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Brucellosis: Pathophysiology and new promising treatments with medicinal plants and natural antioxidants

Asian Pacific Journal of Tropical Medicine 2018年第11期11卷 597-608页

作者： Mohsen Alizadeh Ali Safarzadeh Mahmoud Bahmani Fatemeh BeyranvAND Mehdi Mohammadi kimia azarbaijani Mahmoud Rafieian-Kopaei Saber Abbaszadeh Razi Herbal Medicines Research Center Lorestan University of Medical Sciences Student Research Committee Lorestan University of Medical Sciences Biotechnology and Medicinal Plants Research Center Ilam University of Medical Sciences Medical Plants Research Center Basic Health Sciences Institute Shahrekord University of Medical Sciences

Brucellosis is an old, infectious and common zoonosis whose causative agents are Gramnegative bacteria from the Brucella genus. Brucellosis is transmitted through direct contactwith infected animals or using unpasteurized dairy products of goats, pigs, camels, sheep,buffalo and cows. Brucellosis is still the most common zoonosis in the world, with mostof cases occurring in developing countries. Today, an approach to traditional medicine andmedicinal plants, especially with regards to the repeated recommendations of the World HealthOrganization, is a necessity. One-third of chemical drugs are produced by using plants andthere is a high potential to produce more drugs from plants. Medicinal plants are helpful inthe management of various conditions, especially bacterial diseases. Although there is notenough scientific evidence regarding the clinical effectiveness of herbal drugs for the treatmentof brucellosis, there is strong evidence on the antimicrobial effects of herbal drugs to preventinfection. Therefore, this article seeks to describe the antibacterial effects of some plantderived essential oils or extracts, so that they can serve as promising choices to develop newanti-Brucella medications, as suitable alternatives to conventional antibiotics for brucellosis, asmuch as possible, taking into account the benefits of these herbal drugs.

关键词： Brucellosis Undulant fever Malta fever Herbal drugs Phytotherapy Antioxidant

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