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Improving detection of cerebral small vessel disease aetiology in patients with isolated lobar intracerebral haemorrhage

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Stroke & Vascular Neurology 2023年第1期8卷 26-33页

作者： Alvin S Das Elif Gokcal Robert W Regenhardt mitchell J Horn Kristin Schwab Nader Daoud Anand Viswanathan W Taylor kimberly Joshua N Goldstein Alessandro Biffi Natalia Rost Jonathan Rosand Lee H Schwamm Steven m Greenberg m Edip Gurol Department of Neurology Beth Israel Deaconess Medical CenterHarvard Medical SchoolBostonMassachusettsUSA Department of Neurology Massachusetts General HospitalHarvard Medical SchoolBostonMassachusettsUSA Department of Neurosurgery Massachusetts General HospitalHarvard Medical SchoolBostonMassachusettsUSA Department of Emergency medicine Massachusetts General HospitalHarvard Medical SchoolBostonMassachusettsUSA

Background and purpose We evaluate whether non-haemorrhagic imaging markers(NHIm)(white matter hyperintensity patterns,lacunes and enlarged perivascular spaces(EPVS))can discriminate cerebral amyloid angiopathy(CAA)from hypertensive cerebral small vessel disease(HTN-cSVD)among patients with isolated lobar intracerebral haemorrhage(isolated-LICH).methods In patients with isolated-LICH,four cSVD aetiologic groups were created by incorporating the presence/distribution of NHIm:HTN-cSVD pattern,CAA pattern,mixed NHIm and no *** pattern consisted of patients with any combination of severe centrum semiovale EPVS,lobar lacunes or multiple subcortical spots ***-cSVD pattern consisted of any HTN-cSVD markers:severe basal ganglia PVS,deep lacunes or peribasal ganglia white matter hyperintensity *** NHIm consisted of at least one imaging marker from either *** hypothesis was that patients with HTN-cSVD pattern/mixed NHIm would have a higher frequency of left ventricular hypertrophy(LVH),which is associated with *** In 261 patients with isolated-LICH,CAA pattern was diagnosed in 93 patients,HTN-cSVD pattern in 53 patients,mixed NHIm in 19 patients and no NHIm in 96 *** frequency of LVH was similar among those with HTN-cSVD pattern and mixed NHIm(50%vs 39%,p=0.418)but was more frequent in HTN-cSVD pattern compared with CAA pattern(50%vs 20%,pmodel,HTN-cSVD pattern(OR:7.38;95%CI 2.84 to 19.20)and mixed NHIm(OR:4.45;95%CI 1.25 to 15.90)were found to be independently associated with *** Among patients with isolated-LICH,NHIm may help differentiate HTN-cSVD from CAA,using LVH as a marker for HTN-cSVD.

关键词： patients cerebral hypertensive

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Neuropsychological Assessment of Learning and memory in Rats Following Ketamine Exposure during Late Adolescence

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Journal of Behavioral and Brain Science 2020年第12期10卷 568-589页

作者： Julianna m. Davis David Compton miranda Heit Ashley Fravel kimberly Wood Department of Psychology Behavioral Neuroscience Program Palm Beach Atlantic University West Palm Beach USA

With the prevalent issue of drug abuse in society, research regarding the effects of ketamine, a drug frequently abused by youth in club settings, has increased. Despite its potential for misuse, ketamine has demonstrated potential as a fast-acting antidepressant and seems to work well for relieving treatment-resistant depression. However, previous research has shown ketamine use may cause impairments in frontal and medial temporal lobe functioning, leading to problems with memory. While under the influence of ketamine, individuals also display problems with spatial working memory when compared to individuals not dosed with ketamine. The majority of previous research has examined the short-term impact of ketamine use with studies on neurodevelopment largely confined to postnatal exposure. In the present study, the long-term effects on memory caused by repeated ketamine exposure during late adolescence were examined. Rats were used as nonhuman models in order to investigate the cognitive risks resulting from chronic use of ketamine. The results indicated that low-ketamine dosed rats demonstrated significantly better spatial memory recall compared to high-ketamine dosed rats. In addition, high-ketamine dosed rats appeared to struggle more with working memory than the rats in the low-ketamine and control groups. Similarly, both drug groups showed significantly more working memory and reference memory errors than the control group. This indicates that higher doses of ketamine during late adolescence may cause working and spatial memory impairments later in life.

关键词： Ketamine memory Impairments Long-Term Effects Spatial memory Working memory

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Oral spore-based probiotic supplementation was associated with reduced incidence of post-prandial dietary endotoxin, triglycerides, and disease risk biomarkers

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World Journal of Gastrointestinal Pathophysiology 2017年第3期8卷 117-126页

作者： Brian K mcFarlin Andrea L Henning Erin m Bowman melody A Gary kimberly m Carbajal Applied Physiology Laboratory University of North Texas Department of Biological Sciences University of North Texas

To determine if 30-d of oral spore-based probiotic supplementation could reduce dietary endotoxemia. mETHODSApparently healthy men and women (n = 75) were screened for post-prandial dietary endotoxemia. Subjects whose serum endotoxin concentration increased by at least 5-fold from pre-meal levels at 5-h post-prandial were considered “responders” and were randomized to receive either placebo (rice flour) or a commercial spore-based probiotic supplement [Bacillus indicus (HU36), Bacillus subtilis (HU58), Bacillus coagulans, and Bacillus licheniformis, and Bacillus clausii] for 30-d. The dietary endotoxemia test was repeated at the conclusion of the supplementation period. Dietary endotoxin (LAL) and triglycerides (enzymatic) were measured using an automated chemistry analyzer. Serum disease risk biomarkers were measured using bead-based multiplex assays (Luminex and milliplex) as secondary, exploratory measures. RESULTSData were statistically analyzed using repeated measures ANOVA and a P mentation was associated with a 42% reduction in endotoxin (12.9 ± 3.5 vs 6.1 ± 2.6, P = 0.011) and 24% reduction in triglyceride (212 ± 28 vs 138 ± 12, P = 0.004) in the post-prandial period Placebo subjects presented with a 36% increase in endotoxin (10.3 ± 3.4 vs 15.4 ± 4.1, P = 0.011) and 5% decrease in triglycerides (191 ± 24 vs 186 ± 28, P = 0.004) over the same post-prandial period. We also found that spore-based probiotic supplementation was associated with significant post-prandial reductions in IL-12p70 (24.3 ± 2.2 vs 21.5 ± 1.7, P = 0.017) and IL-1β (1.9 ± 0.2 vs 1.6 ± 0.1, P = 0.020). Compared to placebo post supplementation, probiotic subject had less ghrelin (6.8 ± 0.4 vs 8.3 ± 1.1, P = 0.017) compared to placebo subjects. CONCLUSIONThe key findings of the present study is that oral spore-based probiotic supplementation reduced symptoms indicative of “leaky gut syndrome”.

关键词： metabolic endotoxemia Chronic disease Leaky gut syndrome Probiotics multiplex Cardiovascular disease Inflammatory cytokines High-fat meal challenge

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Low-magnitude high-frequency vibration reduces prostate cancer growth and extravasation in vitro

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mechanobiology in medicine 2024年第4期2卷 83-96页

作者： Amel Sassi kimberly Seaman Xin Song Chun-Yu Lin Yu Sun Lidan You Institute of Biomedical Engineering University of TorontoM5S 3G9Canada Department of mechanical&Industrial Engineering University of TorontoM5S 3G9Canada Department of mechanical and materials Engineering Queen's UniversityK7L 3N6Canada

Prostate cancer(PCa)continues to rank among the most common malignancies in Europe and North America with significant mortality rates despite advancements in detection and *** activity is often recommended to PCa patients due to its benefits in preventing disease recurrence and managing treatment-related side ***,physical activity may be challenging for elderly or bedridden *** such,vibration therapy has been proposed as a safe,effective,and easy to perform alternative treatment that may confer similar effects as physical ***,low-magnitude high frequency(LmHF)vibration has been shown to decrease breast cancer extravasation into the bone and reduce other types of cancer proliferation by impacting cell ***,we investigated the effects of daily application of LmHF vibration(0.3 g,60 Hz,1 hour/day for 3 days)on prostate cancer growth and bone metastasis in *** findings suggest that LmHF vibration significantly reduces colony formation through a decrease in cell growth and ***,using a 3D cell culture model,LmHF vibration significantly reduces PC3 spheroid ***,LmHF vibration reduces PCa cell extravasation into the bone microenvironment through the stimulation of osteocytes and subsequent osteocyte-endothelial cell cross *** findings highlight the potential of LmHF vibration for managing PCa growth and metastasis.

关键词： Low-magnitude high-frequency vibration mechanical loading Vibration Prostate cancer Bone metastasis Osteocyte microfluidic Spheroid

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Addition of hip exercises to treatment of patellofemoral pain syndrome:A meta-analysis

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World Journal of meta-Analysis 2015年第2期3卷 118-124页

作者： kimberly m morelli maria Carrelli maria A Nunez Caroline A Smith Gordon L Warren Department of Physical Therapy Georgia State University

AIm:To determine if the addition of hip-strengthening exercises decreases pain and improves function in patients with patellofemoral pain ***:The authors completed a systematic reviewsearching eight databases(i.e.,Pub med,Cochrane,CINHAL,mEDLINE,Sports Discus,EmBASE,APTA Hooked on Evidence,and PEDro).Two independent reviewers screened and excluded studies if they did not meet the following inclusion criteria:subjects had a primary diagnosis of patellofemoral pain syndrome(PFPS),intervention group included hip-strengthening exercises,control group included a traditional physical therapy intervention,study included outcome measures of pain and/or function,study used a randomized controlled trial design,PEDro score was ≥ 7,and study was published in a peer-reviewed *** outcome measures were subjective scales of pain and *** measures were converted to standardized mean difference [effect size(ES)],and a random-effects model was used to calculate the overall ***:Two hundred eighty-three studies were screened for inclusion in our *** studies were deemed suitable for data extraction and analysis.A total of 426 subjects were used in the nine ***,there was a significant positive effect of hip-strengthening exercises on measures of pain and function in subjects with PFPS(ES = 0.94,P = 0.00004).None of the individual studies had a negative ES,with study ES ranging from 0.35 to *** of the high degree of between-study variance(I2 = 76%;Q = 34.0,P meta-analyses and meta-regressions were *** of the potential moderator variables that were investigated(e.g.,outcome type,hip region targeted,duration of treatment) could explain a significant amount of the between-study variance in ES(P ≥ 0.23).CONCLUSION:Overall,the addition of hip-strengthening exercises to traditional physical therapy produced greater improvements in measures of pain and function.

关键词： Exercise therapy Systematic review Knee joint Physical therapy modalities

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A randomized trial comparing the Tennant Biomodulator to transcutaneous electrical nerve stimulation and traditional Chinese acupuncture for the treatment of chronic pain in military service members

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military medical Research 2020年第2期7卷 140-150页

作者： kimberly S.Peacock Erika Stoerkel Salvatore Libretto Weimin Zhang Alice Inman michael Schlicher John D.Cowsar Jr David Eddie Joan Walter University of Texas Health San Antonio 7703 Floyd Curl DriveSan AntonioTX78229USA TLI Foundation 1750 Tysons BoulevardMcLeanVirginia22102USA Henry m.Jackson Foundation 6720A Rockledge DriveBethesdaMD20817USA BD Life Sciences 1 Becton DriveFranklin LakesNJ07417USA Brooke Army medical Center 3551 Roger Brooke DriveFort Sam HoustonTX78234USA madigan Army medical Center 9040A Jackson AveJoint Base Lewis-McChordWA98431USA medPost Urgent Care Center 513 Cibolo Valley DriveCiboloTX78108USA massachusetts General Hospital Harvard Medical School151 Merrimac St.6th FloorBostonMA02114USA H&S Ventures Samueli Integrative Health Program1800 Diagonal RoadSuite 617AlexandriaVA22314USA

Background:The present investigation tested the efficacy of the Tennant Biomodulator,a novel pain management intervention that uses biofeedback-modulated electrical stimulation,to reduce chronic pain and its psychosocial sequelae in a sample of current and former military service *** Tennant Biomodulator used on its most basic setting was compared to two commonly used,non-pharmacological pain treatments—traditional Chinese acupuncture and transcutaneous electrical nerve stimulation(TENS)—in a comparative efficacy,randomized,open-label ***:Participants included 100 active duty and retired service men and women with chronic pain undergoing treatment at the Brooke Army medical Center in Texas,USA,randomly assigned to receive six,weekly sessions of either Tennant Biomodulator treatment,traditional Chinese acupuncture,or TENS,in addition to usual *** was conducted between may 2010 to September *** measures were collected at intake,before and after each treatment session,and at a 1-month ***-to-treat analyses were used throughout,with mixed models used to investigate main effects of group,time,and group×time interactions with consideration given to quadratic *** measured included ratings of chronic pain,pain-related functional disability,and symptoms of post-traumatic stress disorder(PTSD)and ***:On average,regardless of their treatment group,participants exhibited a 16%reduction in pain measured by the Brooke Army medical Center’s Clinic Pain Log[F(1,335)=55.7,Pmeasured by the million Visual Analog Scale[mVAS:F(1,84)=28.3,Pm baseline to the end of treatment,but no one treatment performed better than the other,and the reductions in pain and pain-related disability were largely lost by 1-month *** of PTSD and depression did not change significantly as a function of time or ***:Findings build on previ

关键词： Tennant biomodulator Acupuncture Transcutaneous electrical nerve stimulation Chronic pain military service members

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Spatiotemporal microRNA profile in peripheral nerve regeneration:miR-138 targets vimentin and inhibits Schwann cell migration and proliferation

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Neural Regeneration Research 2018年第7期13卷 1253-1262页

作者： Travis B.Sullivan Litchfield C.Robert Patrick A.Teebagy Shannon E.morgan Evan W.Beatty Bryan J.Cicuto Peter K.Nowd kimberly m.Rieger-Christ David J.Bryan Department of Translational Research Lahey Hospital & Medical Center Tissue Engineering Laboratory Lahey Hospital & Medical Center Department of Plastic and Reconstructive Surgery Lahey Hospital & Medical Center

While the peripheral nervous system has regenerative ability,restoration of sufficient function remains a *** has been shown to be localized in axonal growth fronts and associated with nerve regeneration,including myelination,neuroplasticity,kinase signaling in nerve axoplasm,and cell migration;however,the mechanisms regulating its expression within Schwann cell（SC） remain *** aim of this study was to profile the spatial and temporal expression profile of micro RNA（mi RNA） in a regenerating rat sciatic nerve after transection,and explore the potential role of mi R-138-5 p targeting vimentin in SC proliferation and migration.A rat sciatic nerve transection model,utilizing a polyethylene nerve guide,was used to investigate mi RNA expression at 7,14,30,60,and 90 days during nerve *** levels of mi RNA expression were determined using microarray analysis and subsequently validated with quantitative real-time polymerase chain *** vitro assays were conducted with cultured Schwann cells transfected with mi RNA mimics and assessed for migratory and proliferative *** top seven dysregulated mi RNAs reported in this study have been implicated in cell migration elsewhere,and GO and KEGG analyses predicted activities essential to wound *** of one of these,mi RNA-138-5 p,into SCs reduced cell migration and *** R-138-5 p has been shown to directly target vimentin in cancer cells,and the luciferase assay performed here in rat Schwann cells confirmed *** results detail a role of mi R-138-5 p in rat peripheral nerve regeneration and expand on reports of it as an important regulator in the peripheral nervous system.

关键词： non-coding RNA neural regeneration nerve guide sciatic nerve transection peripheral nerve injury wound healing Gene Ontology processes Kyoto Encyclopedia of Genes and Genomes pathways microarray luciferase assay

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Pituitary Lesions, Obesity, and mesenteric Lipomas in Insulin-Resistant Horses

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Open Journal of Veterinary medicine 2014年第9期4卷 190-196页

作者： kimberly m. Newkirk Kelly A. Chameroy Elizabeth m. Tadros Barton W. Rohrbach Nicholas Frank Department of Biomedical and Diagnostic Sciences College of Veterinary Medicine University of Tennessee Knoxville TN USA Department of Large Animal Clinical Sciences College of Veterinary Medicine University of Tennessee Knoxville TN USA

The aim of the current study was to identify associations between pituitary lesions, body condition scores, and mesenteric lipomas in horses with insulin resistance. Necropsy examinations were performed following euthanasia in 30 adult horses designated as insulin resistant (n = 11) or insulin sensitive (n = 19). Insulin sensitivity was determined using the insulin-modified frequently sampled intravenous glucose tolerance test and resting insulin concentrations. At necropsy, mesenteric lipomas were measured. The pituitary and adrenal glands, pancreas, and liver were evaluated histologically;pituitary glands were scored based on published criteria. Insulin-resistant horses had significantly higher pituitary scores (p = 0.0035) and body condition scores (p = 0.0001), even when adjusting for age, and a greater frequency of mesenteric lipomas (p = 0.014) and greater lipoma area (p = 0.0332) than insulin-sensitive horses. Regardless of insulin status, horses with pituitary scores ≥3 (diffuse hyperplasia;n = 25) had higher body condition scores (p = 0.0313) and a greater frequency of mesenteric lipomas (p mesenteric lipomas. Detection of higher pituitary scores in insulin-resistant horses suggested an association between insulin resistance and pituitary morphology. Horses in the insulin-resistant group and those with high pituitary scores had higher body condition scores and a greater frequency of mesenteric lipomas. These horses might be at increased risk for lipoma-associated colic.

关键词： Body Condition Score Horse Insulin Resistance mesenteric Lipoma Pituitary

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面向热界面应用的多壁碳纳米管阵列生长优化

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工程热物理学报 2017年第6期38卷 1323-1326页

作者：邱琳 SCHEIDER kimberly RADWAN Abu Suhaib LARKIN Sarah LeighAnn SALTONSTALL Blair Christopher 冯妍卉张欣欣 NORRIS m Pamela 北京科技大学能源与环境工程学院北京100083 北京科技大学冶金工业节能减排北京市重点实验室北京100083 弗吉尼亚大学机械与航空航天工程系夏洛茨维尔va229044746

由于杰出的导热和柔韧性能,碳纳米管被认为是提升大功率微电子系统热耗散性能的理想热界面材料。多壁碳纳米管阵列能实现低成本的大规模生产,成为制备热界面材料的最佳选择。但是多壁碳纳米管阵列的生长过程的最优因素尚未廓清。本文从... 详细信息

由于杰出的导热和柔韧性能,碳纳米管被认为是提升大功率微电子系统热耗散性能的理想热界面材料。多壁碳纳米管阵列能实现低成本的大规模生产,成为制备热界面材料的最佳选择。但是多壁碳纳米管阵列的生长过程的最优因素尚未廓清。本文从实验上系统研究了催化剂的升华温度对浮动催化化学气相沉积法制备出的多壁碳纳米管阵列结构及热输运的影响规律,得到了最佳的催化剂升华温度,为实现最优导热性能的多壁碳纳米管阵列热界面材料提供实验指导。

关键词：热界面材料多壁碳纳米管阵列浮动催化化学气相沉积拉曼光谱

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Understanding the agronomic impacts of defoliation strategies in“Bulldog 805”Alfalfa+“Tifton 85”bermudagrass mixed stands

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Grassland Research 2023年第4期2卷 251-259页

作者： Lisa L.Baxter Justin C.Burt mary kimberly mullenix Sydney L.Payne Kaylyn R.Reagin Katie m.mason Chris G.Prevatt Jennifer J.Tucker Department of Crop and Soil Science University of GeorgiaTiftonGeorgiaUSA Department of Animal Science Auburn UniversityAuburnAlabamaUSA Department of Animal Science University of TennesseeKnoxvilleTennesseeUSA Beef Cattle and Forage Commodity Director Alabama Farmers Federation MontgomeryMontgomeryAlabamaUSA Department of Animal and Dairy Science University of GeorgiaTiftonGeorgiaUSA

Background:The incorporation of legumes,specifically alfalfa(medicago sativa L.),into bermudagrass(Cynodon spp.)-based pasture systems in the southeastern United States has increased in recent years as an alternative to synthetic nitrogen(N)***:A small plot evaluation was conducted in Shorter,Alabama,and Tifton,Georgia,USA,to evaluate the impact of harvest height(HH)and harvest frequency(HF)on agronomic characteristics of alfalfa+bermudagrass mixtures in southeastern United ***:Results from both locations revealed that the longer the HF and the shorter the HH,the greater the alfalfa retention was in the stand(pmpact any of the reported nutritive value parameters,while longer HF resulted in lower total digestible nutrients,lower crude protein,higher acid detergent fiber,and lower 48 h in vitro dry matter digestibility(pmpacted forage accumulation at both locations(pmed recent findings from comparable evaluations in the southeastern United States,in that increasing HH and decreasing HF improved alfalfa retention while having a negligible effect on nutritive value or forage accumulation.

关键词： alfalfa+bermudagrass mixtures defoliation management forage management

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