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人脸检测研究进展

计算机工程与应用 2003年第28期39卷 5-9,21页

作者：刘党辉沈兰荪 kin-man lam 北京工业大学信号与信息处理研究室北京100022 Centrefor Multimedia Signal Processing The Hong Kong Polytechnic UniversityHongKong

人脸检测在人脸识别、基于内容的检索、自动监控、人机交互等方面有着广泛的应用。文章主要从特征和原理方面对已有方法进行分析,表明了人脸检测技术的特点、存在的问题以及发展现状等,也给出了一些新的研究方向和发展前景。

关键词：人脸检测基于知识的方法基于统计的方法

Emerging roles and therapeutic potentials of sphingolipids in pathophysiology:emphasis on fatty acyl heterogeneity

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Journal of Genetics and Genomics 2024年第3期51卷 268-278页

作者： Jinming Mu Sin man lam Guanghou Shui State Key Laboratory of Molecular Developmental Biology Institute of Genetics and Developmental BiologyChinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100101China Lipidall Technologies Company Limited ChangzhouJiangsu 213000China

Sphingolipids not only exert structural roles in cellular membranes,but also act as signaling molecules in various physiological and pathological processes.A myriad of studies have shown that abnormal levels of sphingolipids and their metabolic enzymes are associated with a variety of human ***,blood sphingolipids can also be used as biomarkers for disease *** review summarizes the biosynthesis,metabolism,and pathological roles of sphingolipids,with emphasis on the biosynthesis of ceramide,the precursor for the biosynthesis of complex sphingolipids with different fatty acyl *** possibility of using sphingolipids for disease prediction,diagnosis,and treatment is also *** endogenous ceramides and complex sphingolipids along with their specific fatty acyl chain to promote future drug development will also be discussed.

关键词： Sphingolipids Ceramide Therapeutic targets Microdomain Biomarker

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人脸识别研究进展

电路与系统学报 2004年第1期9卷 85-94页

作者：刘党辉沈兰荪 kin-man lam 北京工业大学信号与信息处理研究室北京100022 Centre for Multimedia Signal Processing The Hong Kong Polytechnic University Hong Kong

近10多年来,人脸识别技术在各种应用的推动下发展很快。而近几年中,为避免各种实际应用环境的限制,非约束环境下的人脸识别也得到了很大的发展。本文概述了人脸识别的一些主要方法,讨论了影响人脸识别的几个主要因素及其处理方法以及基... 详细信息

近10多年来,人脸识别技术在各种应用的推动下发展很快。而近几年中,为避免各种实际应用环境的限制,非约束环境下的人脸识别也得到了很大的发展。本文概述了人脸识别的一些主要方法,讨论了影响人脸识别的几个主要因素及其处理方法以及基于视频的人脸识别技术,最后指出了鲁棒的人脸识别技术的研究方向和发展前景。

关键词：非约束环境人脸识别人脸特征形变模型视频序列

Regulation of PM_(2.5)on mitochondrial damage in H9c2 cells through miR-421/SIRT3 pathway and protective effect of miR-421 inhibitor and resveratrol

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Journal of Environmental Sciences 2024年第4期138卷 288-300页

作者： Shanshan Chen Wenqi Chen Zhiping Li Jianwei Yue Ken kin lam Yung Ruijin Li Institute of Environmental Science Shanxi UniversityTaiyuan 030006China Institute of Judicial Identification Techniques for Environmental Damage Shanxi University and Shanxi Unisdom Testing Technology Co.Ltd.Taiyuan 030006China Department of Biology Hong Kong Baptist UniversityHong KongChina Shanxi Yellow River Laboratory Taiyuan 030006China

Fine particulate matter(PM_(2.5))exposure is associated with cardiovascular disease(CVD)morbidity and *** are sensitive targets of PM_(2.5),and mitochondrial dysfunction is closely related to the occurrence of *** epigenetic mechanism of PM_(2.5)-triggered mitochondrial injury of cardiomyocytes is *** study focused on the mi R-421/SIRT3 signaling pathway to investigate the regulatory mechanism in cardiac mitochondrial dynamics imbalance in rat H9c2 cells induced by PM_(2.5).Results illustrated that PM_(2.5)impaired mitochondrial function and caused dynamics homeostasis ***,PM_(2.5)up-regulated mi R-421 and down-regulated SIRT3 gene expression,along with decreasing p-FOXO3a(SIRT3 downstream target gene)and p-Parkin expression and triggering abnormal expression of fusion gene OPA1 and fission gene ***,mi R-421 inhibitor(mi R-421i)and resveratrol significantly elevated the SIRT3 levels in H9c2 cells after PM_(2.5)exposure and mediated the expression of SOD2,OPA1 and Drp1,restoring the mitochondrial morphology and *** suggests that mi R-421/SIRT3 pathway plays an epigenetic regulatory role in mitochondrial damage induced by PM_(2.5)and that mi R-421i and resveratrol exert protective effects against PM_(2.5)-incurred cardiotoxicity.

关键词： Fine particulate matter Rat H9c2 cells Mitochondrial damage MiR-421 SIRT3 Resveratrol

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改进PF算法对红外图像中瞳孔的跟踪

北京理工大学学报 2009年第11期29卷 994-997页

作者：赵三元沈庭芝林健文胡宇田卉北京理工大学信息与电子学院北京100081

提出一种基于粒子滤波的红外目标跟踪的新算法.用该算法对采样粒子进行优化,改进了重采样环节,在不影响跟踪准确率的条件下,提高了算法的速度.实验结果表明,将此算法运用到瞳孔跟踪中,跟踪比较准确有效.同时,将Hough变换应用到了瞳孔边... 详细信息

提出一种基于粒子滤波的红外目标跟踪的新算法.用该算法对采样粒子进行优化,改进了重采样环节,在不影响跟踪准确率的条件下,提高了算法的速度.实验结果表明,将此算法运用到瞳孔跟踪中,跟踪比较准确有效.同时,将Hough变换应用到了瞳孔边缘的定位领域中,此算法有效改进了红外图像中眼睛瞳孔的跟踪效果.

关键词：瞳孔定位粒子滤波粒子重采样

Comparing 11 early warning scores and three shock indices in early sepsis prediction in the emergency department

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World Journal of Emergency Medicine 2024年第4期15卷 273-282页

作者： Rex Pui kin lam Zonglin Dai Eric Ho Yin Lau Carrie Yuen Ting Ip Ho Ching Chan Lingyun Zhao Tat ChiTsang Matthew Sik Hon Tsui Timothy Hudson Rainer Department of Emergency Medicine School of Clinical MedicineLi Ka Shing Faculty of Medicinethe University of Hong KongHong KongChina School of Public Health Li Ka Shing Faculty of Medicinethe University of Hong KongHong KongChina Accident and Emergency Department Queen Mary HospitalHong KongChina

BACKGROUND:This study aimed to evaluate the discriminatory performance of 11 vital sign-based early warning scores(EWSs)and three shock indices in early sepsis prediction in the emergency department(ED).METHODS:We performed a retrospective study on consecutive adult patients with an infection over 3 months in a public ED in Hong *** primary outcome was sepsis(Sepsis-3 definition)within 48 h of ED *** c-statistics and the DeLong test,we compared 11 EWSs,including the National Early Warning Score 2(NEWS2),Modified Early Warning Score,and Worthing Physiological Scoring System(WPS),etc.,and three shock indices(the shock index[SI],modified shock index[MSI],and diastolic shock index[DSI]),with Systemic Inflammatory Response Syndrome(SIRS)and quick Sequential Organ Failure Assessment(qSOFA)in predicting the primary outcome,intensive care unit admission,and mortality at different time ***:We analyzed 601 patients,of whom 166(27.6%)developed ***2 had the highest point estimate(area under the receiver operating characteristic curve[AUROC]0.75,95%CI 0.70-0.79)and was significantly better than SIRS,qSOFA,other EWSs and shock indices,except WPS,at predicting the primary ***,the pooled sensitivity and specificity of NEWS2≥5 for the prediction of sepsis were 0.45(95%CI 0.37-0.52)and 0.88(95%CI 0.85-0.91),*** discriminatory performance of all EWSs and shock indices declined when used to predict mortality at a more remote time ***:NEWS2 compared favorably with other EWSs and shock indices in early sepsis prediction but its low sensitivity at the usual cut-off point requires further modification for sepsis screening.

关键词： Sepsis Emergency department Clinical prediction rule Early warning score Shock index

Integrated causal inference modeling uncovers novel causal factors and potential therapeutic targets of Qingjin Yiqi granules for chronic fatigue syndrome

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Acupuncture and Herbal Medicine 2024年第1期4卷 122-133页

作者： Junrong Li Xiaobing Zhai Jixing Liu Chi kin lam Weiyu Meng Yuefei Wang Shu Li Yapeng Wang Kefeng Li Faculty of Applied Sciences Macao Polytechnic UniversityMacao SARChina Center for Artificial Intelligence Driven Drug Discovery Faculty of Applied SciencesMacao Polytechnic UniversityMacao SARChina National Key Laboratory of Chinese Medicine Modernization Tianjin Key Laboratory of TCM Chemistry and AnalysisTianjin University of Traditional Chinese MedicineTianjinChina Haihe Laboratory of Modern Chinese Medicine TianjinChina

Objective:Chronic fatigue syndrome(CFS)is a prevalent symptom of post-coronavirus disease 2019(COVID-19)and is associated with unclear disease *** herbal medicine Qingjin Yiqi granules(QJYQ)constitute a clinically approved formula for treating post-COVID-19;however,its potential as a drug target for treating CFS remains largely *** study aimed to identify novel causal factors for CFS and elucidate the potential targets and pharmacological mechanisms of action of QJYQ in treating ***:This prospective cohort analysis included 4,212 adults aged≥65 years who were followed up for 7 years with 435 incident CFS *** modeling and multivariate logistic regression analysis were performed to identify the potential causal determinants of CFS.A proteome-wide,two-sample Mendelian randomization(MR)analysis was employed to explore the proteins associated with the identified causal factors of CFS,which may serve as potential drug ***,we performed a virtual screening analysis to assess the binding affinity between the bioactive compounds in QJYQ and CFS-associated ***:Among 4,212 participants(47.5%men)with a median age of 69 years(interquartile range:69–70 years)enrolled in 2004,435 developed CFS by *** graph analysis with multivariate logistic regression identified frequent cough(odds ratio:1.74,95%confidence interval[CI]:1.15–2.63)and insomnia(odds ratio:2.59,95%CI:1.77–3.79)as novel causal factors of ***-wide MR analysis revealed that the upregulation of endothelial cell-selective adhesion molecule(ESAM)was causally linked to both chronic cough(odds ratio:1.019,95%CI:1.012–1.026,P=2.75 e^(−05))and insomnia(odds ratio:1.015,95%CI:1.008–1.022,P=4.40 e^(−08))in *** major bioactive compounds of QJYQ,ginsenoside Rb2(docking score:−6.03)and RG4(docking score:−6.15),bound to ESAM with high affinity based on virtual ***:Our integrated analytical framework combining epidemiological,genet

关键词： Causal factors Causal graph analysis Chronic fatigue syndrome Drug targets Mendelian randomization Qingjin Yiqi

Long-chain acyl-CoA synthetase regulates systemic lipid homeostasis via glycosylation-dependent lipoprotein production

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Life Metabolism 2024年第2期3卷 38-54页

作者： Jie Li Yue Dong Tianxing Zhou He Tian Xiahe Huang Yong Q.Zhang Yingchun Wang Sin man lam Guanghou Shui State Key Laboratory of Molecular Developmental Biology Institute of Genetics and Developmental BiologyChinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100101China Lipidall Technologies Company Limited ChangzhouJiangsu 213000China

Interorgan lipid transport is crucial for organism development and the maintenance of physiological ***,we demonstrate that Drosophila long-chain acyl-CoA synthetase(dAcsl),which catalyzes the conversion of fatty acids into acyl-coenzyme As(acyl-CoAs),plays a critical role in regulating systemic lipid *** deficiency in the fat body led to the ectopic accumulation of neutral lipids in the gut,along with significantly reduced lipoprotein contents in both the fat body and *** aberrant phenotypes were rescued by fat body-specific overexpression of apolipophorin.A multi-omics investigation comprising lipidomics,metabolomics,and proteomics in conjunction with genetic screening revealed that glycosylation processes were suppressed in dAcsl knockdown *** of CG9035,human ortholog of which is implicated in the congenital disorder of glycosylation,ame-liorated gut lipid accumulation in *** lipoprotein glycosylation led to accelerated proteasome-related degradation and induced ER stress in dAcsl knockdown flies,impairing lipoprotein release into the circulation which compromised interorgan lipid transport between the fat body and the *** of ubiquitin-proteasome-dependent degradation alleviated the phenotype of gut ectopic fat accumulation in dAcsl knockdown ***,we verified that ACSL4,the human homolog of dAcsl,also regulated lipoprotein levels in HepG2 cells,indicating that the role of dAcsl in modulating lipoprotein secretion and systemic lipid homeostasis is possibly conserved in humans.

关键词： lipid homeostasis apolipoprotein glycosylation lipidomics metabolomics proteomics

An AI-empowered indoor digital contact tracing system for COVID-19 outbreaks in residential care homes

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Infectious Disease Modelling 2024年第2期9卷 474-482页

作者： Jiahui Meng Justina Yat Wa Liu Lin Yang man Sing Wong Hilda Tsang Boyu Yu Jincheng Yu Freddy man-Hin lam Daihai He Lei Yang Yan Li Gilman Kit-Hang Siu Stefanos Tyrovolas Yao Jie Xie David man David H.K.Shum School of Nursing The Hong Kong Polytechnic UniversityHong Kong Special Administrative RegionChina Electronic and Information Engineering The Hong Kong Polytechnic UniversityHong Kong Special Administrative RegionChina Research Centre of Textiles for Future Fashion The Hong Kong Polytechnic UniversityHong Kong Special Administrative RegionChina Department of Land Surveying and Geo-Informatics The Hong Kong Polytechnic UniversityHong Kong Special Administrative RegionChina Department of Applied Mathematics The Hong Kong Polytechnic UniversityHong Kong Special Administrative RegionChina The Jockey Club School of Public Health and Primary Care The Chinese University of Hong KongHong Kong Special Administrative RegionChina Department of Rehabilitation Sciences The Hong Kong Polytechnic UniversityHong Kong Special Administrative RegionChina Department of Computing The Hong Kong Polytechnic UniversityHong Kong Special Administrative RegionChina Department of Health Technology and Informatics The Hong Kong Polytechnic UniversityHong Kong Special Administrative RegionChina Department of Nutrition and Food Studies George Mason UniversityUSA Tung Wah College Hong Kong Special Administrative RegionChina Mental Health Research Centre The Hong Kong Polytechnic UniversityHong Kong Special Administrative RegionChina

An AI-empowered indoor digital contact-tracing system was developed using a centralized architecture and advanced low-energy Bluetooth technologies for indoor positioning,with careful preservation of privacy and data *** analyzed the contact pattern data from two RCHs and investigated a COVID-19 outbreak in one study *** evaluate the effectiveness of the system in containing outbreaks with minimal contacts under quarantine,a simulation study was conducted to compare the impact of different quarantine strategies on outbreak containment within *** significant difference in contact hours between weekdays and weekends was observed for some pairs of RCH residents and staff during the two-week data collection *** significant difference between secondary cases and uninfected contacts was observed in a COVID-19 outbreak in terms of their demographics and contact *** results based on the collected contact data indicated that a threshold of accumulative contact hours one or two days prior to diagnosis of the index case could dramatically increase the efficiency of outbreak containment within RCHs by targeted isolation of the close *** study demonstrated the feasibility and efficiency of employing an AI-empowered system in indoor digital contact tracing of outbreaks in RCHs in the post-pandemic era.

关键词： COVID-19 Indoor contact tracing Contact pattern Outbreak containment Artificial intelligence