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The First High-quality Reference Genome of Sika Deer Provides Insights into High-tannin Adaptation

Genomics, Proteomics & Bioinformatics 2023年第1期21卷 203-215页

作者： Xiumei Xing cheng Ai Tianjiao wang Yang Li Huitao Liu Pengfei Hu Guiwu wang Huamiao Liu Hongliang wang Ranran Zhang junjun Zheng Xiaobo wang Lei wang yuxiao Chang Qian Qian Jinghua yu Lixin Tang Shigang Wu Xiujuan Shao Alun Li Peng Cui Wei Zhan Sheng Zhao Zhichao Wu Xiqun Shao Yimeng Dong min Rong Yihong Tan Xuezhe Cui Shuzhuo Chang Xingchao Song Tongao Yang Limin Sun Yan ju Pei Zhao Huanhuan Fan Ying Liu Xinhui wang Wanyun Yang min Yang Tao Wei Shanshan Song Jiaping Xu Zhigang yue Qiqi Liang Chunyi Li jue Ruan Fuhe Yang Key Laboratory of Genetics Breeding and Reproduction of Special Economic AnimalsMinistry of Agriculture and Rural AffairsInstitute of Special Animal and Plant SciencesChinese Academy of Agricultural SciencesChangchun 130112China Shenzhen Branch Guangdong Laboratory of Lingnan Modern AgricultureGenome Analysis Laboratory of the Ministry of Agriculture and Rural AffairsAgricultural Genomics Institute at ShenzhenChinese Academy of Agricultural SciencesShenzhen 518120China CAS Key Laboratory of Forest Ecology and Management Institute of Applied EcologyChinese Academy of SciencesShenyang 110016China Annoroad Gene Technology(Beijing)Co. LtdBeijing 100176China Novogene Bioinformatics Institute Beijing 100083China

Sika deer are known to prefer oak leaves,which are rich in tannins and toxic to most mammals;however,the genetic mechanisms underlying their unique ability to adapt to living in the jungle are still *** identifying the mechanism responsible for the tolerance of a highly toxic diet,we have made a major advancement by explaining the genome of sika *** generated the first high-quality,chromosome-level genome assembly of sika deer and measured the correlation between tannin intake and RNA expression in 15 tissues through 180 *** genome analyses showed that the UGT and CYP gene families are functionally involved in the adaptation of sika deer to high-tannin food,especially the expansion of the UGT family 2 subfamily B of UGT *** first chromosome-level assembly and genetic characterization of the tolerance to a highly toxic diet suggest that the sika deer genome may serve as an essential resource for understanding evolutionary events and tannin *** study provides a paradigm of comparative expressive genomics that can be applied to the study of unique biological features in non-model animals.

关键词： Sika deer Whole-genome sequencing Chromosome-scale assembly Oak leaf Tannin tolerance

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醒脑开窍针刺法通过调控mTOR-EAAT2通路影响脑卒中后痉挛大鼠大脑皮层神经递质代谢

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中国病理生理杂志 2021年第11期37卷 2001-2007页

作者：庞青民赵欲晓邵素菊李鸿章王承惠郑州大学附属郑州中心医院针灸理疗科河南郑州450000 河南邵氏针灸流派传承工作室河南郑州450008 河南省中医院康复科河南郑州450002

目的:探究醒脑开窍针刺法通过调控哺乳动物雷帕霉素靶蛋白-兴奋性氨基酸转运体2(mTOR-EAAT2)通路对脑卒中后痉挛大鼠大脑皮层神经递质的影响。方法:SD大鼠按随机数字表法分为假手术组、模型组、针刺组、非穴位组和针刺+抑制剂组,每组10... 详细信息

目的:探究醒脑开窍针刺法通过调控哺乳动物雷帕霉素靶蛋白-兴奋性氨基酸转运体2(mTOR-EAAT2)通路对脑卒中后痉挛大鼠大脑皮层神经递质的影响。方法:SD大鼠按随机数字表法分为假手术组、模型组、针刺组、非穴位组和针刺+抑制剂组,每组10只,采用改良的大脑中动脉闭塞(MCAO)线栓法+内囊注射N-甲基-D-天门冬氨酸(NMDA)受体法制作脑卒中后痉挛大鼠模型。Zea Longa评分评价神经功能;改良Ashworth肌张力评分评价肌张力;邻苯二甲醛(OPA)柱前衍生高效液相色谱(HPLC)荧光检测法测定大脑皮层γ-氨基丁酸(GABA)、天门冬氨酸(Asp)、谷氨酸(Glu)和甘氨酸(Gly)含量;RT-qPCR和Western blot检测大脑皮层mTOR和EAAT2的mRNA和蛋白水平。结果:造模后,与假手术组相比,模型组、针刺组、非穴位组和针刺+抑制剂组神经功能评分、肌张力评分升高(P<0.05)。实验结束后,与假手术组相比,模型组神经功能评分、肌张力评分及大脑皮层Glu和Asp含量升高(P<0.05),GABA、Gly含量及mTOR、EAAT2的mRNA和蛋白水平降低(P<0.05);与模型组相比,针刺组神经功能评分、肌张力评分,大脑皮层Glu和Asp含量降低(P<0.05),GABA和Gly含量及mTOR和EAAT2的mRNA和蛋白水平升高(P<0.05);与针刺组相比,针刺+抑制剂组神经功能评分、肌张力评分及大脑皮层Glu和Asp含量升高(P<0.05),GABA和Gly含量及mTOR和EAAT2的mRNA和蛋白水平降低(P<0.05)。结论:醒脑开窍针刺法能够激活mTOR-EAAT2通路从而减轻神经功能损伤症状、抑制肌张力提高、改善大脑皮层氨基酸类神经递质的代谢,从而缓解脑卒中造成的痉挛现象。

关键词：醒脑开窍针刺法 mTOR-EAAT2信号通路脑卒中后痉挛神经递质

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Advances in nuclear detection and readout techniques

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Nuclear Science and Techniques 2023年第12期34卷 281-358页

作者： Rui He Xiao‑Yang Niu Yi wang Hong‑Wei Liang Hong‑Bang Liu Ye Tian Hong‑Lin Zhang Chao‑Jie Zou Zhi‑Yi Liu yun‑Long Zhang Hai‑Bo Yang ju Huang Hong‑Kai wang Wei‑Jia Han Bei Cao Gang Chen Cong Dai Li‑min Duan Rui‑Rui Fan Fang‑Fa Fu Jian‑Hua Guo Dong Han Wei Jiang Xian‑Qin Li Xin Li Zhuo‑Dai Li yu‑Tie Liang Shun Liao De‑Xu Lin cheng‑ming Liu Guo‑Rui Liu jun‑Tao Liu Ze Long Meng‑Chen Niu Hao Qiu Hu Ran Xiang‑ming Sun Bo‑Tan wang Jia wang Jin‑Xiang wang Qi‑Lin wang Yong‑Sheng wang Xiao‑Chuan Xia Hao‑Qing Xie He‑Run Yang Hong Yin Hong yuan Chun‑Hui Zhang Rui‑Guang Zhao Ran Zheng cheng‑Xin Zhao Institute of Modern Physics Chinese Academy of SciencesLanzhou 730000China School of Nuclear Science and Technology University of Chinese Academy of SciencesBeijing 100049China Advanced Energy Science and Technology Guangdong Laboratory Huizhou 516000China Key Laboratory of Particle and Radiation Imaging Department of Engineering PhysicsTsinghua UniversityBeijing 100084China School of Integrated Circuits Dalian University of TechnologyDalian 116020China Guangxi Key Laboratory for Relativistic Astrophysics School of Physical Science and TechnologyGuangxi UniversityNanning 530004China School of Nuclear Science and Technology Lanzhou UniversityLanzhou 730000China State Key Laboratory of Particle Detection and Electronics University of Science and Technology of ChinaHefei 230026China Department of Radiation Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Electronic Engineering School Heilongjiang UniversityHarbin 150080China Spallation Neutron Source Science Center Dongguan 523803China Micro‑electronic Department Harbin Institute of TechnologyHarbin 150001China Purple Mountain Observatory Chinese Academy of SciencesNanjing 210034China Liaoning Academy of Materials Shenyang 110167China Istituto Nazionale di Fisica Nucleare Sezione di PerugiaPerugiaItaly School of Mathematics and Physics Chengdu University of TechnologyChengdu 620035China PLAC Key Laboratory of Quark and Lepton Physics(MOE)Central China Normal UniversityWuhan 430079China School of Electronics and Information Northwestern Polytechnical UniversityXi’an 710129China State Key Lab of Superhard Materials College of PhysicsJilin UniversityChangchun 130012China School of Computer Science Northwestern Polytechnical UniversityXi’an 710129China

“A Craftsman Must Sharpen His Tools to Do His Job,”said *** detection and readout techniques are the foundation of particle physics,nuclear physics,and particle astrophysics to reveal the nature of the ***,they are being increasingly used in other disciplines like nuclear power generation,life sciences,environmental sciences,medical sciences,*** article reviews the short history,recent development,and trend of nuclear detection and readout techniques,covering Semiconductor Detector,Gaseous Detector,Scintillation Detector,Cherenkov Detector,Transition Radiation Detector,and Readout *** explaining the principle and using examples,we hope to help the interested reader underst and this research field and bring exciting information to the community.

关键词： Silicon detector Wide bandgap detector Time projection chamber(TPC) Multigap resistive plate chamber detector(MRPC) Scintillation detector Calorimeters Cherenkov detector Transition radiation detector Artificial intelligence Trigger-less readout

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一种基于技术状态变更的可靠性综合评估方法

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火力与指挥控制 2019年第4期44卷 179-183页

作者：鞠成玉杨胜学王守敏中国飞行试验研究院西安710089

目前,航空武器装备在外场鉴定阶段可靠性评价一般采用指数分布进行计算,但是指数分布具有较大的局限性,并且外场鉴定过程中存在技术状态频繁变更的问题。针对上述问题,利用多种分布进行数据建模,并采用贝叶斯数据融合和蒙特卡罗等方法... 详细信息

目前,航空武器装备在外场鉴定阶段可靠性评价一般采用指数分布进行计算,但是指数分布具有较大的局限性,并且外场鉴定过程中存在技术状态频繁变更的问题。针对上述问题,利用多种分布进行数据建模,并采用贝叶斯数据融合和蒙特卡罗等方法结合建模求解,给出最终状态的航空武器装备可靠性评估结果,对于后续开展可靠性评价具有重要意义。

关键词：技术状态可靠性综合评估蒙特卡罗威布尔分布飞行试验

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飞行试验阶段航空装备可靠性评估方法

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火力与指挥控制 2021年第2期46卷 163-168,173页

作者：鞠成玉王守敏任智勇中国飞行试验研究院西安710089

目前,飞机试飞阶段遇到的情况复杂多样,对于可靠性评估提出了极大的挑战,传统可靠性评估方法在试飞过程中逐渐显得力不从心,因此,通过系统分析不纠正、即时纠正、提前纠正、延迟纠正、部分即时纠正、单设备复杂纠正和多设备复杂纠正等... 详细信息

目前,飞机试飞阶段遇到的情况复杂多样,对于可靠性评估提出了极大的挑战,传统可靠性评估方法在试飞过程中逐渐显得力不从心,因此,通过系统分析不纠正、即时纠正、提前纠正、延迟纠正、部分即时纠正、单设备复杂纠正和多设备复杂纠正等飞机试飞阶段实际遇到的情况,提出了相应的可靠性评估方法,可实现更精确评估试飞阶段飞机的可靠性结果,为工程推广应用奠定了良好的基础。

关键词：飞行试验可靠性评估延迟纠正复杂纠正

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Chemoprophylaxis, diagnosis, treatments, and discharge management of COVID-19: An evidence-based clinical practice guideline(updated version)

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Military Medical Research 2020年第3期7卷 249-282页

作者： Ying-Hui Jin Qing-yuan Zhan Zhi-Yong Peng Xue-Qun Ren Xun-Tao Yin Lin Cai yu-Feng yuan Ji-Rong yue Xiao-Chun Zhang Qi-Wen Yang Jianguang Ji Jian Xia Yi-Rong Li Fu-Xiang Zhou Ya-Dong Gao Zhui yu Feng Xu ming-Li Tu Li-ming Tan min Yang Fang Chen Xiao-ju Zhang Mei Zeng yu Zhu Xin-Can Liu Jian Yang Dong-Chi Zhao yu-Feng Ding Ning Hou Fu-Bing wang Hao Chen Yong-Gang Zhang Wei Li Wen Chen yue-Xian Shi Xiu-Zhi Yang Xue-jun wang Yan-jun Zhong ming-juan Zhao Bing-Hui Li Lin-Lu Ma Hao Zi Na wang yun-yun wang Shao-Fu yu Lu-Yao Li Qiao Huang Hong Weng Xiang-Ying Ren Li-Sha Luo Man-Ru Fan Di Huang Hong-Yang Xue Lin-Xin yu Jin-Ping Gao Tong Deng Xian-Tao Zeng Hong-jun Li Zhen-Shun cheng Xiao-Mei Yao Xing-Huan wang Center for Evidence-Based and Translational Medicine Zhongnan Hospital of Wuhan UniversityWuhan 430071China National Clinical Research Center for Respiratory Diseases China-Japan Friendship HospitalBeijing 100029China Department of Pulmonary and Critical Care Medicine China-Japan Friendship HospitalBeijing 10029China Leishenshan Hospital in Wuhan Wuhan 430200China Department of Critical Care Medicine Zhongnan Hospital of Wuhan UniversityWuhan 430071China Institutes of Evidence-based Medicine and Knowledge Translation Henan UniversityKaifeng 475000HenanChina Department of Medical Imaging Guizhou Provincial People’s HospitalGuiyang 550002China Departments of Orthopedics Zhongnan Hospital of Wuhan UniversityWuhan 430071China Department of Hepatobiliary Surgery Zhongnan Hospital of Wuhan UniversityWuhan 430071China National Clinical Research Center for Geriatrics West China Hospital of Sichuan UniversityChengdu 610041China Department of Geriatrics West China Hospital of Sichuan UniversityChengdu 610041China Department of Radiology Zhongnan Hospital of Wuhan UniversityWuhan 430071China Department of Clinical Laboratory Peking Union Medical College Hospital(PUMCH)Peking Union Medical CollegeChinese Academy of Medical Sciences(CAMS)Beijing 100730China Center for Primary Health Care Research Lund University and Region Skåne25002 MalmöSweden Emergency Center Zhongnan Hospital of Wuhan UniversityWuhan 403371China Department of Allergology Zhongnan Hospital of Wuhan UniversityWuhan 430071China Department of Radiation and Medical Oncology Zhongnan Hospital of Wuhan UniversityWuhan 43071China Department of Critical Care Medicine Renmin Hospital of Wuhan UniversityWuhan 430060China Department of Emergency Medicine and Chest Pain Center Qilu Hospital of Shandong UniversityJinan 250002China Department of Respiratory and Critical Care Medicine Suizhou Central HospitalHubei University of MedicineSuizhou 441300HubeiChina Department of Clinic Pharmacy Second People’s Hospital of Huaihua Ci

The novel severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)is the cause of a rapidly spreading illness,coronavirus disease 2019(COVID-19),affecting more than seventeen million people around the *** and treatment guidelines for clinicians caring for patients are *** the early stage,we have issued"A rapid advice guideline for the diagnosis and treatment of 2019 novel coronavirus(2019-nCoV)infected pneumonia(standard version)";now there are many direct evidences emerged and may change some of previous recommendations and it is ripe for develop an evidence-based *** formed a working group of clinical experts and *** steering group members proposed 29 questions that are relevant to the management of COVID-19 covering the following areas:chemoprophylaxis,diagnosis,treatments,and discharge *** searched the literature for direct evidence on the management of COVID-19,and assessed its certainty generated recommendations using the Grading of Recommendations,Assessment,Development and Evaluation(GRADE)*** were either strong or weak,or in the form of ungraded consensus-based ***,we issued 34 *** them,6 were strong recommendations for,14 were weak recommendations for,3 were weak recommendations against and 11 were ungraded consensus-based *** covered topics of chemoprophylaxis(including agents and Traditional Chinese Medicine(TCM)agents),diagnosis(including clinical manifestations,reverse transcription-polymerase chain reaction(RT-PCR),respiratory tract specimens,IgM and IgG antibody tests,chest computed tomography,chest X-ray,and CT features of asymptomatic infections),treatments(including lopinavirritonavir,umifenovir,favipiravir,interferon,remdesivir,combination of antiviral drugs,hydroxychloroquine/chloroquine,interleukin-6 inhibitors,interleukin-1 inhibitors,glucocorticoid,qingfei paidu decoction,lianhua qingwen granules/capsules,convalescent plasma,lung

关键词： COVID-19 SARS-CoV-2 Recommendation Chemoprophylaxis Diagnosis Treatment Discharge management Traditional Chinese medicine guideline

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年龄因素对患者硬膜外注射左旋布比卡因药效学和药代动力学的影响

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中华麻醉学杂志 2009年第7期29卷 617-620页

作者：马民玉王艳萍冉菊红阚全程郑州大学第一附属医院麻醉科 450052 郑州大学第一附属医院临床药理基地河南省高等学校临床医学重点学科开放实验室

目的探讨年龄因素对患者硬膜外注射左旋布比卡因药效学和药代动力学的影响。方法择期拟行下肢手术患者45例，年龄30-72岁，体重52—83kg，ASAI或Ⅱ级，按不同年龄分为3组：I组（≤45岁）、Ⅱ组（46-64岁）和Ⅲ组（〉64岁），每组15例，... 详细信息

目的探讨年龄因素对患者硬膜外注射左旋布比卡因药效学和药代动力学的影响。方法择期拟行下肢手术患者45例，年龄30-72岁，体重52—83kg，ASAI或Ⅱ级，按不同年龄分为3组：I组（≤45岁）、Ⅱ组（46-64岁）和Ⅲ组（〉64岁），每组15例，均采用腰段硬膜外麻醉，左旋布比卡因（7．5mg／m1）用量1．8mg／kg（含肾上腺素5μg／m1）。经L1-2硬膜外穿刺成功后，注射试验量0．5％左旋布比卡因3ml，3rain后注射剩余量O．75％左旋布比卡因。硬膜外注药后记录感觉和运动阻滞效果及不良反应的发生情况；每组随机选择9例，于注药后即刻、注药后10、20、30、45、60、90、120、180、240、360,480、840、和1440min时采用高效液相色谱法测定血浆左旋布比卡因浓度，绘制血浆左旋布比卡因浓度．时间曲线，计算3组药代动力学参数。结果与I组比较，Ⅲ组最高感觉阻滞平面高，感觉和运动阻滞维持时间长，（P〈O．05）；各组麻醉效果优良率均达100％；各组左旋布比卡因的血浆药物浓度．时间曲线均符合二房室开放模型；硬膜外注药后1440min时Ⅱ组和Ⅲ组左旋布比卡因血药浓度高于I组（P〈0．05）；Ⅱ组和Ⅲ组左旋布比卡因消除半衰期明显长于I组，Ⅲ组明显长于Ⅱ组（P〈0．05）。结论不同年龄患者硬膜外注射0．75％左旋布比卡因1．8mg／kg安全有效；随年龄增加，感觉阻滞平面升高、感觉和运动阻滞恢复时间延长，药物代谢明显减慢。

关键词：年龄因素布比卡因药代动力学麻醉硬膜外

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Does Early Postsurgical Temozolomide Plus Concomitant Radiochemotherapy Regimen Have Any Benefit in Newly-diagnosed Glioblastoma Patients？ A Multi-center, Randomized, Parallel, Open-label, Phase II Clinical Trial

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Chinese Medical Journal 2015年第20期128卷 2751-2758页

作者： Ying Mao yu Yao Li-Wei Zhang Yi-cheng Lu Zhong-Ping Chen Jian-min Zhang Song-Tao Qi Chao You Ren-Zhi wang Shu-yuan Yang Xiang Zhang Ji-Sheng wang ju-Xiang Chen Qun-Ying Yang Hong Shen Zhi-Yong Li Xiang wang Wen-Bin Ma Xue-jun Yang Hai-Ning Zhen Liang-Fu Zhou Department of Neurosurgery Huashan Hospital Fudan University Shanghai 200040 China Department of Neurosurgery Beijing Tiantan Hospital Capital Medical University Beijing 100050 China Department of Neurosurgery Changzheng Hospital Second Military Medical University Shanghai 200003 China Sun Yat-Sen University Cancer Center Guangzhou Guangdong 510060 China Department of Neurosurgery The Second Affiliated Hospital of Zhejiang University School of Medicine Hangzhou Zhejiang 310009 China Department of Neurosurgery Nanfang Hospital Southern Medical University Guangzhou Guangdong 510515 China Department of Neurosurgery West China Hospital of Sichuan University Chengdu Sichuan 610041 China Department of Neurosurgery Peking Union Medical College Hospital Beijing 100032 China Department of Neurosurgery General Hospital Tianjin Medical University Tianjin 300070 China Department of Neurosurgery Xijing Hospital The Fourth Military Medical University Xi'an Shaanxi 710032 China

Background： The radiochemotherapy regimen concomitantly employing temozolomide （TMZ） chemotherapy and radiotherapy （RT） 4 weeks after surgery, followed by 6 cycles of TMZ is a common treatment for glioblastoma （GBM）. However, its median overall survival （OS） is only 14.6 months. This study was to explore the effectiveness and safety of early TMZ chemotherapy between surgery and chemoradiotherapy plus the standard concomitant radiochemotherapy regimen. Methods： A randomized, parallel group, open-label study of 99 newly diagnosed GBM patients was conducted at 10 independent Chinese neurosurgical departments from june 2008 to june 2012. Patients were treated with concomitant radiochemotherapy regimen plus early postsurgical temozolomide （early TMZ group） or standard concomitant radiochemotherapy regimen （control group）. Overall response was assessed based on objective tumor assessments, administration ofcorticosteroid and neurological status test. Hematological, biochemical, laboratory, adverse event （AE）, and neurological condition were measured for 24 months of tbllow-up. The primary efficacy endpoint of this study was overall survival （OS）. The secondary endpoint was progression free survival （PFS）. Results： The median OS time in the early TMZ group was 17.6 months, compared with 13.2 months in the control group （log-rank test P 0.021 ）. In addition, the OS rate in the early TMZ group was higher at 6, 12, and 18 months than in the control group, respectively （P 〈 0.05）. The median PFS time was 8.7 months in the early TMZ group and 10.4 months in the control group （log-rank test P = 0.695）. AEs occurred in 29 （55.8%） and 31（73.8%） patients respectively in early and control groups, including nausea （15.4% vs. 33.3%）, vomiting （7.7% vs. 28.6%）, fever （7.7% vs. 11.9%）, and headache （3.8% vs. 23.8%）. Only 30.8% and 33.3% were drug-related, respectively. Conclusions： Addition of TMZ chemotherapy in the early break of the standard concomitant radiochemotherapy regimen was

关键词： Chemoradiotherapy Chemotherapy: Glioblastoma Malignant Glioma Temozolomide

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Performances of a prototype point-contact germanium detector immersed in liquid nitrogen for light dark matter search

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Science China(Physics,Mechanics & Astronomy) 2019年第3期62卷 58-65页

作者： Hao Jiang LiTao Yang Qian yue Kejun Kang JianPing cheng yuanJing Li Henry Tsz-king Wong M.A?artio?lu HaiPeng An JianPing Chang JingHan Chen yunHua Chen Zhi Deng Qiang Du Hui Gong Li He Jin Wei Hu QingDong Hu HanXiong Huang LiPing Jia HauBin Li Hong Li Jian min Li Jin Li Xia Li XueQian Li yuLan Li Bin Liao FongKay Lin ShinTed Lin ShuKui Liu YanDong Liu yuanyuan Liu ZhongZhi Liu Hao Ma JingLu Ma Hui Pan Jie Ren XiChao Ruan B.Sevda Vivek Sharma ManBin Shen Lakhwinder Singh Monoj Kumar Singh TianXi Sun ChangJian Tang WeiYou Tang Yang Tian GuangFu wang Jimin wang Li wang Qing wang Yi wang ShiYong Wu yucheng Wu HaoYang Xing Yin Xu Tao Xue SongWei Yang Nan Yi ChunXu yu Haijun yu JianFeng yue XiongHui Zeng ming Zeng Zhi Zeng FengShou Zhang yunHua Zhang mingGang Zhao JiFang Zhou ZuYing Zhou Jingjun Zhu ZhongHua Zhu Key Laboratory of Particle and Radiation Imaging (ministry of Education)and Department of Engineering Physics Tsinghua University College of Nuclear Science and Technology Beijing Normal University Institute of Physics Academia Sinica Department of Physics Dokuz Eylül University Department of Physics Tsinghua University NUCTECH Company Ya Long River Hydropower Development Company College of Physical Science and Technology Sichuan University Department of Nuclear Physics China Institute of Atomic Energy School of Physics Nankai University Department of Physics Banaras Hindu University Department of Physics Beijing Normal University

The CDEX-10 experiment searches for light weakly interacting massive particles, a form of dark matter, at the China Jinping Underground Laboratory, where approximately 10 kg of germanium detectors are arranged in an array and immersed in liquid nitrogen. Herein, we report on the experimental apparatus, detector characterization, and spectrum analysis of one prototype detector. Owing to the higher rise-time resolution of the CDEX-10 prototype detector as compared with CDEX-1 B, we identified the origin of an observed category of extremely fast events. For data analysis of the CDEX-10 prototype detector, we introduced and applied an improved bulk/surface event discrimination method. The results of the new method were compared to those of the CDEX-1 B spectrum. Both sets of results showed good consistency in the 0-12 ke Vee energy range, except for the 8.0 keV K-shell X-ray peak from the external copper.

关键词： WIMP pPCGe liquid nitrogen bulk/surface event discrimination extremely fast events

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基于微纳光纤与平面光栅的复合光波导折射率传感器

引用

光电子．激光 2017年第9期28卷 941-945页

作者：马成举常会敏王晨羽韩佟飞韩学峰西安石油大学理学院陕西西安710065

利用微纳光纤强的倏逝场特性和平面光栅的折射率周期性分布特性,设计了一种新型的基于微纳光纤和平面光栅复合光波导折射率传感器,并利用时域有限差分(FDTD)方法,对复合光波导的光学特性和折射率传感特性进行了仿真研究。结果表明,本文... 详细信息

利用微纳光纤强的倏逝场特性和平面光栅的折射率周期性分布特性,设计了一种新型的基于微纳光纤和平面光栅复合光波导折射率传感器,并利用时域有限差分(FDTD)方法,对复合光波导的光学特性和折射率传感特性进行了仿真研究。结果表明,本文的复合光波导的透射光谱中心波长对其周围物质折射率变化非常敏感,灵敏度为346nm/RIU(refractive index unit)。

关键词：折射率传感器微纳光纤平面光栅时域有限差分(FDTD)方法

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