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Differential Expressionof D-type cyclins and p27 in Human Gastric Carcinoma

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Differential Expressionof D-type cyclins and p27 in Human Ga...

The Effect of Catalyst Preparation on the Catalytic Activity of Ni/Mgo-ZrO2

2000全国肿瘤学术大会

作者： WK Leung EKW Ng MYY go JJY Sung

＜正＞BackgroundD type（D1,D2,D3）cyclins play a critical role in regulating cell cycle *** cyclin-dependent kinase inhibitor,p27,is a negative regulator of the cell cycle and is a potential tumor suppressor gene. Enhanced expression of D-type cyclins and the decreased p27 expression have been implicated in the pathogenesis of cancer but the role in gastric car- cinogenesis is *** To investigate the roles of cyclin D1,D2,D3 and

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材料科学与工程（中英文B版） 2011年第6期1卷 710-717页

作者： Louie Chua Shieh Teddy go Monroy Leonila Cobacha Abella Chemical Engineering Department De La Salle University Manila 1004 Philippines

This study investigated on the difference of the surface characteristics of Ni/Mgo-ZrO2 prepared by the Pechini sol-gel method (PCH) and the co-precipitation method (CP). The catalysts were characterized using the Autosorb, Scanning Electron Microscope, Elemental Dispersive X-ray, Transmission Electron Microscope, X-ray Diffraction, and Atomic Absorption Spectroscopy to measure the surface area, pore size, and pore volume, the surface morphology and surface elemental composition, the crystal structure, and total nickel content of the prepared catalysts, respectively. The co-precipitation catalyst resulted in a higher surface nickel concentration compared to the Pechini catalyst due to nickel encapsulation for the Pechini catalyst, which caused a higher catalytic activity for the co-precipitation catalyst. However, the co-precipitation catalyst exhibited rapid deactivation due to severe coking, as supported by the post-reaction results of the Scanning Electron Microscope, Elemental Dispersive X-ray, X-ray Diffraction and Gravimetric Analysis. The Pechini catalyst, on the other hand, maintained a lower catalytic activity for over 16 h, with minimal coking, due to a stronger metal-support interaction, and to a higher concentration of m-ZrO2.

关键词：催化剂制备催化活性 X射线衍射分析扫描电子显微镜透射电子显微镜原子吸收光谱法 ni催化剂共沉淀法

Single-Incision Robotic Surgery

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Surgical Science 2012年第2期3卷 84-86页

作者： Norihiko Ishikawa Masahiko Kawaguchi Hideki Moriyama go Watanabe Department of General and Cardiothoracic Surgery Kanazawa University Kanazawa Japan

Introduction: Single Incision Laparoscopic Surgery (SILSTM) has been developed as a less invasive laparoscopic surgery. On the other hand, robotically assisted surgical technology has offered new options for minimally invasive surgery. In this study, we report a new surgical technology to perform SILS using the da Vinci S surgical system (Intuitive Surgical Inc., Sunnyvale, CA). Materials and Surgical Technique: A porcine liver with gallbladder was placed on an endoscopic surgery trainer, and a 25 mm incision was made for one robotic camera and two instruments at the umbilicus position. Both instruments were crossed while preventing them from colliding with each other, and Robot-assisted single-incision cholecyctectomy was perfumed. Discussion: This technique is expected to contribute to the development of a number of procedures in the future.

关键词： Single-Incision Laparoscopic Surgery Robotic Surgery Surgical System of da Vinci S

Modeling and analysis of Hayabusa2 touchdown

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Astrodynamics 2020年第2期4卷 119-135页

作者： Kent Yoshikawa Hirotaka Sawada Shota Kikuchi Naoko Ogawa Yuya Mimasu go Ono Yuto Takei Fuyuto Terui Takanao Saiki Seiji Yasuda Kota Matsushima Tetsuya Masuda Yuichi Tsuda Japan Aerospace Exploration Agency Sagamihara252-5210Japan NEC Corporation Fuchu183-8501Japan

The Hayabusa2 asteroid explorer mission focuses principally on the touchdown and sampling on near-Earth asteroid 162173 ***2 successfully landed on its surface and ejected a projectile for sample collection on February 22,***2 later landed near a crater formed by an impactor and executed the sampling sequence again on July 11,*** a successful mission,a thorough understanding and evaluation of spacecraft dynamics during touchdown were *** most challenging aspect of this study was the modeling of such spacecraft phenomena as the dynamics of landing on a surface with unknown *** particular,a Monte Carlo analysis was used to determine the parameters of the operational design for the final descent and touchdown *** paper discusses the dynamical modeling of the simulation during the touchdown of Hayabusa2.

关键词： contact dynamics resistive force theory(RFT) astrodynamics Hayabusa2 planetary exploration

Relationship between post-ERCP pancreatitis and the change of serum amylase level after the procedure

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World Journal of Gastroenterology 2007年第28期13卷 3855-3860页

作者： Kei Ito Naotaka Fujita Yutaka Noda go Kobayashi Jun Horaguchi Osamu Takasawa Takashi Obana Department of Gastroenterology Sendai City Medical Center5-22-1TsurugayaMiyagino-kuSendaiMiyagi 983-0824Japan

AIM: To clarify the relationship between the change of serum amylase level and post-ERCP pancreatitis. METHODS: Between January 1999 and December 2002, 1291 ERCP-related procedures were performed. Serum amylase concentrations were measured before the procedure and 3, 6, and 24 h afterward. The frequency and severity of post-ERCP pancreatitis and the relationship between these phenomena and the change in amylase level were estimated. RESULTS: Post-ERCP pancreatitis occurred in 47 patients (3.6%). Pancreatitis occurred in 1% of patients with normal amylase levels 3 h after ERCP, and in 1%, 5%, 20%, 31% and 39% of patients with amylase levels elevated 1-2 times, 2-3 times, 3-5 times, 5-10 times and over 10 times the upper normal limit at 3 h after ERCP, respectively (level < 2 times vs ≥ 2 times, P < 0.001). Of the 143 patients with levels higher than the normal limit at 3 h after ERCP followed by elevation at 6 h, pancreatitis occurred in 26%. In contrast, pancreatitis occurred in 9% of 45 patients with a level higher than two times the normal limit at 3 h after ERCP followed by a decrease at 6 h (26% vs 9%, P < 0.05). CONCLUSION: Post-ERCP pancreatitis is frequently associated with an increase in serum amylase level greater than twice the normal limit at 3 h after ERCP with an elevation at 6 h. A decrease in amylase level at 6 h after ERCP suggests the unlikelihood of development of post-ERCP pancreatitis.

关键词： Acute pancreatitis Endoscopic retrograde cholangiopancreatography Serum amylase

Yearly variation in the structure and diversity of a non-breeding passerine bird community in a Mediterranean wetland

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Avian Research 2020年第3期11卷 238-245页

作者： Juan Arizaga Daniel Alonso ArinCrespo Xabier Esparza Efrén Fernández Iógo López David Martín Antonio Vilches Department of Ornithology Aranzadi Sciences Society S. Sebastián Spain

Background:The dynamics and structure of many bird communities are changing due to the global warming and changes in the land use and *** Ebro Valley constitutes one of the chief wintering areas for several passerine species in Iberia,and the reed beds spread across this Valley concentrate huge numbers of birds that use them to roost,while the surrounding agricultural areas serve as main foraging *** aims of this work are(1)to quantify how variable a non-breeding passerine bird community associated to a reed bed area in the Ebro Valley is,and,(2)to test for the effect of weather on possible annual fluctuations in species’proportions at a regional/local ***:We used for that ringing data collected at Badina de Escudera lagoon(Navarra)over a 12-year ***:Though,overall,the assemblage did not vary strongly among years(most similarity values were>0.8),we still found a significant linear effect of year on the proportion of captures of Reed Buntings(Emberiza schoeniclus),i.e.,the dominant species detected in our passerine *** increasing loss of weight of Reed Buntings in the community was due to a progressive decrease in its ***:The structure and diversity of passerine community in Badina Escudera was not influenced by meteorological conditions at a local scale,suggesting that local weather would not have an impact on numbers of Reed Buntings in winter.

关键词： Navarra Emberiza schoeniclus Ringing Long-term monitoring

Hazardous metals emissions from e-waste-processing sites in a village in northern Vietnam

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Emerging Contaminants 2018年第1期4卷 11-21页

作者： Natsuyo Uchida Hidenori Matsukami Masayuki Someya Nguyen Minh Tue Le Huu Tuyen Pham Hung Viet Shin Takahashi Shinsuke Tanabe go Suzuki Center for Material Cycles and Waste Management Research National Institute for Environmental Studies(NIES)16-2 OnogawaTsukubaIbaraki305-8506Japan Tokyo Metropolitan Research Institute for Environmental Protection 1-7-5 Shinsuna KotoTokyo136-0075Japan Center for Marine Environmental Studies(CMES) Ehime University2-5 Bunkyo-choMatsuyama790-8577Japan Center for Environmental Technology and Sustainable Development(CETASD) Hanoi University of Science334 Nguyen TraiHanoiViet Nam Center of Advanced Technology for the Environment Graduate School of AgricultureEhime University3-5-7 TarumiMatsuyama790-8566Japan

Inappropriate e-waste-processing operation is a serious issue in developing countries since the early 2000'*** research was conducted to clarify its influences and diffuse toxic substances in the environment at e-waste-processing sites in a village in northern Vietnam from 2012 to *** investigated surface soil samples collected from e-waste-processing sites,open burning sites,and rice paddy *** samples and water samples were also collected from a river that runs through the *** hazardous metal concentration in soil and river sediment samples indicated that 7 elements(Ca,Cu,Mo,Ni,Pb,Sn,and Zn)had high concentrations as a result of *** notably,Pb and Cu had high concentrations in soil samples(Pb:26e2200 mg/kg,Cu:22e3000 mg/kg).The results of a multivariate analysis indicated that these 7 elements were closely correlated with *** of hazardous metals showed an upward trend where e-waste-processing occurred during the 3-year study period,although it was not significant statistically at *** burning activity had a great influence on Cu accumulation,and maximum Cu concentrations increased from 340 mg/kg in 2012e3000 mg/kg in 2014 in soil samples from open-burning *** were large differences in the dominant hazardous metal depending on the type of e-waste-processing workshop because hazardous metal composition was influenced by the types of e-waste and the processing *** is necessary to avoid e-waste processing in open-air environment to control emissions of hazardous ***,open burning should be prohibited.

关键词： E-waste-processing Open burning Soil pollution Hazardous metal

Ssu72 is a T-cell receptor-responsive modifier that is indispensable for regulatory T cells

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Cellular & Molecular Immunology 2021年第6期18卷 1395-1411页

作者： Jin-Kwan Lee Seo-Young Koo Hye-Mi Nam Jee-Boong Lee Jiwon Ko Kyung-Mo Kim Eun-Ji Park Tae Jin Kim Ho Lee Heounjeong go Chang-Woo Lee Research Institute Curogen TechnologySuwonSouth Korea Department of Molecular Cell Biology Samsung Medical CenterSungkyunkwan University School of MedicineSuwonSouth Korea MOGAM Institute for Biomedical Research GyeonggiSouth Korea Department of Pathology Asan Medical CenterUniversity of Ulsan College of MedicineSeoulSouth Korea Asan Institute for Life Sciences Asan Medical CenterUniversity of Ulsan College of MedicineSeoulSouth Korea Department of Immunology Sungkyunkwan University School of MedicineSeoulSouth Korea Department of Cancer Biomedical Science Graduate School of Cancer Science and PolicyResearch InstituteNational Cancer CenterGyeonggiSouth Korea

The homeostatic balance between effector T cells and regulatory T cells(Tregs)is crucial for adaptive immunity;however,epigenetic programs that inhibit phosphorylation to regulate Treg development,peripheral expression,and suppressive activity are ***,we found that the Ssu72 phosphatase is activated by various T-cell receptor signaling pathways,including the T-cell receptor and IL-2R pathways,and localizes at the cell *** of Ssu72 in T cells disrupts CD4+T-cell differentiation into Tregs in the periphery via the production of high levels of the effector cytokines IL-2 and IFNγ,which induce CD4+T-cell activation and differentiation into effector cell *** also found a close correlation between downregulation of Ssu72 and severe defects in mucosal tolerance in ***,Ssu72 forms a complex with PLCγ1,which is an essential effector molecule for T-cell receptor signaling as well as Treg development and ***72 deficiency impairs PLCγ1 downstream signaling and results in failure of Foxp3 ***,our studies show that the Ssu72-mediated cytokine response coordinates the differentiation and function of Treg cells in the periphery.

关键词： Ssu72 Regulatory T cells FoxP3 T cell receptor Autoimmunity

Vitisin B inhibits influenza A virus replication by multi-targeting neuraminidase and virusinduced oxidative stress

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Acta Pharmaceutica Sinica B 2023年第1期13卷 174-191页

作者： Eun-Bin Kwon Wei Li Young Soo Kim Buyun Kim Hwan-Suck Chung Younghoon go Hyun-Jeong Ko Jae-Hyoung Song Young Ho Kim Chun Whan Choi Jang-Gi Choi Korean Medicine(KM)Application Center Korea Institute of Oriental MedicineDaegu 41062Republic of Korea College of Pharmacy Chungnam National UniversityDaejeon 34134Republic of Korea Natural Product Research Team BiocenterGyeonggido Business and Science AcceleratorGyeonggi-Do 16229Republic of Korea Laboratory of Microbiology and Immunology College of PharmacyKangwon National UniversityChuncheon 24341Republic of Korea

The development of drug-resistant influenza and new pathogenic virus strains underscores the need for antiviral ***,neuraminidase(NA)inhibitors are commonly used antiviral drugs approved by the US Food and Drug Administration(FDA)for the prevention and treatment of ***,we show that vitisin B(VB)inhibits NA activity and suppresses H1N1 viral replication in MDCK and A549 *** oxygen species(ROS),which frequently occur during viral infection,increase virus replication by activating the NF-κB signaling pathway,downmodulating glucose-6-phosphate dehydrogenase(G6PD)expression,and decreasing the expression of nuclear factor erythroid2-related factor 2(Nrf2)antioxidant response *** decreased virus-induced ROS generation by increasing G6PD expression and Nrf2 activity,and inhibiting NF-κB translocation to the nucleus through IKK *** addition,VB reduced body weight loss,increased survival,decreased viral replication and the inflammatory response in the lungs of influenza A virus(IAV)-infected *** together,our results indicate that VB is a promising therapeutic candidate against IAV infection,complements existing drug limitations targeting viral *** modulated the intracellular ROS by G6PD,Nrf2 antioxidant response pathway,and NF-κB signaling *** results demonstrate the feasibility of a multi-targeting drug strategy,providing new approaches for drug discovery against IAV infection.

关键词： Influenza Vitisin B Vitis vinifera L. Neuraminidase Reactive oxygen species NF-κB Multi-targeting Nrf2 G6PD