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Child-Pugh-Turcott versus Meld score for predicting survival in a retrospective cohort of black African cirrhotic patients

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World Journal of Gastroenterology 2008年第2期14卷 286-291页

作者： KA Attia KC Ackoundou-n'guessan AT n’dri-yoman AK Mahassadi E Messou YF Bathaix YH Kissi Service of Hepatology Gastroenterology and Generalmedicine Yopougon Teaching Hospital Abidjan Ivory Coast Service of nephrology Dialysis andHypertension Yopougon Teaching Hospital Abidjan Ivory Coast Centre for the Management Research and Training onHIV/AIDS infection and related diseases (CEPREF-ACONDAVS) Yopougon-Attié Abidjan Ivory Coast

AIM: To compare the performance of the Child-Pugh-Turcott (CPT) score to that of the model for end-stage liver disease (MELD) score in predicting survival of a retrospective cohort of 172 Black African patients with cirrhosis on a short and mid-term ***: Univariate and multivariate (Cox model) analyses were used to identify factors related to mortality. Relationship between the two scores was appreciated by calculating the correlation coefficient. The Kaplan Meier method and the log rank test were used to elaborate and compare survival respectively. The Areas Under the Curves were used to compare the performance between scores at 3, 6 and 12 ***: The study population comprised 172 patients, of which 68.9% were male. The mean age of the patient was 47.5 ± 13 years. Hepatitis B virus infection was the cause of cirrhosis in 70% of the cases. The overall mortality was 31.4% over 11 years of follow up. Independent factors significantly associated with mortality were: CPT score (HR = 3.3, 95% CI [1.7-6.2]) (P ne (HR = 2.5, 95% CI [1.4-4.3]) (P = 0.001) (Serum creatine > 1.5 mg/dL versus serum creatine 21 vs MELD nder the curves (AUC) that predict survival was 0.72 and 0.75 at 3 mo (P = 0.68), 0.64 and 0.62 at 6 mo (P = 0.67), 0.69 and 0.64 at 12 mo (P = 0.38) respectively for the CPT score and the MELD ***: The CPT score displays the sameprognostic significance as does the MELD score in black African patients with cirrhosis. Moreover, its handling appears less cumbersome in clinical practice as compared to the latter.

关键词： Model for end-stage liver disease score Child score Cirrhosis Black African Survival

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Volatile Compounds Selection via Quantile Correlation and Composite Quantile Correlation: A Whiting Case Study

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Open Journal of Statistics 2016年第6期6卷 995-1002页

作者： Ibrahim Sidi Zakari Assi n’guessan Alexandre Dehaut Guillaume Duflos Department of Mathematics and Computer Science Abdou Moumouni University Niamey Niger Paul Painlevé Laboratory UMR CNRS 8524 Lille 1 University Lille France AnSES Laboratoire de Sécurité des Aliments Département des Produits de la Pêche et de l’Aquaculture Boulevard du Bassin Napoléon Boulogne-Sur-Mer France

The freshness and quality indices of whiting (Merlangius merlangus) influenced by a large number of chemical volatile compounds, are here analyzed in order to select the most relevant compounds as predictors for these indices. The selection process was performed by means of recent statistical variable selection methods, namely robust model-free feature screening, based on quantile correlation and composite quantile correlation. On the one hand, compounds 2-Methyl-1-butanol, 3-Methyl-1-butanol, Ethanol, Trimethylamine, 3-Methyl butanal, 2-Methyl-1-propanol, Ethylacetate, 1-Butanol and 2,3-Butanedione were identified as major predictors for the freshness index and on the other hand, compounds 3-Methyl-1-butanol, 2-Methyl-1- butanol, Ethanol, 3-Methyl butanal, 3-Hydroxy-2-butanone, 1-Butanol, 2,3-Butane- dione, 3-Pentanol, 3-Pentanone and 2-Methyl-1-propanol were identified as major predictors for the quality index.

关键词： Volatile Compounds Freshness and Spoilage Indices Quantile Correlation Composite Quantile Correlation Sure Independence Screening

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Theoretical Analysis of the Effect of the Interfacial MoSe2Layer in CIGS-Based Solar Cells

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Open Journal of Modelling and Simulation 2021年第4期9卷 339-350页

作者： Adama Sylla n’guessan Armel Ignace Touré Siaka Jean-Pierre Vilcot Laboratoitre d’Energie Solaire Universit&#233 F&#233lix Houphou&#235t Boigny Abidjan C&#244te d’Ivoire. Institut d’Electronique de Micro&#233lectronique et de Nanotechnologie (IEMN) UMR CNRS 8520. Laboratoire Central Villeneuve d’Ascq Cedex Lille France

The aim of this work is to analyze the influence of the interfacial MoSe2 layer on the performance of a /n-ZnO/i-ZnO/n-Zn(O,S)/p-CIGS/p+-MoSe2/Mo/SLG solar cell. In this investigation, the numerical simulation softwar... 详细信息

The aim of this work is to analyze the influence of the interfacial MoSe2 layer on the performance of a /n-ZnO/i-ZnO/n-Zn(O,S)/p-CIGS/p+-MoSe2/Mo/SLGn> solar cell. In this investigation, the numerical simulation software AFORS-HET is used to calculate the electrical characteristics of the cell with and without this MoSe2 layer. Different reported experimental works have highlighted the presence of a thin-film MoSe2 layer at the CIGS/Mo contact interface. Under a tunneling effect, this MoSe2 layer transforms the Schottky CIGS/Mo contact nature into a quasi-ohmic one. Owing to a heavily p-doping, the MoSe2 thin layer allows better transport of majority carrier, tunneling them from CIGS to Mo. Moreover, the bandgap of MoSe2 is wider than that of the CIGS absorbing layer, such that an electric field is generated close to the back surface. The presence of this electric field reduces carrier recombination at the interface. Under these conditions, we examined the performance of the cell with and without MoSe2n style="font-famil

关键词： CIGS numerical Simulation AFORS-HET Quasi-Ohmic Contact Schottky Contact MoSe2 Tunnel Layer

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Description of Post-Stroke Cognitive Disorders at Abidjan University Hospitals, Côte d’Ivoire

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neuroscience & Medicine 2024年第2期15卷 92-105页

作者： n’guessan n’cho Arthur Kouassi Kouamé Léonard Ouattara niemtiah Tako neme Antoine Biology and Health Laboratory Felix Houphout-Boigny University Abidjan Cte dIvoire Department of neurology CHU Yopougon Felix Houphout-Boigny University Abidjan Cte dIvoire

Stroke patients often experience motor deficits and cognitive problems after a stroke. Objective: To improve our understanding of the cognitive consequences of stroke. Method: a descriptive and analytical cross-sectional study was conducted over 12-month period in the neurology departments of the Cocody and Treichville Hospitals in Côte d’Ivoire. Results: Out of 724 patients admitted to the neurology department, 415 (57.32%) were stroke patients, of which 145 (34.94%) were screened. The frequency of global cognitive functioning impairment was 86.21%, significantly higher than the frequency of patients without impairment, which was 13.79%. The study focused on detailing the cognitive status of stroke patients in neurology departments, assessing several cognitive functions during the subacute phase of stroke. These functions included global cognitive functioning, executive functions, language and memory. The frequency of post-stroke cognitive impairment is high among stroke patients in Abidjan. This frequency is comparable to figures found in Subsaharian stroke populations. Demographic and clinical characteristics studied included age, gender, education level, employment status, vascular diseases and cerebral affected area. Among these characteristics, only the education level and the cerebral affected area have been found significant. Conclusion: The incidence of cognitive impairment after a stroke is significantly high among stroke patients in Abidjan.

关键词： Cognitive Disorders Subacute Stroke Related Risk Factors

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SARs Investigation of α-, β-, γ-, δ-, ε-RuCl₂(Azpy)₂ Complexes as Antitumor Drugs

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Computational Chemistry 2016年第1期4卷 1-10页

作者： Kafoumba Bamba Ouattara Wawohinlin Patrice n’guessan Kouakou nobel nahossé Ziao Laboratoire de Thermodynamique et de Pysico-Chimie du Milieu UFR-SFA Université Nangui Abrogoua Abidjan C&ocirc te d’Ivoire

Structure Activity-Relationships (SARs) of the five possible isomers of RuCl2(Azpy)2 were predicted thanks to DFT method. Azpy stands for 2-phenylazopyridine and the structure of the isomers α-RuCl2(Azpy)2, β-RuCl2(Azpy)2, γ-RuCl2(Azpy)2, δ-RuCl2(Azpy)2 and ε-RuCl2(Azpy)2 call respectively α-Cl, β-Cl, γ-Cl, δ-Cl and ε-Cl are defined according to chlorine atoms orientations. Hence, they are divided into two groups. In the first group comprising α-Cl, β-Cl and ε-Cl, both chlorine atoms are in cis position and Azpy ligands are intervertical. Whereas the two others isomers (γ-Cl and δ-Cl), they form the second group. Here, both chlorine are in trans position and Azpy are planar. The five synthesized isomers were investigated as potential antitumor agents. Then, regarding the DnA, its bases are stacked by pair. Therefore, complexes are assumed to insert and to stack on them through intercalative mode. So the electronic and geometric structures become more important to describe their SARs. Consequently, group 2 regarding γ-Cl and δ-Cl presents the best structure to allow intercalation between DnA base-pairs. Besides, the energy order of the lower unoccupied molecular orbital (LUMO) of the isomers is ELUMO(β-Cl) > ELUMO(α-Cl) > ELUMO(ε-Cl) > ELUMO(γ-Cl) > ELUMO(δ-Cl). The energy gap between LUMO and HOMO was also sorted as Δ(L-H)(β-Cl) > Δ(L-H)(α-Cl) > Δ(L-H)(ε-Cl) > Δ(L-H)(γ-Cl) > Δ(L-H)(δ-Cl). In addition, the total dipole moment was classified as μ(ε-Cl) > μ(β-Cl) > μ(α-Cl) > μ(γ-Cl) > μ(δ-Cl). Finally, net charge of the ligand Azpy was also classified as QL(δ-Cl) > QL(γ-Cl) > QL(ε-Cl) > QL(α-Cl) > QL(β-Cl). All those parameters show that δ-Cl isomer displays the highest activity as antitumor drug when intercalating between the DnA basepairs Cytosine-Guanine/Cytosine-Guanine (CG/CG).

关键词： Structure Activity-Relationship (SARs) Ru (II) Complexes Azpy DFT Lanl2dz DnA-Binding

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Hydrogen Bonds Sites of Amylose or Amylopectin from Starch at the OnIOn Level (B3LYP/6-311++G [d, p]: AM1)

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Computational Chemistry 2021年第1期9卷 85-96页

作者： Ablé Anoh Valentin n’guessan Boka Robert Bamba El Hadji Sawaliho Laboratoire de Constitution et de Réaction de la Matière UFR SSMT Université Félix Houphou&#235t-Boigny Abidjan C&#244te d’Ivoire

The research aims to help reduce the enormous post-harvest losses of rice or bananas in Cote d’Ivoire. It focuses on the breakdown mechanism of their starch. This process contributes to their decay. This study wants to elucidate it;to do this, it analyzes the tetra or penta saccharide reactions with the water or dioxide carbon. It calculates the geometric, energetic and spectroscopic parameters at the OnIOM level (B3LYP/6-311++G [d, p]: AM1). These quantities allow establishing that oxygen represents the privileged hydrogen bond (HB) site for amylose with four or five D-glucose building blocks. They suggest and are respectively those of amylopectin when the latter consists of four and five D-glucose synthons. They prove that amylose deteriorates before it;the degradation of starch begins with its alteration into disaccharides. It continues with that of amylopectin into tri or tetra-saccharides with four or five building blocks.

关键词： Hydrogen Bonds Glucose Amylose Amylopectin

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Epidemiological and Histological Aspects of Women Genital Cancers in Cote d’Ivoire

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Open Journal of Obstetrics and Gynecology 2014年第9期4卷 516-523页

作者： Kouamé Justin n’Dah Brahima Doukoure Emile Troh n’guessan Alphonse Aman Kouakou Emmanuel koffi Arthur Didier Kouamé Ahoua Benjamin Effi Ahoua Francois de Salès D’Horpock Mohénou Isidore Jean-Marie Diomande Laboratory of Pathology University Hospital of CocodyAbidjanCôte d’Ivoire Department of Pathology Saint-Louis HospitalParisFrance Laboratory of Pathology University Hospital of BouakeBouakeCôte d’Ivoire Laboratory of Pathology University Hospital of TreichvilleAbidjanCôte d’Ivoire Department of Obstetrical Gynecology University Hospital of CocodyAbidjanCôte d’Ivoire

Genital cancers in women play an important role in cancer pathology in the developing countries. Objectives: This study aimed at clarifying the epidemiological and histopathological aspects of woman genital cancers in C?te d’Ivoire. Materials and Methods: This was a retrospective and descriptive study conducted in the anatomical pathology laboratories of the university hospitals in Abidjan. The study was carried out over a period of twenty-four years (1984-2007). The variables studied were: frequency, age, histological type and prognosis. Results: Genital cancers in women accounted for 41.28% (n = 2491) of cancer in women and 21% of cancers. The average age of patients was 46.65 years (range 2 - 88 years). The cervix (82.85%) was the main location followed by the ovary (8.6%). Histologically, carcinomas (92.93%) were the most common types of sarcomas. Cervical cancers were diagnosed at an average age of 47.36 years (range 2 to 88 years). Carcinomas were the predominant histological type (92.88%) with 57.4% (n = 450) diagnosed at pT2n0M0 stage. The average age of patients bearing ovarian cancer was 39.13 years (range 8 to 82 years).Common malignant epithelial tumours were the most common histological type (57.48%) (n = 123) followed by non-Hodgkin lymphoma (14.95%). Conclusion: Genital cancers in women are common and poorly prognosed in Cote d’Ivoire. The adoption of a policy of routine screening is needed to improve the prognosis of these tumours.

关键词： Cancer Genital Women Epidemiology-Histology-C?te d’Ivoire

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nBO Population Analysis and Electronic Calculation of Four Azopyridine Ruthenium Complexes by DFT Method

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Computational Chemistry 2017年第1期5卷 51-64页

作者： n’guessan Kouakou nobel Kafoumba Bamba Ouattara Wawohinlin Patrice nahossé Ziao Laboratoire de Thermodynamique et de Physico-Chimie du Milieu UFR-SFA Université Nangui Abrogoua Abidjan C&ocirc te d’Ivoire

The molecular structure, the natural Bond orbital (nBO) and the Time Dependent-DFT of both isomers cis or γ-Cl and trans or δ-Cl of RuCl2(L)2, where L stands respectively for 2-phenylazopyridine (Azpy), 2,4-dimethyl-6-[phenylazo]pyridine (Dazpy), 2-[(3,5-dimethylphenyl)azopyridine] (Mazpy) and 2-pyridylazonaphtol (nazpy) were calculated with DFT method at B3LYP/LAnL2DZ level. The prediction of the frontier orbitals (Highest Occupied Molecular Orbital or HOMO and Lowest Unoccupied Molecular Orbital or LUMO) shows that the most active complexes suitable for electronic reactions are admitted to be the trans isomers. Moreover, δ-RuCl2 (Azpy)2 is discovered to react more actively as photo-sensitizer since its energy gap is the minimum. Besides, electronic structures of all complexes through nBO calculation indicate that Ru-n bonds are made of delocalization of occupancies from lone pair orbital of n atoms to the ruthenium. Moreover, Ru was assumed to have almost the same charge regardless the structure of the azopyridine ligands in the complex indicating that the ligands provide only a steric effect that is responsible for the ruthenium’s selectivity. Concerning the transition state, nBO analysis also highlights that the transition LP(Ru) π*(n1-n2) does correspond to t2g?π*(L). This transition is assumed to correspond to Metal to Ligand Charge Transfer (MLCT) that is responsible for the photo-sensitiveness of the metallic complex. Besides, TDDFT calculation of complexes showed that δ-RuCl2(nazpy)2 displays the largest band during the absorption. For that reason, it is admitted to be the best photosensitizer due to a large system of conjugation provided by nazpy ligand.

关键词： natural Bond Orbital (nBO) HOMO LUMO Azopyridine Ligand MLCT LLCT

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Theoretical and Electrochemical Characterization of δ-RuCl₂(nazpy)₂: Application to Oxidation of D-Glucose

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American Journal of Analytical Chemistry 2016年第1期7卷 57-66页

作者： Wawohinlin Patrice Ouattara Kafoumba Bamba nahossé Ziao Kouakou nobel n’guessan Laboratoire de Thermodynamique et de Physico-Chimie du Milieu UFR-SFA Université Nangui-Abrogoua Abidjan Cote d’Ivoire

The heterogenized δ-RuCl2(nazpy)2 deposited on carbon toray (CT) was studied for the first time as electrochemical catalyst. Before, it was characterized by visible-ultraviolet spectra and theoretically by TDDFT method at B3LYP/Lanl2DZ level. It displayed an MLCT t2geg → π* transition where t2geg due to the structure of nazpy that considerably reduces energy between d AOs of Ru represents the HOMO of the complex and π* is identified as the LUMO. Electrochemistry study shows two redox ranges in both negative and positive sides of the potential. The positive side that corresponds to the couple RuIV/RuIII of catalyst appears to be active for oxidation of D-glucose in carbonate buffer with a high turnover. Therefore, Keto-2-gluconic and gluconic acids were the two main products obtained with respectively 80% and 17.6% of selectivity. Moreover, a small amount of tartaric and glycol acids coming from the c-c bond cleavage due to non-protection of the anomeric carbon of D-glucose were also observed.

关键词： DFT Calculation HOMO-LUMO Analysis nBO Electrochemistry Ruthenium Complex D-Glucose

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Molecular Structure, Electronic Structure, Properties and Analyses of Five Azopyridine Ruthenium Complexes α-Cl, β-Cl, γ-Cl, δ-Cl and ε-Cl of RuCl2(4,6-Dimethyl-Phenylazopyridine)2as Potential Cancer Drugs: DFT and TD-DFT Investigations

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Computational Chemistry 2018年第3期6卷 27-46页

作者： nobel Kouakou n’guessan Kafoumba Bamba Ouattara Wawohinlin Patrice nahosséZiao Laboratoire de Thermodynamique et Physico-Chimie du Milieu UniversitéNangui AbrogouaAbidjanC&ocirc te d’Ivoire

Ground state geometries, natural bond orbital (nBO), analysis of frontier molecular orbitals (FMOs), analysis and spectral (RMn and UV-Visible) properties of five azopyridine ruthenium (II) complexes α-Cl, β-Cl, γ-Cl, δ-Cl and ε-Cl of RuCl2(Dazpy)2 have been theoretically studied by the Density Functional Theory (DFT) and Time-Dependent Density Functional Theory (TD-DFT) methods using two basis sets: Lanl2DZ and a generic basis set in gas or in chloroform solvent. Dazpy stands for 4,6-dimethyl-phenylazopyridine. Optimized geometry shows that, except β-Cl, all the other four isomers α-Cl, γ-Cl, δ-Cl and ε-Cl are C2 symmetrical. Otherwise, a good agreement was found between experimental and the calculated geometry and nMR data. Moreover, Lanl2DZ effective core potential basis set provides good chemical shifts and geometric properties. Furthermore, the prediction of the frontier orbitals (Highest Occupied Molecular Orbital or HOMO and Lowest Unoc-cupied Molecular Orbital or LUMO) shows that the most active isomer suita-ble for electronic reactions is admitted to be δ-Cl. Besides, the nBO analysis indicates that the Ru-n is formed by the electron delocalization of lone pair atomic orbital of n2 and npy to Ru. Also, the strongest interactions between LP(n) with LP*(Ru) and LP(Cl) with LP*(Ru) stabilize the molecular struc-ture. In addition, nBO shows that the five d orbitals of Ru in the complex are organized so that there is no order of priority from one complex to another. Therefore, the transition LP(Ru) → π*(n1 = n2) corresponding to Metal to Li-gand Charge Transfer (MLCT) is in reality no more than d → π*. Besides, TDDFT prediction in chloroform solvent reveals that all the five isomerics complexes absorb in the visible region as well as efficient photosensitizers. What’s more, δ-RuCl2(dazpy)2 can potentially act as the excellent sensitizer with a large band of absorption in visible region and a small excited energy. This study can help design and find out the abili

关键词： Azopyridine DFT nBO Pseudo-Potential Ru(II) Complexes

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