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Current standard values of health utility scores for evaluating costeffectiveness in liver disease:A meta-analysis

World Journal of Gastroenterology 2022年第31期28卷 4442-4455页

作者： Tomohiro Ishinuki Shigenori Ota kohei harada Masaki Kawamoto Makoto Meguro Goro Kutomi Hiroomi Tatsumi Keisuke harada Koji Miyanishi Toru Kato Toshio Ohyanagi Thomas T Hui Toru Mizuguchi Department of Nursing Surgical SciencesSapporo Medical UniversitySapporo 0608556Japan Departments of Surgery Surgical Science and OncologySapporo Medical UniversitySapporo 0608543Japan Department of Radiology Sapporo Medical UniversitySapporo 0608543Japan Departments of Surgery Nemuro City HospitalNemuro 0870008Japan Departments of Surgery Sapporo Satozuka HospitalSapporo 0040811Japan Department of Intensive Care Medicine Sapporo Medical UniversitySapporo 0608543Japan Department of Emergency Medicine Sapporo Medical UniversitySapporo 0608543Japan Department of Medical Oncology Sapporo Medical UniversitySapporo 0608543Japan Department of Liberal Arts and Sciences Center for Medical EducationSapporo Medical UniversitySapporo 0608556Japan Departments of Surgery Stanford University School of MedicineStanford94598United States

BACKGROUND Health utility assessments have been developed for various conditions,including chronic liver *** utility scores are required for socio-economic evaluations,which can aid the distribution of national ***,the standard health utility assessment scores for specific health conditions are largely *** To summarize the health utility scores,including the EuroQOL 5-dimensions 5-levels(EQ-5D-5L),EuroQol-visual analogue scale,short from-36(SF-36),RAND-36,and Health Utilities Index(HUI)-Mark2/Mark3 scores,for the normal population and chronic liver disease *** A systematic literature search of PubMed and MEDLINE,including the Cochrane Library,was ***-analysis was performed using the RevMan *** means and standard deviations were combined using the StatsToDo online web *** The EQ-5D-5L and SF-36 can be used for health utility evaluations during antiviral therapy for hepatitis ***-Mark2/Mark3 indicated that the health utility scores of hepatitis B patients are roughly 30% better than those of hepatitis C *** The EQ-5D-5L is the most popular questionnaire for health utility *** assessments that allow free registration would be useful for evaluating health utility in patients with liver disease.

关键词： Quality of life EuroQOL 5-dimensions 5-levels Short from-36 RAND-36 Health Utilities Index-Mark

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Monogenic gene therapy for glaucoma and optic nerve injury

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Neural Regeneration Research 2025年第3期20卷 815-816页

作者： Chikako harada Xiaoli Guo Takayuki harada Visual Research Project Tokyo Metropolitan Institute of Medical ScienceTokyoJapan

The prevalence of glaucoma, the second leading cause of global blindness, is increasing due to aging populations. In glaucoma, degeneration of the optic nerve and retinal ganglion cells(RGCs) causes visual field defec... 详细信息

关键词： visual glaucoma degeneration

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Asking one mechanism in glial cells during neuroinflammation

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Neural Regeneration Research 2025年第4期20卷 1077-1078页

作者： Xiaoli Guo Chikako harada Takayuki harada Visual Research Project Tokyo Metropolitan Institute of Medical ScienceTokyoJapan

Multiple sclerosis(MS),which is characterized by inflammatory demyelination in the central nervous system(CNS),is the most common neurological disease in the young adult *** autoimmune encephalomyelitis(EAE),an animal model of MS,is often used in preclinical *** data indicate that in addition to immune cells such as T cells and dendritic cells,CNS resident microglia and astrocytes play important roles in demyelinating neuroinflammation(Healy et al.,2022).In particular,microglia are key immune-competent cells that can respond to environmental *** depletion of transforming growth factor-β-activated kinase 1,a mitogen-associated protein kinase kinase kinase,in microglia is reported to reduce CNS inflammation and diminish axonal and myelin damage *** suggests that elucidating the mechanisms of microglia-specific responses during pathologies may help in the development of treatments that reduce EAE/MS disease severity(Goldmann et al.,2013).

关键词： inflammation clinical

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MAVEN observation of magnetosonic waves in the Martian magnetotail region

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Earth and Planetary Physics 2024年第2期8卷 317-325页

作者： ShangChun Teng JiCheng Sun JiaWei Gao Y.harada Markus Fraenz DeSheng Han State Key Laboratory of Marine Geology School of Ocean and Earth ScienceTongji UniversityShanghai 200092China MNR Key Laboratory for Polar Science Polar Research Institute of ChinaShanghai 200136China Key Laboratory of Earth and Planetary Physics Institute of Geology and GeophysicsChinese Academy of SciencesBeijing 100029China College of Earth and Planetary Sciences University of Chinese Academy of SciencesBeijing 100049China Department of Geophysics Kyoto UniversityKyotoJapan Max-Planck-Institute for Solar System Research GoettingenGermany

Magnetosonic waves are an important medium for energy transfer in collisionless space *** waves have been widely investigated in the upstream of the bow shock at *** waves are believed to originate from pickup ions or reflected *** utilizing MAVEN spacecraft data,we have observed the occurrence of quasi-perpendicularly propagating magnetosonic emissions near the proton gyrofrequency in the Martian magnetotail *** plasma waves are associated with a significant enhancement of proton and oxygen *** excited magnetosonic waves could possibly heat the protons through resonance and facilitate the ionospheric plasma *** results could be helpful to better understand the Mars’magnetospheric dynamics and offer insights into possible energy redistribution between waves and plasma in the Martian nightside magnetosphere.

关键词： Martian magnetotail region magnetosonic waves proton escape

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Low skeletal muscle mass and high visceral adiposity are associated with recurrence of acute cholecystitis after conservative management:A propensity score-matched cohort study

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Hepatobiliary & Pancreatic Diseases International 2024年第1期23卷 64-70页

作者： Yudai Koya Michihiko Shibata Yuki Maruno Yoshitaka Sakamoto Shinji Oe Koichiro Miyagawa Yuichi Honma Masaru harada Department of Gastroenterology Kyushu Rosai HospitalMoji Medical Center3-1 HigashiminatomachiMoji-kuKitakyushu 801-8502Japan Third Department of Internal Medicine School of MedicineUniversity of Occupational and Environmental HealthKitakyushu 807-8555Japan Department of Surgery Kyushu Rosai Hospital Moji Medical CenterKitakyushu 801-8502Japan

Background:Recurrent acute cholecystitis(RAC)can occur after non-surgical treatment for acute cholecystitis(AC),and can be more severe in comparison to the first episode of *** skeletal muscle mass or adiposity have various effects in several *** aimed to clarify the relationship between RAC and body ***:Patients with AC who were treated at our hospital between January 2011 and March 2022 were *** psoas muscle mass and adipose tissue area at the third lumbar level were measured using computed tomography at the first episode of *** areas were divided by height to obtain the psoas muscle mass index(PMI)and subcutaneous/visceral adipose tissue index(SATI/VATI).According to median VATI,SATI and PMI values by sex,patients were divided into the high and low PMI *** performed propensity score matching to eliminate the baseline differences between the high PMI and low PMI groups and analyzed the cumulative incidence and predictors of ***:The entire cohort was divided into the high PMI(n=81)and low PMI(n=80)*** the propensity score-matched cohort there were 57 patients in each *** Kaplan-Meier analysis,the low PMI group and the high VATI group had a significantly higher cumulative incidence of RAC than their counterparts(log-rank P=0.001 and 0.015,respectively).In a multivariate Cox regression analysis,the hazard ratios of low PMI and low VATI for RAC were 5.250(95%confidence interval 1.083-25.450,P=0.039)and 0.158(95%confidence interval:0.026-0.937,P=0.042),***:Low skeletal muscle mass and high visceral adiposity were independent risk factors for RAC.

关键词： Acute cholecystitis Low skeletal muscle mass Recurrent acute cholecystitis Sarcopenia Visceral adiposity

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World Journal of Meta-Analysis 2021年第1期9卷 88-100页

作者： Tomohiro Ishinuki Shigenori Ota kohei harada Hiroomi Tatsumi Keisuke harada Koji Miyanishi MinoruNagayama Ichiro Takemasa Toshio Ohyanagi Thomas T Hui Toru Mizuguchi Department of Nursing Surgical SciencesSapporo Medical UniversitySapporo 060-8556Japan Departments of Surgery Surgical Science and OncologySapporo Medical UniversitySapporo 060-8543Japan Division of Radiology Sapporo Medical UniversitySapporo 060-8543Japan Department of Intensive Care Medicine Sapporo Medical University HospitalSapporo 060-8543Japan Department of Emergency Medicine Sapporo Medical University HospitalSapporo 060-8543Japan Department of Medical Oncology Sapporo Medical University HospitalSapporo 060-8543Japan Department of Liberal Arts and Sciences Center for Medical EducationSapporo Medical UniversitySapporo 060-8556Japan Department of Surgery Division of Pediatric SurgeryStanford University School of MedicineStanfordCA 94598United States

BACKGROUND Mortality after hepatectomy has decreased,and the quality of various surgical approaches to hepatectomy have been *** assessments of quality of life(QOL)after hepatectomy have been developed and investigated in different clinical *** To conduct a systematic review and meta-analysis to examine two clinical topics:Laparoscopic hepatectomy vs open hepatectomy,and preoperative QOL status vs postoperative QOL *** A systematic literature search was performed using PubMed and MEDLINE,including the Cochrane Library *** following inclusion criteria were set for inclusion in this meta-analysis:(1)Studies comparing preoperative QOL and postoperative QOL;and(2)Studies comparing QOL between laparoscopic hepatectomy and open *** A total of 8 articles were included in this *** was better after laparoscopic hepatectomy than after open *** The outcomes of evaluations of QOL after hepatectomy can depend on the type of questionnaire used,the timing of the assessment,and the etiology of the hepatic disease.

关键词： Quality of life Hepatectomy Laparoscopy Transarterial chemoembolization Functional Assessment of Cancer Therapy–Hepatobiliary 36-Item Short-Form Health Survey European Organisation for Research and Treatment of Cancer Quality of Life Core Questionnaire

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Maturation of robotic liver resection during the last decade:A systematic review and meta-analysis

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World Journal of Meta-Analysis 2021年第5期9卷 462-473页

作者： Tomohiro Ishinuki Shigenori Ota kohei harada Makoto Meguro Masaki Kawamoto Goro Kutomi Hiroomi Tatsumi Keisuke harada Koji Miyanishi Ichiro Takemasa Toshio Ohyanagi Thomas T Hui Toru Mizuguchi Department of Nursing Surgical SciencesSapporo Medical UniversitySapporo 0608556HokkaidoJapan Departments of Surgery Surgical Science and OncologySapporo Medical UniversitySapporo 0608543HokkaidoJapan Division of Radiology Sapporo Medical UniversitySapporo 060-8543HokkaidoJapan Departments of Surgery Sapporo Satozuka HospitalSapporo 0048686Japan Departments of Surgery Nemuro City HospitalNemuro 0878686HokkaidoJapan Department of Surgery School of MedicineSapporo Medical UniversitySapporo 0608543HokkaidoJapan Department of Intensive Care Medicine Sapporo Medical University HospitalSapporo 0608543HokkaidoJapan Department of Emergency Medicine Sapporo Medical UniversitySapporo 0606543HokkaidoJapan Department of Medical Oncology Sapporo Medical UniversitySapporo 0608543HokkaidoJapan Department of Liberal Arts and Sciences Center for Medical EducationSapporo Medical UniversitySapporo 0608556HokkaidoJapan Department of Surgery Division of Pediatric SurgeryStanford University School of MedicineStanfordCA 94598United States

BACKGROUND Minimally invasive hepatectomy techniques have developed rapidly since *** laparoscopic liver resection(LLR)has become the primary approach for managing liver tumors and procuring donor organs for liver *** liver resection(RLR)has emerged during the last *** technical status of RLR seems to be *** To conduct a systematic review and meta-analysis comparing the short-term clinical outcomes of LLR and RLR over two 5-year *** A systematic literature search was performed using PubMed and Medline,including the Cochrane *** following inclusion criteria were set for the meta-analysis:(1)Studies comparing LLR vs RLR;and(2)Studies that described clinical outcomes,such as the operative time,intraoperative bleeding,intraoperative conversion rate,and postoperative *** A total of 25 articles were included in this meta-analysis after 40 articles had been subjected to full-text *** studies were divided into early(n=14)and recent(n=11)*** the recent group,the operative time did not differ significantly between LLR and RLR(P=0.70),whereas in the early group the operative time of LLR was significantly shorter than that of RLR(P<0.001).CONCLUSION The initial disadvantages of RLR,such as its long operation time,have been overcome during the last 5 *** other clinical outcomes of RLR are comparable to those of *** cost and quality-of-life outcomes of RLR should be evaluated in future studies to promote its routine clinical use.

关键词： Hepatectomy Laparoscopy Robot Operation time

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Correlation between dose-volume parameters and rectal bleeding after 12 fractions of carbon ion radiotherapy for prostate cancer

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World Journal of Radiology 2024年第7期16卷 256-264页

作者： Takashi Ono Hiraku Sato Yuya Miyasaka Yasuhito Hagiwara Natsuko Yano Hiroko Akamatsu Mayumi harada Mayumi Ichikawa Department of Radiation Oncology Faculty of MedicineYamagata UniversityYamagata 990-9585Japan Department of Heavy Particle Medical Science Yamagata University Graduate School of Medical ScienceYamagata 990-9585Japan

BACKGROUND Carbon ion radiotherapy(CIRT)is currently used to treat prostate *** bleeding is a major cause of toxicity even with ***,to date,a correlation between the dose and volume parameters of the 12 fractions of CIRT for prostate cancer and rectal bleeding has not been ***,the clinical risk factors for rectal bleeding were absent after 12 fractions of *** To identify the risk factors for rectal bleeding in 12 fractions of CIRT for prostate *** Among 259 patients who received 51.6 Gy[relative biological effectiveness(RBE)],in 12 fractions of CIRT,15 had grade 1(5.8%)and nine had grade 2 rectal bleeding(3.5%).The dose-volume parameters included the volume(cc)of the rectum irradiated with at least x Gy(RBE)(Vx)and the minimum dose in the most irradiated x cc normal rectal volume(Dx).RESULTS The mean values of D6cc,D2cc,V10 Gy(RBE),V20 Gy(RBE),V30 Gy(RBE),and V40 Gy(RBE)were significantly higher in the patients with rectal bleeding than in those *** cutoff values were D6cc=34.34 Gy(RBE),D2cc=46.46 Gy(RBE),V10 Gy(RBE)=9.85 cc,V20 Gy(RBE)=7.00 cc,V30 Gy(RBE)=6.91 cc,and V40 Gy(RBE)=4.26 *** D2cc,V10 Gy(RBE),and V20 Gy(RBE)cutoff values were significant predictors of grade 2 rectal *** The above dose-volume parameters may serve as guidelines for preventing rectal bleeding after 12 fractions of CIRT for prostate cancer.

关键词： Carbon ion radiotherapy Prostate cancer Rectal bleeding Dose volume parameters Prevention

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日本心血管疾病患者的安宁疗护及启示

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中华护理杂志 2024年第5期59卷 533-539页

作者：彭梦云原田奈穂子齋藤信也岡山大学保健学研究科日本岡山市7008558 岡山大学医学部保健学科日本岡山市7008558

WHO呼吁全球医疗保健工作者重视非癌症患者的安宁疗护实践,目前国内安宁疗护主要以癌症患者为中心,在心血管疾病等慢性病人群中的实践和发展相对薄弱。近年来,日本开展的心血管疾病安宁疗护经实践验证可有效缓解患者的终末期症状,提高... 详细信息

WHO呼吁全球医疗保健工作者重视非癌症患者的安宁疗护实践,目前国内安宁疗护主要以癌症患者为中心,在心血管疾病等慢性病人群中的实践和发展相对薄弱。近年来,日本开展的心血管疾病安宁疗护经实践验证可有效缓解患者的终末期症状,提高患者及家庭成员的生活质量。该文介绍了日本心血管疾病患者安宁疗护的发展历程、规模及需求、团队成员及协作、介入时间、评估与筛查、服务内容与流程、质量评价及困境等,提出对国内心血管疾病患者实施安宁疗护的启示,为开展心血管疾病患者的安宁疗护提供借鉴。

关键词：心血管疾病安宁疗护姑息护理

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白石画廊（中国台北）

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城市环境设计 2024年第1期147卷 146-149页

作者：虎尾亮太原田爽一朗 Studio Millspace

白石画廊台北空间立面和室内都采用了木材，“嵌入”一栋办公室的底层。基材是截面尺寸为105毫米的柏木板。通过板材的堆叠和挪动，我们在城市中创造出一个有机而人性化的空间，它似乎独立于建筑的刚性框架。柏木板材的使用也在室内继...

白石画廊台北空间立面和室内都采用了木材，“嵌入”一栋办公室的底层。基材是截面尺寸为105毫米的柏木板。通过板材的堆叠和挪动，我们在城市中创造出一个有机而人性化的空间，它似乎独立于建筑的刚性框架。柏木板材的使用也在室内继续，在柜台之间形成了楼梯和屏风。这是使用单个模块生成复杂且多样房间的一个范例。画廊内展出了大量当代艺术作品，探索了从传统的白色立方体建筑中“生长”出来的艺术空间的新潜力。

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