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Treatment strategy for metastatic prostate cancer with extremely high PSA level： reconsidering the value of vintage therapy

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Asian Journal of Andrology 2018年第5期20卷 432-437页

作者： Yasutaka Yamada Shinichi Sakamoto Yoshiyasu Amiya Makoto Sasaki Takayuki Shima Akira Komiya Noriyuki Suzuki koichiro akakura Tomohiko Ichikawae Hiroomi Nakatsu Department of Urology Asahi General Hospital Asahi 289-2511 Japan Department of Urology Chiba University Graduate School of Medicine Chiba 260-8677 Japan Department of Urology Japan Community Healthcare Organization Tokyo Shinjuku Medical Center Tokyo 162-8543 Japan

The prognostic significance of initial prostate-specific antigen （PSA） level for metastatic prostate cancer remains uncertain. We investigated the differences in prognosis and response to hormonal therapies of metastatic prostate cancer patients according to initial PSA levels. We analyzed 184 patients diagnosed with metastatic prostate cancer and divided them into three PSA level groups as follows： low （〈100 ng ml-1）, intermediate （100–999 ng ml-1）, and high （≥1000 ng ml-1）. All patients received androgen deprivation therapy （ADT） immediately. We investigated PSA progression-free survival （PFS） for first-line ADT and overall survival （OS） within each of the three groups. Furthermore, we analyzed response to antiandrogen withdrawal （AW） and alternative antiandrogen （AA） therapies after development of castration-resistant prostate cancer （CRPC）. No significant differences in OS were observed among the three groups （P = 0.654）. Patients with high PSA levels had significantly short PFS for first-line ADT （P = 0.037）. Conversely, patients in the high PSA level group had significantly longer PFS when treated with AW than those in the low PSA level group （P = 0.047）. Furthermore, patients with high PSA levels had significantly longer PFS when provided with AA therapy （P = 0.049）. PSA responders to AW and AA therapies had significantly longer survival after CRPC development than nonresponders （P = 0.011 and P 〈 0.001, respectively）. Thus, extremely high PSA level predicted favorable response to vintage sequential ADT and AW. The current data suggest a novel aspect of extremely high PSA value as a favorable prognostic marker after development of CRPC.

关键词： alternative antiandrogen therapy antiandrogen withdrawal hormonal therapy metastatic prostate cancer prostate-specificantigen

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Mapping of metastasis suppressor genes for prostate cancer by microcell-mediated chromosome transfer

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Asian Journal of Andrology 2000年第3期2卷 167-171页

作者： Tomohiko ICHIKAWA Shigeru HOSOKI Hiroyoshi SUZUKI koichiro akakura Tatsuo IGARASHI Yuzo FURUYA Mitsuo OSHIMURA Carrie W.RINKER-SCHAEFFER Naoki NIHEI J.Carl BARRETT John T.ISAACS Haruo ITO Department of Urology Chiba University School of MedicineChiba 260-8670Japan Department of Urology Teikyo University School of MedicineIchihara HospitalIchihara 299-0111Japan Department of Molecular and Cell Genetics School of MedicineTottori UniversityYonago 683-8503Japan Department of Surgery Section of UrologyUniversity of ChicagoChicagoIllinois 60637USA Laboratory of Molecular Carcinogenesis National Institute of Environmental Health SciencesNational Insitute of HealthResearch Triangle ParkNorth Carolina 27709USA The Johns Hopkins Oncology Center BaltimoreMaryland 21231USA

Aim:To identify the metastasis suppressor genes for prostate ***:A copy of human chromosomeswas introduced into the highly metastatic Dunning R-3327 rat prostate cancer cells by the use of microcell-mediatedchromosome *** between the size of human chromosomes introduced into microcell hybrid clonesand the number of lung metastases produced by the clones were analyzed to determine which part of human chromo-somes contained the metastasis suppressor gene(s)for prostate *** determine portions of human chromosomesintroduced,G-banding chromosomal analysis,fluorescence in sim hybridization analysis,and polymerase chain reac-tion analysis were ***:Each of microcell hybrid clones containing human chromosomes 7,8,10,11,12,or 17 showed decreased ability to metastasize to the lung without any loss of *** demonstratesthat these human chromosomes contain metastasis suppressor genes for prostate *** deletion of portionsof human chromosomes was observed in the human chromosome 7,10,11,12,and 17 *** the human chromo-some 8 study,irradiated microcell-mediated chromosome transfer was performed to enrich chromosomal arm deletionsof human chromosome *** and cytogenetic analyses of microcell hybrid clones demonstrated that metastasissuppressor genes on human chromosomes were located on 7q21-22,7q31.2-32,8p21-12,10q11-22,11p13-11.2,12p11-q13,12q24-ter,and *** and MKK4/SEKI were identified as metastasis suppressor genes from11p11.2 and 17p12,***:This assay system is useful to identify metastasis suppressor gene(s)for prostate cancer.

关键词： prostate cancer metastasis metastasis suppressor gene chromosome

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