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Level of Adherence to Breast Cancer Molecular Subtyping among Women with Breast Cancer Attending Tertiary Health Facilities

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Journal of Biosciences and Medicines 2023年第10期11卷 255-264页

作者： kingsley chidi anochiwa Sally Nkechinyere Onyeka Ibe Eunice Anyalewechi Nwoke Okwuchi Blessed Nworuh Asinobi Oluchi Darlington chidi Amadi Emmanuel Okechukwu Nna Department of Pathology Federal University Teaching Hospital Owerri Nigeria Department of Public Health Federal University of Technology Owerri Nigeria College of Medicine Imo State University Owerri Nigeria Safety Molecular Pathology Laboratory Molecular Pathology Institute Enugu Nigeria

Background: Breast cancer is a genetically and clinically heterogeneous disease with multiple subtypes. The classification of these subtypes has evolved over the years. The most common and widely accepted classification of breast cancer is from an immunohistochemical perspective, based on the expression of the following hormone receptors: Estrogen Receptor (ER), Progesterone Receptor (PR) and Human Epidermal Growth Factor (HER2). Accordingly, the following four subtypes of breast cancer are widely recognized—Luminal A, Luminal B, HER2 Enriched and Triple Negative. Breast cancer management approaches include surgery, chemotherapy, radiotherapy and targeted hormone therapy necessitated by molecular subtyping. Aims: This study aimed to determine the level of adherence to breast cancer molecular subtyping among women with breast cancer attending tertiary health facilities in Imo State. Methodology: Immunohistochemistry reports of women with breast cancer attending tertiary health facilities in Imo State were retrieved from patient’s case files. Tissue blocks were also retrieved from tissue block archives of both hospitals for women who did not take up immunohistochemistry services after their initial diagnosis and also those whose immunohistochemistry reports were not found in their case files. Results: Among the 121 women that participated in the study, there were in all 74 (61.2%) had molecular subtyping of their tumour blocks. Up to 45 (37.2%) did not go for molecular subtyping of their tumour blocks while 2 (1.7%) were not sure whether they had or not. Conclusion: It, therefore, depicts that the rate of uptake was found as 61.2% among the participants and there is a need to create more awareness of the importance of molecular subtyping, which necessitates the use of targeted hormone therapy.

关键词： Breast Cancer Subtypes Immunohistochemistry Estrogen Progesterone Human Epidermal Growth Factor 2 Receptor

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Influence of Socioeconomic Profile on Uptake of Immunohistochemistry Services among Women with Breast Cancer Attending Tertiary Health Facilities

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Journal of Biosciences and Medicines 2023年第10期11卷 126-135页

作者： kingsley chidi anochiwa Sally Nkechinyere Onyeka Ibe Eunice Anyalewechi Nwoke Onyinyechi Blessed Nworuh Asinobi Oluchi Darlington chidi Amadi Emmanuel Okechukwu Nna Department of Pathology Federal University Teaching Hospital Owerri Nigeria Department of Public Health Federal University of Technology Owerri Nigeria College of Medicine Imo State University Owerri Nigeria Safety Molecular Pathology Laboratory Molecular Pathology Institute Enugu Nigeria

Background: Breast cancer is the leading cause of death from cancer in women worldwide. It can be stratified by histological and immunopathological analysis as well as by molecular subtypes. Socioeconomic and cultural-mediated factors contribute to breast cancer heterogeneity and overall survivability. Objective: The aim of this study was to determine the influence of socioeconomic profile on the uptake of immunohistochemistry (IHC) services among women with breast cancer attending tertiary health facilities in Imo State. Methodology: This descriptive cross-sectional study was carried out among women with breast cancer in Imo State. The instrument for data collection used was a structured questionnaire constructed in line with the objectives of the study. A total of 121 respondents were selected randomly from a target study population of 891 using a systematic sampling technique. The software Statistical Package for Social Sciences (SPSS) version 21 was used for data analysis. Results: The mean age of the 121 respondents in this study was 45.2 ± 0.7 years. Age and education levels of the respondents were found to significantly influence the utilization of IHC services (P Conclusion: In our study, the consumption of IHC services was influenced significantly by the respondents’ age and level of education. Consequently, public health awareness programmes centred on the importance of IHC services in the management of breast cancer should be encouraged, so as to reach the less educationally endowed and older women in order to save more lives.

关键词： Breast Cancer Uptake Immunohistochemistry Socioeconomics Profile Age Education

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Influence of Cues to Action towards Uptake of Immunohistochemistry Services among Women with Breast Cancer Attending Tertiary Health Facilities

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Journal of Biosciences and Medicines 2023年第10期11卷 90-102页

作者： kingsley C. anochiwa Sally Nkechinyere Onyeka Ibe Eunice Anyalewechi Nwoke Okwuchi B. Nworuh Asinobi Oluchi Darlington chidi Amadi Emmanuel Okechukwu Nna Department of Pathology Federal University Teaching Hospital Owerri Nigeria Department of Public Health Federal University of Technology Owerri Nigeria College of Medicine Imo State University Owerri Nigeria The Molecular Pathology Institute Safety Molecular Lab Enugu Nigeria

Background: Breast cancer is the most frequently diagnosed cancer among women, making it a significant global public health issue. Although developed countries have a higher incidence of breast cancer, developing countries like Nigeria have a low incidence rate but higher rates of morbidity and mortality from the disease. Objective: This study explored how cues to action influenced the use of immunohistochemistry by women in Imo State and how many of them used immunohistochemistry (IHC) to diagnose their condition. Methodology: We used a descriptive study methodology for the investigation, and 121 participants were chosen at random from the 891 total population. The respondents were chosen through a systematic sampling procedure. Structured questionnaire was used as the data collection tool, and the statistical software for social science (SPSS) was used to analyze the data. Results: The mean age of the 121 participants in the study was 45.2 ± 0.7 years. The study found that awareness of IHC services is a significant influencing factor for the uptake and health personnel is the major source of awareness of IHC services. Cues to action particularly from health workers, as well as knowledge of any victim of breast cancer and user of IHC services, also significantly influenced uptake of the IHC services (P Conclusion: In our study, utilization of IHC services was also impacted by cues to action, particularly from healthcare professionals, as well as awareness of any breast cancer victims and those who used IHC services thus cues to action is a major predicator of immunohistochemistry uptake among women with breast cancer.

关键词： Breast Cancer Uptake Immunohistochemistry Cues to Action

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