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Low skeletal muscle mass and high visceral adiposity are associated with recurrence of acute cholecystitis after conservative management:A propensity score-matched cohort study

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Hepatobiliary & Pancreatic Diseases International 2024年第1期23卷 64-70页

作者： Yudai Koya Michihiko Shibata Yuki Maruno Yoshitaka Sakamoto Shinji Oe koichiro miyagawa Yuichi Honma Masaru Harada Department of Gastroenterology Kyushu Rosai HospitalMoji Medical Center3-1 HigashiminatomachiMoji-kuKitakyushu 801-8502Japan Third Department of Internal Medicine School of MedicineUniversity of Occupational and Environmental HealthKitakyushu 807-8555Japan Department of Surgery Kyushu Rosai Hospital Moji Medical CenterKitakyushu 801-8502Japan

Background:Recurrent acute cholecystitis(RAC)can occur after non-surgical treatment for acute cholecystitis(AC),and can be more severe in comparison to the first episode of *** skeletal muscle mass or adiposity have various effects in several *** aimed to clarify the relationship between RAC and body ***:Patients with AC who were treated at our hospital between January 2011 and March 2022 were *** psoas muscle mass and adipose tissue area at the third lumbar level were measured using computed tomography at the first episode of *** areas were divided by height to obtain the psoas muscle mass index(PMI)and subcutaneous/visceral adipose tissue index(SATI/VATI).According to median VATI,SATI and PMI values by sex,patients were divided into the high and low PMI *** performed propensity score matching to eliminate the baseline differences between the high PMI and low PMI groups and analyzed the cumulative incidence and predictors of ***:The entire cohort was divided into the high PMI(n=81)and low PMI(n=80)*** the propensity score-matched cohort there were 57 patients in each *** Kaplan-Meier analysis,the low PMI group and the high VATI group had a significantly higher cumulative incidence of RAC than their counterparts(log-rank P=0.001 and 0.015,respectively).In a multivariate Cox regression analysis,the hazard ratios of low PMI and low VATI for RAC were 5.250(95%confidence interval 1.083-25.450,P=0.039)and 0.158(95%confidence interval:0.026-0.937,P=0.042),***:Low skeletal muscle mass and high visceral adiposity were independent risk factors for RAC.

关键词： Acute cholecystitis Low skeletal muscle mass Recurrent acute cholecystitis Sarcopenia Visceral adiposity

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A new electric field mill array with each of the mill’s rotor controlled precisely by a GPS module:Equipment and initial results

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Earth and Planetary Physics 2024年第2期8卷 423-435页

作者： Kozo Yamashita Hironobu Fujisaka DaoHong Wang Hiroyuki Iwasaki Kazuo Yamamoto koichiro Michimoto Masashi Hayakawa Department of Production Systems Engineering and Sciences Komatsu UniversityNu 1-3 Shicho-machiKomatsuIshikawa 923-8511Japan Fujisaka Technology Office 1058-5 Yoshizawa-choOhta-shiGunma 373-0019Japan Department of Electrical Electronic and Computer EngineeringGifu University1-1 YanagidoGifu CityGifu 501-1193Japan Cooperative Faculty of Education Gunma University4-2-Aramaki-machiMaebashiGunma 371-8510Japan Department of Electrical and Electronic Engineering Chubu University1200 Matsumoto-choKasugaiAichi 487-8501Japan Independent Researcher Kosenba Town 2-44-11-406Kawagoe CitySaitama350-0036Japan Advanced Wireless&Communications Research Center The University of Electro-Communications1-5-1 ChofugaokaChofuTokyo 182-8585Japan

We have newly designed an electrostatic sensor,called an electric field mill(EFM),to simplify the estimation of the charge position and charge amount transferred by lightning *** is necessary for this remote estimation of the transferred charge to measure electric field changes caused by charge loss at the time of a lightning strike at multiple *** multiple-station measurement of electric field changes,not only speed but also phase for exposure and shielding of the sensing plates inside each EFM of the array should be synchronized to maintain the sensitivities of the deployed ***,there is no such EFM with specified speed and phase control performance of the rotary ***,we developed a new EFM in which the rotary mechanism was controlled consistently to within 3%error by a GPS *** EFMs had been distributed in the Hokuriku area of Japan during the winter season of 2022-2023 for a test *** we describe the design and a simple calibration method for our new EFM *** analysis method based on the assumption of a simple monopole charge structure is also *** validation,locations of assumed point charges were compared with three-dimensional lightning mapping data estimated by radio observations in the MF-HF *** results indicated the validity to estimate transferred charge amounts and positions of winter cloud-to-ground lightning discharges with our new EFM array.

关键词： lightning electrostatic field electric field mill electric field change

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Hepatitis A complicated with acute renal failure and high hepatocyte growth factor: A case report

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World Journal of Gastroenterology 2015年第32期21卷 9671-9674页

作者： Shinji Oe Michihiko Shibata koichiro miyagawa Yuichi Honma Masaaki Hiura Shintaro Abe Masaru Harada Department of Internal Medicine School of Medicine University of Occupational and Environmental Health

A 58-year-old man was admitted to our hospital. Laboratory data showed severe liver injury and that the patient was positive for immunoglobulin M anti-hepatitis A virus(HAV) antibodies. He was also complicated with severe renal dysfunction and had an extremely high level of serum hepatocyte growth factor(HGF). Therefore, he was diagnosed with severe acute liver failure with acute renal failure(ARF) caused by HAV infection. Prognosis was expected to be poor because of complications by ARF and high serum HGF. However, liver and renal functions both improved rapidly without intensive treatment, and he was subsequently discharged from our hospital on the 21 st hospital day. Although complication with ARF and high levels of serum HGF are both important factors predicting poor prognosis in acute liver failure patients, the present case achieved a favorable outcome. Endogenous HGF might play an important role as a regenerative effector in injured livers and kidneys.

关键词： Acute hepatitis Acute renal failure Hepatitis A vi

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Getting a Sense of ATP in Real Time

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Neuroscience Bulletin 2022年第7期38卷 834-836页

作者： Anthony D.Umpierre koichiro Haruwaka Long-Jun Wu Department of Neurology Mayo ClinicRochesterMN55905USA Department of Neuroscience Mayo ClinicJacksonvilFL32224USA Department of Immunology Mayo ClinicRochesterMN55905USA

Adenosine 5'-triphosphate(ATP)is a purinergic signal that can be sensed by all major cell classes in the *** is a key signal released during periods of physical damage/injury,inflammation,and neurological events,such as *** ATP signaling in the living brain is complicated by its fast enzymatic degradation,its action at multiple receptors,and its somewhat elusive.

关键词： signal damage somewhat

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Effects of pore interconnectivity on bone regeneration in carbonate apatite blocks

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Regenerative Biomaterials 2022年第1期9卷 30-40页

作者： Maab Elsheikh Ryo Kishida koichiro Hayashi Akira Tsuchiya Masaya Shimabukuro and Kunio Ishikawa Department of Biomaterials Faculty of Dental ScienceKyushu University3-1-1 Maidashi Higashi-kuFukuoka 812-8582Japan

Porous architecture in bone substitutes,notably the interconnectivity of pores,is a critical factor for bone ***,controlling the pore interconnectivity while maintaining the microarchitecture has not yet been achieved using conventional methods,such as ***,we fabricated a porous block using the crystal growth of calcium sulfate dihydrate,and controlled the pore interconnectivity by limiting the region of crystal *** calcium sulfate dihydrate blocks were transformed to bone apatite,carbonate apatite(CO_(3)Ap)through dissolution–precipitation ***,CO_(3)Ap blocks with 15%and 30%interconnected pore volumes were obtained while maintaining the microarchitecture:they were designated as CO_(3)Ap-15 and CO_(3)Ap-30,*** 4 weeks after implantation in a rabbit femur defect,new bone formed throughout CO_(3)Ap-30,whereas little bone was formed in the center region of CO_(3)*** 12 weeks after implantation,a large portion of CO_(3)Ap-30 was replaced with new bone and the boundary with the host bone became *** contrast,CO_(3)Ap-15 remained in the defect and the boundary with the host bone was still ***,the interconnected pores promote bone ingrowth,followed by replacement of the material with new *** findings provide a useful guide for designing bone substitutes for rapid bone regeneration.

关键词： bone substitutes carbonate apatite pore interconnectivity bone regeneration

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Hydrogen gas and preservation of intestinal stem cells in mesenteric ischemia and reperfusion

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World Journal of Gastrointestinal Surgery 2022年第12期14卷 1329-1339页

作者： Ryo Yamamoto Sayuri Suzuki koichiro Homma Shintaro Yamaguchi Tomohisa Sujino Junichi Sasaki Department of Emergency and Critical Care Medicine Keio University School of MedicineTokyo 1608582Japan Division of Endocrinology Metabolism and NephrologyDepartment of Internal MedicineKeio University School of MedicineTokyo 1608582Japan Division of Gastroenterology and Hepatology Department of Internal MedicineKeio University School of MedicineTokyo 1608582Japan

BACKGROUND Patients with mesenteric ischemia frequently suffer from bowel necrosis even after *** gas has showed promising effects for ischemiareperfusion injury by reducing reactive oxygen species in various animal and clinical *** examined intestinal tissue injury by ischemia and reperfusion under continuous initiation of 3%hydrogen *** To clarify the treatment effects and target cells of hydrogen gas for mesenteric *** Three rat groups underwent 60-min mesenteric artery occlusion(ischemia),60-min reperfusion following 60-min occlusion(reperfusion),or ischemiareperfusion with the same duration under continuous 3%hydrogen gas inhalation(hydrogen).The distal ileum was *** staining with caspase-3 and leucine-rich repeat-containing G-protein-coupled 5(LGR5),a specific marker of intestinal stem cell,was conducted to evaluate the injury location and cell types protected by *** expressions of LGR5,olfactomedin 4(OLFM4),hairy and enhancer of split 1,Jagged 2,and Neurogenic locus notch homolog protein 1 were measured by quantitative polymerase chain *** oxidative stress was analyzed with immunostaining for 8-hydroxy-2'-deoxyguanosine(8-OHdG).Systemic oxidative stress was evaluated by plasma *** Ischemia damaged the epithelial layer at the tip of the villi,whereas reperfusion induced extensive apoptosis of the cells at the crypt base,which were identified as intestinal stem cells with double immunofluorescence *** mitigated such apoptosis at the crypt base,and the LGR5 expression of the tissues was higher in the hydrogen group than in the reperfusion ***4 was also relatively higher in the hydrogen group,whereas other measured RNAs were comparable between the groups.8-OHdG concentration was high in the reperfusion group,which was reduced by hydrogen,particularly at the crypt *** 8-OHdG concentrations were relatively higher in both reperfusion and

关键词： Hydrogen molecule Intestinal ischemia Ischemia-reperfusion injury Tissue protection Nonoperative management Leucine-rich repeat-containing G-protein-coupled 5

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Oxalic acid in ginger specifically denatures the acrid raphides in the unprocessed dried tuber of Pinellia ternata

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Acupuncture and Herbal Medicine 2022年第1期2卷 33-40页

作者： Tsukasa Fueki Itsuki Nose Yan Liu koichiro Tanaka Takao Namiki Toshiaki Makino Matsuya Pharmacy NiigataJapan Department of Pharmacognosy Graduate School of Pharmaceutical SciencesNagoya City UniversityNagoyaJapan Department of Traditional Medicine Toho University School of MedicineTokyoJapan Department of Japanese-Oriental(Kampo)Medicine Graduate School of MedicineChiba UniversityChibaJapan

Objective:Pinellia Tuber,the dried tuber of Pinellia ternata,is widely used in Japanese Kampo medicines and traditional Chinese *** unprocessed Pinellia Tuber is known to cause very strong acrid irritation at oral and laryngopharynx *** studies have shown that the sharp needle-like crystals called raphides,that are composed of calcium oxalate and proteins,are the main causative substances of the ***,the rhizome of Zingiber officinale,has been used in the processing to reduce the acridity of Pinellia Tuber since before the sixth century,however,the mechanisms of reducing acridity have not been scientifically proved ***:We developed the raphides denaturation assay(RDA)to quantify the degree of denaturation in the raphides to cause *** their lipophilic characters,the raphides could be extracted in petroleum ether(PE)layer from powdered Pinellia Tuber suspended in water,and the contents of the raphides in PE layer were measured by the *** this assay,we conducted the activity-guided fractionation from the boiling water extract of ginger to find the ingredients to denature the *** also conducted the gustatory tests to detect the change of the irritation of the denatured ***:The treatment of powdered Pinellia Tuber suspension with ginger extract reduced the distribution of raphides in PE layer in RDA in a concentration-dependent *** activity-guided fractionation using RDA revealed that oxalic acid was the main active ingredient in ginger extract to denature the raphides of Pinellia *** acid reduced the lipophilicity of the raphides in the thermo-,time-,and concentration-dependent manners,and its activity was affected by *** treatment of powdered Pinellia Tuber suspension with oxalic acid significantly reduced its acrid irritation in gustatory test in ***:We found that oxalic acid is the main active ingredient in ginger to reduce the acrid irritation of Pinell

关键词： Acridity Ginger Pinellia ternata Pinellia Tuber Processing Raphide

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Indium chloride bone marrow scintigraphy for hepatic myelolipoma: A case report

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World Journal of Clinical Cases 2023年第18期11卷 4377-4383页

作者： Akio Sato Kazuhiro Saito koichiro Abe Katsutoshi Sugimoto Toshitaka Nagao Aoi Sukeda Daisuke Yunaiyama Department of Radiology Tokyo Medical University HospitalShinjuku-ku 160-0023TokyoJapan Department of Gastroenterology and Hepatology Tokyo Medical University HospitalShinjuku-ku 160-0023TokyoJapan Department of Anatomic Pathology Tokyo Medical University HospitalShinjuku-ku 160-0023TokyoJapan

BACKGROUND As hepatic myelolipoma is rarely encountered,its radiological diagnosis using ultrasonography(US),computed tomography(CT),and magnetic resonance imaging(MRI)is *** myelolipoma is similar to fat-contained hepatic lesions seen in hepatocellular carcinoma and ***,further development of techniques to diagnose hepatic myelolipoma is *** SUMMARY A 44-year-old obese man was found to have a hepatic lesion during his medical *** lesion was 50 mm×57 mm in size and was detected in segment 8(S8)of the liver by *** patient was diagnosed with hepatic lesion 20 years ago,but it was left *** patient had no symptoms,liver dysfunction,hepatitis virus antibody,or tumor marker *** CT showed a welldefined lesion in S8 of the *** central and peripheral areas of the lesion primarily exhibited fat density and hypodensity,*** revealed a capsule-like *** was performed to address the probability of hepatocellular *** lesion was pathologically confirmed as a *** marrow scintigraphy performed using 111InCl3 revealed accumulation of the radiopharmaceutical in the soft tissue component,except in the fat-dominant part of the tumor,as well as in the surrounding liver parenchyma due to the presence of reticuloendothelial cells in the *** This is the first report on the diagnosis of hepatic myelolipoma using 111InCl3 *** effectiveness of bone marrow scintigraphy for diagnosing hepatic myelolipoma might be *** radiopharmaceuticals accumulate in both hematopoietic and reticuloendothelial cells,the accumulation of radiopharmaceuticals in the lesion is obscure.

关键词： Liver 111InCl3 Myelolipoma Magnetic resonance imaging Benign tumor Case report

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Geochemistry of Rare Earth Elements(REE) in the Weathered Crusts from the Granitic Rocks in Sulawesi Island, Indonesia

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Journal of Earth Science 2014年第3期25卷 460-472页

作者： Adi Maulana Kotaro Yonezu koichiro Watanabe Department of Geology Engineering Faculty of Engineering Hasanuddin University Department of Earth Resources Engineering Kyushu University

We report for the first time the geochemistry of rare earth elements（REE） in the weathered crusts of I-type and calc-alkaline to high-K（shoshonitic） granitic rocks at Mamasa and Palu region, Sulawesi Island, Indonesia. The weathered crusts can be divided into horizon A（lateritic profile） and B（weathered horizon）. Quartz, albite, kaolinite, halloysite and montmorrilonite prevail in the weathered crust. Both weathered profiles show that the total REE increased from the parent rocks to the horizon B but significantly decrease toward the upper part（horizon A）. LREE are enriched toward the upper part of the profile as shown by La/YbN value. However, HREE concentrations are high in horizon B1 in Palu profile. The total REE content of the weathered crust are relatively elevated compared to the parent rocks, particularly in the lower part of horizon B in Mamasa profile and in horizon B2 in Palu profile. This suggests that REE-bearing accessory minerals may be resistant against weathering and may remain as residual phase in the weathered crusts. The normalized isocon diagram shows that the mass balance of major and REE components between each horizon in Mamasa and Palu weathering profile are different. The positive Ce anomaly in the horizon A of Mamasa profile indicated that Ce is rapidly precipitated during weathering and retain at the upper soil horizon.

关键词： rare earth element geochemistry weathered crust granitic rock Sulawesi Indonesia.

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Tensile force correction calculation method for prestressed construction of tension structures

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2008年第9期9卷 1201-1207页

作者： Xin ZHUO Guo-fa ZHANG koichiro ISHIKAWA Dao-an LOU Department of Civtl Engmeermg Zhejiang University Hangzhou 310027 China Department of Architecture and Civil Engineering Fukui University Fukui 910-8507 Japan Zhejiang Zhancheng Construction Group Co. Ltd. Hangzhou 310005 China

Factors such as errors during the fabrication or construction of structural components and errors of calculation as- sumption or calculation methods, are very likely to cause serious deviation of many strings’ actual prestressing forces from the designed values during tension structure construction or service period, and further to threaten the safety and reliability of the structure. Aiming at relatively large errors of the prestressing force of strings in a tension structure construction or service period, this paper proposes a new finite element method (FEM), the "tensile force correction calculation method". Based on the measured prestressing forces of the strings, this new method applies the structure from the zero prestressing force status approach to the measured prestressing force status for the first phase, and from the measured prestressing force status approach to the designed prestressing force status for the second phase. The construction tensile force correction value for each string can be obtained by multi-iteration with FEM. Using the results of calculation, the strings’ tensile force correction by group and in batch will be methodic, simple and accurate. This new calculation method can be applied to the prestressed correction construction simulation analysis for tension structures.

关键词：建筑结构建筑施工高精度技术预应力混凝土

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