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Fulminant amebic colitis in a patient with concomitant cytomegalovirus infection after systemic steroid therapy:A case report

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World Journal of Clinical Cases 2021年第15期9卷 3726-3732页

作者： Naoki Shijubou Toshiyuki Sumi koki kamada Takeyuki Sawai Yuichi Yamada Tatsuru Ikeda HisashiNakata Yuji Mori Hirofumi Chiba Department of Respiratory Medicine Hakodate Goryoukaku HospitalHakodate 040-8611Japan Department of Respiratory Medicine and Allergology Sapporo Medical University School of MedicineSapporo 060-8556Japan Department of Pathology and Diagnosis Hakodate Goryoukaku HospitalHakodate 040-8611Japan

BACKGROUND Amebic colitis is an infection caused by Entamoeba histolytica and most commonly observed in regions with poor *** is also seen as a sexually transmitted disease in developed *** amebic colitis usually has a chronic course with repeated exacerbations and remissions,it may also manifest as a fulminant form that rapidly progresses and leads to severe,life-threatening complications,such as intestinal perforation,peritonitis,and sepsis,that have a high mortality *** SUMMARY A 68-year-old man was admitted to our hospital with chest pain and acute *** was diagnosed with acute coronary syndrome,acute heart failure,and bacterial *** respiratory condition worsened despite receiving intensive care and intravenous *** the fifth day of hospitalization,he was diagnosed with acute respiratory distress syndrome and was started on steroid *** subsequently developed bloody stools and was diagnosed with cytomegalovirus(CMV)enterocolitis based on biopsy results and a peripheral blood CMV pp65 antigenemia test *** we started antiviral therapy with ganciclovir,which was successful in reducing his antigen titers,he continued to have bloody *** weeks after initiation of ganciclovir therapy and six weeks after his admission,the patient died from intestinal *** only posthumously diagnosed him with amebic colitis and CMV enterocolitis based on autopsy findings of transmural necrosis of the entire colon with massive ameba *** We urge clinicians to consider Entamoeba histolytica infection if severe colitis progresses after steroid *** treatment is recommended then.

关键词： Amebiasis Intestinal Colitis Cytomegalovirus Glucocorticoids Perforation Case report

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Successful treatment of warfarin-induced skin necrosis using oral rivaroxaban: A case report

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World Journal of Clinical Cases 2019年第24期7卷 4285-4291页

作者： Momoka kamada Tsuneaki Kenzaka Department of Internal Medicine Hyogo Prefectural Tamba Medical CenterTamba 669-3395Japan Division of Community Medicine and Career Development Kobe University Graduate School of MedicineKobe 652-0032Japan

BACKGROUND Heparin is commonly recommended for warfarin-induced skin necrosis;however, there is currently no established therapy for this disease. We present a serious case of warfarin-induced skin necrosis that was successfully treated with oral rivaroxaban, a factor Xa *** SUMMARY A 48-year-old woman was admitted to the hospital for cellulitis of the right lower extremity. After antibiotic treatment, she developed pain and swelling of the left lower extremity, and deep vein thrombosis of both lower extremities was diagnosed. She was treated with a continuous heparin injection;subsequently,oral warfarin was concomitantly administered. Heparin was terminated after the therapeutic range was reached. On the following day, the patient had swelling and pain in the left lower extremity. In addition to decrease in protein S activity due to systemic lupus erythematosus, warfarin also reduced protein C activity,resulting in further hypercoagulation and skin necrosis. Warfarin was discontinued, and continuous heparin injection was resumed. Although the patient had to undergo amputation of the distal end of her left foot, continuous heparin injection was switched to oral rivaroxaban, and she was eventually discharged from the hospital in *** Administration of direct oral anticoagulants instead of warfarin is important in patients with decreased protein S and C activity.

关键词： Skin necrosis Warfarin Heparin Rivaroxaban Systemic lupus erythematosus Case report

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Study on Blade Surface Flow around Wind Turbine by Using LDV Measurements

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Journal of Thermal Science 2015年第2期24卷 131-139页

作者： Tinnapob Phengpom Yasunari kamada Takao Maeda Junsuke Murata Shogo Nishimura Tasuku Matsuno Division of System Engineering Mie University Division of Mechanical Engineering Mie University

This paper has attempted to study a mechanism of three-dimensional flow around a horizontal axis wind turbine(HAWT) rotor blade. An experimental study of the flow phenomenon in the vicinity of the wind turbine blade is a challenging endeavor. In this research, the HAWT model with 2.4 m diameter was tested in the large wind tunnel. The flow around the rotating blade surface was measured simultaneously for three velocity components, and two probes were used for the synchronized measurement of three-dimensional flow components. The local velocity was detected for the single seeding particle measured in the point where three pairs of laser beams intersected. Blade sections of interest in this study are composed of radial positions r/R = 0.3, 0.5 and 0.7. Optimum and low tip speed ratio flow characteristics were also compared. The velocity flow vector, skin friction coefficient and bound circulation were calculated from LDV measurements, and the experimental research showed reasonably and clearly the experimental results.

关键词： LDV measurement Sectional performance Wind turbine Boundary layer flow Span-wise flow

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Analysis of Aerodynamic Load on Straight-bladed Vertical Axis Wind Turbine

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Journal of Thermal Science 2014年第4期23卷 315-324页

作者： Qing’an LI Takao MAEDA Yasunari kamada Junsuke MURATA Toshiaki KAWABATA Kazuma FURUKAWA Division of System Engineering Mie University1577 Kurimamachiya-choTsuMie 514-8507JAPAN Division of Mechanical Engineering Mie University1577 Kurimamachiya-choTsuMie 514-8507JAPAN

This paper presents a wind tunnel experiment for the evaluation of energy performance and aerodynamic forces acting on a small straight-bladed vertical axis wind turbine(VAWT) depending on several values of tip speed ratio. In the present study, the wind turbine is a four-bladed VAWT. The test airfoil of blade is symmetry airfoil(NACA0021) with 32 pressure ports used for the pressure measurements on blade surface. Based on the pressure distributions which are acted on the surface of rotor blade measured during rotation by multiport pressure-scanner mounted on a hub, the power, tangential force, lift and drag coefficients which are obtained by pressure distribution are discussed as a function of azimuthally position. And then, the loads which are applied to the entire wind turbine are compared with the experiment data of pressure distribution. As a result, it is clarified that aerodynamic forces take maximum value when the blade is moving to upstream side, and become small and smooth at downstream side. The power and torque coefficients which are based on the pressure distribution are larger than that by torque meter.

关键词： Wind Turbine Wind Energy Straight-bladed VAWT Tip Speed Ratio Pressure Distribution

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A Straight-bladed Vertical Axis Wind Turbine with a Directed Guide Vane Row-Effect of Guide Vane Geometry on the Performance-

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Journal of Thermal Science 2009年第1期18卷 54-57页

作者： Manabu TAKAO Hideki KUMA Takao MAEDA Yasunari kamada Michiaki OKI Atsushi MINODA Department of Mechanical Engineering Matsue National College of Technology Department of Mechanical Engineering Mie University

The objective of this study is to show the effect of guide vane geometry on the performance. In order to overcome the disadvantages of vertical axis wind turbine, a straight-bladed vertical axis wind turbine （S-VAWT） with a directed guide vane row has been proposed and tested by the authors. According to previous studies, it was clarified that the performance of the turbine can be improved by means of the directed guide vane row. However, the guide vane geometry of S-VAWT has not been optimized so far. In order to clarify the effect of guide vanegeometry, the effects of setting angle and gap between rotor blade and guide vane on power coefticlent and start- ing characteristic were investigated in the experiments. The experimental study of the proposed wind turbine was carried out by a wind tunnel. The wind tunnel with a diameter of 1.8m is open jet type. The wind velocity is 8 m/s in the experiments. The rotor has three straight blades with a profile of NACA0018 and a chord length of 100 mm, a diameter of 0.6 m and a blade height of 0.7 m. The guide vane row consists of 3 arc plates.

关键词： fluid machinery wind energy vertical axis wind turbine guide vane

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Wind Tunnel Study on Wind and Turbulence Intensity Profiles in Wind Turbine Wake

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Journal of Thermal Science 2011年第2期20卷 127-132页

作者： Takao MAEDA Yasunari kamada Junsuke MURATA Sayaka YONEKURA Takafumi ITO Atsushi OKAWA Tetsuya KOGAKI Division of Mechanical Engineering Mie University National Institute of Advanced Industrial Science and Technology

In recent years, there has been a rapid development of the wind farms in Japan. It becomes very important to investigate the wind turbine arrangement in wind farm, in order that the wake of one wind turbine does not to interfere with the flow in other wind turbines. In such a case, in order to achieve the highest possible efficiency from the wind, and to install as many as possible wind turbines within a limited area, it becomes a necessity to study the mutual interference of the wake developed by wind turbines. However, there is no report related to the effect of the turbulence intensity of the external flow on the wake behind a wind turbine generated in the wind tunnel. In this paper, the measurement results of the averaged wind profile and turbulence intensity profile in the wake in the wind tunnel are shown when the turbulence intensity of the external wind was changed. The wind tunnel experiment is performed with 500mm-diameter two-bladed horizontal axis wind turbine and the wind velocity in wake is measured by an I-type hot wire probe. As a result, it is clarified that high turbulence intensities enable to the entrainment of the main flow and the wake and to recover quickly the velocity in the wake.

关键词： Horizontal axis wind turbine Wake Wind profile Turbulence intensity Power output

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Improving conditional random field model for prediction of protein-RNA residue-base contacts

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Frontiers of Electrical and Electronic Engineering in China 2018年第2期6卷 155-162页

作者： Morihiro Hayashida Noriyuki Okada Mayumi kamada Hitoshi Koyano Department of Electrical Engineering and Computer Science National Institute of Technology Matsue College Shimane 690- 8518 Japan Graduate School of Medicine Kyoto University Kyoto 606-8507 Japan Riken Quantitative Biology Center Hyogo 650-0047 Japan

Background： For understanding biological cellular systems, it is important to analyze interactions between protein residues and RNA bases. A method based on conditional random fields （CRFs） was developed for predicting contacts between residues and bases, which receives multiple sequence alignments for given protein and RNA sequences, respectively, and learns the model with many parameters involved in relationships between neighboring residue-base pairs by maximizing the pseudo likelihood function. Methods： In this paper, we proposed a novel CRF-based model with more complicated dependency relationships between random variables than the previous model, but which takes less parameters for the sake of avoidance of overfitting to training data. Results： We performed cross-validation experiments for evaluating the proposed model, and took the average of AUC （area under receiver operating characteristic curve） scores. The result suggests that the proposed CRF-based model without using Ll-norm regularization （lasso） outperforms the existing model with and without the lasso under several input observations to CRFs. Conclusions： We proposed a novel stochastic model for predicting protein-RNA residue-base contacts, and improved the prediction accuracy in terms of the AUC score. It implies that more dependency relationships in a CRF could be controlled by less parameters.

关键词： protein-RNA interaction residue-base contact conditional random field

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Impact of continuous local lavage on pancreatic juice-related postoperative complications: Three case reports

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World Journal of Clinical Cases 2019年第17期7卷 2526-2535页

作者： Tomohide Hori Kohei Ogawa Hidekazu Yamamoto Hideki Harada Kazuyoshi Matsumura Michihiro Yamamoto Masahiro Yamada Takefumi Yazawa Katsutoshi Kuriyama Masaki Tani Daiki Yasukawa Yasuyuki kamada Yuki Aisu Ryotaro Tani Ryuhei Aoyama Shinnosuke Nakayama Yudai Sasaki koki Nishimoto Masazumi Zaima Department of Surgery Shiga General HospitalMoriyama 524-8524Japan Department of Hepatobiliary Pancreatic and Breast Surgery Ehime UniversityToon 791-0295Japan Department of Gastroenterology and Hepatology Shiga General HospitalMoriyama 524- 8524Japan Department of Surgery Shiga University of Medical ScienceOtsu 520-2192Japan Department of Surgery Kyoto University Graduate School of MedicineKyoto 606- 8507Japan

BACKGROUND Postoperative pancreatic leakage readily results in intractable pancreatic fistula and subsequent intraperitoneal *** refractory complication can be fatal;therefore,intensive treatment is *** local lavage (CLL) has recently been reevaluated as effective treatment for severe infected pancreatitis,and we report three patients with postoperative intractable pancreatic fistula successfully treated by *** also discuss our institutional protocol for CLL for postoperative pancreatic *** SUMMARY The first patient underwent subtotal stomach-preserving pancreaticoduodenectomy,and pancreatic leakage was observed *** pancreatic fistula led to intraperitoneal abscess,and CLL near the pancreaticojejunostomy site was instituted from postoperative day (POD) *** abscess resolved after 7 d of *** second patient underwent distal *** leakage was observed,and intractable pancreatic fistula led to intraperitoneal abscess near the pancreatic *** was instituted from POD 9,and the abscess resolved after 4 d of *** third patient underwent aneurysmectomy and splenectomy with wide exposure of the pancreatic *** retrograde pancreatic drainage was performed on POD 15 to treat pancreatic fistula;however,intraperitoneal abscess was detected on POD *** performed CLL endoscopically via the transgastric route because the percutaneous approach was *** was instituted from POD 63,and the abscess resolved after 1 wk of *** CLL has therapeutic potential for postoperative pancreatic fistula.

关键词： Surgery Pancreas Pancreatic fistula Pancreatic juice Postoperative complications Case report

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Optical nature of non-substituted triphenylmethyl cation:Crystalline state emission,thermochromism,and phosphorescence

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Aggregate 2021年第6期2卷 99-108页

作者： Tomohiko Nishiuchi Hikaru Sotome Risa Fukuuchi Kenji kamada Hiroshi Miyasaka Takashi Kubo Department of Chemistry Graduate School of ScienceOsaka UniversityToyonakaOsakaJapan Innovative Catalysis Science Division Institute for Open and Transdisciplinary Research Initiatives(ICS-OTRI)Osaka UniversitySuitaOsakaJapan Division of Frontier Materials Science and Center for Advanced Interdisciplinary Research Graduate School of Engineering ScienceOsaka UniversityToyonakaOsakaJapan Nanomaterial Research Institute(NMRI) National Institute of Advanced Industrial Science and Technology(AIST)IkedaOsakaJapan Department of Chemistry Graduate School of Science and TechnologyKwansei Gakuin UniversitySandaHyogoJapan

Since the discovery of the triphenylmethyl(trityl)cation 120 years ago,a variety of aromatic cations having various colors and luminescence properties have been rigorously ***,differently substituted trityl cations have been synthesized,and their optical properties have been ***,the optical properties of the parent,non-substituted and highly reactive trityl cation,which was observed to be very weakly luminescent,have not been subjected to detailed *** the effort described herein,we explored the optical nature of non-substituted trityl hexafluorophosphate(PF_(6))in the crystalline *** PF_(6) was found to exist as two crystal polymorphs including a yellow(Y)and an orange(O)***,we observed that these crystalline forms display crystalline-state emission with different *** results of X-ray crystallographic analysis showed that the two polymorphs have totally different molecular packing ***,an investigation of their optical properties revealed that the O-crystal undergoes a distinct color change to yellow upon cooling as a consequence of a change in the nature of the charge transfer interaction between the cation and PF6 anion,and that both the Y-and O-crystal exhibit phosphorescence.

关键词： aggregation induced emission carbocation phosphorescence crystal phase transition thermochromism

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Aggregation-enhanced direct S_(0)-T_(n) transitions and room-temperature phosphorescence in gold(I)-complex single crystals

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Aggregate 2022年第1期3卷 159-167页

作者： Akihiro Ando Kazuhisa Ozaki Urara Shiina Eikichi Nagao Kyohei Hisano Kenji kamada Osamu Tsutsumi Department of Applied Chemistry Ritsumeikan UniversityKusatsuJapan Nanomaterials Research Institute(NMRI) National Institute of Advanced Industrial Science and Technology(AIST)IkedaJapan

The design of efficient aggregation-induced emission materials requires an improved understanding of photophysical processes in aggregated ***,the photophysical behavior of an Au(I)complex(R6)that exhibits intense roomtemperature phosphorescence(RTP)in crystals is *** addition,the photophysical processes related to RTP are discussed based on the structure of the molecular aggregates and the primary structure of the *** extremely efficient S_(0)-T_(n) direct transition is found to occur in the R6 ***,intermolecular Au-Au interactions and the internal/external heavy-atom effects of Au atoms are demonstrated to enhance the electronic transitions involving intersystem crossing,namely,direct S_(0)-T_(n) excitation,radiative T_(1)-S_(0) transition(phosphorescence),and S_(1)-T_(n) intersystem *** of the dense molecular packing,both Au-Au interactions and heavy-atom effects play important roles in the *** a result,R6 shows more efficient RTP in crystals than in *** insights into the mechanism of highly efficient RTP in Au(I)-complex crystals are expected to advance the development of new luminogens for a variety of sensing and imaging applications.

关键词： aggregation-induced emission aurophilic interaction gold(I)complex phosphorescence spin-forbidden transition

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