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Energy Balance of Irrigated Intercropping Field in the Middle Reaches of Heihe River Basin

Chinese Geographical Science 2006年第3期16卷 243-248页

作者： WU Jinkui DING Yongjian WANG Genxu SHEN Yongping Yusuke YAMAZAKI Jumpei kubota Cold and Arid Regions Environmental and Engineering Research Institute Chinese Academy of Sciences Lanzhou 730000 China The Laboratory of Climate Study of China Meteorological Administration Beijing 100041 China Research Institute for Humanity and Nature Kyoto 602-0778 Japan

Based on the experiments conducted in an irrigated intercropping field in Zhangye Oasis in the middle reaches of Heihe River basin in 2004, the characteristics of radiation budget are analyzed. Furthermore, energy balance is cal- culated by using Bowen-Ratio Energy Balance (BREB) method. The results show that the ratio of the absorbed radiation to the incoming short radiation in intercropping crop canopy-soil system is increasing with growing stages, from 0.81 in the initial growing stage (IGS) to 0.86 in the late growing stage (LGS). The net radiation, which is smaller in IGS, in- creases rapidly in the first period of the middle growing stage (MGS) and reaches the maximum value in the second period of MGS. It then somewhat decreases in LGS. The ratio of net radiation to total radiation has a similar trend with the net radiation. In the whole growing stages, latent heat flux, which takes up 70% or so of the net radiation, is the dominant item in energy balance. Sensible heat flux shares 20% of the net radiation and soil heat flux has a percentage of 10%. The characteristics of heat balance vary distinctly in different growing stages. In IGS, the ratios of latent heat flux, sensible heat flux and soil heat flux to net radiation are 44.5%, 23.8% and 31.7% respectively. In MGS, with the in- creasing of latent heat flux and the decreasing of sensible heat flux and soil heat flux, the ratios turn into 84.4%, 6.3% and 9.3%. In LGS, the soil heat flux maintains 0W/m2 or so, and latent heat flux and sensible heat flux take up 61.4% and 38.6% respectively. The energy balance also shows an obvious daily variation characteristic.

关键词：黑河盆地能量平衡间混作辐射平衡生态系统农业生产

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COVID-19-associated disseminated mucormycosis:An autopsy case report

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World Journal of Clinical Cases 2022年第28期10卷 10358-10365页

作者： Daisuke Kyuno Terufumi Kubo Mitsuhiro Tsujiwaki Shintaro Sugita Michiko Hosaka Hazuki Ito Keisuke Harada Akira Takasawa Yusaku kubota Kumi Takasawa Yusuke Ono Kazufumi Magara Eichi Narimatsu Tadashi Hasegawa Makoto Osanai Department of Pathology Sapporo Medical UniversitySapporo 0608556HokkaidoJapan Department of Surgical Pathology Sapporo Medical UniversitySapporo 0608556Japan Department of Emergency Medicine Sapporo Medical UniversitySapporo 0608556Japan

BACKGROUND Reports of mucormycosis,an infectious disease that commonly affects immunocompromised individuals,have increased during the ongoing coronavirus disease 2019(COVID-19) *** mucormycosis associated with COVID-19 is rare but fatal and is characterized by an aggressive clinical course and delayed *** report documents a case of disseminated mucormycosis after COVID-19 *** is a rare pathological autopsy report on COVID-19-associated *** SUMMARY A 58-year-old man was transferred to our hospital with severe COVID-19 *** treatment for acute respiratory distress syndrome,he developed intra-abdominal bleeding that required a right hemicolectomy and ileostomy for *** ileostoma and surgical wound developed necrosis followed by sepsis and multi-organ failure,which led to *** autopsy revealed multiple thrombi associated with Rhizopus oryzae infection,which led to the necrosis of multiple infected *** Early suspicion and diagnosis followed by treatment are keys to better outcomes of mucormycosis in patients with severe COVID-19.

关键词： COVID-19 Mucormycosis Mucorales infection Rhizopus oryzae SARS-Co V-2 Case report

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Five Decades of Shrinkage of the July 1st Glacier in the Qilian Mountains of China

Five Decades of Shrinkage of the July 1st Glacier in the Qil...

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第四届青藏高原国际学术研讨会

作者： Akiko Sakai koji Fujita Yoshihiro Matsuda Jumpei kubota Masayoshi Nakawo Graduate School of Environmental Studies Nagoya UniversityNagoyaJapan. Graduate School of Environmental Studies Nagoya UniversityNagoyaJapan. Graduate School of Environmental Studies Nagoya UniversityNagoyaJapan. Research Institute for Humanity and Nature KyotoJapan Research Institute for Humanity and Nature KyotoJapan

＜正＞A survey was carded out at the July 1st glacier in Qilian Mountains, China in 2002. There was a record of this glacier boundary in 1956, and research works have been done in the mid-Seventies and Eighties. Our survey of the glacier revealed that the glacier area in 2002 has decreased 4% and 5% since 1985 and 1956, respectively. The average surface lowering rates of the glacier along a longitudinal line were 0.06 m yr-1 and 0.38 m yr-1 from 1975 to 1985 and, from 1985 to 2002, respectively. It was clarified, therefore, that the glacier area shrinkage and surface lowering have accelerated in the most recent 15 years.

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The advantages of radical distribution control and independent dual frequency on etch/ash

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半导体技术 2004年第8期29卷 41-46页

作者： Tanaka Hideaki kubota Kazuhiro Shin Okamoto Tokyo Electron Ltd. Tokyo Electron Ltd.Tokyo Electron Ltd.

The transition to 65 nm beyond and 300 mm wafers posed many challenges on etch depth and critical dimension (CD) uniformity within wafer. In this paper, we introduce a radical distribution con- trol (RDC) system for an excellent uniformity control. Etch depth and CD uniformity within wafer are well controlled by adding RDC function to SCCMTM. For increasing productivity, an all-in-one process, that is, etch/ash at the same chamber continuously is proposed here. By utilizing the advantage of inde- pendent dual frequency, a bias-controlled two-step ash “hybrid ash” is combined in the all-in-one process. Hybrid ash uses bias control and low pres- sure to minimize liner loss and the damage of low-k materials, which is targeting 65nm and beyond.

关键词：蚀刻分布控制独立双频 RDC SCCM

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Multidisciplinary management of acute mesenteric ischemia:Surgery and endovascular intervention

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World Journal of Gastrointestinal Surgery 2021年第8期13卷 806-813页

作者： Takashi Sakamoto Tadao kubota Hiraku Funakoshi Alan Kawarai Lefor Department of Clinical Epidemiology and Health Economics School of Public HealthThe University of TokyoTokyo 1130033Japan Department of Surgery Tokyo Bay Urayasu Ichikawa Medical CenterChiba 2790001Japan Department of Interventional Radiology Tokyo Bay Urayasu Ichikawa Medical CenterChiba 2790001Japan Department of Surgery Jichi Medical UniversityTochigi 3290498Japan

Acute mesenteric ischemia(AMI)is a rare cause of the“acute abdomen”,characterized by impaired blood flow to the *** principle of treatment is restoration of perfusion to ischemic bowel and resection of any necrotic *** and endovascular intervention are two complementary approaches to mesenteric *** intervention is not an alternative to the surgical approach,but it has the potential to improve the prognosis of patients with AMI when judiciously combined with a surgical *** to the need for emergent treatment of patients with acute mesenteric ischemia,the treatment strategy needs to be modified for each *** review aims to highlight cutting-edge studies and provide reasonable treatment strategies for patients with acute mesenteric ischemia based on available evidence.

关键词： Acute mesenteric ischemia Endovascular intervention Acute mesenteric arterial embolism Acute mesenteric arterial thrombosis

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Anoctamin 5 regulates the cell cycle and affects prognosis in gastric cancer

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World Journal of Gastroenterology 2022年第32期28卷 4649-4667页

作者： Tomoyuki Fukami Atsushi Shiozaki Toshiyuki Kosuga Michihiro Kudou Hiroki Shimizu Takuma Ohashi Tomohiro Arita Hirotaka Konishi Shuhei Komatsu Takeshi kubota Hitoshi Fujiwara Kazuma Okamoto Mitsuo Kishimoto Yukiko Morinaga Eiichi Konishi Eigo Otsuji Division of Digestive Surgery Department of SurgeryKyoto Prefectural University of MedicineKyoto 602-8566Japan Department of Pathology Kyoto City HospitalKyoto 604-8845Japan Department of Pathology Kyoto Prefectural University of MedicineKyoto 602-8566Japan

BACKGROUND Anoctamin 5(ANO5)/transmembrane protein 16E belongs to the ANO/transmembrane protein 16 anion channel *** comprise a family of plasma membrane proteins that mediate ion transport and phospholipid scrambling and regulate other membrane proteins in numerous cell *** studies have elucidated the roles and mechanisms of ANO5 activation in various cancer ***,it remains unclear whether ANO5 acts as a plasma membrane chloride channel,and its expression and functions in gastric cancer(GC)have not been *** To examine the role of ANO5 in the regulation of tumor progression and clinicopathological significance of its expression in *** Knockdown experiments using ANO5 small interfering RNA were conducted in human GC cell lines,and changes in cell proliferation,cell cycle progression,apoptosis,and cellular movement were *** gene expression profiles of GC cells were investigated following ANO5 silencing by microarray *** staining of ANO5 was performed on 195 primary tumor samples obtained from patients with GC who underwent curative gastrectomy between 2011 and 2013 at our *** Reverse transcription-quantitative polymerase chain reaction(PCR)and western blotting demonstrated high ANO5 mRNA and protein expression,respectively,in NUGC4 and MKN45 *** these cells,ANO5 silencing inhibited cell proliferation and induced *** addition,the knockdown of ANO5 inhibited G1-S phase progression,invasion,and *** results of the microarray analysis revealed changes in the expression levels of several cyclin-associated genes,such as CDKN1A,CDK2/4/6,CCNE2,and E2F1,in ANO5-depleted NUGC4 *** expression of these genes was verified using reverse transcription-quantitative *** staining revealed that high ANO5 expression levels were associated with a poor *** analysis identified high ANO5 expression as an independent prognostic fa

关键词： Anoctamin 5 Gastric cancer Cell cycle G1/S checkpoint Cell proliferation

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Intraoperative frozen section diagnosis of bile duct margin for extrahepatic cholangiocarcinoma

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World Journal of Gastroenterology 2018年第12期24卷 1332-1342页

作者： Takayuki Shiraki Hajime Kuroda Atsuko Takada Yoshimasa Nakazato Keiichi kubota Yasuo Imai Department of Gastroen- terological Surgery Dokkyo Medical University Department of Diagnostic Pathology Dokkyo Medical University

AIM To evaluate the usefulness of frozen section diagnosis(FSD) of bile duct margins during surgery for extrahepatic cholangiocarcinoma(CCA). METHODS We retrospectively analyzed 74 consecutive patients who underwent surgery for extrahepatic CCA from 2012 to 2017, during which FSD of bile duct margins was performed. They consisted of 40 distant and 34 perihilar CCAs(45 and 55 bile duct margins, respectively). The diagnosis was classified into three categories: negative, borderline(biliary intraepithelial neoplasia-1 and 2, and indefinite for neoplasia), or positive. FSD in the epithelial layer, subepithelial layer, and total layer was compared with corresponding permanent section diagnosis(PSD) ***, association between FSD and local recurrence was analyzed with special reference to *** Analysis of 100 duct margins revealed that concordance rate between FSD and PSD was 68.0% in the total layer, 69.0% in the epithelial layer, and 98.0% in the subepithelial layer. The extent of remaining biliary epithelium was comparable between FSD and PSD, and more than half of the margins lost > 50% of the entire epithelium, suggesting low quality of the samples. In FSD, the rate of negative margins decreased and that of borderline and positive margins increased according to the extent of the remaining epithelium. Diagnostic discordance between FSD and PSD was observed in 31 epithelial layers and two subepithelial layers. Alteration from borderline to negative was the most frequent(20 of the 31 epithelial layers). Patients with positive margin in the total and epithelial layers by FSD demonstrated a significantly worse local recurrence-free survival(RFS) compared with patients with borderline and negative margins, which revealed comparable local RFS. Patients with borderline and negative margins in the epithelial layer by PSD also revealed comparable local RFS. These results suggested that epithelial borderline might be regarded substantially as negati

关键词： Cholangiocarcinoma Bile duct cancer Frozen section diagnosis Permanent section diagnosis Bile duct margin Biliary intraepithelial neoplasia Dysplasia Indefinite for neoplasia Borderline lesion Local recurrence

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Early effects of oral administration of omeprazole and roxatidine on intragastric pH

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2012年第1期13卷 29-34页

作者： Hiroshi IIDA Shingo KATO Yusuke SEKINO Eiji SAKAI Takashi UCHIYAMA Hiroki ENDO Kunihiro HOSONO Yasunari SAKAMOTO koji FUJITA Masato YONEDA Tomoko KOIDE Hirokazu TAKAHASHI Chikako TOKORO Ayumu GOTO Yasunobu ABE Noritoshi KOBAYASHI Kensuke kubota Eiji GOTOH Shin MAEDA Atsushi NAKAJIMA Masahiko INAMORI Gastroenterology Division Yokohama City University School of Medicine Department of Medical Education Yokohama City University School of Medicine Office of Postgraduate Medical Education Yokohama City University Hospital

Objective:The ideal medication for the treatment of acid-related diseases,e.g.,peptic ulcers,stress-related gastric bleeding,functional dyspepsia,and gastroesophageal reflux disease,should have a rapid onset of action to promote hemostasis and relieve the *** aim of our study was to investigate the inhibitory effects on gastric acid secretion of a single oral administration of a proton pump inhibitor,omeprazole 20 mg,and an H2-receptor antagonist,roxatidine 75 ***:Ten Helicobacter pylori-negative male subjects participated in this randomized,two-way crossover *** pH was monitored continuously for 6 h after single oral administration of omeprazole 20 mg and roxatidine 75 *** administration was separated by a 7-d washout ***:During the 6-h study period,the average pH after administration of roxatidine was higher than that after administration of omeprazole(median:4.45 vs.2.65;P=0.0367).Also during the 6-h study period,a longer duration of maintenance at pH above 2,5,and 6 was observed after administration of roxatidine 75 mg than after administration of omeprazole 20 mg(median:90.6% vs.55.2%,P=0.0284;43.7% vs.10.6%,P=0.0125;40.3% vs.3.3%,P=0.0125;respectively).Conclusions:In Helicobacter pylori-negative healthy male subjects,oral administration of roxatidine 75 mg increased the intragastric pH more rapidly than that of omeprazole 20 mg.

关键词：奥美拉唑胃溃疡 pH值口服早期质子泵抑制剂相关性疾病受体拮抗剂

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eGFR is a reliable preoperative renal function parameter in patients with gastric cancer

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World Journal of Gastroenterology 2010年第19期16卷 2417-2420页

作者： Takayuki Kosuge Tokihiko Sawada Yoshimi Iwasaki Junji Kita Mitsugi Shimoda Nobumi Tagaya Keiichi kubota Sec-ond Department of Surgery Dokkyo Medical University Kitako-bayashi 880 Mibu Shimotsuga Tochigi 321-0293 Japan

AIM: To evaluate the validity of the estimated glomerular filtration rate (eGFR) as a preoperative renal function parameter in patients with gastric cancer. METHODS: A retrospective study was conducted in 147 patients with gastric cancer. Preoperative creatinine clearance (Ccr), eGFR, and preand postoperative serum creatinine (sCr) data were examined. Preoperative Ccr and eGFR were then compared for their reliability in predicting postoperative renal dysfunction. RESULTS: Among 110 patients with normal preoperative Ccr values, 7 (6.3%) had abnormal postoperative sCr values, and among 112 patients with normal preoperative eGFR values, postoperative sCr was abnormal in 5 (4.5%) (P = 0.53). Among 37 patients with abnormal preoperative Ccr values, 30 (81.1%) had normal postoperative sCr values, and of 35 patients with abnormal preoperative eGFR values, postoperative sCr was normal in 25 (71.4%) (P = 0.34). PreoperativeCcr was signifi cantly correlated with eGFR (r = 0.514), and postoperative sCr was significantly correlated with preoperative Ccr (r = -0.334) and eGFR (r = -0.02). CONCLUSION: Preoperative eGFR is as effective as Ccr for predicting postoperative renal dysfunction. eGFR should therefore be used as an indicator of preoperative renal function in place of Ccr since it is a cheaper and easier to perform test.

关键词： Estimated glomerular filtration rate Creatinine clearance test Gastric cancer

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Analysis of hepcidin expression: In situ hybridization and quantitative polymerase chain reaction from paraffin sections

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World Journal of Gastroenterology 2012年第28期18卷 3727-3731页

作者： Yuhki Sakuraoka Tokihiko Sawada Takayuki Shiraki Kyunghwa Park Yuhichiro Sakurai Naohisa Tomosugi Keiichi kubota Second Department of Surgery School of Medicine Dokkyo Medical University Kitakobayashi 880 Mibu Shimotsuga Tochigi 321-0293 Japan Proteomics Research Unit Division of Advanced Medicine Medical Research Institute Kanazawa Medical College Daigaku 1-1 Uchinada Kanazawa 920-0293 Japan

AIM: To establish methods for quantitative polymerase chain reaction (PCR) for hepcidin using RNAs isolated from paraffin-embedded sections and in situ hybridization of hepatocellular carcinoma (HCC). METHODS: Total RNA from paraffin-embedded sections was isolated from 68 paraffin-embedded samples of HCC. Samples came from 54 male and 14 female patients with a mean age of 66.8 ± 7.8 years. Quantitative PCR was performed. Immunohistochemistry and in situ hybridization for hepcidin were also performed. RESULTS: Quantitative PCR for hepcidin using RNAs isolated from paraffin-embedded sections of HCC was performed successfully. The expression level of hepcidin mRNA in cancer tissues was significantly higher than that in non-cancer tissues. A method of in situ hybridization for hepcidin was established successfully, and this demonstrated that hepcidin mRNA was expressed in non-cancerous tissue but absent in cancerous tissue. CONCLUSION: We have established novel methods for quantitative PCR for hepcidin using RNAs isolated from paraffin-embedded sections and in situ hybridization of HCC.

关键词：荧光定量聚合酶链反应 RNA原位杂交石蜡切片 hepcidin 定量PCR 石蜡包埋 mRNA 癌组织

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