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Regulation of sleep by astrocytes in the hypothalamic ventrolateral preoptic nucleus

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Neural Regeneration Research 2025年第4期20卷 1098-1100页

作者： Jae-Hong kim Ruqayya Afridi Il-Sung Jang Maan Gee Lee Kyoungho suk Brain Korea 21 four KNU Convergence Educational Program of Biomedical Sciences for Creative Future Talents School of MedicineKyungpook National UniversityDaeguRepublic of Korea Department of Pharmacology School of MedicineKyungpook National UniversityDaeguRepublic of Korea Department of Pharmacology School of DentistryKyungpook National UniversityDaeguRepublic of Korea Brain Science&Engineering Institute Kyungpook National UniversityDaeguRepublic of Korea

Astrocytes are functionally dynamic cells that support neurons in multiple ways throughout an organism’s *** astrocytic regulation of neuronal activity has been increasingly recognized in recent *** are now recognized as playing a more complex role than mere bystanders in the central nervous ***,their role in regulating the sleep neurocircuitry is not well *** this perspective,we highlight the role of astrocytes in sleep modulation,with a particular focus on regulatory mechanisms related to the ventrolateral preoptic nucleus(VLPO)of the *** briefly discuss recent literature reporting the role of VLPO astrocytes in regulating sleep-associated behaviors.

关键词： sleep ventrolateral astrocytes

High mobility group box 1 in the central nervous system:regeneration hidden beneath inflammation

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Neural Regeneration Research 2025年第1期20卷 107-115页

作者： Hanki kim Bum Jun kim Seungyon Koh Hyo Jin Cho Xuelian Jin Byung Gon kim Jun young Choi Department of Brain Science Ajou University School of MedicineSuwonSouth Korea Department of Biomedical Sciences Ajou University Graduate School of MedicineSuwonSouth Korea Department of Neurology Ajou University School of MedicineSuwonSouth Korea Department of Geriatrics The Affiliated Suqian First People’s Hospital of Nanjing Medical UniversitySuqianJiangsu ProvinceChina

High-mobility group box 1 was first discovered in the calf thymus as a DNA-binding nuclear protein and has been widely studied in diverse fields,including neurology and ***-mobility group box 1 in the extracellular space functions as a pro-inflammatory damage-associated molecular pattern,which has been proven to play an important role in a wide variety of central nervous system disorders such as ischemic stroke,Alzheimer’s disease,frontotemporal dementia,Parkinson’s disease,multiple sclerosis,epilepsy,and traumatic brain *** drugs that inhibit high-mobility group box 1 as a damage-associated molecular pattern,such as glycyrrhizin,ethyl pyruvate,and neutralizing anti-high-mobility group box 1 antibodies,are commonly used to target high-mobility group box 1 activity in central nervous system *** it is commonly known for its detrimental inflammatory effect,high-mobility group box 1 has also been shown to have beneficial pro-regenerative roles in central nervous system *** this narrative review,we provide a brief summary of the history of high-mobility group box 1 research and its characterization as a damage-associated molecular pattern,its downstream receptors,and intracellular signaling pathways,how high-mobility group box 1 exerts the repair-favoring roles in general and in the central nervous system,and clues on how to differentiate the pro-regenerative from the pro-inflammatory *** targeting high-mobility group box 1 in the central nervous system may benefit from differentiating between the two functions rather than overall suppression of high-mobility group box 1.

关键词： central nervous system damage-associated molecular pattern ethyl pyruvate glycyrhizzin high mobility group box 1 inflammation neural stem cells neurodevelopment oligodendrocyte progenitor cells redox status regeneration

A New Encryption Mechanism Supporting the Update of Encrypted Data for Secure and Efficient Collaboration in the Cloud Environment

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Computer Modeling in Engineering & Sciences 2025年第1期142卷 813-834页

作者： Chanhyeong Cho Byeori kim Haehyun Cho Taek-young Youn Department of Cyber Security Dankook UniversityYongin16890Republic of Korea Department of Software Soongsil UniversitySeoul07027Republic of Korea

With the rise of remote collaboration,the demand for advanced storage and collaboration tools has rapidly ***,traditional collaboration tools primarily rely on access control,leaving data stored on cloud servers vulnerable due to insufficient *** paper introduces a novel mechanism that encrypts data in‘bundle’units,designed to meet the dual requirements of efficiency and security for frequently updated collaborative *** bundle includes updated information,allowing only the updated portions to be reencrypted when changes *** encryption method proposed in this paper addresses the inefficiencies of traditional encryption modes,such as Cipher Block Chaining(CBC)and Counter(CTR),which require decrypting and re-encrypting the entire dataset whenever updates *** proposed method leverages update-specific information embedded within data bundles and metadata that maps the relationship between these bundles and the plaintext *** utilizing this information,the method accurately identifies the modified portions and applies algorithms to selectively re-encrypt only those *** approach significantly enhances the efficiency of data updates while maintaining high performance,particularly in large-scale data *** validate this approach,we conducted experiments measuring execution time as both the size of the modified data and the total dataset size *** show that the proposed method significantly outperforms CBC and CTR modes in execution speed,with greater performance gains as data size ***,our security evaluation confirms that this method provides robust protection against both passive and active attacks.

关键词： Cloud collaboration mode of operation data update efficiency

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核心价值观教育与终极美德实践研究（英文）

文化发展论丛 2015年第3期 21-36页

作者：金英硕 IANC

最初,学习的目的是＂格物致知＂,即揭示事物的本质。而宗教的目的则是追求不变的有效真理并使其成为现实.我认为哲学和神学也开始揭示人类的起源（始原）与基础,并寻求上天的智慧来解答“何为公义？”在众多教育学派中,没有人找到真相... 详细信息

最初,学习的目的是＂格物致知＂,即揭示事物的本质。而宗教的目的则是追求不变的有效真理并使其成为现实.我认为哲学和神学也开始揭示人类的起源（始原）与基础,并寻求上天的智慧来解答“何为公义？”在众多教育学派中,没有人找到真相和幸福.据《圣经》箴言1：7中写道,“敬畏耶和华乃是知识之始”,《约翰福音》8：32说道,“知识将让你自由”.而在《中庸》第20章中也写道：“知天命”,“知人“事亲”,“修身”,“君子”.这意味着人类作为上帝的孩子,当他们知道上帝的时候,他们才能看到真相.迄今为止,无知的学习与教育固定了所有人的思维模式.人们想挣脱意识的精神牢笼,但却被自身错误的意识所束缚,被欲望牢牢捆绑住,最终缓缓消亡.意识使人们的关系既不舒适也不高兴.我在学校执教29年,从未见过公共教育体系能使学生满意或高兴.这是因为学校并没有优先教授学生共同利益的伦理观,共生共荣的道德观,也没有教会学生尊重生命.学校强调的是学生被不错的大学录取,或是拥有好工作,从而鼓励极端个人利己主义.也就是说,学校提倡学生以自我为中心.因此,学生会漠视或麻烦弱势学生.学生之间不互相爱护彼此,而是把别人都当自己的对手.自然而然地,学生关系变得冷淡和无情,渐渐地人类的幸福越来越小.换句话说,学校并没有传授真正的教育理念和核心价值使学生认识到自身内在的无限快乐,也没有将学生们从他们的意识（自我）中解放出来.这就是学校教育的现状.现在,学校应该避免会培养自私主义的竞争性的教育.学校应当以促进人类的共同利益为教育目标.此外迫切需要教育培养正直的人和圣人,在地球村上开启一个新的和平年代.现在正是学校揭示真相、实践至善,教导学生使其重生为新人类和圣人的时候.在本文中,笔者将提到作为全人类和平、真正幸福的选择的核心价值的重要性.本文建议用方法论来实践“共同利益”和“至善”,具有一定的意义.

关键词：尊重生命新人类文化公共福利大众哲学人类的共同利益共生共荣至善共同利益

Maximizing biomass utilization: An integrated strategy for coproducing multiple chemicals

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Journal of Energy Chemistry 2025年第1期100卷 180-191页

作者： Byeongchan Ahn Sua Jo Jonggeol Na J.Jay Liu young-Ju kim Wangyun Won Department of Chemical and Biological Engineering Korea University Department of Chemical Engineering (Integrated process) Kyung Hee University Department of Chemical Engineering and Materials Science Ewha Womans University Department of Chemical Engineering Pukyong National University Resources Engineering Plant Research Department Korea Institute of Geoscience and Mineral Resources

Lignocellulosic biomass is one of the viable solutions to alleviate the global warming. However, the limited utilization of biomass majorly focused on cellulose and hemicellulose restricts the economic and environmental feasibilities. To cope with this issue, we proposed an integrated process of co-producing 1,6-hexanediol（1,6-HDO） with tetrahydrofuran and adipic acid from biomass, referred to as Strategy A. To compare the impacts of lignin upgrading and feedstock, Strategy B, which co-produces tetrahydrofuran alone, and Strategy C, which is the traditional route to produce 1,6-HDO from fossil fuels, were used. Heat networks are also designed to reduce operating costs and indirect carbon emissions due to energy consumption, saving 87% and 83% of the heat and cooling requirements, respectively, in Strategy A. The market competitiveness of Strategy A was evaluated by determining the minimum selling price through techno-economic analysis, and sustainability was thoroughly investigated by quantifying the environmental impacts through both midpoint and endpoint life-cycle assessments（LCAs）.Strategy A was found to be the most favorable both economically（USRDSCHARDOLLAR3,402/ton） and environmentally（-26.9 kg CO2eq.）. This indicates that lignin valorization is not only economically but also environmentally preferred. Finally, changes in economic and environmental feasibilities depending on economic, process, and environmental parameters were investigated using sensitivity and uncertainty analyses. The results of these analyses provide valuable insight into bio-based chemical production.

关键词： Carbon capture and utilization

A Rapid Adaptation Approach for Dynamic Air‑Writing Recognition Using Wearable Wristbands with Self‑Supervised Contrastive Learning

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Nano-Micro Letters 2025年第2期17卷 417-431页

作者： Yunjian Guo Kunpeng Li Wei Yue Nam‑young kim Yang Li Guozhen Shen Jong‑Chul Lee Department of Electronic Convergence Engineering Kwangwoon UniversitySeoul 01897South Korea Radio Frequency Integrated Circuit(RFIC)Bio Centre Kwangwoon UniversitySeoul 01897South Korea Department of Electronic Engineering Kwangwoon UniversitySeoul 01897South Korea School of Microelectronics Shandong UniversityJinan 250101People’s Republic of China State Key Laboratory of Integrated Chips and Systems Fudan UniversityShanghai 200433People’s Republic of China School of Integrated Circuits and Electronics Beijing Institute of TechnologyBeijing 100081People’s Republic of China

Wearable wristband systems leverage deep learning to revolutionize hand gesture recognition in daily *** existing approaches that often focus on static gestures and require extensive labeled data,the proposed wearable wristband with selfsupervised contrastive learning excels at dynamic motion tracking and adapts rapidly across multiple *** features a four-channel sensing array composed of an ionic hydrogel with hierarchical microcone structures and ultrathin flexible electrodes,resulting in high-sensitivity capacitance *** wireless transmission from a Wi-Fi module,the proposed algorithm learns latent features from the unlabeled signals of random wrist ***,only few-shot labeled data are sufficient for fine-tuning the model,enabling rapid adaptation to various *** system achieves a high accuracy of 94.9%in different scenarios,including the prediction of eight-direction commands,and air-writing of all numbers and *** proposed method facilitates smooth transitions between multiple tasks without the need for modifying the structure or undergoing extensive task-specific *** utility has been further extended to enhance human–machine interaction over digital platforms,such as game controls,calculators,and three-language login systems,offering users a natural and intuitive way of communication.

关键词： Wearable wristband Self-supervised contrastive learning Dynamic gesture Air-writing Human-machine interaction

仪轨和图屏的呈才——以丁亥《进馔仪轨》为例

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当代舞蹈艺术研究 2018年第4期3卷 8-18页

作者：金英淑韩国呈才研究会韩国雅乐佾舞保存会

朝鲜王朝十分重视反映儒家礼乐思想的五礼(吉礼、嘉礼、宾礼、军礼、凶礼)。仪轨是整理有关王室和国家践行礼仪的始末以便日后作为实用规范而编纂的文献。韩国仪轨作为记录文化的精髓已被联合国教科文组织列入世界遗产名录。宫廷仪礼记... 详细信息

朝鲜王朝十分重视反映儒家礼乐思想的五礼(吉礼、嘉礼、宾礼、军礼、凶礼)。仪轨是整理有关王室和国家践行礼仪的始末以便日后作为实用规范而编纂的文献。韩国仪轨作为记录文化的精髓已被联合国教科文组织列入世界遗产名录。宫廷仪礼记作仪轨的同时一般也会制作成图屏。图屏由于使用了天然色绘制而成,弥补了仪轨只能记录黑白资料的不足。仪轨和图屏既是展现朝鲜时代宫廷文化的韵味与绚丽的文字资料,也是画作。笔者欲根据仪轨来研究当时的公演文化。同时,由于这一时期孝明世子创作的唐乐呈才和乡乐呈才盛行,因此也将考察影响其创作的中国文献的内容。

关键词：丁亥《进馔仪轨》 “丁亥进馔图屏” 唐乐呈才乡乐呈才

Apolipoprotein A-I binding protein-mediated neuroprotection in glaucomatous neuroinflammation and neurodegeneration

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Neural Regeneration Research 2025年第5期20卷 1414-1415页

作者： Sinwoo Hwang Seunghwan Choi Soo-Ho Choi Keun-young kim Yury I.Miller Won-Kyu Ju Hamilton Glaucoma Center and Shiley Eye Institute The Viterbi Family Department of OphthalmologyUniversity of California San DiegoLa JollaCAUSA Department of Medicine University of California San DiegoLa JollaCAUSA National Center for Microscopy and Imaging Research Department of NeurosciencesUniversity of California San DiegoLa JollaCAUSA

Glaucoma is a multifactorial eye disorder that can cause vision loss and irreversible blindness,affecting individ uals aged 40 to 80 yea rs *** to the aging population,it is expected that the number of people affected by glaucoma will surpass 111 million by 2040 as the disease becomes more *** primarily contributes to optic nerve axon loss and the progressive degeneration of retinal ganglion cells (RGCs),subsequently leading to vision impairment.

关键词： irreversible pass primarily

Effect of Plastic Anisotropy on the Formability of Aluminum 6016-T4 Sheet Material

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Chinese Journal of Mechanical Engineering 2017年第3期30卷 625-631页

作者： young-suk kim Seung-Han YANG kyungpook national university Daegu 41566Republic of Korea

Sheet metal formed of lightweight materials such as aluminum sheeting has received great attention related to the reduction of vehicle emissions. This paper evaluates the anisotropic yield locus using Kuwabara＇s biaxial tensile tester and stretches formability using Hecker＇s hemispheri- cal punch stretching test for aluminum 6016-T4 sheet material. The anisotropic yield locus of the A16016-T4 sheet measured is fitted well by the modified Drucker yield func- tion. Moreover the best fitting to the experimental stress- strain curve from the tensile test was obtained by taking an appropriate hardening model. Analytical study to predict the stretch formability by using Hora＇s Modified Maximum Force Criterion （MMFC） was performed. The predicted forming limit curves （FLC） based on various yield functions were compared with the experiments and discussed.

关键词： Anisotropic yield function AluminumA16016-T4 Biaxial tensile test Forming limit curve