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Effects of length alteration of OPE-containing mono- and dinuclear alkynylplatinum(II) terpyridine complexes on photophysical, structural and morphological properties

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Nano Research 2024年第10期17卷 8893-8903页

作者： Jason Koon-Lam Poon Sammual yu-Lut Leung Eric Ka-Ho Wong Vivian Wing-wah Yam Institute of Molecular Functional Materials State Key Laboratory of Synthetic Chemistry and Department of ChemistryThe University of Hong KongHong Kong 999077China

A series of mononuclear complexes and unsymmetric dinuclear alkynylplatinum(II)terpyridine complexes with oligo(paraphenylene ethynylene)(OPE)-derived backbone with a variation of the lengths of alkoxy chains and OPE backbones was *** morphological properties,packing lattice and gelation behaviors of the mononuclear complexes were systematically studied,and the thermodynamic parameters and packing lattices of the dinuclear complexes were also investigated,providing further insights into the roles of the non-covalent interactions and their delicate balance in constructing sophisticated supramolecular *** and nanotube formation have been observed upon a delicate control of the intermolecular interactions by altering the lengths and structural dimensions of the complexes.

关键词： supramolecular chemistry self-assembled nanostructures platinum(II)complexes metallogel

Small-molecule agents for cancer immunotherapy

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Acta Pharmaceutica Sinica B 2024年第3期14卷 905-952页

作者： Fang Wang Kai Fu yujue Wang Can Pan Xueping Wang Zeyu Liu Chuan Yang Ying Zheng Xiaopeng Li yu Lu Kenneth kin wah To Chenglai Xia Jianye Zhang Zhi Shi Zeping Hu Min Huang Liwu Fu State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer MedicineGuangdong Esophageal Cancer InstituteGuangdong Provincial Clinical Research Center for CancerSun Yat-sen University Cancer CenterGuangzhou 510060China School of Pharmaceutical Sciences Tsinghua-Peking Center for Life SciencesBeijing Frontier Research Center for Biological StructureTsinghua UniversityBeijing 100084China State Key Laboratory of Drug Research Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China Department of Cell Biology&Institute of Biomedicine National Engineering Research Center of Genetic MedicineMOE Key Laboratory of Tumor Molecular BiologyGuangdong Provincial Key Laboratory of Bioengineering MedicineCollege of Life Science and TechnologyJinan UniversityGuangzhou 510632China Guangzhou Municipal and Guangdong Provincial Key Laboratory of Molecular Target&Clinical Pharmacology NMPA and State Key Laboratory of Respiratory DiseaseSchool of Pharmaceutical Sciences and the Fifth Affiliated HospitalGuangzhou Medical UniversityGuangzhou 511436China School of Pharmacy The Chinese University of Hong KongHong Kong 999077China Affiliated Foshan Maternity and Child Healthcare Hospital Southern Medical UniversityFoshan 528000China

Cancer immunotherapy,exemplified by the remarkable clinical benefits of the immune checkpoint blockade and chimeric antigen receptor T-cell therapy,is revolutionizing cancer *** induce long-term tumor regression and overall survival benefit in many types of *** the advances in our knowledge about the tumor immune microenvironment,remarkable progress has been made in the development of small-molecule drugs for *** molecules targeting PRR-associated pathways,immune checkpoints,oncogenic signaling,metabolic pathways,cytokine/chemokine signaling,and immune-related kinases have been extensively *** of smallmolecule immunotherapeutic drugs and their combinations with other antitumor modalities are under active clinical investigations to overcome immune tolerance and circumvent immune checkpoint inhibitor ***,we review the latest development of small-molecule agents for cancer immunotherapy by targeting defined pathways and highlighting their progress in recent clinical investigations.

关键词： Cancer immunotherapy Small-molecule agents Immune checkpoints Oncogenic signaling Metabolic pathways Cytokine/chemokine signaling Antitumor immunity Tumor immune microenvironment

Spectral Representation Theory for Dielectric Behavior of Nonspherical Cell Suspensions

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Communications in Theoretical Physics 2002年第7期38卷 113-120页

作者： HUANG Ji-Ping yu kin-wah LEI Jun SUN Hong Department of Physics the Chinese University of Hong Kong Shatin NT Hong Kong China Department of Physics the Chinese University of Hong Kong Shatin NT Hong Kong China Department of Applied Physics Shanghai Jiao Tong University Shanghai 200030 China Department of Applied Physics Shanghai Jiao Tong University Shanghai 200030 China Department of Physics University of California Berkeley California 94720-7300 U.S.A.

Recent experiments revealed that the dielectric dispersion spectrum of fission yeast cells in a suspension was mainly composed of two sub-dispersions. The low-frequency sub-dispersion depended on the cell length, while the high-frequency one was independent of it. The cell shape effect was simulated by an ellipsoidal cell model but the comparison between theory and experiment was far from being satisfactory. Prompted by the discrepancy, we proposed the use of spectral representation to analyze more realistic cell models. We adopted a shell-spheroidal model to analyze the effects of the cell membrane. It is found that the dielectric property of the cell membrane has only a minor effect on the dispersion magnitude ratio and the characteristic frequency ratio. We further included the effect of rotation of dipole induced by an external electric field, and solved the dipole-rotation spheroidal model in the spectral *** agreement between theory and experiment has been obtained.

关键词： dielectric relaxation, interfacial polarization, cell model

Design, Synthesis, Photophysical Studies and Electrochemistry of Carbazole-, Oxadiazole-, and Oxadiazole-Triarylamine-Containing Rhenium(Ⅰ) Diimine Alkynyl Complexes

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Chinese Journal of Chemistry 2014年第10期32卷 1015-1021页

作者： Wai-kin Chung Keith Man-Chung Wong Vivian Wing-wah Yam and Department of ChemistryThe University of Hong KongPokfulam RoadHong KongChina

A series of rhenium(I)diimine alkynyl complexes with various electron-and hole-transporting moieties has been synthesized and *** electronic absorption,emission and electrochemical properties have also been studied.

关键词： electrochemistry luminescence metal alkynyl rhenium(Ⅰ)diimine,UV/Vis spectroscopy

CircTUBD1: A Novel Circular RNA Molecule as a Therapeutic Target in Radiation-induced Liver Fibrosis

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Journal of Clinical and Translational Hepatology 2022年第4期10卷 571-573页

作者： Catherine yujia Gu Terence kin wah Lee Department of Applied Biology and Chemical Technology The Hong Kong Polytechnic UniversityHong KongChina State Key Laboratory of Chemical Biology and Drug Discovery The Hong Kong Polytechnic UniversityHong KongChina

Citation of this article:Gu CY,Lee ***1:A Nov-el Circular RNA Molecule as a Therapeutic Target in Radiation-induced Liver Fibrosis.J Clin Transl Hepatol 2022;10(4):***:10.14218/*** liver cancer is the sixth most commonly diagnosed cancer and the fourth leading cause of cancer mortality worldwide.1 Liver transplantation and surgical resection are two curative therapeutic options for liver cancer patients at the early ***,most patients are diagnosed at advanced stages.

关键词： Liver Therapeutic cancer

A Registry-Based Observational Study on the Maternal and Fetal Outcomes of COVID-19 Patients in Hong Kong,China

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Maternal-Fetal Medicine 2024年第3期6卷 156-163页

作者： Hillary HY Leung Teresa WL Ma Florrie NY yu Meliza CW Kong Tsz kin Lo Pauline PL So Wing-Cheong Leung Wendy Shu Ka Wang Cheung Sakita Moungmaithong Chi Chiu Wang Liona C.Poon Department of Obstetrics and Gynaecology The Chinese University of HongKongHong Kong 999077China Department of Obstetrics and Gynaecology Queen Elizabeth HospitalHong Kong 999077China Department of Obstetrics and Gynaecology United Christian HospitalHong Kong 999077China Department of Obstetrics and Gynaecology Princess Margaret HospitalHong Kong 999077China Department of Obstetrics and Gynaecology Tuen Mun HospitalHong Kong 999077China Department of Obstetrics and Gynaecology Kwong Wah HospitalHong Kong 999077China Department of Obstetrics and Gynaecology Pamela Youde Nethersole Eastern HospitalHong Kong 999077China Department of Obstetrics and Gynaecology Queen Mary HospitalHong Kong 999077China

Objective:To report the clinical maternal and fetal outcomes of pregnant women with coronavirus disease 2019(COVID-19),along with any associated pregnancy complications,in Hong Kong,China,and to assess the impact of COVID-19 vaccination on these ***:This prospective registry-based observational study included pregnant women who were recruited through convenient sampling and had a laboratory-confirmed severe acute respiratory syndrome coronavirus 2 infection with a cycle threshold(Ct)value result available on admission to eight local hospitals in Hong Kong,*** on clinical symptoms,laboratory results,medical treatments,delivery timing and mode,and pregnancy complications were extracted from the Hospital Authority’s electronic medical record ***,fetal,and pregnancy outcomes were compared between unvaccinated pregnant women with COVID-19 and those who had received at least one dose of COVID-19 vaccine before *** continuous variables and categorical variables were analyzed using the Mann-Whitney U test and the Pearson’s chi-squared test respectively.A P value less than 0.05 was considered statistically ***:A total of 164 pregnant women were included,of whom 78(47.56%)were ***-19 was diagnosed before 28 weeks’gestation in 30(18.29%),while 134(81.71%)were diagnosed at or after 28 weeks’***-two(37.80%)women received at least one dose of COVID-19 *** were no significant differences between vaccinated and unvaccinated groups in the time interval between COVID-19 diagnosis and delivery,the Ct value,and the gestational age at infection onset or delivery(P>0.05).The majority of women were symptomatic at diagnosis regardless of vaccination status 55(88.71%)in vaccinated group vs.78(76.47%)in unvaccinated group(P=0.052).Symptoms did not significantly differ between groups except for cough(62.90%vs.47.06%,P=0.049).The overall rate of severe COVID-19 in pregnant women was *** t

关键词： COVID-19 Maternal outcomes Fetal outcomes Pregnancy complications Severe COVID-19

考虑偏好差异的企业环境、社会和公司治理(ESG)综合排序

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系统科学与数学 2024年第2期44卷 342-354页

作者：付业林喻寅昀张帆顺黎建强深圳大学经济学院深圳518060 重庆交通大学经济与管理学院重庆400074 湘潭大学商学院湘潭411105 陕西师范大学国际商学院西安710000

ESG投资理念是指投资者在投资决策过程中除了关注资本收益率,还关注企业在环境(environment)、社会(social)、公司治理(governance)方面的表现.可靠的ESG排名能够对投资者决策行为起到良好的引导作用.前人研究发现,由于ESG评级机构之间... 详细信息

ESG投资理念是指投资者在投资决策过程中除了关注资本收益率,还关注企业在环境(environment)、社会(social)、公司治理(governance)方面的表现.可靠的ESG排名能够对投资者决策行为起到良好的引导作用.前人研究发现,由于ESG评级机构之间缺乏一致性,导致同一家企业在不同评级体系下的ESG排名存在差异,这阻碍了ESG发展.针对决策者偏好差异带来的ESG排序差异问题,文章提出一种融合群决策和吉布斯熵的ESG排序方法.具体来说,对于给定的ESG评价数据,首先,依据评价维度重要性顺序构建初始群决策矩阵;其次,利用吉布斯熵与数理模型计算被评企业的最优熵值;最后,给出ESG指数计算模型,实现对被评企业的排序.该研究使用嘉实基金与秩鼎公司发布的ESG数据对所提方法进行仿真研究.同时,基于斯皮尔曼相关系数和满意度指数对该方法的有效性和先进性进行检验.

关键词： ESG评价偏好差异群决策吉布斯熵

Rociletinib(CO-1686) enhanced the efficacy of chemotherapeutic agents in ABCG2-overexpressing cancer cells in vitro and in vivo

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Acta Pharmaceutica Sinica B 2020年第5期10卷 799-811页

作者： Fanpu Zeng Fang Wang Zongheng Zheng Zhen Chen Kenneth kin wah To Hong Zhang Qian Han Liwu Fu The Third Affiliated Hospital of Sun Yat-sen University Guangzhou 510000China State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer MedicineGuangdong Esophageal Cancer InstituteSun Yat-sen University Cancer CenterGuangzhou 510060China School of Pharmacy Faculty of Medicinethe Chinese University of Hong KongHong KongSARChina Guangzhou Handy Biotechnological Co. Ltd.Guangzhou 511400China

Overexpression of adenosine triphosphate(ATP)-binding cassette subfamily G member 2(ABCG2)in cancer cells is known to cause multidrug resistance(MDR),which severely limits the clinical efficacy of ***,there is no FDA-approved MDR modulator for clinical *** this study,rociletinib(CO-1686),a mutant-selective epidermal growth factor receptor(EGFR)tyrosine kinase inhibitor(TKI),was found to significantly improve the efficacy of ABCG2 substrate chemotherapeutic agents in the transporter-overexpressing cancer cells in vitro and in MDR tumor xenografts in nude mice,without incurring additional *** studies revealed that in ABCG2-overexpressing cancer cells,rociletinib inhibited ABCG2-mediated drug efflux and increased intracellular accumulation of ABCG2 probe ***,rociletinib,inhibited the ATPase activity,and competed with[125I]iodoarylazidoprazosin(IAAP)photolabeling of ***,ABCG2 expression at mRNA and protein levels was not altered in the ABCG2-overexpressing cells after treatment with *** addition,rociletinib did not inhibit EGFR downstream signaling and phosphorylation of protein kinase B(AKT)and extracellular signal-regulated kinase(ERK).Our results collectively showed that rociletinib reversed ABCG2-mediated MDR by inhibiting ABCG2 efflux function,thus increasing the cellular accumulation of the transporter substrate anticancer *** findings advocated the combination use of rociletinib and other chemotherapeutic drugs in cancer patients with ABCG2-overexpressing MDR tumors.

关键词： Rociletinib Tyrosine kinase inhibitor Multidrug resistance ABCG2 ATPase

Supramolecular Self-assembly of Amphiphilic Alkynylplatinum(II)2,6-Bis(N-alkylbenzimidazol-2′-yl)pyridine Complexes

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Chemical Research in Chinese Universities 2021年第5期37卷 1079-1084页

作者： Andy Shun-Hoi CHEUNG Sammual yu-Lut LEUNG Franky Ka-wah HAU Vivian Wing-wah YAM Institute of Molecular Functional Materials and Department of Chemistry The University of Hong KongPokfulam RoadHong KongP.R.China

Alkynylplatinum(II)bzimpy complexes of trimethylammoniumbenzylethynyl ligand have been synthesized and *** with long alkyl chains have been found to exhibit interesting self-assembly properties in the acetonitrile *** amphiphilic nature of the complexes has led to the formation of nanorods,as revealed by electron microscopy *** increasing the polarity of the solvent media has given rise to the enhancement of low-energy emission.

关键词： solution. platinum alkyl