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the lncRNA BORG: a novel inducer of tNBC metastasis, chemoresistance, and disease recurrence

Journal of Cancer Metastasis and treatment 2019年第5期4卷 48-61页

作者： Alex J.Gooding kimberly A.Parker Saba Valadkhan William P.Schiemann Department of Pathology Case Western Reserve UniversityClevelandOH 44106USA Department of Pharmacology Case Western Reserve UniversityClevelandOH 44106USA Department of Molecular Biology and Microbiology Case Western Reserve UniversityClevelandOH 44106USA Case Comprehensive Cancer Center Case Western Reserve UniversityClevelandOH 44106USA

Although greater than 90% of breast cancer-related mortality can be attributed to metastases, the molecular mechanisms underpinning the dissemination of primary breast tumor cells and their ability to establish malignant lesions in distant tissues remain incompletely understood. Genomic and transcriptomic analyses identified a class of transcripts called long noncoding RNA (lncRNA), which interact both directly and indirectly with key components of gene regulatory networks to alter cell proliferation, invasion, and metastasis. We identified a pro-metastatic lncRNA BMP/OP-Responsive Gene (BORG) whose aberrant expression promotes metastatic relapse by reactivating proliferative programs in dormant disseminated tumor cells (DtCs). BORG expression is broadly and strongly induced by environmental and chemotherapeutic stresses, a transcriptional response that facilitates the survival of DtCs. transcriptomic reprogramming in response to BORG resulted in robust signaling via survival and viability pathways, as well as decreased activation of cell death pathways. As such, BORG expression acts as a (1) marker capable of predicting which breast cancer patients are predisposed to develop secondary metastatic lesions;and (2) unique therapeutic target to maximize chemosensitivity of DtCs. Here we review the molecular and cellular factors that contribute to the pathophysiological activities of BORG during its regulation of breast cancer metastasis, chemoresistance, and disease recurrence.

关键词： BORG chemoresistance disease recurrence dormancy long noncoding RNA metastasis triple-negative breast cancer

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Genetics-inspired data-driven approaches explain and predict crop performance fluctuations attributed to changing climatic conditions

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Molecular Plant 2022年第2期15卷 203-206页

作者： Xianran Li tingting Guo Guihua Bai Zhiwu Zhang Deven See Juliet Marshall kimberly A.Garland-Campbell Jianming Yu USDA Agricultural Research ServiceWheat HealthGeneticsand Quality Research UnitPullmanWA 99164USA Department of Agronomy Iowa State UniversityAmesIA 50011USA USDA Agricultural Research ServiceHard Winter Wheat Genetics Research UnitManhattanKS 66506USA Department of Crop and Soil Sciences Washington State UniversityPullmanWA 99164USA Department of Plant Sciences University of Idaho Research and ExtensionIdaho FallsID 83402USA

Dear Editor,Genetics-focused approaches have been widely used to uncover major genetic variants associated with performance ***,manipulating,and editing genetic variants significantly improve crop ***,the genetic component explains a portion of performance variation,and the environ-mental component contributes to the remaining,often large,portion(Laidig et al.,2017;Bonecke et al.,2020;Li et al.,2021).to ensure superior and robust performance,elite varieties are extensively tested across multiple years and *** extensive performance records,coupled with climatic profiles,could be leveraged to understand climate's impact on agriculture through approaches parallel to quantitative genetics approaches(Figure 1A).

关键词： performance attributed Figure

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A randomized trial comparing the tennant Biomodulator to transcutaneous electrical nerve stimulation and traditional Chinese acupuncture for the treatment of chronic pain in military service members

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Military Medical Research 2020年第2期7卷 140-150页

作者： kimberly S.Peacock Erika Stoerkel Salvatore Libretto Weimin Zhang Alice Inman Michael Schlicher John D.Cowsar Jr David Eddie Joan Walter University of texas Health San Antonio 7703 Floyd Curl DriveSan AntonioTX78229USA tLI Foundation 1750 Tysons BoulevardMcLeanVirginia22102USA Henry M.Jackson Foundation 6720A Rockledge DriveBethesdaMD20817USA BD Life Sciences 1 Becton DriveFranklin LakesNJ07417USA Brooke Army Medical Center 3551 Roger Brooke DriveFort Sam HoustonTX78234USA Madigan Army Medical Center 9040A Jackson AveJoint Base Lewis-McChordWA98431USA MedPost Urgent Care Center 513 Cibolo Valley DriveCiboloTX78108USA Massachusetts General Hospital Harvard Medical School151 Merrimac St.6th FloorBostonMA02114USA H&S Ventures Samueli Integrative Health Program1800 Diagonal RoadSuite 617AlexandriaVA22314USA

Background:the present investigation tested the efficacy of the tennant Biomodulator,a novel pain management intervention that uses biofeedback-modulated electrical stimulation,to reduce chronic pain and its psychosocial sequelae in a sample of current and former military service *** tennant Biomodulator used on its most basic setting was compared to two commonly used,non-pharmacological pain treatments—traditional Chinese acupuncture and transcutaneous electrical nerve stimulation(tENS)—in a comparative efficacy,randomized,open-label ***:Participants included 100 active duty and retired service men and women with chronic pain undergoing treatment at the Brooke Army Medical Center in texas,USA,randomly assigned to receive six,weekly sessions of either tennant Biomodulator treatment,traditional Chinese acupuncture,or tENS,in addition to usual *** was conducted between May 2010 to September *** measures were collected at intake,before and after each treatment session,and at a 1-month ***-to-treat analyses were used throughout,with mixed models used to investigate main effects of group,time,and group×time interactions with consideration given to quadratic *** measured included ratings of chronic pain,pain-related functional disability,and symptoms of post-traumatic stress disorder(PtSD)and ***:On average,regardless of their treatment group,participants exhibited a 16%reduction in pain measured by the Brooke Army Medical Center’s Clinic Pain Log[F(1,335)=55.7,Ption in pain-related disability measured by the Million Visual Analog Scale[MVAS:F(1,84)=28.3,Pto the end of treatment,but no one treatment performed better than the other,and the reductions in pain and pain-related disability were largely lost by 1-month *** of PtSD and depression did not change significantly as a function of time or ***:Findings build on previ

关键词： tennant biomodulator Acupuncture transcutaneous electrical nerve stimulation Chronic pain Military service members

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ICC density predicts bacterial overgrowth in a rat model of post-infectious IBS

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World Journal of Gastroenterology 2010年第29期16卷 3680-3686页

作者： Sam-Ryong Jee Walter Morales kimberly Low Christopher Chang Amy Zhu Venkata Pokkunuri Soumya Cha.terjee Edy Soffer Jeffrey L Conklin Mark Pimentel GI Motility Program Division of GastroenterologyCedars-Sinai Medical Center

AIM:to investigate the interstitial cells of Cajal(ICC) number using a new rat ***:Sprague-Dawley rats were assigned to two *** first group received gavage with Campylobacter jejuni(***) *** second group was gavaged with *** months after clearance of Campylobacter from the stool,precise segments of duodenum,jejunum,and ileum were ligated in self-contained loops of bowel that were preserved in anaerobic *** muscular plexus ICC(DMP-ICC) were quantified by two blinded readers assessing the tissue in a random,coded *** number of ICC per villus was compared among controls,Campylobacter recovered rats without small intestinal bacterial overgrowth(SIBO),and Campylobacter recovered rats with ***:three months after recovery,27% of rats gavaged with *** had *** rats with SIBO had a lower number of DMP-ICC than controls in the jejunum and *** there appeared to be a density threshold of 0.12 DMP-ICC/villus that was associated with *** ileal density of DMP-ICC was ts had SIBO compared to 9% among ileal sections with > 0.12(Pthe density of ICC was than one location of the bowel,88% of these had SIBO compared to 6% in those who did not(Pthis post-infectious rat model,the development of SIBO appears to be associated with a reduction in *** study of this rat model might help understand the pathophysiology of postinfectious irritable bowel syndrome.

关键词： Post-infectious irritable bowel syndrome Bacterial overgrowth Interstitial cells of Cajal Campylobacter

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Oncogene addiction and non-oncogene addiction in glioblastoma therapy

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Chinese Medical Journal 2011年第17期124卷 2565-2568页

作者： kimberly Ng Clark C. Chen Department of Radiation Oncology Dana-Farber Cancer Institute Boston MA USA Division of Neurosurgery Beth Israel Deaconess Medical Center Boston MA USA

INtRODUCtIONGlioblastoma is the most common form of primary brain tumor. the incidence of this tumor is fairly low, with 2-3 cases per 100 000 people in Europe and North America.

关键词： Oncogene addiction glioblastoma

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