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3D-QSAR analysis of a new type of acetylcholinesterase inhibitors

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Science China(Life Sciences) 2007年第6期50卷 726-730页

作者： LEE Simon m. Y Institute of Chinese medical Sciences University of Macao Av. Padre Tomas Pereira S. J. Taipa Macao China

Acetylcholinesterase (AChE) inhibitors are an important class of medicinal agents used for the treatment of Alzheimer’s disease. A screening model of AChE inhibitor was used to evaluate the inhibition of a series of phenyl pentenone derivatives. The assay result showed that some compounds displayed higher inhibitory effects. In order to study the relationship between the bioactivities; the structures, 26 compounds with phenyl pentenone scaffold were analyzed. A 3D-QSAR model was constructed using the method of comparative molecular field analysis (ComFA). The results of cross-validated R[2]cv=0.629, non-cross-validated R[2]=0.972, SE=0.331,; F=72.41 indicate that the 3D-model possesses an ability to predict the activities of new inhibitors,; the ComFA model would be useful for the future design of new AChE inhibitors.

关键词： acetylcholinesterase (AChE), comparative molecular field analysis (ComFA), phenyl pentenone derivatives

membrane Fouling in microfiltration of Sanitary Landfill Leachate for Removals of Colourand Solids

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应用与环境生物学报 2013年第1期19卷 184-188页

作者： Emad S.m.Ameen Water Research Alliance Institute of Environmental and Water Resource ManagementFaculty of Civil EngineeringUniversiti Teknologi Malaysia

In this research,the treatability of solids from sanitary landfill leachate by microfiltration membrane was investigated and the fouling of the membrane was carefully *** microfiltration process was carried out for 21 h in experimental system involved coagulation with moringa oleifera followed by filtration using submerged hollow fibre microfiltration membrane (mFm).Coagulation with ***,air diffusers and back flush technique were used for preventing or alleviating fouling of the *** hollow fibre mFm showed high removals of 98%,91% and 99% for turbidity,colour and total suspended solids *** was obtained at the beginning of the ***,quality of the filtrate rapidly declined during the filtration *** was found to proceed according to the classical cake filtration *** with *** as well as the back-flush technique could not fully restore the deterioration occurred to the membrane.

关键词： RAPD ISSR AFLP 环境生物学

The Problems of Inaccuracy in Flow Capacity Definition by Using Different Numerical Techniques

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Journal of Thermal Science 2004年第1期13卷 1-7页

作者： I.V.Afanasiev A.V.Granovski A.m.Kareline m.K.Kostege ALSTOm POWER Uniturbo Ltd.13 Kasatkina St. 129301MoscowRussiaALSTOM POWER Uniturbo Ltd.13 Kasatkina St.129301MoscowRussiaALSTOM POWER Uniturbo Ltd.13 Kasatkina St.129301MoscowRussiaALSTOM POWER Uniturbo Ltd.13 Kasatkina St.129301MoscowRussia

The results of numerical analysis of turbine flow capacity and other parameters at different turbine rows are presented in this paper. mass flow calculations by 3D Euler code has been controlled by means of 3D Navier-Stokes code taking into account inlet turbulence intensity and turbulence scale. The use of complicated numerical approaches (3D Euler or 3D Navier-Stokes codes) for mass flow definition demands close attention to quality of numerical techniques. Various reasons of inaccuracy of mass flow definition by using different 3D numerical approaches are analyzed.

关键词： flow capacity computing accuracy 3D Euler code 3D Navier-Stokes code.

Prediction of flyrock in open pit blasting operation using machine learning method

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International Journal of mining Science and Technology 2013年第3期23卷 313-316页

作者： manoj Khandelwal m. monjezi Department of mining Engineering College of Technology & Engineering Maharana Pratap University of Agriculture and Technology Faculty of Engineering Tarbiat Modares University

Flyrock is one of the most hazardous events in blasting operation of surface mines. There are several empirical methods to predict flyrock. Low performance of such models is due to the complexity of flyrock analysis. Existence of various effective parameters and their unknown relationships are the main reasons for inaccuracy of the empirical models. Presently, the application of new approaches such as artificial intelligence is highly recommended. In this paper, an attempt has been made to predict flyrock in blasting operations of Soungun Copper mine, Iran incorporating rock properties and blast design parameters using support vector machine (SVm) method. To investigate the suitability of this approach, the predictions by SVm have been compared with multivariate regression analysis (mVRA), too. Coefficient of determination (CoD) and mean absolute error (mAE) were taken as performance measures. It was found that CoD between measured and predicted flyrock was 0.948 and 0.440 by SVm and mVRA, respectively, whereas mAE between measured and predicted flyrock was 3.11 and 7.74 by SVm and mVRA, respectively.

关键词： Blasting Soungun Copper mine Flyrock Support vector machine mVRA

轻度认知功能障碍病人mRI显示脉络丛增大的大型队列研究

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国际医学放射学杂志 2024年第5期 625-626页

作者： Y.Umemura K.Watanabe S.Kasai S.Ide Y.Ishimoto m.Sasaki 陈瑾

目的以往研究表明阿尔茨海默病（AD）可能存在脉络丛（CP）功能障碍，并特别提出mRI所见的CP增大可作为AD预测指标。但探讨CP体积（CPV）与轻度认知障碍

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microglia-precursor cell interactions in health and in pathology

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BIOCELL 2018年第2期42卷 41-45页

作者： Estela m.mUÑOZ Instituto de Histología y Embriología de mendoza Dr.mario H.Burgos(IHEm) Universidad Nacional de Cuyo(UNCuyo)Consejo Nacional de Investigaciones Científicas y Técnicas(CONICET)MendozaArgentina

Until recently,microglia were mainly known as the resident phagocytes of the brain,***‘immunological warriors’of the ***,extensive knowledge is being accumulated about the functions of microglia beyond ***,it is well accepted that microglial cells are highly dynamic and responsive,and that they intervene in a dual manner in many developmental processes that shape the central nervous system,including neurogenesis,gliogenesis,spatial patterning,synaptic formation and elimination,and neural circuit establishment and *** differentiation and the pool of precursor cells were also shown to be under microglia regulation via bidirectional *** this concise review,I discuss our recent work in microglia-Pax6+cell interactions in one of the circumventricular organs,the pineal *** analogy with the rest of the central nervous system is also *** addition,I briefly examine mechanisms of interaction between microglia and non-microglial cells in both health and *** avenues are also introduced,which may lead us to better comprehend the impact of microglia in physiological and pathological conditions.

关键词： Phagocyte Phagocytosis Phagoptosis Apoptosis Autophagy

microstructure and Fracture Behavior of 316L Austenitic Stainless Steel Produced by Selective Laser melting

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Journal of materials Science & Technology 2016年第8期32卷 738-744页

作者： R.Casati J.Lemke m.Vedani Department of mechanical Engineering Politecnico di Milano

Selective laser melting is an additive manufacturing method based on local melting of a metal powder bed by a high power laser beam. Fast laser scans are responsible for severe thermal gradients and high cooling rates which produce complex hydrodynamic fluid flow. These phenomena affect crystal growth and orientation and are believed to be the cause of material spattering and microstructural defects, e.g. pores and incompletely melted particles. In this work, the microstructure and texture of 316L bars built along two different orientations and the effect of different distribution of defects on their mechanical response and failure mechanisms were investigated. Partially molten powder particles are believed to be responsible for the scattering in elongation to failure, reduced strength, and premature failure of vertical samples.

关键词： AISI 316L Additive manufacturing Selective laser melting microstructural analysis Fracture behavior

Transient Free Convection and Heat Transfer in a Partitioned Attic-Shaped Space under Diurnal Thermal Forcing

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Energy Engineering 2021年第3期118卷 487-506页

作者： Suvash C.Saha Ali m.Sefidan Atta Sojoudi mohammad m.molla School of mechanical and mechatronic Engineering Faculty of Engineering and Information TechnologyUniversity of Technology SydneyUltimoNSW 2007Australia mechanical Engineering Department University of CanterburyChristchurch8041New Zealand mechanical Engineering Department University of TehranTehranIran Department of mathematics and Physics North South UniversityDhaka1229Bangladesh

One primordial consideration in residential ventilation standards is the comfort of provided to people living in those *** is highly dependent on the thermal and fluid flow conditions,the space geometry and so *** designs may reduce the energy usage,making the buildings more sustainable over a longer period of *** study aims to investigate the impact of whole day thermal conditions on the fluid flow structure and heat transfer phenomena,mainly natural convection,inside a partitioned attic-shaped *** Finite Volume method is applied to solve the governing *** thermal boundary condition is applied on the sloping walls to illustrate the characteristics of primary flow through daily cycles.A highly thermal conductive partition was placed vertically at the middle of the *** that through the partition,only heat could freely transfer between two fluid *** show that,during day time,a stratified fluid flow structure is obtained,which originates from the prevailing conduction heat transfer mechanism,while,for the night-time it changed into a strong convection mechanism which significantly affects the flow *** results are particularly important for understanding the fluid dynamics inside the attic shaped building and also designing new residential building.

关键词： Free convection attic space partitioned diurnal thermal forcing computational fluid dynamics

Planning Target Volume margin in Linac-Based Stereotactic Radiosurgery for Brain metastases

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