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Integration between Genomic and Computational Statistical Surveys for the Screening of SnP Genetic Variants in Inflammatory bowel Disease (IbD) Pediatric Patients*

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Computational Molecular bioscience 2024年第3期14卷 146-191页

作者： Dago Dougba noel koffi n’guessan bénédicte sonia Dagnogo Olefongo Daramcoum Wentoin Alimata Marie-Pierre Mauro Giacomelli Dagnogo Dramane Eboulé Ago Eliane Rebecca Yao Saraka Didier Martial Diarrassouba nafan Giovanni Malerba Raffaele badolato Department of Clinical and Experimental Sciences University of Brescia Brescia Italy Angelo nocivelli Institute of Molecular Medicine Childrens Hospital ASST Spedali Civili Brescia Italy Unit of biostatistics and biomathematics & Unit of bioinformatics Department of Molecular and Translational Medicine University of Brescia Brescia Italy biological Sciences Training and Research Unit Department of Genetic and Biochemistry Peleforo Gon Coulibaly University Korhogo Cte dIvoire Department of neurosciences Biomedicine and Movement Sciences Section of Biology and Genetics University of Verona Verona Italy biosciences Training and Research Unit Biology and Health Laboratory Felix Houphouet-Boigny University Abidjan Cte dIvoire

Inflammatory bowel diseases (IbD) are complex multifactorial disorders that include Crohn’s disease (CD) and ulcerative colitis (UC). Considering that IbD is a genetic and multifactorial disease, we screened for the distribution dynamism of IbD pathogenic genetic variants (single nucleotide polymorphisms;SnPs) and risk factors in four (4) IbD pediatric patients, by integrating both clinical exome sequencing and computational statistical approaches, aiming to categorize IbD patients in CD and UC phenotype. To this end, we first aligned genomic read sequences of these IbD patients to hg19 human genome by using bowtie 2 package. next, we performed genetic variant calling analysis in terms of single nucleotide polymorphism (SnP) for genes covered by at least 20 read genomic sequences. Finally, we checked for biological and genomic functions of genes exhibiting statistically significant genetic variant (SnPs) by introducing Fitcon genomic parameter. Findings showed Fitcon parameter as normalizing IbD patient’s population variability, as well as inducing a relative good clustering between IbD patients in terms of CD and UC phenotypes. Genomic analysis revealed a random distribution of risk factors and as well pathogenic SnPs genetic variants in the four IbD patient’s genome, claiming to be involved in: i) Metabolic disorders, ii) Autoimmune deficiencies;iii) Crohn’s disease pathways. Integration of genomic and computational statistical analysis supported a relative genetic variability regarding IbD patient population by processing IbD pathogenic SnP genetic variants as opposite to IbD risk factor variants. Interestingly, findings clearly allowed categorizing IbD patients in CD and UC phenotypes by applying Fitcon parameter in selecting IbD pathogenic genetic variants. Considering as a whole, the study suggested the efficiency of integrating clinical exome sequencing and computational statistical tools as a right approach in discriminating IbD phenotypes as well as improvi

关键词： Inflammatory bowel Disease (IbD) Crohn Disease (CD) Ulcerative Colitis (UC) Clinical Exome Analysis Computational Statistic SnP Genetic Variants

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Influence of Active Charcoal and Plant Position on Some Morphological Parameters of a Local Variety of Okra (<i>Abelmoschus caillei</i>)

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American Journal of Plant Sciences 2017年第9期8卷 2021-2030页

作者： Kouame n’guessan koffi Ahébé Marie Hélène Kouassi n’Dri Jacob n’guessan n’guessan Alain Yatty Kouadio Justin Unit of Teaching of Plant Physiology and biotechnology UFR Agroforestry UniversityJean Lorougnon GUEDE (UJLoG) Daloa C&ocirc te d’Ivoire

Okra is a plant rich in nutrients and is very well consumed in Côte d’Ivoire. Despite its many benefits, the production of this vegetable is still weak in our country. The reasons for this include the inadequate selection of varieties, the high cost of inputs and the poverty of the soil for its cultivation. One of the alternatives for sustained production is to solve the problem of soil fertility. In the case of our work, the aim is to improve the yield of okra. To achieve this goal, experiments were undertaken to evaluate the impact of activated charcoal on morphological parameters of a local okra variety. For this purpose, the charcoal used was activated in three different times (activation time equal to 0 days, 15 days and 30 days). The experimental device used is a split-plot with three repetitions, each comprising 12 elementary plots. The various charcoals were buried the same day. Then, the seedling was done with two positions including outside position and inside position. Observations were made on 360 plants. An analysis of the variances was carried out on the morphological parameters. Fruit mass is the variable most influenced by activated charcoal. Thus, the greatest value of the mass was obtained with the charcoal CA0, with outside position.

关键词： Activated Charcoal Okra Position Morphological Parameters

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Evaluation of Particle Properties of MgO/TiOb>2b> Material by Monte Carlo Simulation Method

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Journal of Materials Science and Chemical Engineering 2024年第2期12卷 49-60页

作者： koffi n’guessan Placide Gabin Allangba Yves Kily Hervé Fagnidi Hermann n’guessan Zié Traoré koffi Arnaud Kamenan Physics Pedagogical Unit Laboratory of Environmental Science and Technology University Jean Lorougnon Guédé Daloa C&#244te d’Ivoire Laboratory of Fundamental and Applied Physics University Nangui Abrogoua Abidjan C&#244te d’Ivoire Department of Medical Physics University of Trieste and International Centre for Theoretical Physics (ICTP) Trieste Italy Department of Science and Technology University Alassane Ouattara Bouaké C&#244te d’Ivoire nuclear Physics and Radiation Protection Team Laboratory of Material Sciences Environment and Solar Energy University Felix Houphouet-Boigny Abidjan C&#244te d’Ivoire Department of Mathematics Physics and Chemistry UFR Biological Sciences University Peleforo Gon Coulibaly Korhogo C&#244te d’Ivoire

The simulation by the Monte Carlo method executed by the software PyPEnELOPE proved effective to specify the particle propagation characteristics by calculating the absorption fractions, backscattering and transmission of electrons and secondary photons under the incidence of 0.5 to 20 KeV range of primary electrons. More than 99.9% of the primary electrons were transmitted in the 125 nm thick MgO/TiOb>2b> material at 20 KeV. This occurred because several interactions took place in the transmitted primary irradiation such as characteristic, fluorescence, and bremsstrahlung produced when of the occupation of the KL3, KL2, KM3, and KM2 shell and sub-shell of titanium and magnesium which are the elements with a high atomic number in the material. The transmission particle characteristic of this material is therefore an indicator capable of improving the electrical performance and properties of the sensor.

关键词： Monte Carlo PyPEnELOPE Primary Electrons Transmission MgO/TiO2

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Mapping and Petro-Structural Study of northern Komborodougou Formations, in Korhogo Gold District: A Substantial Contribution to the Discovery of a Potential Gold Mineralization in birimian Greenstone belts

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International Journal of Geosciences 2022年第10期13卷 855-874页

作者： Houssou n’guessan nestor Allialy Marc Ephrem Adingra Martial Pohn koffi Pria koffi Kossonou Jean-Marie koffi n’guessan Martial Ahossi Loba Gbriga Franck Cyrille UFHb University of Felix Houphou&#235 t-boigny Abidjan UFR Earth Sciences and Mineral Resources Abidjan C&#244 te d’Ivoire UJLoG University of Jean Lorougnon Guede Daloa C&#244 te d’Ivoire CAREM Sarl Abidjan C&#244 te d’Ivoire

The Gold District of Korhogo, in the northern region of C?te d’Ivoire, holds enormous potential for gold mineralizations, some of which are under exploration phase and others in exploitation phase (example of Tongon Gold Mine). Dormant since 1998, Mapping Services of most of the West African countries hardly provide geological maps at the scales of: 1/200,000, 1/50,000 and 1/25,000. This situation of unavailability of detailed geological maps does not help mining operators in the selection of prolific areas and also in the interpretation of in soil geochem anomies or gold mineralizations. Consequently, during the years 2020 and 2021, we have undertaken a campaign of geological mapping and petro-structural study of the northern sector of Komborodougou, located in the southern extension of banfora birimian belt. This work, which allowed the realization of a geological map at 1/20,000 scale, reveals that: the mapped area includes three (3) major lithological units: 1) a volcano-sedimentary unit made up of metasediments (metaarenites, metasiltites and metaflyschs) and metavolcanites (metabasalts), which are metamorphosed and outcrop in the form of schists;2) a metaplutonic and intrusive unit composed on the one hand of quartz-diorites and metagabbros, and on the other hand of granites and granodiorites;3) and finally, a unit of dikes formed by microgranites, microgabbros, aplites and quartzites. The volcano-sedimentary complex is affected by a regional fold with an axis subparallel to the regional tectonic grain and an S1 schistosity oriented nE-SW to nnE-SSW with steep dips (>60o), except for those of the metaflyschs which are weak (o);a regional nW-SE compression would be at the origin of the setting of this schistosity. The volcano-sediment and metaplutonite complex is crossed in a nnE-SSW direction by a senetral shear-zone or main shear-zone and secondary shear-zones oriented sometimes nE-SW or n-S. These shear-zones are intersected by more or less dextral or senest

关键词： Geological Mapping Petro-Structural Gold Mineralization Komborodougou Côte d’Ivoire

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noise-induced hippocampal damage:potential mechanisms

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neural Regeneration Research 2022年第3期17卷 563-564页

作者： sonia Jazmín Molina Laura Ruth Guelman Universidad de buenos Aires Consejo Nacional de Investigaciones Científicas y TécnicasCentro de Estudios Farmacológicos y Botánicos(CEFyBOUBA-CONICET)Facultad de MedicinaBuenos AiresArgentina Universidad de buenos Aires Facultad de Medicina1^(a) Cátedra de FarmacologíaBuenos AiresArgentina

Exposure to noise of high intensities(> 80 db) is considered a stressful event and might produce both auditory and extra-auditory damage,including different central nervous system(CnS) *** the CnS,the hippocampus(HC),a structure related to several cognitive functions,has shown to be particularly susceptible to the effects of noise.

关键词： damage auditory injuries

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Monitoring Forest Recovery in Protected Forests of northern Côte d’Ivoire Using Landsat Imagery and Intensity Change Analysis

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Advances in Remote Sensing 2022年第2期11卷 17-37页

作者： n’guessan Simon Andon Avy Stéphane koffi Farid Traoré Patrick n’Gatta Department of Geography Université Peleforo GON COULIBALY Korhogo C&ocirc te d’Ivoire Department of Geosciences Université Peleforo GON COULIBALY Korhogo C&ocirc te d’Ivoire Institut de l’Environnement et de Recherches Agricoles Ouagadougou Burkina Faso

In this paper, the initiatives of reforestation of the national forests of the north of the Côte d’Ivoire were examined using geomatics and the analysis of change of intensity by taking the case of the protected Forest of badénou (PFb). A spatial analysis based on multi-spectral and multi-temporal Landsat imagery was carried out to assess land cover changes in the (PFb) over the past two decades and determine whether patterns of change in terms of the intensity of gains/losses of each of the land cover classes were active or dormant between the period before (2000-2013) and after (2013-2019) the reforestation initiative. Five main classes were identified: forest (dry deciduous and gallery forests), tree savannah, shrub/grassy savannah (including agricultural lands), bare lands (bare soils and degraded land areas), and water course. All classes were satisfactorily classified, with an excellent producer’s and user’s and overall accuracies and very good Kappa coefficients. The results showed that between 2000 and 2019, the forest cover in the PFb increased from 7778 ha to 5054 ha, a decrease was marked between 2000 and 2013 of approximately 60% compared to its size in 2000, while a slight increase between 2013 and 2019 (4645 ha to 5054 ha) i.e. around 9%) certainly due to the reforestation since 2016. As for the annual intensities of change for each class in both study periods, changes (gain or loss) in forest and tree savanna were relatively dormant after reforestation, while annual bare land gain was relatively active and marked, indicating that degradation of forests remains a threat to the sustainability of the PFb. Forest degradation has occurred mainly in the eastern parts of the PFb, while the central parts have regained more tree cover. These results can help identify conservation and restoration priorities and improve the overall management of the PFb.

关键词： Forest Degradation Reforestation Forest Cover Monitoring Intensity Change Analysis Desertification

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The Oryzenin’s Effect on Di, Tri and Quadri-Saccharide Degradation. An Investigation by a Mixed Method: OnIOM (DFT/b3LYP/6 - 31 + G(d, p): AM1)

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Computational Chemistry 2022年第2期10卷 97-119页

作者： n’guessan boka Robert bamba El Hadji Sawaliho koffi Kouassi Alain Laboratoire de Constitution et de Réaction de la Matière UFR SSMT Université Félix Houphou&#235 t-boigny Abidjan C&#244 te d’Ivoire

The paddy rice degradation remains a concern for research;the chemical phenomena underlying this process persists unknown. This research aims to identify the mechanism of starch degradation. It determines the nature of the reactions between two, three and four synthons of amylose with oryzenin using theoretical methods. The OnIOM (DFT/b3LYP/6 - 31 + G(d, p): AM1) level of theory is performed on four monomers and eight complexes. Frequencies make it possible to obtain energy and spectroscopic quantities. Calculations after geometry optimization. Following this, a “single point” allows exploiting the “natural bond Orbital (nbO)” analysis. The first three parameters suggest that the main interactions between oryzenin and amylose arise through O29-H30…O46 hydrogen bonds (Hb). Furthermore, this result posits that the length of the amylose doesn’t influence this reaction. The nbO analysis shows that this component of starch degrades first at the end of the chain to produce monosaccharides;it can also alter in the middle of the chain to give disaccharides.

关键词： Paddy Rice Oryzenin Amyloidosis Hydrogen bond

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Assessment of Climate Change Impact on Water Requirement and Rice Productivity

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Rice science 2023年第4期30卷 276-293页

作者： Konan Jean-Yves n’guessan botou ADAHI Arthur-brice KOnAn-WAIDHET Satoh MASAYOSHI nogbou Emmanuel ASSIDJO Environmental Training and Research Unit Laboratory of Environmental Sciences and TechnologiesUniversitéJean Lorougnon GuédéBP 150 DaloaCôte d’Ivoire Department of Training and Research of Rural Engineering and Geographic Sciences Institut National Polytechnique FÉLIX HOUPHOUËT-BOIGNYBP 1093 YamoussoukroCôte d’Ivoire University of Tsukuba Ibaraki 305-8577Japan Department of Training and Research of Chemical and Food Engineering Laboratory of ModellingInformation and ProcessesInstitut National Polytechnique FÉLIX HOUPHOUËT-BOIGNYBP 1093 YamoussoukroCôte d’Ivoire

Assessing the impact of climate change(CC)on agricultural production systems is mainly done using crop models associated with climate model *** review is one of the few,with the main objective of providing a recent compendium of CC impact studies on irrigation needs and rice yields for a better understanding and use of climate and crop *** discuss the strengths and weaknesses of climate impact studies on agricultural production systems,with a particular focus on uncertainty and sensitivity analyses of crop *** the new generation global climate models(GCMs)are more robust than previous ones,there is still a need to consider the effect of climate uncertainty on estimates when using *** GCMs cannot directly simulate the agro-climatic variables of interest for future irrigation assessment,hence the use of intelligent climate ***,sensitivity and uncertainty analyses must be applied to crop models,especially for their calibration under different *** impacts of CC on irrigation needs and rice yields vary across regions,seasons,varieties and crop ***,integrated assessments,the use of remote sensing data,climate smart tools,CO_(2)enrichment experiments,consideration of changing crop management practices and multi-scale crop modeling,seem to be the approaches to be pursued for future climate impact assessments for agricultural systems。

关键词： climate change rice production irrigation crop model climate model

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Tectonic Evolution of Paleoproterozoic Formations in the north-East of Côte d’Ivoire (bondoukou-Tanda, West African Craton)

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International Journal of Geosciences 2024年第10期15卷 774-791页

作者： Kouadio David koffi brice Roland Kouassi Raoul koffi Teha n’guessan Houssou nestor Marc Ephrem Allialy Laboratory of Geology Mineral and Energy Resources/Training and Research Unit in Earth Sciences and Mineral Resources Flix Houphout-Boigny University Abidjan Cte dIvoire UFR-biological Sciences Geosciences Department Peleforo Gon Coulibaly University Korhogo Cte dIvoire

The objective of this work is to contribute to the crustal evolution during the Paleoproterozoic in the northeast of Côte d’Ivoire through the structural study of the bondoukou-tanda locality. To do this, we proceeded by a macroscopic observation of the outcrops for the identification of the structures (schistosity, fold, shear, and lineation). The structures indicated the direction of the main constraints and the relative correlations between the lithologies. The structural measurements, in particular the direction and the dip obtained, were all processed by the GEOrient software to draw up the stereographic projections for a static interpretation of the measurements. Given the rarity of rock outcrops in the study area, the teleanalytical data were of considerable support in the structural analysis. The various treatments carried out on the EnVI 5.2 software made it possible to identify a total of 471 lineaments. They cover the entire area and are of variable lengths (1.24 to 9.73 km). The different directions highlighted from this methodology are a main direction: nnW-SSE to nW-SE;a secondary direction: nnE-SSW to nE-SW;a tertiary direction: EnE-WSW to E-W. Associated with the lithology map, the teleanalytical map shows that the lineaments are unevenly distributed throughout the study area. The lineaments appear more compact in the volcano-sedimentary and sandstone-conglomeratic units than in the granitoid intrusives. However, the bondoukou granodiorite appears to be the least fractured lithology.

关键词： Structural birimian bondoukou-Tanda Tarkwaian WAC

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Petro-Geochemistry Contraints of Côte d’Ivoire north-East Plutonites: Implications for Eoeburnean Magmatism of baoulé-Mossi Domain (Southern of West African Craton)

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Journal of Geoscience and Environment Protection 2022年第9期10卷 185-206页

作者： brice Roland Kouassi Marc Ephrem Allialy n’guessan Houssou nestor Kouadio David koffi UFR-biological Sciences Geosciences Department Peleforo Gon Coulibaly University Korhogo C&#244 te d’Ivoire Laboratory of Geology Mineral and Energy Resources/Training and Research Unit in Earth Sciences and Mineral Resources Félix Houphou&#235 t-boigny University Abidjan C&#244 te d’Ivoire

Plutonites are part of the set of crystallines compose the Precambrian basement. Their study is capital because it allows participating in the debates on the geodynamic evolution of the West African craton. This study concerns granitoids and dioritoids of the north-East of Côte d’Ivoire located in the Man-Leo ridge structured by Eoeburnean magmatism. The petrographic and geochemistry constraints make it possible to say that these rock formations have evolved by the process of fractional crystallization. They have a hybrid origin (mantle and crust), metaluminous to peraluminous highlighted by geochemistry. Concerning the geotectonic context, these plutonites of the baoulé-Mossi domain are emplacement in a context of subduction more precisely in a context of volcanic arc.

关键词： Plutonites Contraints Magmatism Source Geotectonics Côte d’Ivoire West African Craton

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