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电缆电视 1991年第1期 26-30,8页

作者： kochan,r 张万书

Measuring End-to-End Delay in Low Energy SDN IoT Platform

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Computers, Materials & Continua 2022年第1期70卷 19-41页

作者： Mykola Beshley Natalia Kryvinska Halyna Beshley Orest kochan Leonard Barolli Department of Telecommunications Lviv Polytechnic National University79013 LvivUkraine Department of Information Systems Faculty of ManagementComenius University in Bratislava82005 BratislavaSlovakia Department of Information and Communication Engineering Faculty of Information EngineeringFukuoka Institute of Technology(FIT)3-30-1 Wajiro-HigashiHigashi-KuFukuoka 811-0295Japan

In this paper,we developed a new customizable low energy Software Defined Networking(SDN)based Internet of Things(IoT)platform that can be reconfigured according to the requirements of the target IoT ***,the platform consists of a set of low cost and energy efficient single-board computers,which are interconnected within a network with the software defined *** proposed SDN switch is deployed on raspberry Pi 3 board usingOpen vSwitch(OvS)software,while theFloodlight controller is deployed on the Orange Pi Prime *** firstly presented and implemented the method formeasuring a delay introduced by each component of the IoT infrastructure,ranging from the sensor,the core of SDN,the IoT broker,to an IoT ***,we presented the approach for estimating energy efficiency for SDN based IoT platform proportional to the *** experiments carried out on a real SDN topology based on single-board computers show that our approach not only saves up to 53.56%of energy at low traffic intensity,but also provides QoS guarantee for IoT applications.

关键词： Internet of things software defined networking openflow open vswitch raspberry-pi

Metabolism of carbohydrate in alimentary tract of reindeer in winter

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Integrative Zoology 2006年第2期1卷 67-69页

作者： Tatyana I.kochan Institute of Physiology Komi Science CenterUral Branch of Russian Academy of SciencesSyktyvkarPervomayskayaRussia

The study was conducted on six reindeers in *** was established that concentration of reducing sugars in the chyme of jejunum increases substantially(6 times in comparison with abomasum),whereas concentration cellulose,on the contrary,decreases(4.5 times).The maximal increase of monosaccharides in the small intestine testifies to formation of metabolic fund of sugars in this part of the alimentary tract due to high degree of polysaccharides hydrolysis of exogenous,as well as endogenous,microbial *** data assume that the need of the reindeer for glucose is provided for not only by gluconeogenesis as it was considered before,but also by absorption of monosaccharides from the alimentary tract.

关键词： alimentary tract blood glucose carbohydrate metabolism reindeers

Mucosal bacterial microflora and mucus layer thickness in adolescents with inflammatory bowel disease

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World Journal of Gastroenterology 2009年第42期15卷 5287-5294页

作者： Krzysztof Fyderek Magdalena Strus Kinga Kowalska-Duplaga Tomasz Gosiewski Andrzej Wedrychowicz Urszula Jedynak-Wasowicz Malgorzata Sladek Stanislaw Pieczarkowski Pawel Adamski Piotr kochan Piotr B Heczko Department of Pediatrics Gastroenterology and NutritionPolish-American Children's HospitalJagiellonian University Medical College265 Wielicka Str.30-663 CracowPoland Chair of Microbiology Jagiellonian University Medical College18 Czysta Str.31-121 CracowPoland Institute of Nature Conservation Polish Academy of Sciences33 Mickiewicza Ave.31-120 CracowPoland

AIM:To assess the mucosa-associated bacterial microflora and mucus layer in adolescents with inflammatory bowel disease(IBD) .METHODS:Sixty-one adolescents(mean age 15 years,SD ± 4.13) were included in the *** biopsies from inflamed and non-inflamed mucosa of IBD patients and from controls with functional abdominal pain were cultured under aerobic and anaerobic *** number of microbes belonging to the same group was calculated per weight of collected *** mucus thickness in frozen samples was measured under a fluorescent ***:The ratios of different bacterial groups in inflamed and non-inflamed mucosa of IBD patients and controls were specific for particular *** *** predominant in the inflamed mucosa of Crohn's disease(CD) patients(80% of all bacteria) ,and Lactobacillus *** predominant in ulcerative colitis patients(90%) .The differences were statistically significant(P = 0.01-0.001) .Lower number of bifidobacteria was observed in the whole IBD group.A relation was also found between clinical and endoscopic severity and decreased numbers of Lactobacillus and,to a lesser extent,of Streptococcus in biopsies from CD *** mucus layer in the inflamed sites was significantly thinner as compared to controls(P = 0.0033) and to non-inflamed areas in IBD patients(P = 0.031) .CONCLUSION:The significantly thinner mucosa of IBD patients showed a predominance of some aerobes specific for particular diseases,their numbers decreased in relation to higher clinical and endoscopic activity of the disease.

关键词：细菌菌群青少年粘膜厚度粘液炎症肠

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C语言程序设计

作者： (美)Stephen G. kochan

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便携式肠道超声检查对克罗恩病治疗的影响

Gastroenterology report 2021年第5期9卷 418-426,I0002页

作者： Can Gonen Ali Surmelioglu Koray kochan Serhat Ozer Ekrem Aslan Metin Tilki Department of Gastroenterology School of MedicineAcibadem Mehmet Ali Aydınlar UniversityIstanbulTurkey Department of Gastroenterology Haydarpasa Numune Training and Research HospitalIstanbulTurkey Department of General Surgery Haydarpasa Numune Training and Research HospitalIstanbulTurkey

背景:肠道超声(IUS)是评估克罗恩病的一种有效的横断面影像技术。随着技术进步,便携式超声系统的应用越来越广泛,非影像专业的临床医生使用该设备有望大大提高患者的诊治效能。本研究旨在评估胃肠科医生使用便携式超声系统进行IUS检查,... 详细信息

背景:肠道超声(IUS)是评估克罗恩病的一种有效的横断面影像技术。随着技术进步,便携式超声系统的应用越来越广泛,非影像专业的临床医生使用该设备有望大大提高患者的诊治效能。本研究旨在评估胃肠科医生使用便携式超声系统进行IUS检查,作为克罗恩病患者辅助影像学检查的诊断价值。方法:117例克罗恩病患者接受了IUS检查。记录检查前后的治疗决策。主要结局指标是评估IUS检查后治疗决策的改变。以基于患者所有相关资料评估后的多学科团队讨论所制定的治疗决策作为金标准,评估基于胃肠科医生进行IUS检查后所作出治疗决策的准确性。采用克罗恩病简单内镜评分(SES-CD)评估内镜下疾病活动度。结果:IUS检查后,47例(40.2%)患者最初的治疗决策发生了改变(P=0.001)。治疗决策的准确率由63.2%提高到90.6%(P<0.001)。IUS检查后,13例患者被评估为需要急诊外科/介入干预。肠镜(SES-CD≥3)与IUS异常发现用于治疗决策的准确率分别为94%和91%,灵敏度分别为95%和94%。结论:使用便携式超声系统进行IUS检查可显著提高临床决策的准确性。若获得进一步的数据支持,该检查模式可能会成为CD治疗决策的必需。

关键词： Crohn’s disease inflammatory bowel diseases point-of-care portable ultrasound monitoring

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创造“积极主动型”企业

董事会 2015年第11期 100-102页

作者： Thomas A.kochan

希望未来,不同的群体可以联合起来,鼓励未来的企业领导人采取"积极主动型"战略,从而创造一个更具创新性与活力的经济体商界领袖永远面临着选择竞争方式的挑战。最常见的选项有两种":积极主动型"(high-road)和"谨慎稳健型"(low-road)。采... 详细信息

希望未来,不同的群体可以联合起来,鼓励未来的企业领导人采取"积极主动型"战略,从而创造一个更具创新性与活力的经济体商界领袖永远面临着选择竞争方式的挑战。最常见的选项有两种":积极主动型"(high-road)和"谨慎稳健型"(low-road)。采取"积极主动"竞争方式的公司试图通过高效能。

关键词：主动型竞争方式商界领袖联合起来心智模型客户服务稳健型中层管理人员西南航空职能外包

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危机公关别用歪招

董事会 2015年第12期 80-81页

作者： Thomas A.kochan

危机可以毁掉一个公司的声誉,而一份靠谱的计划、一个清醒的头脑、一颗仁慈的心可以将损失降到最低从大众汽车的排放丑闻到英国首相大卫卡梅伦大学时期的丑闻,公关危机一直与头版头条的重磅消息形影相随。大到跨国公司、一国首相,小到... 详细信息

危机可以毁掉一个公司的声誉,而一份靠谱的计划、一个清醒的头脑、一颗仁慈的心可以将损失降到最低从大众汽车的排放丑闻到英国首相大卫卡梅伦大学时期的丑闻,公关危机一直与头版头条的重磅消息形影相随。大到跨国公司、一国首相,小到平民百姓、贩夫走卒,都会受到丑闻的冲击。对企业来说,从安全生产事故到产品召回等,很多事情都可能出现差错。

关键词：危机公关平民百姓安全生产事故卡梅伦英国首相产品召回大卫大学时期西恩里安

以更快的速度获取更好的产品──怎样实现整体开发方案?

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工业工程与管理 1999年第2期4卷 28-32页

作者： D.kochan 陈鸿均德国快速制造模型股份公司

对产品开发和制造作整体考虑，提出了在创造价值链中进行思考的要求。除了产品开发之外，三维ＣＡＤ建模方式的普遍使用使得生产准备和制造的水平有了较大提高。在已改进的快速原型成型技术、材料和后续过程的基础上，产品开发有加强转... 详细信息

对产品开发和制造作整体考虑，提出了在创造价值链中进行思考的要求。除了产品开发之外，三维ＣＡＤ建模方式的普遍使用使得生产准备和制造的水平有了较大提高。在已改进的快速原型成型技术、材料和后续过程的基础上，产品开发有加强转向快速制造的趋势。

关键词：产品开发生产快速制造整体开发

The intracellular signalosome of PD-L1 in cancer cells

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Signal Transduction and Targeted Therapy 2018年第1期3卷 72-80页

作者： David Escors Maria Gato-Canas Miren Zuazo Hugo Arasanz María Jesus García-Granda ruth Vera Grazyna kochan Navarrabiomed Complejo Hospitalario de NavarraIdISNAIrunlarrea 331008 PamplonaNavarraSpain rayne Institute Division of Infection and ImmunityUniversity College London5 University StreetWC1E 6JF LondonUK Oncology Department Complejo Hospitalario de NavarraIdISNAIrunlarrea 331008 PamplonaNavarraSpain

Programmed cell death-1 ligand-1(PD-L1)overexpression in cancer cells accelerates tumor ***-L1 possesses two main pro-oncogenic ***,PD-L1 is a strong immunosuppressive molecule that inactivates tumor-specific T cells by binding to the inhibitory receptor ***,PD-L1 function relies on the delivery of intrinsic intracellular signals that enhance cancer cell survival,regulate stress responses and confer resistance toward pro-apoptotic stimuli,such as ***,we review the current knowledge on intracellular signal transduction pathways regulated by PD-L1,describe its associated signalosome and discuss potential combinations of targeted therapies against the signalosome with PD-L1/PD-1 blockade therapies.

关键词： cancer targeted signal