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High Power Laser Science and Engineering 2018年第4期6卷 133-142页

作者： Paul Mason Saumyabrata Banerjee jodie Smith Thomas Butcher jonathan Phillips Hauke Hoppner Dominik Moller klaus Ertel Mariastefania De Vido Ian Hollingham ANDrew Norton Stephanie Tomlinson Tinesimba Zata jorge Suarez Merchan Chris Hooker Mike Tyldesley Toma Toncian Cristina HernANDez-Gomez Chris Edwards john Collier Central Laser Facility STFC Rutherford Appleton LaboratoryDidcotOX11 0QXUK Institute for Radiation Physics Helmholtz-Zentrum Dresden-Rossendorf e.V.D-01328 DresdenGermany

In this paper we review the design and development of a 100 j, 10 Hz nanosecond pulsed laser, codenamed DiPOLE100 X,being built at the Central Laser Facility(CLF). This 1 kW average power diode-pumped solid-state laser(DPSSL) is based on a master oscillator power amplifier(MOPA) design, which includes two cryogenic gas cooled amplifier stages based on DiPOLE multi-slab ceramic Yb:YAG amplifier technology developed at the CLF. The laser will produce pulses between 2 and 15 ns in duration with precise, arbitrarily selectable shapes, at pulse repetition rates up to 10 Hz, allowing real-time shape optimization for compression experiments. Once completed, the laser will be delivered to the European X-ray Free Electron Laser(XFEL) facility in Germany as a UK-funded contribution in kind, where it will be used to study extreme states of matter at the High Energy Density(HED) instrument.

关键词： cryogenic lasers diode-pumped solid-state laser high energy lasers laser amplifiers Yb:YAG

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爵士钢琴演奏法演奏·和弦·伴奏

Expression and regulation of aldehyde dehydrogenases in prostate cancer

1998年

作者：（德）克劳斯·依格纳切克（klaus Ignatzek）俞人豪译

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journal of Cancer Metastasis and Treatment 2018年第1期4卷 515-531页

作者： Ali I.M.Ibrahim Maria Sadiq Fiona M.Frame Norman j.Maitland klaus Pors Institute of Cancer Therapeutics School of Pharmacy and Medical SciencesFaculty of Life SciencesUniversity of BradfordWest Yorkshire BD71DPUK Department of Pharmacy Al-Zaytoonah University of JordanAmman 11733Jordan Cancer Research Unit Department of BiologyUniversity of YorkHeslingtonNorth Yorkshire YO105DDUK

The functional role of aldehyde dehydrogenases(ALDHs)in prostate cancer remains an area of some *** studies have used high ALDH functional activity to isolate putative cancer stem cells with tumour-initiating and propagating properties,while evidence is also emerging about the involvement of specific isoforms in migration,invasiveness and *** of specific ALDH isoforms,which contribute to both drug resistance and aggressiveness of the disease remains a challenge within the complex heterogeneity of prostate *** purpose of this perspective is to dissect functional roles for ALDH in the tumour microenvironment and to evaluate the potential of the ALDH gene family as biomarkers and/or targets for therapeutic intervention.

关键词： Aldehyde dehydrogenase retinoic acid prostate cancer castration-resistant prostate cancer cancer stem cells multidrug resistance

Nature：死亡的肿瘤细胞释放出胞内钾离子来阻断免疫系统

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现代生物医学进展 2016年第31期16卷 I0002-I0002页

作者： Robert Eil, Suman K. Vodnala, David Clever, Christopher A. Klebanoff, Madhusudhanan Sukumar, jenny H. Pan, Douglas C. Palmer, Alena Gros, Tori N. Yamamoto, Shashank j. Patel, Geoffrey C. Guittard, Zhiya Yu, David S. Schrump, W. Marston Linehan, Nicholas P. Restifo Christopher A. Klebanoff Valentina Carbonaro, klaus Okkenhaug, Rahul Roychoudhuri National Cancer Institute National Institutes of Health (NIH) Bethesda Maryland 20892 USA Center for Cell Engineering and Department of Medicine Memorial Sloan Kettering Cancer Center New York New York 10065 USA Laboratory of Lymphocyte Signalling and Development The Babraham Institute Cambridge CB22 3AT UK

在一项新的研究中。来自美国国家癌症研究所和英国巴布拉汉研究所的研究人员发现当肿瘤组织死亡时从它当中泄露出来的一种无机离子起着阻止抗肿瘤免疫细胞发挥功能的作用。这一发现为开发调动免疫系统抵抗癌症的疗法提供一种新的方法。... 详细信息

在一项新的研究中。来自美国国家癌症研究所和英国巴布拉汉研究所的研究人员发现当肿瘤组织死亡时从它当中泄露出来的一种无机离子起着阻止抗肿瘤免疫细胞发挥功能的作用。这一发现为开发调动免疫系统抵抗癌症的疗法提供一种新的方法。相关研究结果在线发表在Nature期刊上。

关键词：免疫系统肿瘤细胞死亡钾离子免疫细胞无机离子肿瘤组织研究人员

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证券交易法:概念、历史与挑战

证券法苑 2019年第3期 1424-1446页

作者：安德烈斯·弗莱克纳克劳斯·霍普特林蔚然(译) 曾斌(译/校) 陈彬(校) 德国(汉堡)马克斯普朗克国际私法与比较法研究所深圳证券交易所合规检查部深圳证券交易所法律部深圳证券交易所综合研究所

由于证券交易法深受经济、社会和政治各方面因素的影响,因此对其自身及其历史的研究成为了跨学科性的挑战:研究者必须将法学学者、法律史学者以及其他社会科学——诸如经济社会史、政治经济学和现代经济学——的研究成果结合起来。或许... 详细信息

由于证券交易法深受经济、社会和政治各方面因素的影响,因此对其自身及其历史的研究成为了跨学科性的挑战:研究者必须将法学学者、法律史学者以及其他社会科学——诸如经济社会史、政治经济学和现代经济学——的研究成果结合起来。或许研究证券交易法需要的广泛的知识和复杂的跨学科分析方法,能够解释为什么与其本身的经济、社会、政治以及法律意义相比,学术研究对于证券交易法、资本市场或者证券法基本原理的重视程度还远远不够。

关键词：交易所商法典州政府另类交易系统投资者监管者经纪商发行人交易商招股说明书

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QTL analysis for ascorbic acid content in strawberry fruit reveals a complex genetic architecture and association with GDP-L-galactose phosphorylase

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Horticulture Research 2023年第3期10卷 136-150页

作者： Pilar Muñoz Cristina Castillejo joséAntonio Gómez Luis Miranda Silke Lesemann klaus Olbricht Aurélie Petit Philippe Chartier Annika Haugeneder johanna Trinkl Luca Mazzoni Agnieszka Masny Edward Zurawicz Freya Maria Rosemarie Ziegler Björn Usadel Wilfried Schwab Béatrice Denoyes Bruno Mezzetti Sonia Osorio joséFSánchez-Sevilla Iraida Amaya Centro IFAPA de Málaga Instituto Andaluz de Investigación y Formación Agraria y Pesquera(IFAPA)29140MálagaSpain PhD program in Advanced Biotechnology Universidad de Málaga29071MálagaSpain Finca el Cebollar Centro IFAPA las Torres04745HuelvaSpain Hansabred GmbH&Co.KG 01108DresdenGermany INVENIO 33800BordeauxFrance Biotechnology of Natural Products Technische Universität München85354FreisingGermany Dipartimento di Scienze Agrarie Alimentari e AmbientaliUniversitàPolitecnica delle Marche60131AnconaItaly Department of Horticultural Crop Breeding the National Institute of Horticultural ResearchKonstytucji 3 Maja 1/396-100SkierniewicePoland Institute of Bio-and Geosciences Bioinformatics(IBG-4)Forschungszentrum Jülich GmbH52428JülichGermany Univ.Bordeaux INRAEBiologie du Fruit et PathologieUMR 1332F-33140France Departamento de Biología Molecular y Bioquímica Instituto de Hortofruticultura Subtropical y Mediterránea"La Mayora"Universidad de Málaga-Consejo Superior de Investigaciones CientíficasCampus de Teatinos29071 MálagaSpain Unidad Asociada de I+D+i IFAPA-CSIC Biotecnología y Mejora en Fresa 29010MálagaSpain.

Strawberry(Fragaria×ananassa)fruits are an excellent source of L-ascorbic acid(AsA),a powerful antioxidant for plants and *** the genetic components underlying AsA accumulation is crucial for enhancing strawberry nutritional ***,we unravel the genetic architecture of AsA accumulation using an F1 population derived from parental lines‘Candonga’and‘Senga Sengana’,adapted to distinct Southern and Northern European *** account for environmental effects,the F1 and parental lines were grown and phenotyped in five locations across Europe(France,Germany,Italy,Poland and Spain).Fruit AsA content displayed normal distribution typical of quantitative traits and ranged five-fold,with significant differences among genotypes and *** content in each country and the average in all of them was used in combination with 6,974 markers for quantitative trait locus(QTL)*** stable QTLs for AsA content were detected in linkage group(LG)3A,LG 5A,LG 5B,LG 6B and LG *** genes were identified within stable QTL intervals and expression analysis in lines with contrasting AsA content suggested that GDP-L-Galactose Phosphorylase FaGGP(3A),and the chloroplast-located AsA transporter gene FaPHT4;4(7C)might be the underlying genetic factors for QTLs on LG 3A and 7C,*** show that recessive alleles of FaGGP(3A)inherited from both parental lines increase fruit AsA ***,expression of FaGGP(3A)was two-fold higher in lines with high *** here identified represent a useful resource for efficient selection of new strawberry cultivars with increased AsA content.

关键词： straw cultivar content

No association between Parkinson disease and autoantibodies against NMDA-type glutamate receptors

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Translational Neurodegeneration 2019年第1期8卷 127-133页

作者： Franziska Hopfner Stefanie HMüller Dagmar Steppat joanna Miller Nele Schmidt klaus-Peter Wandinger Frank Leypoldt Daniela Berg Andre Franke Wolfgang Lieb Lukas Tittmann Monika Balzer-Geldsetzer Simon Baudrexel Richard Dodel Ruediger Hilker-Roggendorf Elke Kalbe jan Kassubek Thomas Klockgether Inga Liepelt-Scarfone Brit Mollenhauer Petra Neuser Kathrin Reetz Oliver Riedel Claudia Schulte jörg BSchulz Annika Spottke Alexander Storch Claudia Trenkwalder Hans-Ulrich Wittchen Karsten Witt Ullrich Wüllner Günther Deuschl Gregor Kuhlenbäumer Department of Neurology University Hospital Schleswig HolsteinArnold-Heller Str.324105 KielGermany Center of Blood Transfusion University Hospital Schleswig HolsteinKiel&LübeckGermany Department of Clinical Chemistry University Hospital Schleswig-HolsteinKielGermany Institute of Clinical Molecular Biology University Hospital Schleswig-HolsteinKielGermany Institute of Epidemiology University Hospital Schleswig-HolsteinKielGermany Chair of Geriatric Medicine University Hospital EssenEssenGermany Department of Neurology Philipps-University MarburgMarburgGermany Department of Neurology Goethe UniversityFrankfurt/MainGermany Brain Imaging Center Goethe UniversityFrankfurt/MainGermany Department of Medical Psychology|Neuropsychology and Gender Studies&Center for Neuropsychological Diagnostics and Intervention(CeNDI) University Hospital CologneCologneGermany Psychological Gerontology Institute of GerontologyUniversity of VechtaVechtaGermany Department of Neurology University of UlmUlmGermany Department of Neurology University of Bonnand German Center for Neurodegenerative Diseases(DZNE)BonnGermany Center for Neurology Hertie Institute for Clinical Brain ResearchDepartment of Neurodegenerative DiseasesUniversity of TübingenTübingenGermany DZNE German Center for Neurodegenerative DiseasesTübingenGermany Paracelsus-Elena-Klinik KasselGermany Institute of Neuropathology and Department of Neurosurgery University Medical Center GöttingenGöttingenGermany Coordinating Centre for Clinical Trials Philipps-UniversityMarburgGermany Department of Neurology RWTH Aachen UniversityAachenGermany jARA-BRAIN Institute of Molecular Neuroscience and Neuroimaging Forschungszentrum Jülich GmbH and RWTH Aachen UniversityAachenGermany Leibniz Institute for Prevention Research and Epidemiology-BIPS Achterstrasse 3028359 BremenGermany Department of Neurology Technische Universität Dresden01307 DresdenGermany German Center for Neurodegenerative Diseases(DZNE) Research Site Rostock18147 RostockGerma

Background:IgG-class autoantibodies to N-Methyl-D-Aspartate(NMDA)-type glutamate receptors define a novel entity of autoimmune *** examining the prevalence of NMDA IgA/IgM antibodies in patients with Parkinson disease with/without dementia produced conflicting *** measured NMDA antibodies in a large,well phenotyped sample of Parkinson patients without and with cognitive impairment(n=296)and controls(n=295)free of neuropsychiatric *** phenotyping and large numbers allowed statistically meaningful correlation of antibody status with diagnostic subgroups as well as quantitative indicators of disease severity and cognitive ***:NMDA antibodies were analysed in the serum of patients and controls using well established validated *** used anti-NMDA antibody positivity as the main independent variable and correlated it with disease status and phenotypic ***:The frequency of NMDA IgA/IgM antibodies was lower in Parkinson patients(13%)than in controls(22%)and higher than in previous studies in both *** IgA/IgM antibodies were neither significantly associated with diagnostic subclasses of Parkinson disease according to cognitive impairment,nor with quantitative indicators of disease severity and cognitive impairment.A positive NMDA antibody status was positively correlated with age in controls but not in Parkinson ***:It is unlikely albeit not impossible that NMDA antibodies play a significant role in the pathogenesis or progression of Parkinson disease *** Parkinson disease with dementia,while NMDA IgG antibodies define a separate disease of its own.

关键词： NMDA antibody NMDA IgA/IgM antibodies Parkinson disease Cognitive impairment

Reappraisal of Hepatocellular Adenoma from Federal Health System, Rio de janeiro, Brazil

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儿童前庭性偏头痛和儿童复发性眩晕:Bárány协会前庭疾病分类委员会和国际头痛协会诊断标准共识文件

Open journal of Organ Transplant Surgery（器官移植外科学期刊） 2019年第1期

作者： Reinaldo Fernandes klaus Steinbruck Danielle B. Delai júlia R. N. Souza Igor Duque Daniel Barbosa Marcelo Enne Renato Cano Marcelo D’Oliveira Luiza Maciel Giuliano Bento

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神经损伤与功能重建 2021年第8期16卷 435-439页

作者：凌霞(译) 张赛(译) 申博(译) 隋汝波(审校) 杨旭(审校) Raymond van de Berg josine Widdershoven Alexandre Bisdorff Stefan Evers Sylvette Wiener-Vacher Sharon LCushing Kenneth jMack ji Soo Kim klaus jahn Michael Strupp Thomas Lempert 航天中心医院(北京大学航天临床医学院)神经内科河北医科大学第一医院神经内科郑州大学第二附属医院神经内科锦州医科大学附属第一医院神经内科荷兰马斯特里赫特大学医疗中心耳鼻喉-头颈外科卢森堡埃施EmileMayrisch医疗中心眩晕门诊德国科彭布吕格Lindenbrunn医院神经内科德国明斯特大学医学中心法国巴黎罗伯特德布雷儿童医院耳鼻喉科加拿大多伦多大学儿童医院耳鼻喉-头颈外科美国明尼苏达州罗彻斯特市梅奥诊所儿童和青少年神经内科分部韩国首尔大学医学院、首尔大学盆唐医院神经内科、头晕中心、临床神经科学中心德国巴特艾布灵施恩诊所神经内科德国慕尼黑大学眩晕与平衡疾病中心德国慕尼黑大学神经内科德国柏林大学Schlosspark-Klinik医院神经内科

本文介绍了Bárány协会国际前庭疾病分类(International Classification of Vestibular Disorders,ICVD)委员会和国际头痛协会偏头痛分类小组所提出的"儿童前庭性偏头痛"(vestibular migraine of childhood,VMC)、"很可能的儿童前庭性偏头痛"(probable VMC,pVMC)和"儿童复发性眩晕"(recurrent vertigo of childhood,RVC)的诊断标准。偏头痛在儿童期不同复发性眩晕亚型中起着重要作用。在此分类文件中,VMC、p VMC和RVC这3种与偏头痛相关的一组谱系疾病分类,上述诊断标准中的偏头痛成分为确定、很可能及可能不存在。VMC的诊断标准:(A)至少5次中度或重度前庭症状发作,持续时间5分钟~72小时;(B)当前或既往有伴或不伴先兆的偏头痛病史;(C)至少50%的发作与至少1种偏头痛样症状相关。pVMC的诊断标准:至少3次中度或重度前庭症状发作,持续时间5分钟~72小时,符合VMC诊断标准B或C中的1项。RVC的诊断标准:至少3次中度或重度前庭症状发作,持续时间为1分钟~72小时,VMC诊断标准中的B和C均不符合。对于以上3种疾病,患者的年龄必须<18岁。建议将来的研究应特别关注RVC,以研究和确定其可能的亚型及其与偏头痛的关系。

关键词：儿童前庭性偏头痛很可能的儿童前庭性偏头痛儿童复发性眩晕诊断标准 Bárány协会

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经内窥镜的第三脑室切开术(ETV):100例分析

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Oncology and Translational Medicine 1999年第6期16卷 325-325页

作者： Nikolai j.Hopf Peter Grunert Georg Fries klaus.Resch Axel Perneczky 郭东升 Department of Neurosurgery University of Mainz Langenbeckstr. 1 D-55131 Mainz Germany 同济医科大学附属同济医院

脑积水问题仍是现代神经外科领域的主要挑战之一。尽管外科治疗技术已获得长足进步,如程控瓣膜和抗生素包裹插管的使用,但分流管阻塞和感染仍时有发生,导致需要反复手术调整。传统的一些方法,如显微手术打开第三脑室底部或终板,经皮徒... 详细信息

脑积水问题仍是现代神经外科领域的主要挑战之一。尽管外科治疗技术已获得长足进步,如程控瓣膜和抗生素包裹插管的使用,但分流管阻塞和感染仍时有发生,导致需要反复手术调整。传统的一些方法,如显微手术打开第三脑室底部或终板,经皮徒手或立体定向引导第三脑室底部穿刺术、导水管

关键词：第三脑室阻塞性脑积水非交通性脑积水 ETV 切开术内窥镜