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journal of Cancer Therapy 2010年第4期1卷 229-231页

作者： Andreas Bannowsky Hermann Ahlen klaus-Peter jünemann 不详

Moderate activity of systemic chemotherapy for advanced urothelial cancer has been reported for more than 30 years. Only with the advent of potent combination therapy clinically significant response rates as well as prolonged survival were documented. The therapeutic effect of a “second-line” polychemotherapy in metastatic upper tract urothelial cancer is largely unknown caused by the small number of cases and poor prognosis. We report an interesting case of a 59-year-old man suffering from urothelial cancer of the renal pelvis with pulmonary, lymphogenic and bone metastases who showed an unexpected response to a “second-line”chemotherapy after only 2 treatment cycles of Gemcitabine/Paclitaxel (partial remission) after 24 treatment cycles Gemcitabine / Cisplatin in “stable disease” and progression between the treatment intervals. We performed maintenance “second-line” therapy for 24 cycles and the patient showed a remarkable persisting response 54 months after operation.

关键词： Chemotherapy Renal Pelvis Urothelial Cancer Paclitaxel

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杂砂岩碱集料反应特征

硅酸盐学报 2008年第10期36卷 1385-1389页

作者：莫祥银景颖杰 HUNGER klaus-jurgen 康彩荣沈健南京师范大学分析测试中心＆江苏省生物功能材料重点实验室南京210097 Faculty for Architecture Civil Engineeringnd Urban Planning Brandenburg University of Technology Cottbus Cottbus 03046 Germany 南京工业大学材料科学与工程学院南京210009

杂砂岩集料所含的石英组分是引起碱集料反应的主要活性来源,研究该集料中的石英溶出及其在碱溶液中的行为特征,结果发现:石英颗粒尺寸和相应的硅溶出速度之间存在着一定的相关性,即:石英颗粒尺寸越小,其比表面积越大,同等条件下相应的... 详细信息

杂砂岩集料所含的石英组分是引起碱集料反应的主要活性来源,研究该集料中的石英溶出及其在碱溶液中的行为特征,结果发现:石英颗粒尺寸和相应的硅溶出速度之间存在着一定的相关性,即:石英颗粒尺寸越小,其比表面积越大,同等条件下相应的硅溶出速度越大;石英颗粒的结构特征变化规律与杂砂岩试样本身的碱活性大小之间不存在相关性。集料中的铝主要来源于γ-Al2O3纳米相、黑云母和白云母,其对溶液中硅溶出的影响机理不同。集料中的铝溶出生成铝硅酸盐从而引起溶液中溶出硅含量的降低,砂浆或混凝土碱集料反应膨胀率的大小与溶液中所谓的"自由硅"含量有关,即"自由硅"含量越大,同等条件下的碱集料反应膨胀越大。这些相关性对于实际工程应用非常重要,由此可望建立评价杂砂岩碱活性敏感性的直接测试方法。研究还发现通过添加高铝粉可抑制碱集料反应产生的膨胀。

关键词：碱集料反应砂岩铝溶出过程化学测试方法

互补音系学——对一个对话声学资料库进行标记的理论框架

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当代语言学 1995年第1期 34-36页

作者： klaus j.Kohler 曹剑芬中国社会科学院语言研究所

1.科学上的互补性概念 1927年左右,Niels Bohr将互补性的见解引入了物理学。他是出于这样一种考虑,即一些古典的物理学概念已不足以胜任对核子物理现象的描写。例如,由于不同的实验设计,光在一种情况下以“波场”的面目出现,而在另一种... 详细信息

1.科学上的互补性概念 1927年左右,Niels Bohr将互补性的见解引入了物理学。他是出于这样一种考虑,即一些古典的物理学概念已不足以胜任对核子物理现象的描写。例如,由于不同的实验设计,光在一种情况下以“波场”的面目出现,而在另一种情况下则作为一种“粒子云”出现。按照古典物理学的概念,这两个方面是互相排斥的。

关键词：音系学资料库行标记物理学声学超音段音段音位国际音标标音典型形式

Adjuvant effects of different TLR agonists on the induction of allergen-specific Th2 responses

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Open journal of Immunology 2012年第1期2卷 17-24页

作者： Matthias j. Duechs james E. Brunt Florian Gantner klaus j. Erb Respiratory Diseases Research Boehringer Ingelheim Pharma GmbH & Co. KG Biberach an der Riss Germany

Currently different Toll-like receptor (TLR) agonists are tested in humans for their ability to enhance the efficacy of specific immunotherapy (SIT). Recent clinical data suggest that this may be achieved by increasing allergen-specific Th1 responses. However, it is not clear which TLR agonist is best suited to be used in combination with SIT. We tested the ability of five TLR agonists, LTA, poly(I:C), LPS, R848, and CpG-ODN, activating TLR2, 3, 4, 7, and 9, to induce allergen-specific Th1 and suppress allergen-specific Th2 responses in a preclinical setting. Mice were immunized by intraperitoneal injection of ovalbumin (OVA)/Al(OH)3 together with different doses (0.0025, 0.025, 0.25, and 2.5 mg/kg) of agonists followed by two OVA aerosol challenges. The results of these experiments showed, that the suppression of allergen-specific Th2 responses and the induction of Th1 responses dependedon the dose and the agonists used. All TLR agonists increased allergen-specific IgG2a, and with the exception of poly(I:C), reduced allergen-specific IgE levels in the serum. Allergic cutaneous anaphylaxis was also suppressed in mice when LPS or CpG was given together with OVA/alum. The strongest Th1 responses were induced by CpG and poly(I:C), characterized by the presence of IFN-g in the BAL and the highest OVA-specific IgG2a levels in the serum. This study suggests that the TLR9 agonist CpG-ODN and TLR4 agonist LPS have the strongest suppressive effects on the development of aller-gen-specific Th2 responses in mice and CpG-ODN induces the strongest allergen-specific Th1 responses. Therefore these two TLR agonists may be good candidates to combine with allergen in novel SIT formulations in humans.

关键词： Asthma TLR-Agonists Innate-Inflammation Inhibition

Fluorescence Intensity Decay Shape Analysis Microscopy （FIDSAM） for Quantitative and Sensitive Live-Cell Imaging： A Novel Technique for Fluorescence Microscopy of Endogenously Expressed Fusion-Proteins

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Molecular Plant 2010年第3期3卷 555-562页

作者： Frank Schleifenbaum Kirstin Elgass Marcus Sackrow Katharina Caesar Kenneth Berendzen Alfred j. Meixner klaus Hatter Center for Plant Molecular Biology Department of Plant Physiology University of Tubingen Auf der Morgenstelle 1 72076 Tubingen Germany Institute of Physical and Theoretical Chemistry University of Tubingen Auf der Morgenstelle 8 72076 Tubingen Germany

Fluorescent studies of living plant cells such as confocal microscopy and fluorescence lifetime imaging often suffer from a strong autofluorescent background contribution that significantly reduces the dynamic image contrast and the quantitative access to sub-cellular processes at high spatial resolution. Here, we present a novel technique--fluorescence intensity decay shape analysis microscopy （FIDSAM） to enhance the dynamic contrast of a fluorescence image of at least one order of magnitude. The method is based on the analysis of the shape of the fluorescence intensity decay （fluorescence lifetime curve） and benefits from the fact that the decay patterns of typical fluorescence label dyes strongly differ from emission decay curves of autofluorescent sample areas. Using FIDSAM, we investigated Arabidopsis thaliana hypocotyl cells in their tissue environment, which accumulate an eGFP fusion of the plasma membrane marker protein LTI6b （LTI6b-eGFP） to low level. Whereas in conventional confocal fluorescence images, the membranes of neighboring cells can hardly be optically resolved due to the strong autofluorescence of the cell wall, FIDSAM allows for imaging of single, isolated membranes at high spatial resolution. Thus, FIDSAM will enable the sub-cellular analysis of even low-expressed fluorophoretagged proteins in living plant cells. Furthermore, the combination of FIDSAM with fluorescence lifetime imaging provides the basis to study the local physico-chemical environment of fluorophore-tagged biomolecules in living plant cells.

关键词： Cell structure cell walls membrane proteins high-resolution fluorescence microscopy.

Priority areas at the frontiers of ecology and energy

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Ecosystem Health and Sustainability 2018年第10期4卷 2-5页

作者： S.K.Chou Robert Costanza Philip Earis klaus Hubacek B.Larry Li Yonglong Lu Roland Span Hao Wang jianping Wu Yegang Wu jerry j.Yan Department of Mechanical Engineering National University of SingaporeSingaporeSingapore Crawford School of Public Policy The Australian National UniversityCanberraAustralia joule Publication Department CellPressCambridgeMAUSA Geography Department University of MarylandCollege ParkMDUSA Department of Botany and Plant Sciences University of California RiversideRiversideCAUSA State Key Laboratory of Urban and Regional Ecology Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijingChina Thermodynamics Faculty of Mechanical EngineeringRuhr University BochumBochumGermany joule Publication Department China Institute of Hydraulic and Hydropower ResearchBeijingChina School of Civil Engineering Tsinghua UniversityBeijingChina joule Publication Department Beijing Bold Institute of Eco-City Planning&DesignBeijingChina joule Publication Department Royal Institute of Technology(KTH)StockholmSweden

The complexity of economic development and humanitarian crisesmeans that energy science and technology should be involved in actions that address almost everymajor challenges of ecosystem health and *** is the engine of the world economy and the key to ecosystems’functioning,which also has a great impact on global *** energy crisis,environmental pollution,overuse of natural resources,water supply shortages,global climate disruption,and deteriorating ecosystems are major challenges to address in order to achieve the United Nations Sustainable Development Goals(SDGs).In light of the frontiers in energy sciences and disruptive innovation in eco-tech,we recognize the need to review and establish working mechanisms that identify and examine issues that are critical to future sustainable development,to offer advice to decision-makers in different social sectors(public and private),to secure a shared future for mankind,and to achieve shared prosperity and common interests through international communications and collaborations.

关键词： Energy ecology sustainability United Nations Goals

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锂离子在混凝土碱集料反应过程中的作用

东南大学学报（自然科学版） 2009年第1期39卷 127-130页

作者：俞琛捷莫祥银邓敏唐明述沈健 Benoit Fournier klaus-jurgen Hunger 南京师范大学分析测试中心南京210097 南京工业大学材料科学与工程学院南京210009 拉瓦尔大学地质系加拿大魁北克城G1K 7P4 勃兰登堡工业大学建筑和土木工程系德国科特布斯03046

在采用X射线衍射分析、化学组成分析和偏光显微镜分析对硅质碳酸盐集料的矿物学特征充分研究的基础上,研究了锂离子迁移渗透在混凝土碱集料反应过程中的行为特征.混凝土棱柱法(CSA A23.2-14A或ASTM C1293)所测的膨胀结果表明:掺加[Li]/[... 详细信息

在采用X射线衍射分析、化学组成分析和偏光显微镜分析对硅质碳酸盐集料的矿物学特征充分研究的基础上,研究了锂离子迁移渗透在混凝土碱集料反应过程中的行为特征.混凝土棱柱法(CSA A23.2-14A或ASTM C1293)所测的膨胀结果表明:掺加[Li]/[Na+K]摩尔比1.11的LiNO3能有效抑制混凝土碱集料反应膨胀;锂玻璃不仅不能抑制碱集料反应膨胀甚至会在一定程度上促进膨胀;与单一掺加混合材(粉煤灰或矿渣)相比,LiNO3与混合材的复合在一定程度上增强了相应的膨胀抑制效果;在混凝土碱集料反应过程中,存在Li+与Na+,K+之间的竞争.相对而言,Li+具有一定的优势.这与锂盐能表现出一定的混凝土碱集料反应膨胀抑制效果相一致.此外,强度对比研究结果表明,掺加锂盐一定程度上降低了混凝土的强度.

关键词：碱集料反应碱硅酸反应碱碳酸盐反应硅质碳酸盐锂盐混合材

Identification of habitat controls on northern red-legged frog populations: implications for habitat conservation on an urbanizing landscape in the Pacific Northwest

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Ecological Processes 2017年第1期6卷 463-475页

作者： Lauren A.Grand Marc P.Hayes Kristiina A.Vogt Daniel j.Vogt Paul R.Yarnold klaus O.Richter Christopher D.Anderson Elissa C.Ostergaard jo O.Wilhelm College of Forestry Oregon State University996 Jefferson StEugeneOR 97402USA. Science Division Habitat ProgramWashington Department of Fish and Wildlife(WDFW)600 Capitol Way NorthOlympiaWA 98501-1091USA. School of Environmental and Forest Sciences(SEFS) University of WashingtonBox 352100SeattleWA 98195-2100USA. Optimal Data Analysis LLC6348 N.Milwaukee Ave.#163ChicagoIL 60646USA. 11040104th Ave NE KirklandWA 98033-4423USA. District 12 King CountyWashington Department of Fish and Wildlife(WDFW)Region 416018 Mill Creek BlvdMill CreekWA 98012USA. King County Department of Natural Resources and Parks(DNRP) Water and Land Resources Division(WLRD)King Street Center201 S Jackson St.Suite 600SeattleWA 98104USA.

Introduction: In the Pacific Northwest of North America, research addressing lentic-breeding amphibian populationvulnerability has emphasized aquatic habitats, frequently neglecting terrestrial habitats. Consequently, wetlandprotection and restoration often fails to preserve or restore adjacent uplands required by lentic-breeding *** to the juxtaposition and connectivity of uplands to wetlands could locally extirpate lentic-breedingamphibians. The objective of this research is to identify the relative importance of juxtaposed terrestrial and aquatichabitats in a lentic-breeding amphibian, the northern red-legged frog (Rana aurora), by evaluating the relationshipbetween its occurrence and abundance with its aquatic and terrestrial habitats. To accomplish this, egg mass countswere used to quantify R. aurora populations in 30 stillwater habitats across an urbanization gradient. Using aGeographic Information System, seven descriptors of aquatic and surrounding terrestrial habitats were measured toevaluate their relationships to R. aurora occurrence and ***: Rana aurora occurrence and breeding abundance both reflect the forested area around wetland breedingsites and forest connectivity to those sites. Rana aurora breeding abundance also strongly reflects the percent offorested perimeter around wetland breeding sites. The forest habitat most important for R. aurora breeding abundanceseems to be > 200 m from the breeding wetlands. The American bullfrog presence and the two aquatic parametersmeasured, wetland area and vegetated area, were unrelated to R. aurora occurrence and breeding ***: Area and connectivity of juxtaposed forested terrestrial habitat may represent a basic control on R. aurorapresence and population size. Urban development policies should consider preservation and restoration of uplandforest habitats beyond current fixed-width buffers and wetland habitat area at landscape scales.

关键词： Northern red-legged frog Amphibian habitat Rana aurora Land use Landscape planning Urban landscapes Amphibian population

Association of the GNAS1 T393C polymorphism with tumor stage and survival in gastric cancer

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World journal of Gastroenterology 2009年第48期15卷 6061-6067页

作者： Hakan Alakus Stefan P Mnig Ute Warnecke-Eberz Gül Alakus Günther Winde Uta Drebber klaus j Schmitz Kurt W Schmid Kathrin Riemann Winfried Siffert Elfriede Bollschweiler Arnulf H Hlscher Ralf Metzger Department of General Visceral and Cancer SurgeryCenter for Integrated OncologyUniversity of Cologne Department of Gastrointestinal Surgery Klinikum Herford Institute of Pathology University of Cologne Institute of Pathology and Neuropathology University Hospital of EssenUniversity of Duisburg-Essen Institute of Pharmaco-genetics University Hospital of EssenUniversity of Duisburg-Essen

AIM： To analyze the impact of the GNAS1 T393C polymorphism on prognosis and histopathology of gastric cancer. METHODS： Genomic DNA was extracted from paraffinembedded tissues of 122 patients with primary gastric carcinoma and from the blood of 820 healthy white individuals. Allelic discrimination was performed by quantitative real-time polymerase chain reaction. Genotyping was correlated with histopathologic parameters and with overall survival according to the Kaplan-Meier approach and with multivariate analysis by multiple stepwise regression. RESULTS： Thirty-nine （32%） patients displayed a CC genotype, 57 （46.7%） a CT genotype and 26 （21.3%） a TT genotype. The frequency of the C allele （fC） in the patient group was 0.55, which was not significantly different from that of healthy blood donors. The distribution was compatible with the Hardy-Weinberg equilibrium. Analysis of clinicopathological parameters did not show any significant correlation of the T393C genotype with gender （P = 0.50）, differentiation （P = 0.29）, pT-category （P = 0.19）, pN-category （P = 0.30）, pM-category （P = 0.25）, R-category （P = 0.95）, the classifications according to WHO （P = 0.34）, Lauren （P = 0.16）, Goseki （P = 1.00） and Ming （P =0.74）. Dichotomization between C＋（CC＋CT） and C-genotypes （FI）, however, revealed significantly more advanced tumor stages （P = 0.023） and lower survival rates （P = 0.043） for C allele carriers. CONCLUSION： The present study provides strong evidence to suggest that the GNAS1 T393C allele carrier status influences tumor progression and survival in gastric cancer with higher tumor stages and a worse outcome for C allele carriers.

关键词： Gastric cancer G Protein Polymorphism Prognosis Tumor stage

Different types of spin currents in the comprehensive materials database of nonmagnetic spin Hall effect

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npj Computational Materials 2021年第1期7卷 1522-1528页

作者： Yang Zhang Qiunan Xu klaus Koepernik Roman Rezaev Oleg janson jakub Železný Tomáš jungwirth Claudia Felser jeroen van den Brink Yan Sun Max Planck Institute for Chemical Physics of Solids 01187 DresdenGermany Leibniz Institute for Solid State and Materials Research 01069 DresdenGermany Department of Physics Massachusetts Institute of TechnologyCambridgeMA 02139USA Institute of Physics Czech Academy of SciencesCukrovarnicka 1016200 Praha 6Czech Republic School of Physics and Astronomy University of NottinghamNG72RD NottinghamUnited Kingdom Center for Nanoscale Systems Faculty of Arts and SciencesHarvard University11 Oxford StreetLISE 308CambridgeMA 02138USA Institut fur Theoretische Physik and Wurzburg-Dresden Cluster of Excellence ct.qmat Dresden University of Technology01062 DresdenGermany

Spin Hall effect(SHE)has its special position in *** gain new insight into SHE and to identify materials with substantial spin Hall conductivity(SHC),we performed high-precision high-throughput ab initio calculations of the intrinsic SHC for over 20,000 nonmagnetic *** calculations revealed a strong relationship between the magnitude of the SHC and the crystalline symmetry,where a large SHC is typically associated with mirror symmetry-protected nodal line band *** database includes 11 materials with an SHC comparable to or even larger than that of *** with different types of spin currents were additionally ***,we found that different types of spin current can be obtained by rotating applied electrical *** improves our understanding and is expected to facilitate the design of new types of spin-orbitronic devices.

关键词： symmetry magnetic effect