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Sufficiently Elevated Core Body Temperature May Be Necessary to Maintain Cerebral Blood Flow Response throughout the Morning

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Neuroscience & Medicine 2022年第2期13卷 70-90页

作者： Ryohei Tanaka-Kanegae*# Shingo Miyamoto Masao Sakurai koichiro Hamada Saga Nutraceuticals Research Institute Otsuka Pharmaceutical Co. Ltd. Kanzaki Japan

In comparison to a carbohydrate-rich breakfast, a nutritionally balanced breakfast reportedly leads to a higher core body temperature because of diet-induced thermogenesis (DIT) and also results in higher task performance. This study aimed to examine the relationships among the core body temperature, blood glucose level, cerebral blood flow, and cognitive performance when the core body temperature is raised to a similar extent as in DIT in the morning. This crossover study included 18 male participants who performed four sets of cognitive tests in the morning with four different foot baths and glucose intake conditions. In elevated body temperature (EBT) conditions, the core body temperature was increased by a foot bath at 42˚C or 39˚C, while in low body temperature (LBT) conditions, it was maintained at 35˚C by a foot bath;the participants received no glucose or two intakes of 20-g glucose for each thermal condition. In addition to the core body temperature measurement, the cerebral blood flow in the dorsolateral prefrontal cortex (DLPFC) was measured using near-infrared spectroscopy. Three blood collections were performed to measure the changes in blood glucose levels. The results revealed that in the EBT conditions, the core body temperature remained 0.3˚C - 0.5˚C higher than that at wake-up time, while the glucose intake conditions increased blood glucose levels which remained higher than those during fasting. No significant between-treatment difference was observed in the results of cognitive tests. However, the blood flow in the DLPFC increased during the second test period in the EBT/glucose and LBT/glucose conditions, whereas during the fourth test period, it increased solely in the EBT/glucose condition. Thus, in addition to the blood glucose level, an elevated core body temperature within the physiological range may be needed for long-term maintenance of the cerebral blood flow response.

关键词： Elevated Core Body Temperature Cerebral Blood Flow Dorsolateral Prefrontal Cortex Near-Infrared Spectroscopy Cognitive Function Morning Breakfast Foot Bath

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Physiological Analysis for Universal Design of Public Seat Under Diverse Conditions

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Journal of Literature and Art Studies 2013年第2期3卷 125-136页

作者： Takeshi Kitamura koichiro Sato Yoshiyuki Matsuoka Takeo Kato Keio University Yokohama Japan Tokai University Tokyo Japan

Public vehicle seats are used under diverse conditions, therefore, the design of these seats is desired to be universal design. In the past study, seat swing function used in public vehicle seats, and it was optimized from the mechanical aspect under diverse conditions. Seat swing function is the function to prevent hip-sliding force, which causes sitting uncomfortable feeling. Recent study clarified that the reduction of blood flow in the legs causes physiological dysfunction, which is one of the causes of Long Flight Thrombosis, and the social issue. Thus, in the design of seat swing function, it is necessary to consider not only mechanical aspects but also physiological aspects. For the universal design of seat swing function considering the physiological aspect （blood flow）, the influence of blood flow on seat swing function in diverse conditions was analyzed. The method of this study was measuring blood flow and body pressure distribution on seat cushion of seat swing function under diverse conditions. From the analysis, it was indicated that it was necessary to reduce the compressive force behind the knees of the user conditions; the short physique and the high weight physique in standard sitting posture, for the universal design of seat swing function to prevent reduction of blood flow in the legs.

关键词： universal design diverse conditions seat blood flow

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船用柴油机余热回收的涡轮发电装置

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柴油机 1989年第4期11卷 14-14,41,50页

作者： koichiro Imakijre 蒋国鑫

三菱重工制成一种新型船用柴油机余热回收装置。其关键部件有径流废气涡轮和高效率的涡轮增压器,故取名为特制涡轮发电(STG)装置。这种想法并不新奇,但由于三菱重工采用的涡轮增压器MET-SC型效率很高。

关键词：船用柴油机余热回收涡轮发电装置

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Gastric linitis plastica with autoimmune pancreatitis diagnosed by an endoscopic ultrasonography-guided fine-needle biopsy: A case report

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World Journal of Clinical Cases 2022年第31期10卷 11607-11616页

作者： Ryosuke Sato Kazuyuki Matsumoto Hiromitsu Kanzaki Akihiro Matsumi Kazuya Miyamoto Kosaku Morimoto Hiroyuki Terasawa Yuki Fujii Tatsuhiro Yamazaki Daisuke Uchida koichiro Tsutsumi Shigeru Horiguchi Hironari Kato Gastroenterology and Hepatology Okayama University HospitalOkayama 700-8558Japan

BACKGROUND Gastric linitis plastica(GLP)is a subset of gastric cancer with a poor *** is difficult to obtain a definitive diagnosis by endoscopic mucosal biopsies,and the usefulness of an endoscopic ultrasonography-guided fine-needle biopsy(EUSFNB)for GLP has been recently ***,autoimmune diseases are occasionally known to coexist with malignant tumors as paraneoplastic *** herein report the usefulness of an EUS-FNB for detecting GLP and the possibility of paraneoplastic syndrome coexisting with *** SUMMARY An 81-year-old man was admitted to our hospital for a 1-mo history of epigastric pain that increased after *** laboratory data revealed high levels of serum carbohydrate antigen 19-9 and *** examinations showed giant gastric folds and reddish mucosa;however,no epithelial changes were *** gastric lumen was not distensible by air inflation,suggesting *** tomography showed the thickened gastric wall,the diffuse enlargement of the pancreas,and the peripancreatic rim,which suggested autoimmune pancreatitis(AIP)coexisting with *** the pathological findings of the endoscopic biopsy showed no malignancy,he underwent an EUSFNB and was diagnosed with *** received chemotherapy for unresectable gastric cancer due to peritoneal metastasis,after which both the gastric wall thickening and diffuse enlargement of the pancreas were *** An EUS-FNB for GLP with a negative endoscopic biopsy is useful,and AIP may develop as a paraneoplastic syndrome.

关键词： Endoscopic ultrasound-guided fine needle aspiration Linitis plastica Autoimmune pancreatitis Paraneoplastic syndromes Case report

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SYNERGISTIC EXTRACTION OF EUROPIUM（Ⅲ） WITH 2-THENOYLTRIFLUOROACETONE AND A LEWIS BASE AND THE APPLICATION TO PREPARATION OF BINUCLEAR COMPLEXES

SYNERGISTIC EXTRACTION OF EUROPIUM（Ⅲ） WITH 2-THENOYLTRIFL...

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International Solvent Extraction Conference 2005

作者： Yuko Hasegawa Satoshi Kumaki koichiro Tanaka Department of Chemistry Faculty of Science Science University of Tokyo Kagurazaka Shinjuku-ku Tokyo 162-8601 Japan Department of Chemistry Faculty of Science Science University of Tokyo Kagurazaka Shinjuku-ku Tokyo 162-8601 Japan Department of Chemistry Faculty of Science Science University of Tokyo Kagurazaka Shinjuku-ku Tokyo 162-8601 Japan

In the extraction of lanthanoids(III) with 2-thenoyltrifluoroacetone (Htta) and a Schiff base complexed copper(II), the distribution ratio of europium(III) has been measured as a function of pH, Htta

关键词： Synergistic extraction Schiff base Cu(saltn) lanthanoids(III) stability constants binuclear complexes

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Isolation of a Novel Lodging Resistance QTL Gene Involved in Strigolactone Signaling and Its Pyramiding with a QTL Gene Involved in Another Mechanism

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Molecular Plant 2015年第2期8卷 303-314页

作者： Kenji Yano Taiichiro Ookawa koichiro Aya Yusuke Ochiai Tadashi Hirasawa Takeshi Ebitani Takeshi Takarada Masahiro Yano Toshio Yamamoto Shuichi Fukuoka Jianzhong Wu Tsuyu Ando Reynante Lacsamana Ordonio Ko Hirano Makoto Matsuoka Bioscience and Biotechnology Center Nagoya University Nagoya Aichi 464-8601 Japan Graduate School of Agriculture Tokyo University of Agriculture and Technology Fuchu Tokyo 183-8509 Japan Agricultural Research Institute Toyama Agricultural Forestry & Fisheries Research Center Toyama 939-8153 Japan National Institute of Agrobiological Sciences Tsukuba Ibaraki 305-8602 Japan These authors contributed equally to this article.

Lodging has been a major roadblock to attaining increased crop productivity. In an attempt to understand the mechanism for culm strength in rice, we isolated an effective quantitative trait locus （QTL）, STRONG CULM3 （SCM3）, the causal gene of which is identical to rice TEOSINTE BRANCHED1 （OsTB1）, a gene previously reported to positively control strigolactone （SL） signaling. A near-isogenic line （NIL） carrying SCM3 showed enhanced culm strength and increased spikelet number despite the expected decrease in tiller number, indicating that SL also has a positive role in enhancing culm strength and spikelet number. We produced a pyramiding line carrying SCM3 and SCM2, another QTL encoding AP01 involved in panicle development. The NIL-SCM2＋SCM3 showed a much stronger culm than NIL-SCM2 and NIL-SCM3 and an increased spikelet number caused by the additive effect of these QTLs. We discuss the importance of utilizing suitable alleles of these STRONG CULM QTLs without inducing detrimental traits for breeding.

关键词： culm OsTB1 strigolactone lodging resistance quantitative trait loci

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钢铁中多元夹杂物颗粒的三维评估

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冶金分析 2012年第8期32卷 1-8页

作者： RY0 noue KEI iyokawa koichiro Tomoda SHIGERU Ueda TATSURO Ariyama 日本东北大学高级材料多学科研究所日本仙台980-8577 日本东芝纳米分析有限公司物理分析技术中心日本川崎212-8583

为了从钢铁中提取各种夹杂物颗粒,考察了采用无水电解质的恒电位和恒电流的提取方法。结果认为,4%的MS[4%(V/V)甲基水杨酸-1%(m/V)水杨酸-1%(m/V)四甲基氯化铵-甲醇)和10%AA(10%(V/V)乙酰丙酮-1%(m/V)四甲基氯化铵-甲醇]电解质溶液适用... 详细信息

为了从钢铁中提取各种夹杂物颗粒,考察了采用无水电解质的恒电位和恒电流的提取方法。结果认为,4%的MS[4%(V/V)甲基水杨酸-1%(m/V)水杨酸-1%(m/V)四甲基氯化铵-甲醇)和10%AA(10%(V/V)乙酰丙酮-1%(m/V)四甲基氯化铵-甲醇]电解质溶液适用于提取钢铁中夹杂物TiOx和TiAl2O5。尽管这些电解提取法可以提取化学性能不稳定的夹杂物颗粒,然而,因为对夹杂物的观察是在萃取完成后于一个滤膜中进行,因此无法确定金属中每种夹杂物的具体位置。为了确定金属中夹杂物的具体位置,将卤-醇的光蚀刻方法用于以Ti和Al除氧的钢样品表面附近出现的夹杂颗粒,使用扫描电子显微技术和俄歇电子能谱(AES)对精细夹杂物颗粒形貌、尺寸和元素的偏析进行评估,不过卤醇却和钢铁中的金属钛和金属铝发生还原反应。对微小夹杂物颗粒的成分的形态、分离进行估测,然后,使用一种低加速能-扫描电子显微技术和俄歇电子能谱(AES)对用聚焦离子束制备微小夹杂物颗粒截面上元素的微观偏析进行评定。在这些研究结果基础上讨论了多元夹杂物颗粒的形成机理。

关键词：三维评估多元夹杂物光蚀刻俄歇电子能谱(AES) 聚焦离子束形成机理

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The Concept Study of Recombinant Human Soluble Thrombomodulin in Patients with Acute Respiratory Distress Syndrome

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International Journal of Clinical Medicine 2013年第11期4卷 488-495页

作者： Kenji Tsushima Toshiki Yokoyama Tomonobu Koizumi Keishi Kubo koichiro Tatsumi Department of Pulmonary Medicine Shinonoi General Hospital Nagano Japan Department of Respirology Graduate School of Medicine Chiba Uni-versity Chiba Japan Department of Respirology Graduate School of Medicine Chiba Uni-versity Chiba Japan First Department of Internal Medicine Shinshu University School of Medicine Nagano Japan

Background: Recombinant human soluble thrombomodulin (rhTM) was approved for the treatment of disseminated intravascular coagulation in Japan, and rhTM has anti-inflammatory effects. Disordered coagulation is a part of the acute respiratory distress syndrome (ARDS) pathophysiology and thus we hypothesize that anticoagulant therapy may help. This preliminary study was to observe the safety of rhTM administration and the improvement on biomarker levels after the therapy for ARDS-patients. Objectives: Case series of ARDS-patients. Methods: Seventeen ARDS-patients that required ventilatory management were treated with rhTM and clinical and laboratory data were collected including platelets, thrombin-antithrombin complex (TAT), fibrinogen degradation products, oxygen saturation/the fraction of inspired oxygen (SpO2/FIO2), and high-mobility group-1 (HMG-1). The administration of rhTM was started during 6 days at a bolus dose of 0.06 mg/kg/day immediately after the diagnosis of ARDS. Results: Eleven of the 17 ARDS-patients were alive at 28 days after the beginning of the administration of rhTM. The serial pattern of the SpO2/FIO2 showed remarkable differences between the survivors and nonsurvivors from day 5 to day 7. The TAT in the survivors significantly decreased after treatment, and there were significantly lower levels in the TAT on day 7 in comparison to that of the nonsurvivors. The serial changes of HMG-1 showed increased levels in the nonsurvivors until day 5 after the administration of rhTM. Conclusions: Additional rhTM administration can safely improve the parameters in survival ARDS-patients, as demonstrated by significant improvements in the SpO2/FIO2, HMG-1 and TAT.

关键词： Acute Respiratory Distress Syndrome Recombinant Human Soluble Thrombomodulin Thrombin-Antithrombin Complex SpO2/FIO2 High-Mobility Group-1

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Stability of cirrhotic systemic hemodynamics ensures sufficient splanchnic blood flow after living-donor liver transplantation in adult recipients with liver cirrhosis

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World Journal of Gastroenterology 2007年第44期13卷 5918-5925页

作者： Tomohide Hori Shintaro Yagi Taku Iida Kentaro Taniguchi Kentaro Yamagiwa Chiduru Yamamoto Takashi Hasegawa koichiro Yamakado Takuma Kato Kanako Saito Linan Wang Mie Torii Yukinobu Hori Kan Takeda Kazuo Maruyama Shinji Uemoto Departments of Hepatobiliary Pancreatic Surgery Mie University Hospital 2-174 Edobashi Tsu City Mie Prefecture 514-8507 Japan Department of Cellular and Molecular Immunology Mie University Graduate School of Medicine 2-174 Edobashi Tsu City Mie Prefecture 514-8507 Japan Department of Hepatobiliary Pancreatic and Transplant Surgery Kyoto University Hospital 54 Kawahara-cho Shogoin Sakyo-ku Kyoto 606-8507 Japan Department of Anesthesiology and Critical Care Medicine Mie University Hospital 2-174 Edobashi Tsu City Mie Prefecture 514-8507 Japan Department of Radiology Mie University Hospital 2-174 Edobashi Tsu City Mie Prefecture 514-8507 Japan Department of Medical Oncology and Immunology Mie University Graduate School of Medicine 2-174 Edobashi Tsu City Mie Prefecture 514-8507 Japan Nagoya Economic University Graduate School of Law 61-1 Uchikubo Inuyama City Aichi Prefecture 484-8504 Japan

AIM： To investigate the correlation between systemic hemodynamics and splanchnic circulation in recipients with cirrhosis undergoing living-donor liver transplantation （LDLT）, and to clarify how systemic hemodynamics impact on local graft circulation after LDLT.METHODS： Systemic hemodynamics, indocyanine green （ICG） elimination rate （K,cG） and splanchnic circulation were simultaneously and non-invasively investigated by pulse dye densitometry （PDD） and ultrasound. Accurate estimators of optimal systemic hyperdynamics after LDLT [i.e., balance of cardiac output （CO） to blood volume （BV） and mean transit time （MTT）, defined as the time required for half the administered ICG to pass through an attached PDD sensor in the first circulation] were also measured. Thirty recipients with cirrhosis were divided into two groups based on clinical outcomes corresponding to postoperative graft function.RESULTS： Cirrhotic systemic hyperdynamics characterized by high CO, expanded BV and low total peripheral resistance （TPR） were observed before LDLT. TPR reflecting cirrhotic vascular alterations was slowly restored after LDLT in both groups. Although no significant temporal differences in TPR were detected between the two groups, CO/BV and M＇IT differed significantly. Recipients with good outcomes showed persistent cirrhotic systemic hyperdynamics after LDLT, whereas recipients with poor outcomes presented with unstable cirrhotic systemic hyperdynamics and severely decreased KICG. Systemic hyperdynamic disorders after LDLT impacted on portal venous flow but not hepatic arterial flow.CONCLUSION： We conclude that subtle systemic hyperdynamics disorders impact on splanchnic circulation, and that an imbalance between CO and BV decreases portal venous flow, which results in critical outcomes.

关键词： Cirrhosis Hyperdynamic Portal hypertension Splanchnic Indocyanine green

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Mapping of metastasis suppressor genes for prostate cancer by microcell-mediated chromosome transfer

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Asian Journal of Andrology 2000年第3期2卷 167-171页

作者： Tomohiko ICHIKAWA Shigeru HOSOKI Hiroyoshi SUZUKI koichiro AKAKURA Tatsuo IGARASHI Yuzo FURUYA Mitsuo OSHIMURA Carrie W.RINKER-SCHAEFFER Naoki NIHEI J.Carl BARRETT John T.ISAACS Haruo ITO Department of Urology Chiba University School of MedicineChiba 260-8670Japan Department of Urology Teikyo University School of MedicineIchihara HospitalIchihara 299-0111Japan Department of Molecular and Cell Genetics School of MedicineTottori UniversityYonago 683-8503Japan Department of Surgery Section of UrologyUniversity of ChicagoChicagoIllinois 60637USA Laboratory of Molecular Carcinogenesis National Institute of Environmental Health SciencesNational Insitute of HealthResearch Triangle ParkNorth Carolina 27709USA The Johns Hopkins Oncology Center BaltimoreMaryland 21231USA

Aim:To identify the metastasis suppressor genes for prostate ***:A copy of human chromosomeswas introduced into the highly metastatic Dunning R-3327 rat prostate cancer cells by the use of microcell-mediatedchromosome *** between the size of human chromosomes introduced into microcell hybrid clonesand the number of lung metastases produced by the clones were analyzed to determine which part of human chromo-somes contained the metastasis suppressor gene(s)for prostate *** determine portions of human chromosomesintroduced,G-banding chromosomal analysis,fluorescence in sim hybridization analysis,and polymerase chain reac-tion analysis were ***:Each of microcell hybrid clones containing human chromosomes 7,8,10,11,12,or 17 showed decreased ability to metastasize to the lung without any loss of *** demonstratesthat these human chromosomes contain metastasis suppressor genes for prostate *** deletion of portionsof human chromosomes was observed in the human chromosome 7,10,11,12,and 17 *** the human chromo-some 8 study,irradiated microcell-mediated chromosome transfer was performed to enrich chromosomal arm deletionsof human chromosome *** and cytogenetic analyses of microcell hybrid clones demonstrated that metastasissuppressor genes on human chromosomes were located on 7q21-22,7q31.2-32,8p21-12,10q11-22,11p13-11.2,12p11-q13,12q24-ter,and *** and MKK4/SEKI were identified as metastasis suppressor genes from11p11.2 and 17p12,***:This assay system is useful to identify metastasis suppressor gene(s)for prostate cancer.

关键词： prostate cancer metastasis metastasis suppressor gene chromosome

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