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Methods for engineering therapeutic peptides

Chinese Chemical Letters 2018年第7期29卷 1074-1078页

作者： Yaohao Li kimberly a.clark Zhongping Tan Department of Chemistry and Biochemistry and BioFrontiers Institute University of Colorado

Peptides are a class of drugs that have become increasingly important and influential for the treatment of many human diseases. Compared to traditional small molecule drugs, peptides have the potential for higher target specificity and potency, along with better safety profiles. On the other hand, the complex and fragile nature of peptides poses significant challenges for their administration. Of particular concern is that they are often unstable and can be rapidly degraded by various proteases after dosing. To address these inherent problems of peptides, many different methods have been attempted. Here, we briefly review these methods, with an emphasis on the effect of each method.

关键词： Therapeutic peptides Engineering Half-life Stability Solubility Aggregation Permeability

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The Role of Impulsivity and Addiction in Gambling Behaviors: How Applied Neuroscience Research Can Help in the Monitoring and Management of Mental Health Issues

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Open Journal of Medical Psychology 2024年第1期13卷 11-24页

作者： Yingzhen Jia kimberly Rose clark College of Arts and Sciences Boston University Boston MA USA Department of Psychological and Brain Sciences Dartmouth College Hanover NH USA

One in five Americans experience symptoms associated with at least one mental health disorder every year. These include behavioral addictions, which have long been overlooked despite their similar neural bases with substance addictions. Gambling addiction, a type of behavioral addiction, deserves particular attention given the significant negative effects, this addiction has on financial and interpersonal health. The purpose of this paper is to review the available literature concerning the behavioral and neural processes involved in gambling addiction, including: the anticipation of reward, the role of dopamine, and the neural substrates of the decision-making processes involved in gambling addiction. Market research has also identified solutions that integrate applied neuroscience and self-tracking systems to monitor and manage mental health issues associated with gambling addiction. The authors then propose a gambling treatment-focused mobile app solution that addresses outstanding issues with a special design aimed at reversing plasticity in order to relieve the effects of gambling addiction. .

关键词： Applied Neuroscience Gambling Addiction Mental Health Management

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Oncogene addiction and non-oncogene addiction in glioblastoma therapy

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Chinese Medical Journal 2011年第17期124卷 2565-2568页

作者： kimberly Ng clark C. Chen Department of Radiation Oncology Dana-Farber Cancer Institute Boston MA USA Division of Neurosurgery Beth Israel Deaconess Medical Center Boston MA USA

INTRODUCTIONGlioblastoma is the most common form of primary brain tumor. The incidence of this tumor is fairly low, with 2-3 cases per 100 000 people in Europe and North America.

关键词： Oncogene addiction glioblastoma

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