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Effect of Sim-eui point on causes of nasal obstruction such as allergic rhinitis and rhinosinusitis

World Journal of Acupuncture-Moxibustion 2010年第4期20卷 53-53页

作者： Kwon.HJ kim.CH kim.yong-suk Kyung Hee University

Purpose This study was done to verify the effectiveness of acupuncture treatment on nasal obstruction caused by allergic rhinitis or rhinosinusitis, and to know the clinical effect of a novel acupuncture point named Sim-eui. Method Rhinitis patients with at least two visits to the hospital from September, 2009 to November, 2009 were randomized into either experiment or control group. The experiment group were treated with acupuncture on generally used points of rhinitis, that are GV 22, GV 23, GV 24, ST 8 (both sides), BL 2 (both sides), ST 4 (both sides), as well as Sim-eui point. The control group were treated with the general points and LI20(both sides) instead of Sim-eui point. Acupuncture needles were left in for 15 minutes for both groups. The initial and final symptom scores of SNOT-20 and a modified VAS were used to evaluate the effectiveness. The program used for statistical analysis was SPSS 15.0 for window. Wilcoxon Signed Ranks Test was done to analyze the intra-group symptom score change before and after treatment, and Mann-Whitney Test was used to compare inter-group VAS change. All the statistics were verified at a signifi cance level of 5%. Result The SNOT-20 scores before and after acupuncture treatment showed significant changes on both experiment and control groups, but there was no signifi cant difference between the two groups. All categories of the SNOT-20 showed signifi cant result, except the 'Wake up at night' and 'Lack of a good night's sleep' entries. The modifi ed VAS showed significant improvement of symptom in the experiment group compared with control group. Conclusion Acupuncture treatment using Sim-eui point seems to be helpful in improving quality of life by immediate relief of nasal obstruction.

关键词：中医学针灸学针法灸法

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Regulation of sleep by astrocytes in the hypothalamic ventrolateral preoptic nucleus

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Neural Regeneration Research 2025年第4期20卷 1098-1100页

作者： Jae-Hong kim Ruqayya Afridi Il-Sung Jang Maan Gee Lee Kyoungho suk Brain Korea 21 four KNU Convergence Educational Program of Biomedical Sciences for Creative Future Talents School of MedicineKyungpook National UniversityDaeguRepublic of Korea Department of Pharmacology School of MedicineKyungpook National UniversityDaeguRepublic of Korea Department of Pharmacology School of DentistryKyungpook National UniversityDaeguRepublic of Korea Brain Science&Engineering Institute Kyungpook National UniversityDaeguRepublic of Korea

Astrocytes are functionally dynamic cells that support neurons in multiple ways throughout an organism’s *** astrocytic regulation of neuronal activity has been increasingly recognized in recent *** are now recognized as playing a more complex role than mere bystanders in the central nervous ***,their role in regulating the sleep neurocircuitry is not well *** this perspective,we highlight the role of astrocytes in sleep modulation,with a particular focus on regulatory mechanisms related to the ventrolateral preoptic nucleus(VLPO)of the *** briefly discuss recent literature reporting the role of VLPO astrocytes in regulating sleep-associated behaviors.

关键词： sleep ventrolateral astrocytes

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Prominent cycling reversibility and kinetics enabled by CaTiO3 protective layer on Zn metal for aqueous Zn-ion batteries

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Journal of Energy Chemistry 2025年第1期100卷 245-258页

作者： Gaeun Lee yong Nam Ahn Seongjoon So Chanwoo Park Jong-Seong Bae Taehyun Park Il Tae kim Jaehyun Hur School of Chemical Biological and Battery Engineering Gachon University Seongnam Busan Center Korea Basic Science Institute

Aqueous Zn-ion batteries （AZIBs） have received considerable attention owing to their various advantages such as safety,low cost,simple battery assembly conditions,and high ionic ***,they still suffer from serious problems,including uncontrollable dendrite growth,corrosion,hydrogen evolution reaction （HER） from water decomposition,electrode passivation,and unexpected *** creation of a uniform artificial nanocrystal layer on the Zn anode surface is a promising strategy for resolving these ***,we propose the use of a perovskite CaTiO3（CTO） protective layer on Zn（CTO@Zn） as a promising approach for improving the performance of *** CTO artificial layer provides an efficient pathway for Zn ion diffusion towards the Zn metal because of the high dielectric constant （εr=180） and ferroelectric characteristics that enable the alignment of dipole moments and redistribute the Zn2+ions in the CTO *** avoiding the direct contact of the Zn anode with the electrolyte solution,the uneven dendrite growth,corrosion,parasitic side reactions,and HER are mitigated,while CTO retains its mechanical and chemical robustness during ***,CTO@Zn demonstrates an improved lifespan in a symmetric cell configuration compared with bare ***@Zn shows steady overpotential （～68 m V） for 1500 h at 1 mA cm-2/0.5 mA h cm-2,excelling bare ***,when paired with the V2O5-C cathode,the CTO@Zn//V2O5-C full battery delivers 148.4 mA h g-1（based on the mass of the cathode） after 300 *** study provides new insights into Zn metal anodes and the development of high-performance AZIBs.

关键词： Perovskite

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Optimal Cyber Attack Strategy Using Reinforcement Learning Based onCommon Vulnerability Scoring System

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Computer Modeling in Engineering & Sciences 2024年第11期141卷 1551-1574页

作者： Bum-Sok kim Hye-Won suk yong-Hoon Choi Dae-Sung Moon Min-suk kim Department of Electronic Information System Engineering Sangmyung UniversityCheonan31066Republic of Korea Department of Human Intelligence&Robot Engineering Sangmyung UniversityCheonan31066Republic of Korea Intelligent Convergence Research Laboratory Electronics and Telecommunications Research InstituteDaejeon34129Republic of Korea

Currently,cybersecurity threats such as data breaches and phishing have been on the rise due to the many differentattack strategies of cyber attackers,significantly increasing risks to individuals and *** technologies such as intrusion detection have been developed to respond to these cyber ***,advanced integrated cybersecurity that incorporates Artificial Intelligence has been the *** this paper,wepropose a response strategy using a reinforcement-learning-based cyber-attack-defense simulation tool to addresscontinuously evolving cyber ***,we have implemented an effective reinforcement-learning-basedcyber-attack scenario using Cyber Battle Simulation,which is a cyber-attack-defense *** scenarioinvolves important security components such as node value,cost,firewalls,and ***,we applieda new vulnerability assessment method based on the Common Vulnerability Scoring *** approach candesign an optimal attack strategy by considering the importance of attack goals,which helps in developing moreeffective response *** attack strategies are evaluated by comparing their performance using a variety ofReinforcement Learning *** experimental results show that RL models demonstrate improved learningperformance with the proposed attack strategy compared to the original *** particular,the success rateof the Advantage Actor-Critic-based attack strategy improved by 5.04 percentage points,reaching 10.17%,whichrepresents an impressive 98.24%increase over the original ***,the proposed method canenhance security and risk management capabilities in cyber environments,improving the efficiency of securitymanagement and significantly contributing to the development of security systems.

关键词： Reinforcement learning common vulnerability scoring system cyber attack cyber battle simulation

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Associations of non-high-density lipoprotein cholesterol with metabolic syndrome and its components in Korean children and adolescents: the Korea National Health and Nutrition Examination Surveys 2008–2014

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World Journal of Pediatrics 2018年第5期14卷 461-469页

作者： yong Min kim So Hyun kim Young suk Shim Department of Pediatrics Hallym University Dongtan Sacred Heart HospitalHallym University College of Medicine7Keunjaebong-gilHwaseong-siGyeonggi-doSeoul 18450Republic of Korea

Background In this study, we aimed to investigate the relationship between single-gender Korean references for non-high-density lipoprotein cholesterol (non-HDL-C) and metabolic syndrome (MetS) in childhood. Methods A total of 5742 Korean children aged 10–18 years who participated in a national survey were included. The sub-jects were classified into three groups based on single-gender non-HDL-C levels as follows: <120 mg/dL (desirable), ≥120 and <150 mg/dL (borderline high), and ≥150 mg/dL (high). Results Males in the borderline high non-HDL-C group had odds ratios (ORs) of 2.86 (95% confidence interval, 2.30–3.56) for elevated triglycerides (TG), 1.73 (1.08–1.79) for reduced high-density lipoprotein cholesterol (HDL-C) and 1.73 (1.08–2.78) for MetS compared with males in the desirable non-HDL-C group after adjusting for covariates. Males in the high non-HDL-C group had ORs of 1.65 (1.14–2.41) for elevated blood pressure (BP), 6.21 (4.27–9.05) for elevated TG, and 3.29 (1.49–7.26) for MetS compared with males in the desirable non-HDL-C group. Females in the borderline high non-HDL-C group had ORs of 3.03 (2.43–3.76) for elevated TG, 1.63 (1.13–2.35) for reduced HDL-C, and 4.53 (2.47–8.31) for MetS compared with females in the desirable non-HDL-C group. Females in the high non-HDL-C group had ORs of 1.43 (1.00–2.04) for elevated BP, 6.36 (4.45–9.08) for elevated TG, and 7.64 (3.65–15.96) for MetS compared with females in the desirable non-HDL-C group. Conclusion Our results suggest that, in a Korean population, a non-HDL-C level of 120 mg/dL for males and 150 mg/dL for females is the threshold between borderline high and high risk for MetS.

关键词： Adolescents Cardiovascular risk Children Metabolic syndrome Non-high-density lipoprotein cholesterol

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Evaluation of lubrication performance of crank pin bearing in a marine diesel engine

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Friction 2018年第4期6卷 464-471页

作者： suk Man MOON yong Joo CHO Tae Wan kim School of Mechanical Engineering Pusan National University Department of Mechanical Engineering Pukyong National University

In this study, the lubrication performance of the crank pin bearing in a marine two–stroke diesel engine is evaluated to investigate the adhesional failure on the crank pin bearing. A numerical algorithm for the lubrication analysis considering motion analysis of the crank pin system is developed. The film pressure and thickness for three clearances and three lubricant temperatures are calculated. The results show that the lubricant temperature has a higher effect on film thickness than clearance. In terms of the film parameter, the operating condition that can result in solid–solid contact is investigated. We also suggest the desirable operating conditions of clearance and lubricant temperature to prevent the solid–solid contact.

关键词： crank pin bearing film thickness lubricant film parameter diesel engine

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SVC bitstream adaptation in MPEG-21 multimedia framework

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2006年第5期7卷 764-772页

作者： THANG Truong Cong kim Young suk RO yong Man KANG Jungwon kim Jae-Gon Department of Engineering Information and Communications UniversityDaejeon 305-732 Korea Department of Engineering Information and Communications University Daejeon 305-732 Korea Electronics and Telecommunications Research Institute Daejeon 305-732 Korea

Scalable video coding (SVC) is the most promising video format for applications of collaborative communication. MPEG-21 standard has newly emerged to enable the interoperability of multimedia delivery in heterogeneous environments. In this paper we study adaptation of SVC bitstream in the context of MPEG-21 multimedia framework. For interfacing SVC bit- stream with MPEG-21 based adaptation system, we propose three SVC specific adaptation operators. Based on our previous work with multidimensional video adaptation, we present an effective approach, using MPEG-21 DIA AdaptationQoS description tool, to model QoS control for SVC adaptation. Then we show how the operator values could be computed from that representation. For the actual adaptation at bitstream level, we propose a procedure to remove the unnecessary NAL units from an SVC bitstream. The result of this study enables QoS management of SVC streaming in an efficient and standardized manner.

关键词： Multidimensional video adaptation, Scalable video coding (SVC), MPEG-21 DIA (Digital Item Adaptation), QoS

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MICROMECHANICS OF ROUGH SURFACE ADHESION:A HOMOGENIZED PROJECTION METHOD

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Acta Mechanica Solida Sinica 2009年第5期22卷 377-390页

作者： Kyung-suk kim Division of Engineering Brown UniversityProvidenceRI 02912USA

A quasistatic homogenized projection is made to characterize the effective cohesive zone behavior for rough-surface adhesion. In the context of the homogenized projection, the traction versus separation relation for the homogenized cohesive zone （HCZ） of a rough interface can be highly oscillatory due to instabilities during microscopic adhesion and decohesion processes. The instabilities are found to occur not only individually but also collectively among the adhesive micro-asperity contacts, leading to extensive energy dissipation. Based on the behaviors of the HCZ relations, a framework for describing instability-induced energy dissipation in rough-surface adhesion is proposed to elucidate the effect of roughness on apparent interface adhesion. Two non- dimensional parameters, α related to roughness morphology and n related to flaw distribution, are identified to be most crucial for controlling the energy dissipation. For an interface with a shallow roughness and a strong intrinsic adhesive strength, the interface adhesion can be stronger if we make it rougher （reducing α） or lower its flaw density （increasing n）. The HCZ projection method can be potentially extended and employed to bridge the apparent adhesion from intrinsic adhesion properties for engineering surfaces with multi-scale shallow roughness.

关键词： homogenized cohesive zone interface adhesion roughness effect instability energy dissipation

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Serum cytokine levels in chronic hepatitis B patients receiving peginterferon alpha-2a therapy

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Hepatobiliary & Pancreatic Diseases International 2012年第5期11卷 499-506页

作者： yongjung Park Jun yong Park Kwang-Hyub Han Hyon-suk kim Department of Laboratory Medicine Yonsei University College of Medicine Department of Internal Medicine Institute of GastroenterologyYonsei University College of Medicine

BACKGROUND: The relationship between cytokines and responses to peginterferon α-2a treatment in chronic hepatitis B patients has not yet been fully elucidated. We analyzed the serum levels of interleukin (IL)-1α, IL-1β, IL-2, IL-4, IL-6, IL-8, IL-10, vascular endothelial growth factor, interferon-γ, tumor necrosis factor-α, monocyte chemotactic protein-1 (MCP1) and epidermal growth factor during the treatment with peginterferon α-2a. METHODS: Ninety-three serum samples from 20 chronic hepatitis B patients were collected before, during and after 48 weeks of peginterferon therapy and were assayed for 12 cytokines. The patients were categorized as either virologic responders (VRs) or non-responders (NRs) according to their HBV DNA levels taken at 6th month during treatment. The Evidence Investigator (Randox, Antrim, UK), a protein chip analyzer, was used to quantify cytokines. RESULTS: Among the 12 cytokines, the levels of MCP1 were increased and the levels of IL-4 were decreased during the treatment in VRs. However these cytokines were not significantly changed in NRs in the treatment phases. Area under the receiver operating characteristic curve (AUROC) value of HBV DNA measured before the treatment was 0.81 in predicting VRs, and that of the baseline MCP1 was 0.76. IL-6 levels at 3rd and 6th months during the treatment also showed AUROC values 0.85 and 0.78 respectively in predicting sustained VRs. CONCLUSION: Serum cytokine levels reflect the pathological differences of individual treatment phases and could also be useful in monitoring responses to peginterferon treatment in chronic hepatitis B patients.

关键词： chronic hepatitis B cytokine hepatitis B virus peginterferon protein chip array

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Comprehensive molecular characterization to predict immunotherapy response in advanced biliary tract cancer: a phase II trial of pembrolizumab

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Oncology research 2025年第1期33卷 57-65页

作者： Ryul kim Joo Kyung Park Minsuk Kwon Minae An Jung yong Hong Joon Oh Park Sung Hee Lim Seung Tae kim Division of Hematology-Oncology Department of Medicine Samsung Medical Center Sungkyunkwan University School of Medicine Seoul Korea. Division of Gastroenterology Department of Medicine Samsung Medical Center Sungkyunkwan University School of Medicine Seoul Korea. Department of Hematology-Oncology Ajou University School of Medicine Suwon-si Gyeonggi-do Korea. Samsung Advanced Institute of Health Science and Technology Sungkyunkwan University School of Medicine Seoul Korea.

Background:Immune checkpoint inhibitors (ICIs) are effective in a subset of patients with metastatic solid tumors. However, the patients who would benefit most from ICIs in biliary tract cancer (BTC) are still controversial.Materials and methods:We molecularly characterized tissues and blood from 32 patients with metastatic BTC treated with the ICI pembrolizumab as second-line therapy.Results:All patients had microsatellite stable (MSS) type tumors. Three of the 32 patients achieved partial response (PR), with an objective response rate (ORR) of 9.4% (95% confidence interval [CI], 2.0-25.2) and nine showed stable disease (SD), exhibiting a disease control rate (DCR) of 37.5% (95% CI, 21.1-56.3). For the 31 patients who had access to PD-1 ligand 1 (PD-L1) combined positive score (CPS) testing (cut-off value ≥1%), the ORR was not different between those who had PD-L1-positive (PD-L1+; 1/11, 9.1%) and PDL1-(2/20, 10.0%) tumors ( = 1.000). The tumor mutational burden (TMB) of PD-L1+ BTC was comparable to that of PD-L1-BTC ( = 0.630). TMB and any exonic somatic mutations were also not predictive of pembrolizumab response. Molecular analysis of blood and tumor samples demonstrated a relatively high natural killer (NK) cell proportion in the peripheral blood before pembrolizumab treatment in patients who achieved tumor response. Moreover, the tumors of these patients presented high enrichment scores for NK cells, antitumor cytokines, and Th1 signatures, and a low enrichment score for cancer-associated fibroblasts.Conclusions:This study shows the molecular characteristics associated with the efficacy of pembrolizumab in BTC of the MSS type.

关键词： Biliary tract cancer Pembrolizumab Whole-exome sequencing Whole-transcriptome sequencing

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