检索结果-南通市图书馆

Role of mammogram and ultrasound imaging in predicting breast cancer subtypes in screening and symptomatic patients

World Journal of Clinical Oncology 2021年第9期12卷 808-822页

作者： tay Wei Ming Ian Ern Yu Tan Niketa Chotai Department of Diagnostic Radiology Singapore General HospitalSingapore 101070Singapore Department of General Surgery Tan Tock Seng HospitalSingapore 308433Singapore Department of Diagnostic Radiology Tan Tock Seng HospitalSingapore 308433Singapore

BACKGROUND Breast cancer(BC)radiogenomics,or correlation analysis of imaging features and BC molecular subtypes,can complement genetic analysis with less resourceintensive diagnostic methods to provide an early and accurate triage of *** is pertinent because BC is the most prevalent cancer amongst adult women,resulting in rising demands on public health *** To find combinations of mammogram and ultrasound imaging features that predict BC molecular subtypes in a sample of screening and symptomatic *** This retrospective study evaluated 328 consecutive patients in 2017-2018 with histologically confirmed BC,of which 237(72%)presented with symptoms and 91(28%)were detected via a screening *** the patients underwent mammography and ultrasound imaging prior to *** images were retrospectively read by two breast-imaging radiologists with 5-10 years of experience with no knowledge of the histology results to ensure statistical *** test the hypothesis that imaging features are correlated with tumor subtypes,univariate binomial and multinomial logistic regression models were *** study also used the multivariate logistic regression(with and without interaction terms)to identify combinations of mammogram and ultrasound(US)imaging characteristics predictive of molecular *** The presence of circumscribed margins,posterior enhancement,and large size is correlated with triple-negative BC(TNBC),while high-risk microcalcifications and microlobulated margins is predictive of HER2-enriched *** carcinoma in situ is characterized by small size on ultrasound,absence of posterior acoustic features,and architectural distortion on mammogram,while luminal subtypes tend to be small,with spiculated margins and posterior acoustic shadowing(Luminal A type).These results are broadly consistent with findings from prior *** addition,we also find that US size signals a higher odds ratio for TNBC if presented

关键词： Hormone receptor Molecular subtype Ultrasonography Mammography Triple-negative cancer Breast cancer screening

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

可可豆奶的研制

引用

中国油脂 1998年第5期23卷 37-39页

作者：王岚王以群丁福祺 E.B.tay 国内贸易部西安油脂科学研究设计院马来西亚可可局

介绍了中国的传统饮料——豆奶配以可可粉，通过使用多种乳化剂和分散剂解决沉淀严重等问题，研制出了营养丰富、风味独特的可可豆奶。

关键词：可可豆奶豆奶豆奶加工工艺

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Polyphosphate-crosslinked collagen scaffolds for hemostasis and alveolar bone regeneration after tooth extraction

引用

Bioactive Materials 2022年第9期7卷 68-81页

作者： Jun-ting Gu Kai Jiao Jing Li Jian-fei Yan Kai-yan Wang Fu Wang Yan Liu Franklin R.tay Ji-hua Chen Li-na Niu National Clinical Research Center for Oral Diseases State Key Laboratory of Military StomatologyShaanxi Key Laboratory of StomatologyDepartment of ProsthodonticsSchool of StomatologyThe Fourth Military Medical UniversityXi’anShaanxiChina Department of Endodontics The Dental College of GeorgiaAugusta UniversityAugustaGA30912USA

Post-extraction bleeding and alveolar bone resorption are the two frequently encountered complications after tooth extraction that result in poor healing and rehabilitation *** present study covalently bonded polyphosphate onto a collagen scaffold(P-CS)by *** P-CS demonstrated improved hemostatic property in a healthy rat model and an anticoagulant-treated rat *** improvement is attributed to the increase in hydrophilicity,increased thrombin generation,platelet activation and stimulation of the intrinsic coagulation *** addition,the P-CS promoted the in-situ bone regeneration and alveolar ridge preservation in a rat alveolar bone defect *** promotion is attributed to enhanced osteogenic differentiation of bone marrow stromal *** was improved by both polyphosphate and blood *** together,P-CS possesses favorable hemostasis and alveolar ridge preservation *** may be used as an effective treatment option for post-extraction bleeding and alveolar bone *** of significance:Collagen scaffold is commonly used for the treatment of post-extraction bleeding and alveolar bone loss after tooth ***,its application is hampered by insufficient hemostatic and osteoinductive *** polyphosphate with collagen produces a modified collagen scaffold that possesses improved hemostatic performance and augmented bone regeneration potential.

关键词： Alveolar ridge preservation Blood clotting Osteogenesis Polyphosphate

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Metabolic biomarkers and long-term blood pressure variability in military young male adults

引用

World Journal of Clinical Cases 2020年第11期8卷 2246-2254页

作者： Yu-Kai Lin Pang-Yen Liu Chia-Hao Fan Kun-Zhe Tsai Yen-Po Lin Ju-Mi Lee Jiunn-tay Lee Gen-Min Lin Department of Medicine Hualien Armed Forces General HospitalHualien 970Taiwan Departments of Neurology Tri-Service General Hospitaland Graduate Institute of Medical SciencesNational Defense Medical CenterTaipei 114Taiwan Department of Medicine Tri-Service General Hospital and National Defense Medical CenterTaipei 114Taiwan Department of Critical Care Medicine Taipei Tzu-Chi General HospitalNew Taipei City 231Taiwan Department of Preventive Medicine Eulji College of MedicineDaejeon 34824South Korea Department of Preventive Medicine Northwestern University Feinberg School of MedicineChicagoIL 60611United States

BACKGROUND Metabolic syndrome is a cluster of cardiovascular risk factors, including central obesity, high blood pressure, elevated plasma glucose, reduced high-density lipoprotein and elevated triglyceride *** To investigate the relationship between metabolic biomarkers and long-term blood pressure variability(BPV) in young *** A cohort of 1112 healthy military males aged 18-40 years from the cardiorespiratory fitness and hospitalization events in armed forces study in eastern Taiwan was prospectively included. The following metabolic biomarkers were used: Waist circumference, serum uric acid(SUA), triglycerides, high density lipoprotein, triglycerides, and fasting glycose. BPV was assessed by average real variability(ARV) and standard deviation(SD) across 4 clinic visits during the study period(2012-14, 2014-15, 2015-16, and 2016-18). Multivariable linear regression analysis was used to determine the association after adjusting for age, body mass index, systolic and diastolic blood pressure(SBP and DBP),lipid profiles, physical activity, alcohol intake and tobacco smoking *** In the unadjusted model, waist circumference was significantly and positively correlated with ARVDBP and SDDBP [β(standard errors) = 0.16(0.049) and 0.22(0.065), respectively], as was SUA [β = 0.022(0.009) and 0.038(0.012),respectively]. High-density lipoprotein was negatively correlated with ARVSBP [β=-0.13(0.063)]. There were no associations with the other metabolic *** contrast, only SUA was significantly correlated with SDSBP and SDDBP [β = 0.019(0.011) and 0.027(0.010), respectively] in the adjusted *** Our findings showed that of traditional metabolic biomarkers, SUA had the strongest positive correlation with long-term systolic and diastolic BPV in young male adults, and the clinical relevance needs further investigation.

关键词： Blood pressure variability Metabolic syndrome Serum uric acid Young males

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

用于神经形态学计算的低能耗、高稳定性2D-3D钙钛矿忆阻器

引用

Science China Materials 2023年第5期66卷 2013-2022页

作者：孙凯旋王庆瑞周龙王静娟常晶晶郭瑞 Beng Kang tay 闫小兵 Key Laboratory of Brain-like Neuromorphic Devices and Systems of Hebei Province College of Electron and Information EngineeringHebei UniversityBaoding 071002China State Key Discipline Laboratory of Wide Band Gap Semiconductor Technology School of MicroelectronicsXidian UniversityXi’an 710071China Centre for Micro-and Nano-Electronics(CMNE) School of Electrical and Electronic EngineeringNanyang Technological UniversitySingapore 639798Singapore UMI 3288 CINTRA(CNRS-NTU-THALES Research Alliances) Nanyang Technological UniversitySingapore 637553Singapore

近年来,有机-无机卤化物钙钛矿在忆阻器和人工突触器件等电子器件中的应用取得了快速进展.由于其离子迁移特性和制造上的优势,有机-无机卤化物钙钛矿有望成为下一代计算设备的候选材料.本文采用ITO/FA_(1-y)MA_(y)PbI_(3-x)Cl_(x)/(PEA)... 详细信息

近年来,有机-无机卤化物钙钛矿在忆阻器和人工突触器件等电子器件中的应用取得了快速进展.由于其离子迁移特性和制造上的优势,有机-无机卤化物钙钛矿有望成为下一代计算设备的候选材料.本文采用ITO/FA_(1-y)MA_(y)PbI_(3-x)Cl_(x)/(PEA)_(2)PbI_(4)/Au的叠层结构,研究了2D-3D有机-无机杂化钙钛矿忆阻器.结果表明,这种新型忆阻器具有新颖的电阻开关特性,如扫描速率相关的电流开关特性、良好的电流-电压曲线重复性和超低能耗.利用p-i-n结模型证实了缺陷调制电子隧穿机制,并证明了忆阻器件的电导状态由电极侧附近钙钛矿薄膜中的缺陷浓度决定.除了良好的忆阻特性外,这种2D-3D钙钛矿型忆阻器还可以很好地用作人工突触,其内部缺陷运动可以真实地模拟生物突触中Ca^(2+)的流入和挤出.此外,由于有机-无机卤化物钙钛矿中的可切换p-i-n结构,这种基于钙钛矿的人工突触具有超低功耗.我们的发现展示了2D-3D钙钛矿忆阻器在未来神经形态计算系统中的巨大应用潜力.

关键词： perovskite ion migration memristor low energy consumption neuromorphic computing

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Analysis of core protein clusters identifies candidate variable sites conferring metronidazole resistance in Helicobacter pylori

引用

Gastroenterology Report 2019年第1期7卷 42-49,I0002页

作者： Eng-Guan Chua Aleksandra W.Debowski KMary Webberley Fanny Peters Binit Lamichhane Mun-Fai Loke Jamuna Vadivelu Chin-Yen tay Barry J.Marshall Michael J.Wise The Marshall Centre for Infectious Diseases Research and Training University of Western AustraliaPerthWestern AustraliaAustralia School of Biomedical Sciences Faculty of Health and Medical SciencesUniversity of Western AustraliaPerthWestern AustraliaAustralia Department of Medical Microbiology University of MalayaKuala LumpurWilayah PersekutuanMalaysia Shenzhen Dapeng New District Kuichong People Hospital ShenzhenGuangdongChina UM Marshall Centre University of MalayaKuala LumpurWilayah PersekutuanMalaysia School of Computer Science and Software Engineering University of Western AustraliaPerthWestern AustraliaAustralia

Background:Metronidazole is one of the first-line drugs of choice in the standard triple therapy used to eradicate Helicobacter pylori ***,the global emergence of metronidazole resistance in Hp poses a major challenge to health *** of RdxA is known to be a major mechanism of conferring metronidazole resistance in ***,metronidazole resistance can also arise in *** strains expressing functional RdxA protein,suggesting that there are other mechanisms that may confer resistance to this ***:We performed whole-genome sequencing on 121 *** clinical strains,among which 73 were ***-alignment analysis of core protein clusters derived from clinical strains containing full-length RdxA was *** sites in each alignment were statistically compared between the resistant and susceptible groups to determine candidate genes along with their respective amino-acid changes that may account for the development of metronidazole resistance in ***:Resistance due to RdxA truncation was identified in 34%of metronidazole-resistant *** of core protein clusters derived from the remaining 48 metronidazole-resistant strains and 48 metronidazole-susceptible identified four variable sites significantly associated with metronidazole *** sites included R16H/C in RdxA,D85N in the inner-membrane protein RclC(HP0565),V265I in a biotin carboxylase protein(HP0370)and A51V/T in a putative threonylcarbamoyl–AMP synthase(HP0918).Conclusions:Our approach identified new potential mechanisms for metronidazole resistance in *** that merit further investigation.

关键词： Helicobacter pylori metronidazole antibiotic resistance whole-genome sequencing core protein clusters sequence alignment

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Bioengineered materials with selective antimicrobial toxicity in biomedicine

引用

Military Medical Research 2023年第6期10卷 798-817页

作者： Pooyan Makvandi Hao Song Cynthia K.Y.Yiu Rossella Sartorius Ehsan Nazarzadeh Zare Navid Rabiee Wei-Xi Wu Ana Cláudia Paiva-Santos Xiang-Dong Wang Cheng-Zhong Yu Franklin R.tay The Quzhou Affiliated Hospital of Wenzhou Medical University Quzhou People’s HospitalQuzhou 324000ZhejiangChina Istituto Italiano di Tecnologia Centre for Materials InterfacesPontedera 56025Italy Australian Institute for Bioengineering and Nanotechnology The University of QueenslandBrisbaneQLD 4072Australia Paediatric Dentistry and Orthodontics Faculty of DentistryThe University of Hong KongPrince Philip Dental HospitalHong Kong SARChina Institute of Biochemistry and Cell Biology(IBBC) National Research Council(CNR)80131 NaplesItaly School of Chemistry Damghan UniversityDamghan 36716‑45667Iran School of Engineering Macquarie UniversitySydneyNSW 2109Australia Centre for Molecular Medicine and Innovative Therapeutics Murdoch UniversityPerthWA 6150Australia Department of Pharmaceutical Technology Faculty of Pharmacy of the University of CoimbraUniversity of Coimbra3000‑548 CoimbraPortugal REQUIMTE/LAQV Group of Pharmaceutical TechnologyFaculty of Pharmacy of the University of CoimbraUniversity of Coimbra3000‑548 CoimbraPortugal Department of Pulmonary and Critical Care Medicine Zhongshan HospitalFudan University Shanghai Medical CollegeShanghai 200032China School of Chemistry and Molecular Engineering East China Normal UniversityShanghai 200241China The Graduate School Augusta UniversityAugustaGA 30912USA

Fungi and bacteria afflict humans with innumerous pathogen-related infections and *** of the commonly employed microbicidal agents target commensal and pathogenic microorganisms without *** distinguish and fight the pathogenic species out of the microflora,novel antimicrobials have been developed that selectively target specific bacteria and *** cell wall features and antimicrobial mechanisms that these microorganisms involved in are highlighted in the present *** is followed by reviewing the design of antimicrobials that selectively combat a specific community of microbes including Gram-positive and Gram-negative bacterial strains as well as ***,recent advances in the antimicrobial immunomodulation strategy that enables treating microorganism infections with high specificity are *** basic tenets will enable the avid reader to design novel approaches and compounds for antibacterial and antifungal applications.

关键词： Antimicrobial nanotechnology Immumodualtion Selective toxicity Smart nanomaterials Targeting microorganism

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Perceptions of non-alcoholic fatty liver disease–an Asian community-based study

引用

Gastroenterology Report 2016年第2期4卷 131-135,I0002页

作者： George B.B.Goh Clarence Kwan Sze Ying Lim Nanda KK Venkatanarasimha Rafidah Abu-Bakar Thinesh L Krishnamoorthy Hang Hock Shim Kiang Hiong tay Wan Cheng Chow Department of Gastroenterology&Hepatology Singapore General HospitalSingapore Duke-NUS Graduate Medical School Singapore Department of Diagnostic Radiology Singapore General HospitalSingapore

Background and Aims:Non-alcoholic fatty liver disease(NAFLD)is the most common chronic liver disease and is closely related to metabolic syndrome and its risk ***,epidemiological studies have reported NAFLD prevalence rates of 5%to 30%depending on geographical *** epidemiological data suggest a progressively increasing prevalence of metabolic risk factors in Singapore,there are limited data about NAFLD per se in the *** aim to explore the prevalence and perceptions of NAFLD in ***:Attendees at a gastroenterology public forum were enrolled in a cross-sectional observational study evaluating demographic,anthropometric and clinical *** diagnosis of NAFLD was based on sonographic *** syndrome was defined according to International Diabetes Federation *** of NAFLD were explored using a self-administered survey ***:A total of 227 subjects were recruited,with NAFLD being diagnosed in 40%of the *** to those without NAFLD,subjects with NAFLD had higher male preponderance,older age,higher body mass index,waist circumference and more metabolic syndrome(all P0.05).Of note,75.6%of subjects with one or more metabolic risk factors did not think that they were at risk of ***:Our study suggests a significant local prevalence of NAFLD in the community including non-obese *** the tendency to underestimate risk of NAFLD,enhanced public education about NAFLD is warranted to improve understanding.

关键词： non-alcoholic fatty liver disease epidemiology perceptions Singapore

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Whole-genome sequencing to detect mutations associated with resistance to insecticides and Bt proteins in Spodoptera frugiperda

引用

Insect Science 2021年第3期28卷 627-638页

作者： Fang Guan Jianpeng Zhang Huiwen Shen Xingliang Wang Amanda Padovan Tom K.Walsh Wee Tek tay Karl H.J.Gordon William James Cecilia Czepak Michael Hilary Otim Donald Kachigamba Yidong Wu College of Plant Protection Nanjing Agricultural UniversityNanjingChina CSIRO Black Mountain Laboratories Clunies Ross StreetCanberraACTAustralia Escola de Agronomia Universidade Federal de GoiasGoianiaBrazil National Crops Resources Research Institute NamulongeKampalaUganda Department of Agricultural Research Services(DARS) LilongweMalawi

The fall armyworm(FAW),Spodoptera frugiperda,is a major pest native to the Americas that has recently invaded the Old *** mutations in the target-site proteins acetylcholinesterase-1(ace-1),voltage-gated sodium channel(VGSC)and ryanodine receptor(RyR)have been identified in *** as major resistance mechanisms to organophosphate,pyrethroid and diamide insecticides *** in the adenosine triphosphate-binding cassette transporter C2 gene(ABCC2)have also been identified to confer resistance to Cry IF *** this study,we applied a whole-genome sequencing(WGS)approach to identify point mutations in the target-site genes in 150 FAW individuals collected from China,Malawi,Uganda and *** approach revealed three amino acid substitutions(A201S,G227A and F290V)of *** ace-1,which are known to be associated with organophosphate *** Brazilian population had all three ace-1 point mutations and the 227A allele(mean frequency=0.54)was the most *** from China,Malawi and Uganda harbored two of the three ace-1 point mutations(A201S and F290V)with the 290V allele(0.47-0.58)as the dominant *** mutations in VGSC(T929I,L932F and L1014F)and RyR(I4790M and G4946E)were not detected in any of the 150 individuals.A novel 12-bp insertion mutation in exon 15 of the ABCC2 gene was identified in some of the Brazilian individuals but absent in the invasive *** results not only demonstrate robustness of the WGS-based genomic approach for detection of resistance mutations,but also provide insights for improvement of resistance management tactics in ***.

关键词： Bt resistance insecticide resistance mutation detection Spodoptera frugiperda whole-genome sequencing

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

New interchange English for international communication 2

引用

2005年

作者： Jack C. Richards tay Lesley

本教材主要使用美国英语，但涉及许多国家、地区和文化，它强调在实际交流活动中培养语言，主要活动有主题讨论、语法结构、语言功能、词汇扩展和语言训练。

ISBN: (纸本)7560022154

关键词：英语

来源：畅想之星图书光盘版（南... 评论

在线全文

畅想之星图书光盘版（南通市图书馆镜像）

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：