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Epithelial markers of colorectal carcinogenesis in ulcerative colitis and primary sclerosing cholangitis

World Journal of Gastroenterology 2013年第14期19卷 2234-2241页

作者： Pavel Wohl Tomas Hucl Pavel Drastich David Kamenar Julius Spicak eva Honsova eva Sticova Alena Lodererova Jan Matous Martin Hill Petr Wohl Milos Kucera Department of Hepatogastroenterology Institute for Clinical and Experimental MedicineVidenska 195814021 Prague 4Czech Republic Department of Pathology Institute for Clinical and Experimental Medicine(IKEM)Videnska 195814021 Prague 4Czech Republic 2~(nd) Department of Internal Medicine Third Faculty of MedicineCharles University11640 Prague 1Czech Republic Department of Biostatistics Institute of EndocrinologyCharles University11640 Prague 1Czech Republic Institute for Clinical and Experimental Medicine(IKEM) Videnska 195814021 Prague 4Czech Republic

AIM:To evaluate the expression of epithelial markers of colorectal carcinogenesis in patients with long-term ulcerative colitis(UC) and primary sclerosing cholangitis(PSC) before and after ***:Eight patients with UC and PSC prior to liver transplantation(PSC-UC),22 patients with UC after liver transplantation for PSC(OLT),9 patients with active ulcerative colitis without PSC(UCA),7 patients withUC in remission(UCR) and 10 controls(N) underwent colonoscopy with multiple *** were analysed histologically and semi-quantitatively immunohistochemically for p53,Bcl-2 and cyclooxygenase-2(COX-2) *** analysis was performed by Kruskal-Wallis and Fisher's exact ***:PSC-UC had a statistically significantly higher expression of p53 in the nondysplastic mucosa as compared to OLT,UCA,UCR and N(P evaluated with the Mayo ***:Our study shows that the nondysplatic mucosa of UC patients with PSC is characterised by a higher expression of the tumour suppressor gene p53,suggesting a higher susceptibility of *** p53 overexpression correlates with the presence of PSC whilst it is not present in patients with UC after liver transplantation for

关键词： Imunohistochemistry Ulcerative colitis Primary sclerosing cholangitis Colorectal carcinoma Liver transplantation p53 bcl2 Cyclooxygenase-2

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Kinetic study of phytotoxicity induced by foliar lead uptake for vegetables exposed to fine particles and implications for sustainable urban agriculture

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Journal of Environmental Sciences 2016年第8期28卷 16-27页

作者： TianTian Xiong Annabelle Austruy Antoine Pierart Muhammad Shahid eva Schreck Stéphane Mombo Camille Dumat Université de Toulouse Institut National Polytechnique de Toulouse-Ecole Nationale Supérieure Agronomique de Toulouse (INP-ENSAT) Centre National de la Recherche Scientifique Institut Ecocitoyen Centre de Vie la Fossette RD 268 Department of Environmental Sciences COMSATS Institute of Information Technology Géosciences Environnement Toulouse (GET) Observatoire Midi Pyrénées Université de Toulouse Centre d'Etude et de Recherche Travail Organisation Pouvoir (CERTOP) UMR5044 Universite J. Jaurès - Toulouse II

At the global scale, foliar metal transfer occurs for consumed vegetables cultivated in numerous urban or industrial areas with a polluted atmosphere. However, the kinetics of metal uptake, translocation and involved phytotoxicity was never jointly studied with vegetables exposed to micronic and sub-micronic particles（PM）. Different leafy vegetables（lettuces and cabbages） cultivated in RHIZOtest？ devices were, therefore, exposed in a greenhouse for 5, 10 and 15 days to various Pb O PM doses. The kinetics of transfer and phytotoxicity was assessed in relation to lead concentration and exposure duration. A significant Pb accumulation in leaves（up to 7392 mg/kg dry weight（DW） in lettuce） with translocation to roots was observed. Lead foliar exposure resulted in significant phytotoxicity, lipid composition change, a decrease of plant shoot growth（up to 68.2% in lettuce） and net photosynthesis（up to 58% in lettuce）. The phytotoxicity results indicated plant adaptation to Pb and a higher sensitivity of lettuce in comparison with cabbage. Air quality needs, therefore, to be considered for the health and quality of vegetables grown in polluted areas, such as certain megacities（in China, Pakistan, Europe, etc.） and furthermore, to assess the health risks associated with their consumption.

关键词： Metallic particles Vegetables Foliar uptake Transfer kinetics and phytotoxicity

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Are assemblages of the fireworm Hermodice carunculata enhanced in sediments beneath offshore fish cages?

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Acta Oceanologica Sinica 2014年第4期33卷 108-111页

作者： Rodrigo Riera Oscar Pérez Myriam Rodríguez eva Ramos óscar Monterroso Centro de Investigaciones Medioambientales del Atlántico (CIMA SL) Department of Biodiversity Qatar Environment and Energy Research Institute (QEERI)

Abundances of the fireworm Hermodice carunculata were counted through a monitoring assessment study of fish cages in Barranco Hondo（NE Tenerife）. Seven campaigns were conducted from November 2007 to June 2010 and temporal variations were found, as well as differences among sampling stations. The polychaete H. carunculata obtained its highest abundance in sediments beneath fish cages throughout the study period. Thus, the assemblages of this omnivorous species were favoured by the presence of fish cages.

关键词： aquaculture organic enrichment environmental impact Polychaeta Hermodice carunculata Tenerife Canary Islands Atlantic Ocean

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Reproductive performance and gestational effort in relation to dietary fatty acids in guinea pigs

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Journal of Animal Science and Biotechnology 2017年第3期8卷 613-623页

作者： Matthias Nemeth eva Millesi Carina Siutz Karl-Heinz Wagner Ruth Quint Bernard Wallner Department of Behavioural Biology University of ViennaAlthanstrasse 141090 ViennaAustria Department of Nutritional Sciences University of ViennaAlthanstrasse 141090 ViennaAustria Department of Anthropology University of ViennaAlthanstrasse 141090 ViennaAustria

Background： Dietary saturated（SFAs） and polyunsaturated（PUFAs） fatty acids can highly affect reproductive functions by providing additional energy, modulating the biochemical properties of tissues, and hormone secretions. In precocial mammals such as domestic guinea pigs the offspring is born highly developed. Gestation might be the most critical reproductive period in this species and dietary fatty acids may profoundly influence the gestational effort. We therefore determined the hormonal status at conception, the reproductive success, and body mass changes during gestation in guinea pigs maintained on diets high in PUFAs or SFAs, or a control ***： The diets significantly affected the females＇ plasma fatty acid status at conception, while cortisol and estrogen levels did not differ among groups. SFA females exhibited a significantly lower body mass and litter size, while the individual birth mass of pups did not differ among groups and a general higher pup mortality rate in larger litters was diminished by PUFAs and SFAs. The gestational effort, determined by a mother＇s body mass gain during gestation, increased with total litter mass, whereas this increase was lowest in SFA and highest in PUFA individuals. The mother＇s body mass after parturition did not differ among groups and was positively affected by the total litter mass in PUFA ***： While SFAs reduce the litter size, but also the gestational effort as a consequence, PUFA supplementation may contribute to an adjustment of energy accumulations to the total litter mass, which may both favor a mother＇s body condition at parturition and perhaps increase the offspring survival at birth.

关键词： Body mass Female reproduction Gestation Litter size Polyunsaturated fatty acid Saturated fatty acid Total litter mass

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Structural damage response of lanthanum and yttrium aluminate crystals to nuclear collisions and electronic excitation:Threshold assessment of irradiation damage

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Journal of Materials Science & Technology 2021年第31期90卷 95-107页

作者： Yong Liu Xinqing Han Qing Huang Miguel L.Crespillo Peng Liu eva Zarkadoula Xuelin Wang Institute of Frontier and Interdisciplinary Science and Key Laboratory of Particle Physics and Particle Irradiation(MOE) Shandong UniversityQingdao 266237China Shanghai Institute of Applied Physics Chinese Academy of Sciences(CAS)Shanghai 201800China Department of Materials Science&Engineering University of TennesseeKnoxvilleTN 37996United States Materials Science&Technology Division Oak Ridge National LaboratoryOak RidgeTN 37831United States

A comparative analysis is performed on the structural damage response and associated mechanisms in lanthanum aluminate and yttrium aluminate crystals under various irradiation conditions by a combination of experimental and theoretical *** low-energy Au~+irradiation,the damage accumulation curve shows a higher damage rate for LaAlO_(3)crystals than YAlO_(3)*** relatively low irradiation tolerance of LaAlO_(3)to the action of nuclear collisions is ascribed to the large amorphization cross-section and effective cross-section for defect-stimulated *** swift Ar^(12+),Ni^(19+)and Kr^(17+)irradiation with different ion energies and velocities,the formed highly-disordered/amorphous latent tracks with different morphologies in pristine and predamaged crystals are discussed,and the corresponding electronic energy loss and lattice temperature thresholds are quantitatively *** to YAlO_(3),LaAlO_(3)exhibits lower sensitivity and higher damage tolerance to the electronic energy loss process,attributing to its relatively high recrystallization efficiency during the rapid quenching ***,the introduction of lattice defects into LaAlO_(3)and YAlO_(3)crystals considerably enhances the sensitivity and intensity of thermal spike response to the electronic energy loss,and the induced effective modification of track morphologies demonstrates the synergistic effect between the electronic energy loss and pre-existing defects created by nuclear *** this case,even under the action of electronic energy loss below the threshold,the lattice temperature in the nuclear-collision damaged crystalline system could still meet the criterion for track *** irradiation energy deposited to atoms and induced lattice temperature evolution discussed in this work provide a deeper insight into the complex processes involved in irradiation-induced latent track behaviors.

关键词： Nuclear energy loss Electronic energy loss Synergistic effect Irradiation damage Latent ion track

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Establishment of Rhodiola quadrifida Hairy Roots and Callus Culture to Produce Bioactive Compounds

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Phyton-International Journal of Experimental Botany 2021年第2期90卷 543-552页

作者： Anna Stepanova Maria Malunova Svetlana Salamaikina Renat Selimov Aleksandra Solov’eva Group of Specialized Root Metabolism К.А.Timiryazev Institute of Plant Physiology RASMoscow127276Russia Bioanalytical laboratory OOO“NVC Agrovetzaschita”Moscow129329Russia

Rhodiola quadrifida is a rare mountain medicinal plant whose root extracts are used in traditional Chinese medicine as a hemostatic,antitussive,and tonic in the treatment of gynecological *** aim of the study was to obtain *** cultures at different degrees of differentiation in vitro and compare their growth characteristics and the content of salidroside and *** roots were obtained by incubating cotyledons and hypocotyls in a suspension of Agrobacterium rhizogenes strain *** presence of the rolB and rolC genes was proven by polymerase chain *** obtained roots were cultivated in Murashige-Skoog medium(MS).Calluses were obtained from the hairy roots in MS medium with the addition of hormones:3 mg/L 2,4 D and 0.5 mg/L *** presence of the main secondary metabolites of ***,salidroside and rosavin,in calluses and salidroside in hairy roots by HPLC/MS was *** content of salidroside in callus culture was significantly higher than in hairy roots,0.158 and 0.047%,*** content of rosavin in callus culture was 0.07%.The content of rosavin and salidroside in callus culture was close to the level of these substances in the rhizomes of *** plants growing in vivo,making this culture promising for its possible biotechnological use.

关键词： Rhodiola quadrifida hairy roots callus culture HPLC salidroside rosavin

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DEVELOPMENT OF ENVIRONMENTAL RIGHTS IN CHINA： SUBSTANTIVE ENVIRONMENTAL RIGHTS OR PROCEDURAL ENVIRONMENTAL RIGHTS

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Frontiers of Law in China-Selected Publications from Chinese Universities 2017年第1期12卷 24-56页

作者： ZHU Xiao WANG Shenghang eva-Maria Ehemann Renmin University of China Beijing 100872 China Faculty of Law LMU Munich Munich

The relationship between environmental and human rights is very significant. On this basis, humans shall have the right to claim to live in a healthy environment. In China, the study of environmental rights began in the 1980＇s. After more than thirty years of discussions on environmental rights, there are a series of environmental rights theories in China. However, scholars have not formed a consensus on some fundamental theories of environmental rights. Moreover, some experts consider that environmental rights include substantive environmental rights and procedural environmental rights, whereas others argue that environmental rights only include substantive environmental rights. Furthermore, the nexus and difference between the right to environment and environmental rights are not clear. ＂Environmental rights＂ are treated as a broad concept, its scope includes all rights which are related to the environment. They certainly do not only include substantive, but also procedural environmental rights. Even though the introduction of substantive environmental rights has faced both legislative and practical difficulties, the topic has become a central issue in Chinese academic research.

关键词： environmental right substantive right procedural right

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Electronic energy loss and ion velocity correlation effects in track production in swift-ion-irradiated LiNbO_(3):A quantitative assessment between structural damage morphology and energy deposition

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Journal of Materials Science & Technology 2022年第21期116卷 30-40页

作者： Xinqing Han Qing Huang Miguel L.Crespillo eva Zarkadoula Yong Liu Xuelin Wang Peng Liu Institute of Frontier and Interdisciplinary Science and Key Laboratory of Particle Physics and Particle Irradiation(MOE) Shandong UniversityQingdao 266237China Shanghai Institute of Applied Physics Chinese Academy of Sciences(CAS)Shanghai 201800China Centro de Micro-Análisis de Materiales(CMAM) Universidad Autónoma de MadridMadrid E-28049Spain Materials Science&Technology Division Oak Ridge National LaboratoryOak RidgeTennessee 37831USA

The primary motivation for studying how irradiation modifies the structures and properties of solid materials involves the understanding of undesirable phenomena,including irradiation-induced degradation of components in nuclear reactors and space exploration,and beneficial applications,including material performance tailoring through ion beam modification and defect *** this work,the formation mechanism of latent tracks with different damage morphologies in LiNbO_(3)crystals under 0.09-6.17 Me V/u ion irradiation with an electronic energy loss from 2.6-13.2 ke V/nm is analyzed by experimental characterizations and numerical ***-induced damage is preliminarily evaluated via the prism coupling technique to analyze the correlation between the dark-mode spectra and energy loss profiles of irradiated *** the irradiation conditions of different ion velocities and electronic energy losses,different damage morphologies,from individual spherical defects to discontinuous and continuous tracks,are experimentally *** ion penetration process,the ion velocity determines the spatiotemporal distribution of deposited irradiation energy induced by electronic energy loss,meaning that the two essential factors including electronic energy loss and ion velocity coaffect the track *** inelastic thermal spike model is used to numerically calculate the spatiotemporal evolutions of energy deposition and the corresponding atomic temperature under different irradiation conditions,and a quantitative relationship is proposed by comparison with corresponding experimentally observed track damage *** obtained quantitative relationship between irradiation conditions and track damage provides deep insight and guidance for understanding the damage behavior of crystal materials in extreme radiation environments and selecting irradiation parameters,including ion species and energies,for ion beam technique application in atom

关键词： Latent track damage Thermal spike model Electronic energy loss Velocity effect Ion modification

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Effectiveness of intermittent preventive treatment in pregnancy with sulfadoxine-pyrimethamine: An in silico pharmacological model

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Asian Pacific Journal of Tropical Medicine 2020年第8期13卷 366-374页

作者： Mila Nu Nu Htay Ian M Hastings eva Maria Hodel Katherine Kay Liverpool School of Tropical Medicine Liverpool L35QAUnited Kingdom Department of Community Medicine Melaka-Manipal Medical CollegeManipal Academy of Higher Education(MAHE)MelakaMalaysia Malawi-Liverpool-Wellcome Trust Clinical Research Programme BlantyreMalawi University of Liverpool Liverpool L693GFUnited Kingdom Metrum Research Group TariffvilleConnecticut06081United States of America

Objective:To explore the efficacy of intermittent preventive treatment in pregnancy(IPTp)with sulfadoxine and pyrimethamine(SP)against sensitive ***:A pharmacological model was used to investigate the effectiveness of the previous recommended at least two-dose regimen,currently recommended three-dose regimen and 4,6,8-weekly regimens with specific focus on the impact of various nonadherence patterns in multiple transmission ***:The effectiveness of the recommended three-dose regimen is high in all the transmission intensities,i.e.>99%,98%and 92%in low,moderate and high transmission intensities *** simulated 4 and 6 weekly IPTp-SP regimens were able to prevent new infections with sensitive parasites in almost all women(>99%)regardless of transmission ***,8 weekly interval dose schedules were found to have 71%and 86%protective efficacies in high and moderate transmission areas,*** highlights that patients are particularly vulnerable to acquiring new infections if IPTp-SP doses are ***:The pharmacological model predicts that full adherence to the currently recommended three-dose regimen should provide almost complete protection from malaria infection in moderate and high transmission ***,it also highlights that patients are particularly vulnerable to acquiring new infections if IPTp doses are spaced too widely or if doses are *** to the recommended IPTp-SP schedules is recommended.

关键词： Intermittent preventive treatment in pregnancy Sulfadoxine-pyrimethamine Malaria infection in pregnancy Three-dose regimen In silico pharmacological model

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A Three-Dimensional Multi-scale Plasticity Model for Metal-Intermetallic Laminate Composites Containing Phases of the L12 Structure

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Acta Metallurgica Sinica(English Letters) 2018年第12期31卷 1265-1271页

作者： Yana D.Lipatnikova Vladimir A.Starenchenko Yuliya V.Solov'eva Larisa A.Valuiskaya Tomsk State University of Architecture and Building Solyanaya Sq.2TomskRussia 634003 Siberian State Medical University 2 Moskovsky traktTomskRussia 634055

A three-dimensional plasticity model was developed and applied to metal-intermetallic laminate composites containingphases of the L12 structure. A multi-scale approach that combined the methods of continuum mechanics and dislocationkinetics was used. This model takes account of the different mechanisms of self-locking superdislocations, the dislocationsand the dislocation walls＇ density storage for each type of layer at the micro-scale. At the meso-scale, the solutions to thedislocation kinetics equations, in the form of stress-strain curves, were used to create the properties of a three-dimensionalrepresentative element. The numerical simulation study of the macroscopic deformation was carried out with the finiteelement method using the dynamic model of continuum mechanics, which included the classical conservation laws,constitutive equations and the equation of state. It was shown that the simulation results generated using this model were ingood agreement with the mechanical tests conducted on the single crystals of the L12 structure. The model provides anexcellent description of the high-temperature plastic strain superlocalization effect of single crystal intermetallics of theLI2 structure. This paper describes the numerical results of the study of the tension and compression tests of metal-intermetallic laminate composites containing phases of the L12 structure. The model allows the description of the dis-tribution of the accumulated plastic strain inhomogeneities and is capable of predicting the strengthening properties andplastic behaviour of the metal-intermetallic laminate composites containing phases of the L12 structure.

关键词： Plasticity model Metal-intermetallic laminate composites Layered composites L12 structure Tension Compression

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