检索结果-南通市图书馆

Neural Regeneration Research 2025年第2期20卷 487-488页

作者： Shunsuke koga Wei Du Department of Pathology and Laboratory Medicine Hospital of the University of PennsylvaniaPhiladelphiaPAUSA

Large language models(LLMs),such as ChatGPT developed by OpenAI,represent a significant advancement in artificial intelligence(AI),designed to understand,generate,and interpret human language by analyzing extensive text *** potential integration into clinical settings offers a promising avenue that could transform clinical diagnosis and decision-making processes in the future(Thirunavukarasu et al.,2023).This article aims to provide an in-depth analysis of LLMs’current and potential impact on clinical *** ability to generate differential diagnosis lists underscores their potential as invaluable tools in medical practice and education(Hirosawa et al.,2023;koga et al.,2023).

关键词： image diagnosis text

维普期刊数据库

外周炎症或神经损伤导致小鼠前扣带皮层神经元信息编码的时间准确性降低

在线全文

学校读者我要写书评

暂无评论

外周炎症或神经损伤导致小鼠前扣带皮层神经元信息编码的时间准确...

Advances in polymer-stabilized Au nano-cluster catalysis : Interplay of theoretical calculations and experiments

中华医学会疼痛学分会第十一届学术年会

作者：李相尧王宁王永杰左振兴 kohei koga 罗非 Min Zhuo 西安交通大学前沿科学技术研究院神经和疾病研究中心浙江大学医学院生理学系中国科学技术研究院心理研究所健康与遗传心理学研究室多伦多大学生理学系疼痛研究中心

＜正＞目的:研究慢性痛状态下前扣带皮层神经元时间性信息编码的改变情况,以及引起改变的机制方法:C57B1/6J成年小鼠、SD大鼠,CFA足底注射或者腓总神经结扎动物模型,电生理脑片记录或者在体细胞外记录。结果:在体记录发现,大约有51%的...

＜正＞目的:研究慢性痛状态下前扣带皮层神经元时间性信息编码的改变情况,以及引起改变的机制方法:C57B1/6J成年小鼠、SD大鼠,CFA足底注射或者腓总神经结扎动物模型,电生理脑片记录或者在体细胞外记录。结果:在体记录发现,大约有51%的前扣带皮层神经元,它们的信息编码的时间准确性在CFA注射后1天和3天均表现出降低趋势。脑片记录发现,多数前扣带皮层神经元在注射CFA或者外周神经结扎后

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Chinese Journal of Catalysis 2016年第10期37卷 1588-1593页

作者： Hiroaki koga Yoshinori Ato Akihide Hayashi kohei Tada Mitsutaka Okumura 京都大学催化剂与电池元素战略研究基地大阪大学科学研究院化学系

Polymer‐stabilized Au nano clusters （NCs） with mean diameters of 2–10 nm exhibit unique catalytic properties. Several studies have shown that the key factors affecting the catalytic activity of poly‐mer‐stabilized Au NCs are control of the Au NC size, appropriate selection of polymers and optimi‐zation of the reaction conditions. This is because polymer‐stabilized Au NCs exhibit a clear size effect in several catalytic reactions, and the catalytic activity differs with the type of polymer used and the reaction conditions. In order to elucidate the reason underlying the catalytic activity of the polymer‐stabilized Au NCs, much attention is being devoted to the interplay of theoretical calcula‐tions and experiments in catalysis by polymer stabilized Au NCs. The present article mainly summa‐rizes our progress in understanding this interplay in polymer‐stabilized Au NC catalysis.

关键词： Polymer-stabilized Au nano-clusterAerobic oxidation of alcoholsInterplay of theoretical calculations and experimentsSize effect ofAu nano-clusterRole of the polymers

维普期刊数据库

Microbiota in the stomach and application of probiotics to gastroduodenal diseases

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2022年第47期28卷 6702-6715页

作者： Yasuhiro koga Japanese Society for Probiotic Science Isehara 259-1143Japan

The stomach is a hostile environment for most microbes because strong gastric acid kills indigenous ***,the mass of indigenous microbes detected by traditional culturing method in a highly acidic stomach is reported to be very ***,in a stomach with less acidity due to atrophic changes of the gastric mucosa,the number of live gastric microbiota dramatically increases and their composition changes.A probiotic is defined as a live microorganism that,when administered in adequate amounts,confers a health benefit on the *** administration of probiotics to the stomach has thus far been considered impractical,mainly due to the strong acidity in the *** identification of candidate probiotic strains with sufficient resistance to acidity and the ability to achieve close proximity to the gastric mucosa could enable the application of probiotics to the *** utilization of probiotics alone for Helicobacter pylori(***)infection significantly improves gastric mucosal inflammation and decreases the density of *** on the mucosa,although complete eradication of *** has not yet been *** use of probiotics in combination with antimicrobial agents significantly increases the *** eradication rate,especially when the *** strains are resistant to antimicrobial *** *** has been considered the most important pathogenic bacterium for the development of gastric cancer,bacteria other than *** are also suggested to be causative pathogens that promote the development of gastric cancer,even after the eradication of *** *** Gram-negative bacteria in the stomach with weak acidity accompanying atrophic gastritis may perpetuate gastric mucosal inflammation and accelerate carcinogenic progression,even after *** *** restore the acidity in this stomach environment and may therefore prevent the development of gastric cancer by termination of Gram-negative ba

关键词： Stomach Microbiota Probiotics Helicobacter pylori Post-eradication gastric cancers Functional dyspepsia

Beyond management to conquer life-threatening tumor thrombosis in hepatocellular carcinoma

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Hepatobiliary Surgery and Nutrition 2022年第5期11卷 773-774页

作者： Hironori koga Division of Gastroenterology Department of MedicineKurume University School of MedicineKurumeJapan

Hepatic vein tumor thrombus(HVTT),together with portal vein tumor thrombus(PVTT),is a major determinant of survival outcome in patients with advanced hepatocellular carcinoma(HCC).HVTT can be an oncologic emergency,especially when it invades beyond IVC into the right atrium,where it can cause sudden death from pulmonary *** studies using large numbers of patients are generally difficult in this relatively rare and urgent *** this context,the multicenter study conducted by Chen et *** significant,albeit retrospective(1).

关键词： hepatocellular thrombus al.

前扣带皮层两种形式LTP的突触机制揭示焦虑和慢性疼痛相互作用

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

科学新闻 2016年第1期 74-74页

作者： kohei koga Giannina Descalzi 陈涛 Hyoung-Gon Ko Jinshan Lu Shermaine Li Junehee Son TaeHyun Kim Chuljung Kwak Richard L.Huganir 招明高 Bong-Kiun Kaang Graham L.Collingridge 卓敏日本Alima大学西安交通大学美国约翰·霍普金斯大学韩国国立大学英国布里斯托大学西安交通大学前沿科学技术研究院神经和疾病研究中心加拿大皇家科学院

文章简介慢性疼痛可导致焦虑,焦虑能增强痛觉。不幸的是,对这些现象的关联的基本神经机制了解很少。在这篇文章里,研究发现了和痛/焦虑相关的ACC有两种完全不同的长期可塑性(LTP):突触前和突触后。突触前LTP需要有腺苷酸环化酶和蛋白激... 详细信息

文章简介慢性疼痛可导致焦虑,焦虑能增强痛觉。不幸的是,对这些现象的关联的基本神经机制了解很少。在这篇文章里,研究发现了和痛/焦虑相关的ACC有两种完全不同的长期可塑性(LTP):突触前和突触后。突触前LTP需要有腺苷酸环化酶和蛋白激酶A的参与,而它的表达是通过一种机制涉及超极化激活环核苷酸门控通道(HCN)。有趣的是,慢性疼痛和焦虑都能选择性抑制突触前LTP。更重要的,将HCN的阻滞剂

关键词：慢性疼痛突触前 LTP 两种

HYDRATION AND PHASE SEPARATION OF TEMPERATURE-SENSITIVE WATER-SOLUBLE POLYMERS

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Chinese Journal of Polymer Science 2011年第1期29卷 13-21页

作者： Fumihiko Tanaka Tsuyoshi koga Hiroyuki Kojima Francoise M.Winnik Department of Polymer Chemistry Graduate School of EngineeringKyoto University Department of Chemistry and Faculty of Pharmacy University of Montréal

Collapse of a poly（N-isopropylacrylamide）（PNIPAM） chain upon heating and phase diagrams of aqueous PNIPAM solutions with very fiat LCST phase separation line are theoretically studied on the basis of cooperative dehydration （simultaneous dissociation of bound water molecules in a group of correlated sequence）, and compared with the experimental observation of temperature-induced coil-globule transition by light scattering methods. The transition becomes sharper with the cooperativity parameter σ of hydration. Reentrant coil-globule-coil transition in mixed solvent of water and methanol is also studied from the viewpoint of competitive hydrogen bonds between polymer-water and polymer-methanol. The downward shift of the cloud-point curves （LCST cononsolvency） with the mole fraction of methanol due to the competition is calculated and compared with the experimental data. Aqueous solutions of hydophobically-modified PNIPAM carrying short alkyl chains at both chain ends （telechelic PNIPAM） are theoretically and experimentally studied. The LCST of these solutions is found to shift downward along the sol-gel transition curve as a result of end-chain association （association-induced phase separation）, and separate from the coil-globule transition line. Associated structures in the solution, such as flower micelles, mesoglobules and higher fractal assembly, are studied by USANS with theoretical modeling of the scattering function.

关键词： Cooperative dehydration LCST phase separation Poly(N-isopropylacrylamide) Cononsolvency Coil-globule transition Flower micelle.

维普期刊数据库

Update on targeted therapy and immune therapy for gastric cancer, 2018

在线全文

学校读者我要写书评

暂无评论

Journal of Cancer Metastasis and Treatment 2018年第1期4卷 365-379页

作者： Yuki Kiyozumi Masaaki Iwatsuki kohei Yamashita Yuki koga Naoya Yoshida Hideo Baba Department of Gastroenterological Surgery Kumamoto UniversityGraduate School of Medical SciencesKumamoto 860-8556Japan

Gastric cancer(GC)remains one of the most common cancers and serious health problems *** unresectable or metastatic advanced gastric cancer,chemotherapy treatment is first *** chemotherapy has improved survival in patients with advanced gastric cancer(AGC),the prognosis of these patients remains *** recent years,some therapies targeting biological molecules have been reported to prolong the survival of patients with *** trastuzumab,a monoclonal antibody that targets HER2,was established as standard therapy for unresectable GC in a HER2-positive patient,many other targets have been reported as new therapy *** molecular targeted therapies,such as HER2,VEGFR or EGFR,have been verified as established standard treatments with or without chemotherapy in clinical ***,immunotherapy is expected to be an effective treatment with promising clinical trial ***,immune checkpoint inhibiters,such as PD-1/PD-L1 or CTLA-4,have demonstrated innovative progression in GC ***,ongoing clinical trials including targeted therapy and immunotherapy have shown promising results in improving clinical outcomes,safety,and *** this article,we review targeting therapies and immunotherapies for GC and summarize future prospective treatments.

关键词： Gastric cancer targeted therapy immunotherapy immune checkpoint inhibitor

Spin Interference in Rectangle Loop Based on Rashba and Dresselhaus Spin-Orbit Interactions

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Physics Letters 2009年第12期26卷 210-212页

作者：倪佳婷梁小婉陈斌 T.koga Department of Physics Hangzhou Normal University Hangzhou 310018 Department of Physics Oklahoma State University Stillwater 74075 USA Zhejiang Economic and Trade Polytechnic Hangzhou 310036 Division of Electronics for Informatics Graduate School of Information Science and Technology Hokkaido University N-14 W-9 Kita-ku Sapporo Hokkaido 060-0814 Japan CREST Japan Science and Technology Agency 4-1-8 Honchou Kawaguchi Saitama 332-0012 Japan

We demonstrate the amplitude and spin polarization of AAS oscillation changing with Rashba spin-orbit interaction （SOI） and Dresselhaus SOI. The amplitude and spin polarization of AB oscillation changing with Rashba SOI and Dresselhaus SOI are demonstrated as well. The ideal quasi-one-dimensional square loop does not exist in reality, therefore to match the experiment better we should consider the shape of the rectangle loop in theory.

关键词： Chinese climate network complex systems small world community