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Epidemiology and risk factors for mortality in critically ill patients with pancreatic infection

Journal of Intensive Medicine 2024年第1期4卷 81-93页

作者： Marie Dejonckheere Massimo Antonelli Kostoula Arvaniti koen.blot Ben CreaghBrown Dylan Wde Lange Jan De Waele Mieke Deschepper Yalim Dikmen George Dimopoulos Christian Eckmann Guy Francois Massimo Girardis Despoina Koulenti Sonia Labeau Jeffrey Lipman Fernando Lipovestky Emilio Maseda Philippe Montravers Adam Mikstacki JoseArtur Paiva Cecilia Pereyra Jordi Rello JeanFrancois Timsit Dirk Vogelaers Stijn blot the Abdominal Sepsis Study(AbSeS)group on behalf of the Trials Group of the European Society of Intensive Care Medicine Department of Internal Medicine and Pediatrics Faculty of Medicine and Health SciencesGhent UniversityGhentBelgium Department of Anesthesiology Intensive Care and Emergency MedicineFondazione Policlinico Universitario A.Gemelli IRCCSRomeItaly UniversitàCattolica del Sacro Cuore RomeItaly Intensive Care Unit Papageorgiou University Affiliated HospitalThessaloníkiGreece Department of Epidemiology and Public Health SciensanoIxellesBelgium Surrey Perioperative Anaesthetic Critical Care Collaborative Research Group(SPACeR) Royal Surrey County HospitalGuildfordUK Department of Clinical and Experimental Medicine University of SurreyGuildfordUK Department of Intensive Care Medicine University Medical Center UtrechtUniversity UtrechtUtrechtthe Netherlands Department of Intensive Care Medicine Ghent University HospitalGhentBelgium Data Science Institute Ghent University HospitalGhentBelgium Department of Anesthesiology and Reanimation Cerrahpasa School of MedicineIstanbul University-CerrahpasaIstanbulTurkey rd Department of Critical Care “EVGENIDIO”HospitalNational and Kapodistrian University of AthensAthensGreece Department of General Visceral and Thoracic SurgeryKlinikum Hannoversch-MuendenGoettingen UniversityGöttingenGermany Division of Scientific Affairs-Research European Society of Intensive Care MedicineBrusselsBelgium Anesthesia and Intensive Care Department University Hospital of ModenaModenaItaly UQ Centre for Clinical Research Faculty of MedicineThe University of QueenslandBrisbaneQLDAustralia nd Critical Care Department Attikon University HospitalAthensGreece Department of Nursing Faculty of EducationHealth and Social WorkUniversity College GhentGhentBelgium Jamieson Trauma Institute The University of QueenslandBrisbaneQLDAustralia Nimes University Hospital University of MontpellierNimesFrance Critical Care Department Hospital of the Interamerican Open University(UAI)Buenos AiresArgentina Surgical Critical Care Department of AnesthesiaHospital Universitario

Background:The AbSeS-classification defines specific phenotypes of patients with intra-abdominal infection based on the(1)setting of infection onset(community-acquired,early onset,or late-onset hospital-acquired),(2)presence or absence of either localized or diffuse peritonitis,and(3)severity of disease expression(infection,sepsis,or septic shock).This classification system demonstrated reliable risk stratification in intensive care unit(ICU)patients with intra-abdominal *** study aimed to describe the epidemiology of ICU patients with pancreatic infection and assess the relationship between the components of the AbSeS-classification and ***:This was a secondary analysis of an international observational study(“AbSeS”)investigating ICU patients with intra-abdominal *** patients with pancreatic infection were included in this analysis(n=165).Mortality was defined as ICU mortality within 28 days of observation for patients discharged earlier from the *** with mortality were assessed using logistic regression analysis and reported as odds ratio(OR)and 95%confidence interval(CI).Results:The overall mortality was 35.2%(n=58).The independent risk factors for mortality included older age(OR=1.03,95%CI:1.0 to 1.1 P=0.023),localized peritonitis(OR=4.4,95%CI:1.4 to 13.9 P=0.011),and persistent signs of inflammation at day 7(OR=9.5,95%CI:3.8 to 23.9,P<0.001)or after the implementation of additional source control interventions within the first week(OR=4.0,95%CI:1.3 to 12.2,P=0.013).Gramnegative bacteria were most frequently isolated(n=58,49.2%)without clinically relevant differences in microbial etiology between survivors and ***:In pancreatic infection,a challenging source/damage control and ongoing pancreatic inflammation appear to be the strongest contributors to an unfavorable short-term *** this limited series,essentials of the AbSeS-classification,such as the setting of infection onset,diffuse

关键词： Pancreatic infection Intensive care unit Mortality Intra-abdominal infection Sepsis

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Association of Serum Folate and Vitamin B_(12) Concentrations with Obesity in Chinese Children and Adolescents

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Biomedical and Environmental Sciences 2024年第3期37卷 242-253页

作者： ZHU Qian Rang KOK E Dieuwertje BEKELE Hailu Tesfaye MANUSAMA koen ZHANG Jing Xian XIE Wei ZONG Wen Qi ZUO Hui ZHANG Jian KAMPMAN Ellen DAI Yue Jiangsu Provincial Center for Disease Control and Prevention Nanjing 210009JiangsuChina Division of Human Nutrition and Health Wageningen University&ResearchWageningen 176700 AAThe Netherlands School of Public Health Medical College of Soochow UniversitySuzhou 215123JiangsuChina National Institute for Nutrition and Health Chinese Center for Disease Control and PreventionBeijing 100050China

Objective This study aimed to evaluate the associations of serum folate and/or vitamin B12 concentrations with obesity among Chinese children and *** A cross-sectional study was conducted including 3,079 Chinese children and adolescents,aged 6 to 17 years,from Jiangsu,*** indices,such as,children's body mass index(BMI),BMI z-scores,waist circumference,and waist-to-height ratio were *** linear regression and generalized additive models were used to investigate the associations of serum folate and vitamin B12 levels with anthropometric indices and odds of *** We observed that serum vitamin B12 concentrations were inversely associated with all anthropometric indices and the odds of general obesity[odds ratio(OR)=0.68;95%confidence interval(CI)=0.59,0.78]and abdominal obesity(OR=0.68;95%CI=0.60,0.77).When compared to participants with both serum vitamin levels in the two middle quartiles,those with both serum folate and vitamin B12 levels in the highest quartile were less prone to general(OR=0.31,95%CI=0.19,0.50)or abdominal obesity(OR=0.46,95%CI=0.31,0.67).Conversely,participants with vitamin B12 levels in the lowest quartile alongside folate levels in the highest quartile had higher odds of abdominal obesity(OR=2.06,95%CI=1.09,3.91).Conclusion Higher serum vitamin B12 concentrations,but not serum folate concentrations,were associated with lower odds of childhood *** and adolescents with high levels of vitamin B12 and folate were less likely to be obese.

关键词： Folate Vitamin B12 Childhood obesity Micronutrient

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A new perspective on intervertebral disc calcification—from bench to bedside

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Bone Research 2024年第1期12卷 50-61页

作者： Emanuel J.Novais Rajkishen Narayanan Jose A.Canseco koen van de Wetering Christopher K.Kepler Alan S.Hilibrand Alexander R.Vaccaro Makarand V.Risbud Department of Orthopaedic Surgery Sidney Kimmel Medical CollegeThomas Jefferson UniversityPhiladelphiaPAUSA Unidade Local de Saúde do Litoral Alentejano Orthopedic DepartmentSantiago do CacémPortugal Rothman Orthopedic Institute at Thomas Jefferson University PhiladelphiaPAUSA

Disc degeneration primarily contributes to chronic low back and neck ***,there is an urgent need to understand the spectrum of disc degeneration phenotypes such as fibrosis,ectopic calcification,herniation,or mixed *** these phenotypes,disc calcification is the least *** calcification,by definition,is the pathological mineralization of soft tissues,widely studied in the context of conditions that afflict vasculature,skin,and ***,disc calcification is associated with poor surgical outcomes and back pain refractory to conservative *** is frequently seen as a consequence of disc aging and progressive degeneration but exhibits unique molecular and morphological characteristics:hypertrophic chondrocyte-like cell differentiation;TNAP,ENPP1,and ANK upregulation;cell death;altered Pi and PPi homeostasis;and local *** studies in mouse models have provided a better understanding of the mechanisms underlying this *** is essential to recognize that the presentation and nature of mineralization differ between AF,NP,and EP ***,the combination of anatomic location,genetics,and environmental stressors,such as aging or trauma,govern the predisposition to ***,the systemic regulation of calcium and Pi metabolism is less important than the local activity of PPi modulated by the ANK-ENPP1 axis,along with disc cell death and differentiation *** there is limited understanding of this phenotype,understanding the molecular pathways governing local intervertebral disc calcification may lead to developing disease-modifying drugs and better clinical management of degeneration-related pathologies.

关键词： degeneration metabolism intervertebral

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Improving Radiation Pattern Roundness of Henge-Like Metaring-Loaded Monopoles Above a Finite Ground for MIMO Systems

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Electromagnetic Science 2024年第2期2卷 104-115页

作者： Bo Zhang Zhi Ning Chen Yucong Zhou Qun Lou Jiahao Wang koen Mouthaan Department of Electrical and Computer Engineering National University of SingaporeSingapore 117583Singapore Huawei Technologies Co. Ltd.Shenzhen 518129China

A henge-like metaring(HMR)is proposed for improving the radiation pattern roundness of monopole antennas offcenter mounted on a finite ground by localizing the radiation from the monopole and suppressing the scattering by the *** improved patterns enhance uniform coverage of multiple-input and multiple-output(MIMO)*** study reveals that the radiation pattern of an off-center monopole is distorted by the asymmetric ground currents excited by both the feed and the radiation of the *** distorted radiation patterns severely degrade wireless communication link *** HMR,composed of an annular array of mushroom unit cells,simultaneously functions as an electromagnetic bandgap(EBG)and a radiator,and encircles the monopole to form a henge monopole antenna(HMA).The HMR as an EBG is used to suppress the ground currents outside the HMR analyzed by an equivalent circuit *** HMR as a radiator is designed to decouple the monopole from the ground with its elevated radiation pattern using characteristic mode *** examples,two prototypes of single and four off-center MIMO HMAs are designed and investigated in the 2.45-GHz *** and measured results show that the single HMA and each of the four HMAs achieve the un-roundness of the radiation pattern atθ=65°plane lower than 2 dB and 3 dB in the 2.45-GHz *** a result,near the radiation nulls,the SNR is improved by 6 *** compact construction and efficient current suppression facilitate the application of HMAs in multi-antenna systems above a finite ground with uniform coverage and reliable connections.

关键词： Antenna radiation pattern Characteristic mode analysis Metamaterials MIMO communication Omnidirectional antennas Wireless access points

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Application of the Shrinking Particle Model for the Evaluation of Molecular Recyclability of PET versus Semi-Aromatic Polyesters

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Open Journal of Physical Chemistry 2024年第2期14卷 21-35页

作者： Jack van Schijndel Sanne de Krom Dennis Molendijk koen van Beurden Amarante Böttger Research Group Biopolymers/Green Chemistry Centre of Expertise Safe & Resilient Society Avans University of Applied Science Breda Netherlands New Materials and Their Applications Centre of Expertise Safe & Resilient Society Avans University of Applied Science Breda Netherlands Department of Materials Science and Engineering Delft University of Technology Delft Netherlands

The molecular recyclability of poly (ethylene terephthalate) (PET) and three semi-aromatic polyesters poly (phloretic acid) (poly-H), poly (dihydroferulic acid) (poly-G), and poly (dihydrosinapinic acid) (poly-S) is evaluated in this study. PET is an extensively used aromatic polyester, and poly-H, poly-G, and poly-S can be considered semi-aromatic poly (lactic acid) modifications. All these polyesters have been depolymerized at neutral pH and by acid- and base-catalyzed hydrolysis at two temperatures, i.e., 50˚C and 80˚C. Base-catalyzed depolymerization of virgin PET leads to an isolated yield of 38% after 48 hours of reaction at 80˚C. Contrary to these results for PET, almost all the monomers of the semi-aromatic polyesters poly-H, poly-G, and poly-S are recovered with isolated yields larger than 90% at the same temperature after 15 minutes in a facile manner. A shrinking particle model used to determine the global kinetics of the base-catalyzed depolymerization showed that the rate rises with increasing temperature. Using the shrinking particle model, the intrinsic reaction rate constants were determined. It has been demonstrated that the rate coefficients of the depolymerization of the semi-aromatic polyesters poly-H, poly-G, and poly-S are between 2 and 3 orders of magnitude higher than those for PET.

关键词： Depolymerization Molecular Recycling Poly-H Poly-G Poly-S PET Circular Polymers

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Intraoperative application of three-dimensional printed guides in total hip arthroplasty: A systematic review

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World Journal of Orthopedics 2024年第7期15卷 660-667页

作者： Tim P Crone Bart M W Cornelissen Jakob Van Oldenrijk Pieter koen Bos Ewout S Veltman Department of Orthopedic Surgery and Sports Medicine Erasmus Medical CenterRotterdam 3015 GDNetherlands Department of Oral and Maxillofacial Surgery Erasmus Medical CenterRotterdam 3015 GDNetherlands

BACKGROUND Acetabular component positioning in total hip arthroplasty(THA)is of key importance to ensure satisfactory post-operative outcomes and to minimize the risk of *** majority of acetabular components are aligned freehand,without the use of navigation *** specific instruments(PSI)and three-dimensional(3D)printing of THA placement guides are increasingly used in primary THA to ensure optimal *** To summarize the literature on 3D printing in THA and how they improve acetabular component *** PubMed was used to identify and access scientific studies reporting on different 3D printing methods used in *** studies with 236 hips in 228 patients were *** studies could be divided into two main categories;3D printed models and 3D printed *** 3D printing in THA helped improve preoperative cup size planning and post-operative Harris hip scores between intervention and control groups(P=0.019,P=0.009).Otherwise,outcome measures were heterogeneous and thus difficult to *** overarching consensus between the studies is that the use of 3D guidance tools can assist in improving THA cup positioning and reduce the need for revision THA and the associated *** The implementation of 3D printing and PSI for primary THA can significantly improve the positioning accuracy of the acetabular cup component and reduce the number of complications caused by malpositioning.

关键词： Total hip arthroplasty Three-dimensional printing Hip replacement surgery Three-dimensional planning Surgical guides

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Severe Candida infections in critically ill patients with COVID-19

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Journal of Intensive Medicine 2023年第4期3卷 291-297页

作者： Despoina Koulenti Marios Karvouniaris Elisabeth Paramythiotou Nikolaos Koliakos Nikolaos Markou Paschalis Paranos Joseph Meletiadis Stijn blot Second Critical Care Department Attikon University HospitalAthensGreece UQ Centre for Clinical Research Faculty of MedicineThe University of QueenslandBrisbaneAustralia Intensive Care Unit ACHEPA University HospitalThessalonikiGreece ICU of Latseio Burns Centre General Hospital of Elefsis‘Thriasio’AthensGreece Clinical Microbiology Laboratory Medical SchoolNational and Kapodistrian University of AthensAttikon University HospitalAthensGreece Department of Internal Medicine and Pediatrics Ghent UniversityGhentBelgium

The frequency of co-infections with bacterial or fungal pathogens has constantly increased among critically ill patients with coronavirus disease 2019(COVID-19)during the *** was the most frequently reported invasive fungal *** onset of candidemia in COVID-19 patients was often delayed compared to non-COVID-19 ***,Candida invasive infections in COVID-19 patients were more often linked to invasive procedures(e.g.,invasive mechanical ventilation or renal replacement therapy)during the intensive care stay and the severity of illness rather than more“classic”risk factors present in patients without COVID-19(e.g.,underlying diseases and prior hospitalization).Moreover,apart from the increased incidence of candidemia during the pandemic,a worrying rise in fluconazole-resistant strains was reported,including a rise in the multidrug-resistant Candida *** outcomes,the development of invasive Candida co-infection had a negative impact,increasing morbidity and mortality compared to non-co-infected COVID-19 *** this narrative review,we present and critically discuss information on the diagnosis and management of invasive fungal infections caused by Candida *** critically ill COVID-19 patients.

关键词： Critical illness COVID-19 Antifungals Candidiasis Candida spp. Candida auris

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Dopaminergic modulation of synaptic plasticity in rat prefrontal neurons

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Neuroscience Bulletin 2015年第2期31卷 183-190页

作者： Satoru Otani Jing Bai Kevin blot Center for Medical Education Faculty of Health Sciences Ryotokuji University Chinese Medicine Research Laboratory Juntendo University Medical School Pathophysiology Department University of Paris 6

The prefrontal cortex （PFC） is thought to store the traces for a type of long-term memory - the memory that determines the temporal structure of behavior often termed a ＂rule＂ or ＂strategy＂. Long-term synaptic plasticity might serve as an underlying cellular mechanism for this type of memory. We therefore studied the induction of synaptic plasticity in rat PFC neurons, maintained in vitro, with special emphasis on the functionally important neuromodulator dopamine. First, the induction of long-term potentiation （LTP） was facilitated in the presence of tonic/background dopamine in the bath, and the dose-dependency of this background dopamine followed an ＂inverted-U＂ function, where too high or too low dopamine levels could not facilitate LTP. Second, the induction of long-term depression （LTD） by low-frequency stimuli appeared to be independent of background dopamine, but required endogenous, phasically-released dopamine during the stimuli. Blockade of dopamine receptors during the stimuli and exaggeration of the effect of this endogenouslyreleased dopamine by inhibition of dopamine transporter activity both blocked LTD. Thus, LTD induction also followed an inverted-U function in its dopamine-dependency. We conclude that PFC synaptic plasticity is powerfully modulated by dopamine through inverted-U-shaped dose-dependency.

关键词： prefrontal cortex synaptic plasticity long-term memory

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Solid State Structure and Lyotropic Mesomorphism of Rare-Earth Trisdode cylsulphates in the Water-Ethylene Glycol System

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Journal of Rare Earths 2003年第2期21卷 101-104页

作者： Liesbet Jongen koen Binnemans KatholiekeUniversiteitLeuven KatholiekeUniversiteitLeuven DepartmentofChemistryCelestijnenlaan200FB3001LeuvenBelgiumDepartmentofChemistryCelestijnenlaan200FB3001LeuvenBelgium

The phase behaviour of lanthanide(Ⅲ) dodecylsulphates, Ln(C 12 H 25 SO 4) 3, by thermo optical microscopy using Lawrence penetration technique was investigated. The lyotropic phase behaviour of lanthanide(Ⅲ) dodecylsulphates in ethylene glycol water in mixtures hereof, depends on the composition of the solvent. For pure ethylene glycol and mixtures of ethylene glycol and water three different mesophases are formed, i.e. a lamellar, a cubic and a hexagonal phase, whereas when water is used as solvent no cubic phase is formed. The size of the lanthanide ion has no influence on the mesomorphism of these metallomesogens, although the smaller the lanthanide ion the lower the solubility.

关键词： inorgamic chemistry lanthanides liquid crystals lyotropic mesophases metallomesogens surfactants rare earths

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Prevention of ventilator-associated pneumonia through care bundles:A systematic review and meta-analysis

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Journal of Intensive Medicine 2023年第4期3卷 352-364页

作者： Raquel Martinez-Reviejo Sofia Tejada Miia Jansson Alfonsina Ruiz-Spinelli Sergio Ramirez-Estrada Duygu Ege Tarsila Vieceli Bert Maertens Stijn blot Jordi Rello Centro de Investigación Biomédica en Red de Enfermedades Respiratorias(CIBERES) Instituto de Salud Carlos IIIMadrid 28029Spain Clinical Research Epidemiology in Pneumonia&Sepsis(CRIPS) Vall d'Hebron Institute of Research(VHIR)Barcelona 08035Spain Research Unit of Health Sciences and Technology University of OuluOulu90570Finland RMIT University Melbourne3010Australia Critical Care Department Hospital de Clínicas Dr.Manuel QuintelaMontevideo11600Uruguay Critical Care Department Clínica CorachanBarcelona08017Spain Emergency Medicine Department Adnan Menderes UniversityAydin09010Turkey Infectious Diseases Department Hospital de Clínicas de Porto AlegrePorto Alegre90035-903Brazil Department of Internal Medicine and Pediatrics Ghent UniversityGhent9000Belgium FOREVA Clinical Research CHU NimesUniversitéde Nîmes-MontpellierNîmes30012France Medicine Department Universitat Internacional de Catalunya(UIC)Barcelona08017Spain

Background Ventilator-associated pneumonia(VAP)represents a common hospital-acquired infection among mechanically ventilated *** summarized evidence concerning ventilator care bundles to prevent *** A systematic review and meta-analysis were *** controlled trials and controlled observational studies of adults undergoing mechanical ventilation(MV)for at least 48 h were considered for *** of interest were the number of VAP episodes,duration of MV,hospital and intensive care unit(ICU)length of stay,and mortality.A systematic search was conducted in the MEDLINE,the Cochrane Library,and the Web of Science between 1985 and *** are reported as odds ratio(OR)or mean difference(MD)with 95%confidence intervals(CI).The PROSPERO registration number is *** Thirty-six studies including 116,873 MV participants met the inclusion criteria.A total of 84,031 participants underwent care bundles for VAP *** most reported component of the ventilator bundle was head-of-bed elevation(n=83,146),followed by oral care(n=80,787).A reduction in the number of VAP episodes was observed among those receiving ventilator care bundles,compared with the non-care bundle group(OR=0.42,95%CI:0.33,0.54).Additionally,the implementation of care bundles decreased the duration of MV(MD=−0.59,95%CI:−1.03,−0.15)and hospital length of stay(MD=−1.24,95%CI:−2.30,−0.18)in studies where educational activities were part of the *** regarding mortality were *** The implementation of ventilator care bundles reduced the number of VAP episodes and the duration of MV in adult *** application in combination with educational activities seemed to improve clinical outcomes.

关键词： Hospital-acquired pneumonia Ventilator bundle Prevention Quality improvement intervention

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