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Obesity and its influence on liver dysfunction,morbidity and mortality after liver resection

Hepatobiliary Surgery and Nutrition 2023年第5期12卷 704-714,I0018页

作者： Stephanie Kampf Michael Sponder Fabian Fitschek Daniel Laxar Martin Bodingbauer Carina Binder Stefan Stremitzer klaus kaczirek Christoph Schwarz Division of Visceral Surgery Department of General SurgeryMedical University of ViennaViennaAustria Division of Cardiology Department of Internal Medicine IIMedical University of ViennaViennaAustria Clinical Institute of Pathology Medical University of ViennaViennaAustria

Background:Obesity and associated steatosis is an increasing health problem *** influence on post-hepatectomy liver failure(PHLF)and after liver resection(LR)is still ***:Patients who underwent LR were investigated and divided into three groups[normal weight:body mass index(BMI)18.5-24.9 kg/m2,overweight:BMI 25.0-29.9 kg/m2,obese:BMI≥30 kg/m2]in this retrospective *** aim of this study was to assess the influence of BMI and nonalcoholic steatohepatitis(NASH)on PHLF and ***:Of 888 included patients,361(40.7%)had normal weight,360(40.5%)were overweight,167(18.8%)were *** age was 62.5 years(IQR,54-69 years).The primary indication for LR was colorectal liver metastases(CLM)(n=366,41.2%).NASH was present in 58(16.1%)of normal weight,84(23.3%)of overweight and 69(41.3%)of obese patients(P<0.001).PHLF occurred in 16.3%in normal weight,15.3%in overweight and 11.4%in obese patients(P=0.32).NASH was not associated with *** was no association between patients’weight and the occurrence of postoperative complications(P=0.45).At multivariable analysis,solely major LR[odds ratio(OR):2.7,95%confidence interval(CI):1.83-4.04;P<0.001]remained a significant predictor for ***:Postoperative complications and PHLF are comparable in normal weight,overweight and obese patients and LRs using modern techniques can be safely performed in these patients.

关键词： Obesity liver resection(LR) post-hepatectomy liver failure(PHLF) morbidity

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