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Synchronous rectal adenocarcinoma and intestinal mantle cell lymphoma:A case report

世界临床病例杂志 2023年第24期11卷 5772-5779页

作者： kim-van vu Nguyen-van Trong Nguyen-Thi Khuyen Do Huyen Nga Hoang Anh Nguyen Tien Trung PhamTrung Thong Nguyen Minh Duc Department of General Surgery Vietnam National Cancer HospitalHa Noi 100000Viet Nam Department of Practical Surgery Hanoi Medical UniversityHa Noi 100000Viet Nam Department of Oncology Hanoi Medical UniversityHa Noi 100000Viet Nam Pathology and Molecular Biology Center Vietnam National Cancer HospitalHa Noi 100000Viet Nam Department of Hematologic Oncology Vietnam National Cancer HospitalHa Noi 100000Viet Nam Department of Radiology Pham Ngoc Thach University of MedicineHo Chi Minh City 700000Viet Nam

BACKGROUND Mantle cell lymphoma(MCL)of the gastrointestinal tract is a rare malignancy,accounting for about 0.2%of malignant colorectal *** synchronous with rectal adenocarcinoma is extremely *** know of only a few cases reported in the *** describe the case of a patient with synchronous rectal adenocarcinoma and intestinal *** SUMMARY A 63-year-old man was admitted to our hospital due to abdominal pain and hematochezia over the past *** patient was diagnosed with middle rectal cancer cT2N0M0 and underwent ***,we found a large tumor in the small intestine during *** patient underwent total mesorectal excision for rectal cancer and resectioning of the ileal segment containing the large *** and immunohistochemistry revealed the presence of both rectal adenocarcinoma and pathognomonic MCL stage IIE presenting as multiple lymphomatous *** patient subsequently underwent RDHAP/RCHOP chemotherapy and was maintained with rituximab.A Positron Emission Tomography and Computed Tomography(PET/CT)scan showed that the disease responded well to treatment without tumor-increased metabolism in the gastrointestinal *** Synchronous rectal adenocarcinoma and intestinal MCL presenting as multiple lymphomatous polyposis are extremely *** is often discovered fortuitously when rectal cancer is *** coexistence of these tumors poses treatment challenges.

关键词： Mantle cell lymphoma Multiple lymphomatous polyposis Rectal adenocarcinoma Synchronous Gastrointestinal tract Case report

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α1-COP modulates plasmodesmata function through sphingolipid enzyme regulation

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Journal of Integrative Plant Biology 2024年第8期66卷 1639-1657页

作者： Arya Bagus Boedi Iswanto Minh Huy vu Jong Cheol Shon Ritesh Kumar Shuwei Wu Hobin Kang Da-Ran kim Geon Hui Son Woe Yoen kim Youn-Sig Kwak Kwang Hyeon Liu Sang Hee kim Jae-Yean kim Division of Applied Life Science(BK21 FOUR Program) Plant Molecular Biology and Biotechnology Research CenterGyeongsang National UniversityJinju 52828Korea College of Pharmacy and Research Institute of Pharmaceutical Sciences Kyungpook National UniversityDaegu 702-701Korea Departement of Plant Medicine Gyeongsang National UniversityJinju 52828Korea Division of Life Science Gyeongsang National UniversityJinju 52828Korea

Callose,aβ-1,3-glucan plant cell wall polymer,regulates symplasmic channel size at plasmodesmata(PD)and plays a crucial role in a variety of plant ***,elucidating the molecular mechanism of PD callose homeostasis is *** screened and identified an Arabidopsis mutant plant with excessive callose deposition at PD and found that the mutated gene wasα1-COP,a member of the coat protein I(COPI)coatomer *** report that loss of function ofα1-COP elevates the callose accumulation at PD by affecting subcellular protein localization of callose degradation enzyme Pd *** process is linked to the functions of ERH1,an inositol phosphoryl ceramide synthase,and glucosylceramide synthase through physical interactions with theα1-COP ***,the loss of function ofα1-COP alters the subcellular localization of ERH1 and GCS proteins,resulting in a reduction of Glc Cers and Glc HCers molecules,which are key sphingolipid(SL)species for lipid raft *** findings suggest thatα1-COP protein,together with SL modifiers controlling lipid raft compositions,regulates the subcellular localization of GPI-anchored PDBG2 proteins,and hence the callose turnover at PD and symplasmic movement of *** findings provide the first key clue to link the COPI-mediated intracellular trafficking pathway to the callose-mediated intercellular signaling pathway through PD.

关键词： callose coatomer proteins membrane-bound vesicle plasmodesmata sphingolipid enzymes

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Effects of Serum Concentration, Synchronization Time and Confluence on the Cell-Cycle Synchronization Efficiency of Goat Fibroblasts

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Open Journal of Animal Sciences 2024年第3期14卷 194-203页

作者： van Khanh Nguyen Huong Thu Thi vu Au Thi Hoang Yen kim Thi Pham Giang Thi Thanh Nhan Hung Phu Lai Lan Doan Pham Key Laboratory of Animal Cell Biotechnology National Institute of Animal Science Hanoi Vietnam

This study aims to evaluate the effect of serum concentration, synchronization time, and confluence degree on the synchronisation efficiency of goat fibroblast cycle. The results indicated that there was no difference in the percentage of nucleated fibroblasts in the G0/G1 stage between serum concentrations of 0.3% and 0.4% (83.89% and 82.69%, respectively, P > 0.05) as well as between serum concentrations of 0.2% and 0.5% (76.95% and 75.46%, respectively, P > 0.05). The percentage of nucleated fibroblasts in the G0/G1 stage was highest at the concentration of 0.3% and lowest in the control group (83.89% vs. 62.67%, P 0.05). The beneficial effect of high confluence was confirmed by the large percentage of nucleated fibroblasts at the G0/G1 stage. The 60% confluency was significantly lower than the 80% and 100% confluency (73.44%, 86.63%, and 87.17%, respectively, P < 0.05). The results indicate that the goat fibroblast cycle synchronization is the most effective at the serum concentration of 0.3%, 72 hours of synchronization and 100% confluency.

关键词： Goat Fibroblast Cycle Synchronisation Serum Concentration Synchronization Time Confluence

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Upconversion luminescence of Gd2O3:Er3+and Gd2O3:Er3+/silica nanophosphors fabricated by EDTA combustion method

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Journal of Rare Earths 2019年第11期37卷 1126-1131页

作者： Le Quoc Minh Tran kim Anh Nguyen Duy Hung Pham Thi Minh Chau Nguyen Thi Quy Hai Ho van Tuyen vu Thi Thai Ha vu Duc Tu Wieslaw Strek Institute of Theoretical and Applied Research Duy Tan UniversityDa Nang 55000Viet Nam Advanced Institute for Science and Technology Hanoi University of Science and Technology1 Dai Co VietHai Ba TrungHanoiViet Nam Institute of Materials Science Vietnam Academy of Science and Technology18 Hoang Quoc Viet RoadCau Giay DistrictHanoiViet Nam Institute of Low Temperature and Structure Research Polish Academy of Science 2 OkolnaWroclawPoland

Gd2O3:Er^3+nanophosphors were fabricated by the combustion method in presence of Na2 ethylene diamine tetra acetic acid(EDTA-Na2)as fuel at not high temperature(≤350℃)within a very short time of 5 *** added concentration of Er^3+ions in Gd2O3 matrix was changed from 0.5 mol%to 5.0 mol%.The X-ray diffraction pattern of samples indicates the monoclinic structure of Gd2O3:Er^3+.The morphology and chemical composition analysis of the Gd2O3:Er^3+samples are characterized by a field emission scanning electron microscope(FESEM)and a Fourier-transform infrared spectrometer(FTIR).The photoluminescence(PL),photo luminescence excitation(PLE)and upconversion(UC)at room temperature of the prepared materials with different concentrations of Er^3+were *** PL of Gd2O3:Er^3+nanomaterials are shown in visible at 545,594,623,648,688 nm under excitation at 275 *** emission bands from transitions of Er^3+from 2P3/2 to 4F9/2 are observed,UC luminescent spectra of the Gd2O3:Er^3+/silica nanocomposites under 976 nm excitation show the bands at 548 and 670 *** influence of excitation power at 980 nm for transitions were measured and *** results indicate that the upconversion process of Gd2O3:Er^3+/silica is two photons absorption *** low temperature dependence of UC luminescent intensities of the main bands of Gd2O3:Er^3+was investigated towards development of a nanotemperature sensor in the range of 10-300 K.

关键词： Upconversion luminescence Gd2O3:Er3+ Gd2O3:Er3+/silica Nanophosphors EDTA combustion Rare earths

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Optimal Wing Rotation Angle by the Unsteady Blade Element Theory for Maximum Translational Force Generation in Insect-mimicking Flapping-wing Micro Air Vehicle

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Journal of Bionic Engineering 2016年第2期13卷 261-270页

作者： Loan Thi kim Au Hoang vu Phan Hoon Cheol Park Department of Advanced Technology Fusion Konkuk University Seoul 143-701 South Korea

This paper provides a parametric study to obtain the optimal wing rotation angle for the generation of maximum transla- tional force in an insect-mimicking Flapping-Wing Micro Air Vehicle （FWMAV） during hovering. The blade element theory and momentum theory were combined to obtain the equation from which the translational aerodynamic force could be esti- mated. This equation was converted into a non-dimensional form, so that the effect of normalized parameters on the thrust coefficient could be analyzed. The research showed that the thrust coefficient for a given wing section depends on two factors, the rotation angle of the wing section and the ratio of the chord to the travel distance of the wing section in one flapping cycle. For each ratio that we investigated, we could arrive at an optimal rotation angle corresponding to a maximum thrust coefficient. This study may be able to provide guidance for the FWMAV design.

关键词： FWMAV optimal rotation angle parametric study blade element theory momentum theory

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Comparison of Aerodynamic Forces and Moments Calculated by Three-dimensional Unsteady Blade Element Theory and Computational Fluid Dynamics

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Journal of Bionic Engineering 2017年第4期14卷 746-758页

作者： Loan Thi kim Au Hoang vu Phan Hoon Cheol Park Department of Advanced Technology Fusion and Artificial Muscle Research Center Konkuk University Seoul Korea

In previous work, we modified blade element theory by implementing three-dimensional wing kinematics and modeled the unsteady aerodynamic effects by adding the added mass and rotational forces. This method is referred to as Unsteady Blade Element Theory （UBET）. A comparison between UBET and Computational Fluid Dynamics （CFD） for flapping wings with high flapping frequencies （〉30 Hz） could not be found in literature survey. In this paper, UBET that considers the movement of pressure center in pitching-moment estimation was validated using the CFD method. We investigated three three-dimensional （3D） wing kinematics that produce negative, zero, and positive aerodynamic pitching moments. For all cases, the instantaneous aerodynamic forces and pitching moments estimated via UBET and CFD showed similar trends. The differences in average vertical forces and pitching moments about the center of gravity were about 10% and 12%, respectively. Therefore, UBET is proven to reasonably estimate the aerodynamic forces and pitching moment for flight dynamic study of FW-MAV. However, the differences in average wing drags and pitching moments about the feather axis were more than 20%. Since study of aerodynamic power requires reasonable estimation of wing drag and pitching moment about the feather axis, UBET needs further im- provement for hilzher accuracy.

关键词： blade element theory unsteady computational fluid dynamics flapping wings biomimetic

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Longitudinal Flight Dynamic Analysis on Vertical Takeoff of a Tailless Flapping-Wing Micro Air Vehicle

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Journal of Bionic Engineering 2018年第2期15卷 283-297页

作者： Loan Thi kim Au vu Hoang Phan Hoon Cheol Park Department of Advanced Technology Fusion and Artificial Muscle Research Center Konkuk University Seou105029 Korea

This paper first analyzed the longitudinal dynamic behavior during vertical takeoff without control of a Flapping-Wing Micro Air Vehicle （FW-MAV）. The standard linear flight dynamics based on small disturbances from trim condition was not applicable for our analysis because the initial flight condition, which was at rest on the ground, could be such a large disturbance from the trim condition that the linearization is invalid. Therefore, we derived linearized Equations of Motion （EoM） which can treat an untrimmed flight condition as a reference for disturbances. The Computational Fluid Dynamic （CFD） software ANSYS Fluent was used to compute the aerodynamic forces and pitching moments. Three flight modes were found： a fast subsidence mode, a slow subsidence mode and a divergence oscil- latory mode. Due to divergence oscillatory mode, the deviation from the reference flight grew with time; the FW-MAV tumbled without control. The simulation showed for the first 0.5 second after leaving the ground （the time that is long enough for delay of feedback control）, the FW-MAV flew up to a height of 6 cm with small horizontal and pitching motion, which is close to a vertical flight.

关键词： bioinspired FW-MAV flight dynamics vertical takeoff CFD linear theory

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The Obstacles and Potential Solution Clues of Prime Editing Applications in Tomato

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BioDesign Research 2022年第1期2022卷 11-18页

作者： Tien van vu Ngan Thi Nguyen Jihae kim Swati Das Jinsu Lee Jae-Yean kim Division of Applied Life Science(BK21 FOUR Program) Plant Molecular Biology and Biotechnology Research CenterGyeongsang National UniversityJinju 660-701Republic of Korea National Key Laboratory for Plant Cell Biotechnology Agricultural Genetics InstituteKm 02Pham Van Dong RoadCo Nhue 1Bac Tu LiemHanoi 11917Vietnam Division of Life Science Gyeongsang National University501 Jinju-daeroJinju 52828Republic of Korea Nulla Bio Inc. 501 Jinju-daeroJinju 660-701Republic of Korea.

Precision genome editing is highly desired for crop *** recently emerged CRISPR/Cas technology offers great potential applications in precision plant genome engineering.A prime editing(PE)approach combining a reverse transcriptase(RT)with a Cas9 nickase and a“priming”extended guide RNA(gRNA)has shown a high frequency for precise genome modification in mammalian cells and several plant ***,the applications of the PE approach in dicot plants are still limited and *** designed and tested prime editors for precision editing of a synthetic sequence in a transient assay and for desirable alleles of 10 loci in tomato by stable *** data obtained by targeted deep sequencing also revealed only low PE efficiencies in both the tobacco and tomato *** assessment of the activities of the PE components uncovered that the fusion of RT to Cas9 and the structure of PE gRNAs(pegRNAs)negatively affected the cleaving activity of the Cas9 *** self-complementarity between the primer binding sequences(PBSs)and spacer sequence might pose risks to the activity of the Cas9 ***,modifying the pegRNA sequences by shortening or introducing mismatches to the PBSs to reduce their melting temperatures did not enhance the PE efficiency at the MADS-box protein(SlMBP21),alcobaca(SlALC),and acetolactate synthase 1(SlALS1)*** data show challenges of the PE approach in tomato,indicating that a further improvement of the PE system for successful applications is demanded,such as the use of improved expression systems for enriching active PE complexes.

关键词： CRISPR/Cas precise editing

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Analytic Feynman Integrals of Functionals in a Banach Algebra Involving the First Variation

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Chinese Annals of Mathematics,Series B 2016年第2期37卷 281-290页

作者： Hyun Soo CHUNG vu kim TUAN Seung Jun CHANG Department of Mathematics Dankook University Department of Mathematics University of West Georgia

This paper deals with the analytic Feynman integral of functionals on a Wiener space. First the authors establish the existence of the analytic Feynman integrals of functionals in a Banach algebra S_α. The authors then obtain a formula for the first variation of integrals. Finally, various analytic Feynman integration formulas involving the first variation are established.

关键词： Analytic Feynman integral Banach algebra First variation Cameron-Storvick theorem Wiener space

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Stable Vertical Takeoff of an Insect-Mimicking Flapping-Wing System Without Guide Implementing Inherent Pitching Stability

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Journal of Bionic Engineering 2012年第4期9卷 391-401页

作者： Hoang vu Phan Quoc Viet Nguyen Quang Tri Truong Tien van Truong Hoon Cheol Park Nam Seo Goo Doyoung Byun Min Jun kim Department of Advanced Technology Fusion Konkuk University Seoul 143-701 Korea Department of Aerospace Engineering Konkuk University Seoul 143-701 Korea Department of Mechanical Engineering Sungkyunkwan University Seoul 143-701 Korea Department of Mechanical Engineering and Mechanics Drexel University Philadelphia USA

We briefly summarized how to design and fabricate an insect-mimicking flapping-wing system and demonstrate how to implement inherent pitching stability for stable vertical takeoff. The effect of relative locations of the Center of Gravity （CG） and the mean Aerodynamic Center （AC） on vertical flight was theoretically examined through static force balance considera- tion. We conducted a series of vertical takeoff tests in which the location of the mean AC was determined using an unsteady Blade Element Theory （BET） previously developed by the authors. Sequential images were captured during the takeoff tests using a high-speed camera. The results demonstrated that inherent pitching stability for vertical takeoff can be achieved by controlling the relative position between the CG and the mean AC of the flapping system.

关键词： beetle flapping-wing system insect-mimicking insect flight inherent pitching stability vertical takeoff

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