检索结果-南通市图书馆

Incorporation of near-real-time hospital occupancy data to improve hospitalization forecast accuracy during the COVID19 pandemic

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Infectious Disease Modelling 2022年第1期7卷 277-285页

作者： Alexander Preiss Emily Hadley Kasey Jones Marie C.D.Stoner Caroline Kery Peter Baumgartner Georgiy Bobashev Jessica Tenenbaum Charles Carter kimberly Clement Sarah Rhea RTI International Research Triangle ParkNCUSA Explosion BerlinGermany North Carolina Department of Health and Human Services RaleighNCUSA North Carolina State University Department of Population Health and PathobiologyRaleighNCUSA

Public health decision makers rely on hospitalization forecasts to inform COVID-19 pandemic planning and resource *** forecasts are most relevant when they are accurate,made available quickly,and updated *** rapidly adapted an agent-based model(ABM)to provide weekly 30-day hospitalization forecasts(i.e.,demand for intensive care unit[ICU]beds and non-ICU beds)by state and region in North Carolina for public health decision *** ABM was based on a synthetic population of North Carolina residents and included movement of agents(i.e.,patients)among North Carolina hospitals,nursing homes,and the *** assigned SARSCoV-2 infection to agents using county-level compartmental models and determined agents’COVID-19 severity and probability of hospitalization using synthetic population characteristics(e.g.,age,comorbidities).We generated weekly 30-day hospitalization forecasts during MayeDecember 2020 and evaluated the impact of major model updates on statewide forecast accuracy under a SARS-CoV-2 effective reproduction number range of *** the 21 forecasts included in the assessment,the average mean absolute percentage error(MAPE)was 7.8%for non-ICU beds and 23.6%for ICU *** the major model updates,integration of near-real-time hospital occupancy data into the model had the largest impact on improving forecast accuracy,reducing the average MAPE for non-ICU beds from 6.6%to 3.9%and for ICU beds from 33.4%to 6.5%.Our results suggest that future pandemic hospitalization forecasting efforts should prioritize early inclusion of hospital occupancy data to maximize accuracy.

关键词： forecast hospital adapted

Improving bermudagrass in the Southeastern United States with alfalfa as an alternative nitrogen source in grazing systems

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Grassland Research 2022年第4期1卷 280-289页

作者： Justin C.Burt Lisa L.Baxter Christopher G.Prevatt Mary kimberly Mullenix R.Lawton Stewart Jr. Jennifer J.Tucker Department of Animal and Dairy Science University of GeorgiaTiftonGeorgiaUSA Department of Crop and Soil Science University of GeorgiaTiftonGeorgiaUSA Regional Specialized Agent Range Cattle RECUniversity of FloridaGainesvilleFloridaUSA Department of Animal Science Auburn UniversityAuburnAuburnUSA Department of Animal and Dairy Science University of GeorgiaAthensGeorgiaUSA

Background Bermudagrass(Cynodon spp.)is one of the most common perennial warm-season forages grown in the Southeastern United *** incorporation of alfalfa(Medicago sativa)into bermudagrass pastures could serve as an alternative source of nitrogen(N)while also improving the nutritive value of the forage *** A 2-year grazing evaluation arranged in a randomized complete block design was conducted from May to September 2018(Year 1)and May–August 2019(Year 2)in Tifton,GA,*** objective was to compare the production of alfalfa–bermudagrass mixed pastures(BGA)with bermudagrass monoculture pastures with(BGN)or without(BG)the application of synthetic nitrogen on forage production and stocker cattle *** Differences were observed for average daily gain(p=0.10),gain per hectare(p=0.02)and stocking rate(p=0.01),in that BGA was greatest compared to BGN and BG,which did not differ from each ***,BGA had increased forage crude protein(p=0.01)and total digestible nutrients(p=0.01)compared to BGN and ***,BGA provided the greatest economic return per hectare compared to BG or *** These data illustrate improved animal performance and forage nutritive value using alfalfa–bermudagrass systems and offer a viable option for producers seeking alternatives to synthetic N sources for bermudagrass pastures in the Southeastern United States.

关键词： alfalfa-bermudagrass mixtures forage management grazing management

Tobacco cessation pharmacotherapy use among racial/ethnic minorities in the United States:Considerations for primary care

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Family Medicine and Community Health 2017年第3期5卷 193-203页

作者： Monica Webb Hooper Michael Payne kimberly A.Parkinson Case Comprehensive Cancer Center Case Western Reserve UniversityClevelandOHUSA

Pharmacotherapies for tobacco cessation are efficacious and recommended during quit ***/ethnic minorities in the United States are less likely to use medication-based aids for tobacco cessation,despite greater difficulty achieving long-term *** reasons for this include,among others,provider-and patient-level *** care clinicians play an important role in encouraging racial/ethnic minority tobacco users to use cessation *** better understand pharmacotherapy use,we conducted a narrative review of patient-lev-el factors that may determine uptake and *** review indicates that social and cultural factors impact pharmacotherapy use,including health care experiences,beliefs,perceptions,and *** proportion of individuals using pharmacotherapy during quit attempts and adhering to the full course of treatment may be enhanced with greater attention to the ethnocultural concerns of these *** appropriate assessment and brief advice delivered by primary care providers could yield significant benefits in population *** for treating racial/ethnic tobacco users with pharmacotherapy for cessation are offered.

关键词： Tobacco cessation pharmacotherapy racial/ethnic minorities primary care physician advice nicotine replacement therapy varenicline bupropion

Diagnostic Prospectives with Tau Protein and Imaging Techniques to Detect Development of Chronic Traumatic Encephalopathy

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Behavioral and Brain Science 2023年第4期13卷 55-65页

作者： Amit Naskar Danielle Jayanty kimberly Head Gulshan L. Khanna Vatsalya Vatsalya Arpan Banerjee Cognitive Brain Dynamics Lab National Brain Research Centre Manesar India Department of Medicine University of Louisville Louisville KY USA Professor and Pro Vice Chancellor Manav Rachna International Institute of Research and Studies Faridabad India Robley Rex VA Medical Center Louisville KY USA National Institute on Alcohol Abuse and Alcoholism NIH Bethesda MD USA

Brain damage sustained from repeated blows in boxing, wrestling, and other combat sports has serious physical and mental health consequences. The degenerative brain disease, chronic traumatic encephalopathy (CTE), presents clinically with memory loss, aggression, difficulty in rational thinking and other cognitive problems. This spectrum, which mimics Alzheimer’s disease, is diagnosed post-mortem through a brain biopsy in many professional athletes. However, little is known about the process of development and how to identify vulnerable individuals who may be on course for developing CTE. Boxing is a sport that has a severe toll on athletes’ health, primarily on their brain health and function. This review addresses the concerns of brain injury, describes the pathologies that manifest in multiple scales, e.g., molecular and cognitive, and also proposes possible diagnostic and prognostic markers to characterize the early onset of CTE along with the aim to identify a starting point for future precautions and interventions.

关键词： Athletes Axonal Injury Tau Protein Chronic Traumatic Encephalopathy Traumatic Brain Injury Boxing Wrestling

Synthesis of different-sized gold nanostars for Raman bioimaging and photothermal therapy in cancer nanotheranostics

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

中国科学：化学英文版 2017年第9期60卷 1219-1229页

作者： Jie Gao Maria Sanchez-Purra Hao Huang ShunhaoWang Yunan Chen Xuefeng Yu Qian Luo kimberly Hamad-Schifferli Sijin Liu State Key Laboratory of Environmental Chemistry and Ecotoxicology Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China University of Chinese Academy of Sciences.Beijing 100049 China Department of Engineerfng University of Massachusetts BostonBostonMA 02125United States Institute of Biomedicine and Biotechnology Shenzhen Institutes of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China Department of Mechanical Engineering Massachusetts Institute of TechnologyCambridgeMA 02139United States

Gold nanoparticles(AuNPs) have been attractive for nanomedicine because of their pronounced optical ***,we customerized the methods to synthesize two types of gold nanostars,Au nanostars-1 and Au nanostars-2,which have different spire lengths and optical properties,and also spherical *** to nanospheres,gold nanostars were less toxic to a variety of cells,including *** nanostars-1 and Au nanostars-2 also manifested a similar pattern of tissue distribution upon in vivo administration in mice to that of nanospheres,and but reveled less liver retention than *** to their strong absorption in the near-infrared(NIR),Au nanostars-2 induced a strong hyperthermia effect in vitro upon excitation at 808 nm,and elicited a robust photothermal therapy(PTT) efficacy in ablating tumors in a mouse model of orthotopic breast cancer using 4T1 breast cancer ***,Au nanostars-1 showed a great capability to enhance the Raman signal through surface-enhanced Raman spectroscopy(SERS) in 4T1 *** combined results opened a new avenue to develop Au nanostars for cancer imaging and therapy.

关键词： gold nanoparticle, nanostar, surface plasmon resonance, tissue distribution, toxicity profile

Safety and immunogenicity of a third dose of mRNA-1273 vaccine among cancer patients

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Cancer Communications 2023年第7期43卷 749-764页

作者： Anna Giuliano Barbara Kuter Shari Pilon-Thomas Junmin Whiting Qianxing Mo Brett Leav Bradley Sirak Christopher Cubitt Christopher Dukes kimberly Isaacs-Soriano Kayoko Kennedy Somedeb Ball Ning Dong Akriti Jain Patrick Hwu Jeffrey Lancet Department of Cancer Epidemiology Moffitt Cancer CenterTampaFloridaUSA Moderna CambridgeMassachusettsUSA Department of Immunology Moffitt Cancer CenterTampaFloridaUSA Department of Biostatistics and Bioinformatics Moffitt Cancer CenterTampaFloridaUSA Immune Monitoring Core Moffitt Cancer CenterTampaFloridaUSA Non-Therapeutic Research Office(NTRO) Moffitt Cancer CenterTampaFloridaUSA Department of Malignant Hematology Moffitt Cancer CenterTampaFloridaUSA

Background:Compared to the general population,cancer patients are at higher risk of morbidity and mortality following SARS-CoV-2 *** immune response to a two-dose regimen ofmRNA vaccines in cancer patients is generally lower than in immunocompetent *** doses may meaningfully augment immune response in this *** conducted an observational study with the primary objective of determining the immunogenicity of vaccine dose three(100μg)of mRNA-1273 among cancer patients and a secondary objective of evaluating safety at 14 and 28 ***:The mRNA-1273 vaccine was administered~7 to 9 months after administering two vaccine doses(i.e.,the primary series).Immune responses(enzyme-linked immunosorbent assay[ELISA])were assessed 28 days post-dose *** events were collected at days 14(±5)and 28(+5)post-dose *** exact or X^(2)tests were used to compare SARS-CoV-2 antibody positivity rates,and paired t-tests were used to compare SARS-CoV-2 antibody geometric mean titers(GMTs)across different time ***:Among 284 adults diagnosed with solid tumors or hematologic malignancies,dose three of mRNA-1273 increased the percentage of patients seropositive for SARS-CoV-2 antibody from 81.7%pre-dose three to 94.4%28 days post-dose *** increased 19.0-fold(15.8-22.8).Patients with lymphoid cancers or solid tumors had the lowest and highest antibody titers post-dose three,*** responses after dose three were reduced among those who received anti-CD20 antibody treatment,had lower total lymphocyte counts and received anticancer therapy within 3 *** patients seronegative for SARS-CoV-2 antibody pre-dose three,69.2%seroconverted after dose three.A majority(70.4%)experienced mostly mild,transient adverse reactions within 14 days of dose three,whereas severe treatment-emergent events within 28 days were very rare(<2%).Conclusion:Dose three of the mRNA-1273 vaccine was well-tolerated and augmented SAR

关键词： Cancer Coronavirus disease 2019 Immunogenicity Observational study Vaccination

Improving detection of cerebral small vessel disease aetiology in patients with isolated lobar intracerebral haemorrhage

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Stroke & Vascular Neurology 2023年第1期8卷 26-33页

作者： Alvin S Das Elif Gokcal Robert W Regenhardt Mitchell J Horn Kristin Schwab Nader Daoud Anand Viswanathan W Taylor kimberly Joshua N Goldstein Alessandro Biffi Natalia Rost Jonathan Rosand Lee H Schwamm Steven M Greenberg M Edip Gurol Department of Neurology Beth Israel Deaconess Medical CenterHarvard Medical SchoolBostonMassachusettsUSA Department of Neurology Massachusetts General HospitalHarvard Medical SchoolBostonMassachusettsUSA Department of Neurosurgery Massachusetts General HospitalHarvard Medical SchoolBostonMassachusettsUSA Department of Emergency Medicine Massachusetts General HospitalHarvard Medical SchoolBostonMassachusettsUSA

Background and purpose We evaluate whether non-haemorrhagic imaging markers(NHIM)(white matter hyperintensity patterns,lacunes and enlarged perivascular spaces(EPVS))can discriminate cerebral amyloid angiopathy(CAA)from hypertensive cerebral small vessel disease(HTN-cSVD)among patients with isolated lobar intracerebral haemorrhage(isolated-LICH).Methods In patients with isolated-LICH,four cSVD aetiologic groups were created by incorporating the presence/distribution of NHIM:HTN-cSVD pattern,CAA pattern,mixed NHIM and no *** pattern consisted of patients with any combination of severe centrum semiovale EPVS,lobar lacunes or multiple subcortical spots ***-cSVD pattern consisted of any HTN-cSVD markers:severe basal ganglia PVS,deep lacunes or peribasal ganglia white matter hyperintensity *** NHIM consisted of at least one imaging marker from either *** hypothesis was that patients with HTN-cSVD pattern/mixed NHIM would have a higher frequency of left ventricular hypertrophy(LVH),which is associated with *** In 261 patients with isolated-LICH,CAA pattern was diagnosed in 93 patients,HTN-cSVD pattern in 53 patients,mixed NHIM in 19 patients and no NHIM in 96 *** frequency of LVH was similar among those with HTN-cSVD pattern and mixed NHIM(50%vs 39%,p=0.418)but was more frequent in HTN-cSVD pattern compared with CAA pattern(50%vs 20%,p<0.001).In a regression model,HTN-cSVD pattern(OR:7.38;95%CI 2.84 to 19.20)and mixed NHIM(OR:4.45;95%CI 1.25 to 15.90)were found to be independently associated with *** Among patients with isolated-LICH,NHIM may help differentiate HTN-cSVD from CAA,using LVH as a marker for HTN-cSVD.

关键词： patients cerebral hypertensive

High resolution scanning gate microscopy measurements on InAs/GaSb nanowire Esaki diode devices

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Nano Research 2014年第6期7卷 877-887页

作者： James L. Webb Olof Perssor kimberly A. Dick Claes Thelander Rainer Timm Anders Mikkelsen Division of Synchrotron Radiation Research Lund University Sweden Center forAnalysis and Synthesis Lund University Sweden Division of Solid State Physics Lund University Sweden

Gated transport measurements are the backbone of electrical characterization of nanoscale electronic devices. Scanning gate microscopy (SGM) is one such gating technique that adds crucial spatial information, accessing the localized properties of semiconductor devices. Nanowires represent a central device concept due to the potential to combine very different materials. However, SGM on semiconductor nanowires has been limited to a resolution in the 50-100 nm range. Here, we present a study by SGM of newly developed III–V semiconductor nanowire InAs/GaSb heterojunction Esaki tunnel diode devices under ultra-high vacuum. Sub-5 nm resolution is demonstrated at room temperature via use of quartz resonator atomic force microscopy sensors, with the capability to resolve InAs nanowire facets, the InAs/GaSb tunnel diode transition and nanoscale defects on the device. We demonstrate that such measurements can rapidly give important insight into the device properties via use of a simplified physical model, without the requirement for extensive calculation of the electrostatics of the system. Interestingly, by precise spatial correlation of the device electrical transport properties and surface structure we show the position and existence of a very abrupt (<10 nm) electrical transition across the InAs/GaSb junction despite the change in material composition occurring only over 30-50 nm. The direct and simultaneous link between nanostructure composition and electrical properties helps set important limits for the precision in structural control needed to achieve desired device performance.

关键词：半导体纳米线半导体器件隧道二极管高分辨率锑化镓砷化铟测量扫描

Contemporary percutaneous reperfusion therapy for acute myocardial infarction in the elderly

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Geriatric Cardiology 2005年第1期2卷 48-53页

作者： kimberly A.Skelding Charanjit S.Rihal Mayo Clinic Rochester Minnesota USA

Elderly patients with acute myocardial infarction have not been specifically studied in the context of a large randomized clinical trial. Estimates of the efficacy of available treatments are gleaned from subset analyses of clinical trials, retrospective analysis and singlecenter experiences. In western countries the population is aging and a disproportionate number of myocardial infarctions occur in the elderly. Usage of appropriate therapy in this age group is becoming increasingly important given the potential for benefit but also the potential for harm. Recent publications have found steady improvement in outcomes in the elderly population utilizing contemporary interventions.

关键词： acute myocardial infarction elderly percutaneous coronary intervention