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Essential cellular modules for the proliferation of the primitive cell

Geoscience Frontiers 2018年第4期9卷 1155-1161页

作者： koichi Higashi Yoshikazu Kawai Tomoya Baba Ken Kurokawa Taku Oshima Genome Evolution Laboratory National Institute of Genetics Centre for Bacterial Cell Biology Institute for Cell and Molecular BiosciencesMedical SchoolNewcastle University Advanced Genomics Center National Institute of Genetics Earth-Life Science Institute Tokyo Institute of Technology Graduate School of Biological Sciences Nara Institute of Science and Technology

Bacteria appeared early in the evolution of cellular life on planet Earth, and therefore the universally essential genes or biological pathways found across bacterial domains may represent fundamental genetic or cellular systems used in early life. The essential genes and the minimal gene set required to support bacterial life have recently been experimentally and computationally identified. It is, however,still hard to estimate the ancient genes present in primitive cells compared to the essential genes in contemporary bacteria, because we do not know how ancestral primitive cells lived and proliferated, and therefore cannot directly evaluate the essentiality of the genes in ancestral primitive cells. The cell wall is normally essential for bacterial proliferation and cellular division of walled bacterial cells is normally highly controlled by the essential FtsZ cell division machinery. But, bacteria are capable of reverting to their cell wall deficient ancestral form, called the ＂L-form＂. Unlike ＂normal＂ cells, L-forms divide by a simple physical mechanism based on the effects of membrane dynamics, suggesting a mode of primitive proliferation before the appearance of the cell wall. In this review, we summarize the experimental and computational investigations of minimal gene sets and discuss the minimal cellular modules required to support the proliferation of primitive cells, based on L-form proliferation.

关键词： L-form Essential genes Minimal gene set KEGG module Bacteria

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Enamel Matrix Derivative Stimulates Osteogenesis-and Chondrogenesis-related Transcription Factors in C3H10T1/2 Cells

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Acta Biochimica et Biophysica Sinica 2007年第1期39卷 1-7页

作者： Masataka NARUKAWA Naoto SUZUKI Tadahiro TAKAYAMA Yasuhiko YAMASHITA Kichibee OTSUKA koichi ITO Department of Periodontology Nihon University School of DentistryTokyo101-8310Japan Department of Biochemistry Nihon University School of DentustryTokyo 101-8310Japan Division of Functional Morphology Dental Research CenterNihon University School of DentistryTokyo 101-8310Japan Department of Biochemistry Nihon University School of DentistryTokyo101-8310Japan Division of Functional Morphology Dental Research CenterNihon University School of DentistryTokyo101-8310Japan Division of Advanced Dental Treatment Dental Research CenterNihon University School of DentistryTokyo101-8310Japan

Our purpose was to determine how enamel matrix derivative (EMD) affects the expression ofosteogenesis- and chondrogenesis-related transcription factors in undifferentiated mesenchymal cells.C3H10T1/2 cell line,a typical pluripotential mesenchymal cell line,was cultured with or without EMD forup to 7 *** of mRNAs encoding osteogenesis-and chondrogenesis-related transcription factors(Runx2, Osterix,AJ18,Dlx5,Msx2,Sox5,Sox9 and Zfp60) was measured using real-time polymerasechain ***2 and Sox9 protein expression and the presence of bone morphogenetic protein (BMP)-6-like molecules in EMD were determined by Western *** substantially increased mRNA levels ofosteogenesis-and chondrogenesis-related transcription *** also induced Runx2 and Sox9 *** blotting analysis of EMD using anti-BMP-6 antibody revealed immunoreactive bandscorresponding to about 14 kDa and 60 *** results suggest that EMD stimulates osteogenesis- andchondrogenesis-related transcription factors,and these activities may be mediated,at least in part,by BMP-6in EMD.

关键词： enamel matrix derivative osteogenesis chondrogenesis

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High-speed unsteady flows past two-body configurations

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Chinese Journal of Aeronautics 2018年第1期31卷 54-64页

作者： Xiaopeng XUE Yusuke NISHIYAMA Yoshiaki NAKAMURA koichi MORI Yunpeng WANG ChihYung WEN School of Aeronautics and Astronautics Central South University Department of Aerospace Engineering Nagoya University Institute of Mechanics Chinese Academy of Sciences Department of Mechanical Engineering The Hong Kong Polytechnic University

This paper presents a detailed investigation of unsteady supersonic flows around a typical two-body configuration, which consists of a capsule and a canopy. The cases with different trailing distances between the capsule and canopy are simulated. The objective of this study is to examine the detailed effects of trailing distance on the flow fields and analyze the flow physics of the different flow modes around the parachute-like two-body model. The computational results show unsteady pulsating flow fields in the small trailing distance cases and are in reasonable agree- ment with the experimental data. As the trailing distance increases, this unsteady flow mode takes different forms along with the wake/shock and shock/shock interactions, and then gradually fades away and transits to oscillate mode, which is very different from the former. As the trailing distance keeps increasing, only the capsule wake/canopy shock interaction is present in the flow field around the two-body model, which reveals that the unsteady capsule shock/canopy shock interaction is a key mechanism for the pulsation mode.

关键词： Compressible flow Shock/shock interaction Two-body configurations Unsteady flow Wake/shock interaction

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Solvent-free Synthesis of Dihydrofuran-fused [60]Fullerene Derivatives by High-speed Vibration Milling

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Chinese Chemical Letters 2005年第10期16卷 1327-1329页

作者： Xin CHENG Guan Wu WANG Yasujiro MURATA koichi KOMATSU Department of Chemistry University of Science and Technology of China Hefei 230026 Institute for Chemical Research Kyoto University Uji Kyoto 611-0011 Japan

Solvent-free reactions of 1, 3-cyclohexanedione, 5, 5-dimethyl-1, 3-cyclohexanedione, 2, 4-pentanedione and ethyl acetoacetate with C60 in the presence of Mn（OAc）3·2H2O and ceric ammonium nitrate （CAN） under the high-speed vibration milling conditions afforded dihydrofuran-fused C60 derivatives. CAN is the better oxidant than Mn（OAc）3·2H2O in these mechanochemical reactions.

关键词： Fullerene mechanochemical solvent-free 13-dicarbonyl compounds.

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Screening of Rice Germplasm and Processing Methods to Produce Low Glycemic Rice

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Rice science 2022年第2期29卷 101-104页

作者： Sali Atanga NDINDENG koichi FUTAKUCHI Marie-Noelle NDJIONDJOP Africa Rice Center M’be Research StationBouake01 BP 2551Côte d’Ivoire

The search for low glycemic rice to manage type 2 diabetes is of utmost importance due to the increasing trend in diabetic cases and the importance of rice as a staple *** study aimed to investigate the effect of combinations of rice varieties and processing regimes on human glycemic index(GI),and elucidate the relationship between physicochemical properties of rice and human *** polished rice recorded the lowest human *** unpolished rice.

关键词： varieties Germplasm effect

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Linker phosphorylation of Smad3 promotes fibro-carcinogenesis in chronic viral hepatitis of hepatocellular carcinoma

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World Journal of Gastroenterology 2014年第41期20卷 15018-15027页

作者： Miki Murata Katsunori Yoshida Takashi Yamaguchi koichi Matsuzaki Department of Gastroenterology and Hepatology Kansai Medical University

Epidemiological and clinical data point to a close association between chronic hepatitis B virus infection or chronic hepatitis C virus infection and development of hepatocellular carcinoma (HCC). HCC develops over several decades and is associated with fibrosis. This sequence suggests that persistent viral infection and chronic inflammation can synergistically induce liver fibrosis and hepatocarcinogenesis. The transforming growth factor-β (TGF-β) signaling pathway plays a pivotal role in diverse cellular processes and contributes to hepatic fibro-carcinogenesis under inflammatory microenvironments during chronic liver diseases. The biological activities of TGF-β are initiated by the binding of the ligand to TGF-β receptors, which phosphorylate Smad proteins. TGF-β type I receptor activates Smad3 to create COOH-terminally phosphorylated Smad3 (pSmad3C), while pro-inflammatory cytokine-activated kinases phosphorylates Smad3 to create the linker phosphorylated Smad3 (pSmad3L). During chronic liver disease progression, virus components, together with pro-inflammatory cytokines and somatic mutations, convert the Smad3 signal from tumor-suppressive pSmad3C to fibro-carcinogenic pSmad3L pathways, accelerating liver fibrosis and increasing the risk of HCC. The understanding of Smad3 phosphorylation profiles may provide new opportunities for effective chemoprevention and personalized therapy for patients with hepatitis virus-related HCC in the future.

关键词： Chronic viral hepatitis Transforming growth factor-β Smad3 Phosphorylation Fibro-carcinogenesis Hepatocellular carcinoma

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Thermo-fluidic characteristics of natural convection in honeycombs:The role of chimney enhancement

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Science China(Technological Sciences) 2015年第8期58卷 1318-1327页

作者： YANG XiaoHu YAN HongBin WANG WenBin JIN LiWen LU TianJian ICHIMIYA koichi Department of Building Environment and Energy Engineering School of Human Settlements and Civil EngineeringXi'an Jiaotong University MOE Key Laboratory for Multifunctional Materials and Structures Xi'an Jiaotong University School of Energy and Power Engineering Xi'an Jiaotong University State Key Laboratory for Strength and Vibration of Mechanical Structures School of AerospaceXi'an Jiaotong University Department of Mechanical Engineering University of Yamanashi

The natural convective heat transfer performance and thermo-fluidic characteristics of honeycombs with/without chimney extensions are numerically *** present numerical simulations are validated by the purposely-designed experimental measurements on honeycombs with/without *** agreement between numerical simulation and experimental measurement is *** influences of inclination angle and geometric parameters such as cell shape,streamwise and spanwise length are also numerically *** the increment in inclination angle,the overall heat transfer rate decreases for the honeycombs with/without *** honeycombs with the same void volume fraction but different cell shapes,there is little difference on the overall heat transfer *** enhance the natural convective heat transfer of honeycombs,these techniques including increasing the length of honeycomb in the streamwise/spanwise direction,increasing the thermal conductivity of hon-eycomb structure or adding a chimney extension may be helpful.

关键词： natural convection honeycomb adiabatic chimney inclination angle

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文学批评中“人类世”的四个论点

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东北亚外语研究 2024年第3期12卷 85-93,120页

作者： [日]芳贺浩一陈世华(译) 徐诗云(译) 城西国际大学国际人文学部日本千叶283-8555 南京工业大学外国语言文学学院江苏南京211816

诺贝尔化学奖得主大气化学家保罗·克鲁岑,首次提出“人类世”概念,用以描述人类成为影响地球环境主要力量的时代。克鲁岑认为“人类世”始于18世纪后半叶的工业革命,于2002年《自然》杂志发表该观点后,不仅引起科学界的广泛关注,也深... 详细信息

诺贝尔化学奖得主大气化学家保罗·克鲁岑,首次提出“人类世”概念,用以描述人类成为影响地球环境主要力量的时代。克鲁岑认为“人类世”始于18世纪后半叶的工业革命,于2002年《自然》杂志发表该观点后,不仅引起科学界的广泛关注,也深刻影响了历史和文学领域。本文将考察“人类世”概念在文学批评,特别是在生态批评领域中的接受与批评,主要围绕“人类”“替代概念”“尺度”“后殖民”四个核心论点展开,以期明确当前文学批评正在直面何种课题。

关键词：人类世生态批评文学批评

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Characterization of termetallic Pt-Ir-Au catalysts for NO decomposition

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Rare Metals 2011年第1期30卷 53-57页

作者： Akira Morikawa Kohei Okumura Masaru Ishii koichi Kikuta Akihiko Suda Hirofumi Shinjo Catalyst Lab. Toyota Central R&D Labs.Inc.41-1 YokomichiNagakuteNagakute-ChoAichi-GunAichi 480-1192Japan Vehicle Engineering Group Material Engineering Division ⅡToyota Motor Corporation1 Toyota-choToyotaAichi 471-8572Japan Department of Crystalline Materials Science School of EngineeringNagoya UniversityFuro-ChoChikusa-KuNagoyaAichi 464-8603Japan

A termetallic catalyst of Pt-Ir-Au/Al2O3 for NOx decomposition was prepared by loading the metallic colloids in C2H5OH-H2O solution and a surfactant of polyvinyl *** with an impregnated Pt/Al2O3 catalyst,the termetallic catalyst of PtIrAu811/Al2O3,with a Pt：Ir：Au atomic ratio of 8：1：1,exhibited higher NO decomposition and selectivity to *** electron microscopy and X-ray diffraction were conducted to clarify the state of the supported metals and indicate three precious metals alloyed on the *** the study of NO-temperature programmed desorption,oxygen desorption on the PtIrAu811 catalyst shifted to the low temperature side compared to that on Pt/Al2O3,which correlated well with its higher catalytic performance in NO decomposition.

关键词： catalysts iridium gold platinum decomposition nitrogen oxides

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Next-generation power delivery system with resiliency and environmental affinity

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Global Energy Interconnection 2022年第3期5卷 274-280页

作者： koichi Nara IEEE Life Fellow Prof.Emeritus Ibaraki University4-12-1 NakanarusawaHitachi Ibaraki 316-8511Japan

Renewable energy resources play an important role in the realization of the carbon *** microgrid can efficiently integrate numerous renewable energy systems into power distribution systems to realize power supply resiliency and environmental *** paper reviews the current trend of microgrid and networked microgrid technologies worldwide,particularly in Japan,including the Flexible,Reliable,and Intelligent Energy Delivery System(FRIENDS)and some other examples of the networked *** recent digitalized control functions of the microgrid and related systems are also introduced.

关键词： Microgrid Networked microgrid Resilience Carbon neutrality Digitalized control FRIENDS

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