成是胶质瘤细胞过度糖酵解的重要特征,化合物对胶质瘤细胞糖酵解途径的葡萄糖消耗和乳酸生成的改变可反应其对肿瘤细胞糖代谢的影响。我们以与胶质瘤细胞代谢密切相关的生物小分子葡萄糖和乳酸为靶标,从海洋生物中筛选获得36种既有抑制胶质瘤细胞增殖又可影响肿瘤细胞葡萄糖消耗和乳酸生成的活性海洋生物样品,研究了其中8种活性样品的活性成分,发现了20多个具有良好抗胶质瘤活性的新化合物,并研究了这些新化合物对肿瘤代谢特异调控酶的影响,发现了数个化合物对胶质瘤细胞代谢特异酶具有显著的调控作用,显示其独特的抗肿瘤作用机制。

关键词：胶质瘤肿瘤代谢生物小分子肿瘤代谢特异酶海洋生物抗胶质瘤新化合物

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Correlation between the proportion of breast volume involved by locally advanced tumors and invasion of the skin and posterior structures

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World Journal of Clinical Oncology 2012年第3期3卷 43-47页

作者： Parastoo B Dahi komal P Dhiran Constantine A Axiotis Jeremy Weedon Mahmoud El-Tamer Gurinder Sidhu Albert S Braverman Division of Hematology/Oncology Department of Medicine Downstate Medical College of the State university of NY Brooklyn NY 11203 United States Division of Surgical Pathology Kings County Hospital Center Department of Pathology Downstate Medical College of the State University of NY Brooklyn NY 11203 United States Scientific Computing Center Downstate Medical College of the State university of NY Brooklyn NY 11203 United States Breast Surgery Service Memorial Sloan-Kettering Cancer Center New York NY 10065 United States

AIM: To evaluate any differences between the percentages of involved breast volume, pathologic attributes,and tumor marker expression of T3 and T4a-c tumors in locally advanced breast cancers(BC).METHODS: All patients with T3 N > 0 and T4a-c BC without evidence of distant metastasis(M0), presenting to the Breast Clinic from 1980 to 2010, were examinedto determine whether their BC's involved ≥ 50% of their breast volumes, defined by gross replacement of at least one hemisphere. Core needle biopsy or postmastectomy specimens from tumors involving a known percent of breast volume were evaluated for:(1)pathological grades and lympho-vascular invasion(LVI);(2) hormone receptor(ER/PR) expression > 0; and(3)epidermoid growth factor 2(her2) over-expression(3+)by immune-histochemical staining or fluorescent in situ ***: The data base included 98 patients with T3N> 0 M0 and 120 with T4a-c, any N disease, M0 disease. T3 tumor masses involved 50% or more of the breast in 23/98(24%), and T4a-c tumors 65/120(54%)(P < 0.001). Only 1% of T3 tumors and 23% of T4a-c tumors presented with total breast replacement. There were no significant differences between the pathological attributes and marker expression of the T3 and T4a-c ***: These data suggest that erosion of the overlying skin or underlying chest wall by some BC may be due to neglect and delay, rather than inherent biological aggressiveness.

关键词： Breast cancer Locally advanced breast cancer Breast cancer size

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