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A Survey on Neuropsychological State, Oxidative Stress and Hematological Parameters in Coke Oven Workers

Health 2014年第11期6卷 1230-1236页

作者： Behnaz Salehiforouz Ali Akbar Malekirad Mohammad Abdollahi kobra rahzani Sara Mostafalou Biology Department Payame Noor University Tehran Iran Faculty of Nursing and Midwifery Arak University of Medical Science Arak Iran Faculty of Pharmacy Pharmaceutical Sciences Research Center Tehran University of Medical Science Tehran Iran

Coke oven factories are one of the main emitting sources of polycyclic aromatic hydrocarbons (PAH)s which have been identified as highly carcinogenic chemicals by IARC. Induction of oxidative stress and following disrupting pathways has been repeatedly reported in subjects exposed to PAHs. This study was performed to monitor the oxidative stress markers, hematological and biochemical parameters, and psychological states in coke oven workers. 100 male subjects were included in this comparative cross-sectional study. At first 50 male workers who were 22 - 63 and worked in the steel factory located in South-East of Iran were contained. Control subjects were chosen from Esfahan, in the factory’s neighborhood, consisting of 50 office workers without any background of occupational exposure to metals. The blood levels of hematological factors and oxidative stress were measured. In order to compare data, two-sample t test was applied. In order to measure the correlation between variables, Pearson correlation coefficient was applied. The mean level of total antioxidant capacity, hemoglobin (Hb), mean corpuscular hemoglobin concentration (MCHC), and hematocrit were significantly lower in the workers in association with increased lipid per oxidation (LPO). A positive correlation existed between work history, hyper thyroids (r2 = 0.288, p = 0.01), and endocrine disorders (r2 = 0.309, p = 0.028). Occupational exposure of coke oven workers to PAHs can induce oxidative stress and consequent metabolic and neuropsychological disorders. When workers take daily shower and use protective tools, absorption of toxic elements would decrease so that reaching them to the body can be suitably limited.

关键词： Coke Oven Workers Neuropsychological State Oxidative Stress Hematological Parameters

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The Effect of Oral <i>Melissa officinalis</i>on Serum Oxidative Stress and Second Degree Burn Wounds Healing

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Health 2014年第18期6卷 2517-2524页

作者： Masumeh Abbasdust Arbastan kobra rahzani Davood Hekmatpou Shaban Ali Alizadeh Mohammad Rafiei Ali Akbar Malekirad Nursing Department Arak University of Medical Sciences Arak Iran Faculty of Nursing and Midwifery Arak University of Medical Sciences Arak Iran Faculty of Medicine Arak University of Medical Sciences Arak Iran Department of Social Medicine Arak University of Medical Sciences Arak Iran Department of Biology Payame Noor University Tehran Iran

For this aim, this study conducted in order to assess the effect of lemon balm as an antioxidant on second degree wound healing and oxidative stress serum of burning patients. To meet the aim, 60 patients with 15 to 50 burn percent with the age range of 18 to 50 were invited after considering to inclusion criteria by the researchers. First they have been put by non-probable method and then random method in two groups of experiment (30 people) and control (30 people). After that, experiment group in addition to ordinary treatment has been used Melissa officinalis (lemon balm) plant two times a day for two weeks (1.5 g in 100 cc). Oxidative stress parameters included serum total antioxidant and the rate of malondialdehyde (MDA) that is one of total production of lipid peroxidation have been measured in patients’ blood sample in first and last parts of the study. The wound position has been studied by using standard wound BATES-JENSEN assessment tool in first, seventh and fifteenth days of study. In order to analyze data, independent sample t-test, paired sample t-test and repeated measurement variance have been used. These results indicated that the state of wound healing in experimental group was better than that in control group. Results indicated that mean of serum total antioxidant had been increased in both groups. The index of lipid peroxidation at the end of period has been increased in experiment group than control group, whether this index is significantly decreased at the end of 15 days in experimental group. According to the results of this study, the effect of Melissa officinalis (lemon balm) plant was effective in increasing lipid peroxideative in better states of second degree burn wound healing.

关键词： Burn Wounds Healing Lemon Balm Oxidative Stress

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