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β-胡萝卜素对母兔生长性能、抗氧化能力、生殖激素指标及卵泡发育的影响

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动物营养学报 2022年第5期34卷 1885-1894页

作者：孙磊魏宇超刘福鑫陈宝江王志刚河北农业大学动物科技学院保定071000 河北省牛羊胚胎技术创新中心保定071000

本试验旨在研究饲粮中添加不同水平β-胡萝卜素对母兔生长性能、抗氧化能力、生殖激素指标及卵泡发育的影响。选取55~60日龄、体重[(1.679±0.114)kg]相近、健康状态良好的母兔160只,随机分为4组,每组20个重复,每个重复2只。对照组饲喂... 详细信息

本试验旨在研究饲粮中添加不同水平β-胡萝卜素对母兔生长性能、抗氧化能力、生殖激素指标及卵泡发育的影响。选取55~60日龄、体重[(1.679±0.114)kg]相近、健康状态良好的母兔160只,随机分为4组,每组20个重复,每个重复2只。对照组饲喂基础饲粮,试验组分别在基础饲粮中添加15、30、45 mg/kgβ-胡萝卜素。预试期7 d,正试期84 d。结果表明:1)饲粮中添加不同水平β-胡萝卜素对母兔的终末体重、总增重、平均日增重、平均日采食量以及料重比均无显著影响(P>0.05)。2)与对照组相比,饲粮中添加45 mg/kgβ-胡萝卜素显著降低了血清中超氧化物歧化酶(SOD)活性(P<0.05)。3)与对照组相比,饲粮中添加30 mg/kgβ-胡萝卜素显著降低了70 d血清中促卵泡素(FSH)和孕酮(PROG)含量(P<0.05)。与对照组相比,饲粮中添加30 mg/kgβ-胡萝卜素显著提高了卵巢中雌二醇(E2)含量(P<0.05),饲粮中添加15 mg/kgβ-胡萝卜素显著降低了卵巢中PROG含量(P<0.05)。4)与对照组相比,饲粮中添加45 mg/kgβ-胡萝卜素显著提高了母兔初级卵泡比例(P<0.05)。综上所述,饲粮中添加β-胡萝卜素可以改善母兔的抗氧化能力,促进卵泡发育和生殖激素分泌,但剂量过高会降低母兔抗氧化能力。本试验条件下,饲粮中β-胡萝卜素适宜添加水平为30 mg/kg。

关键词： β-胡萝卜素母兔抗氧化能力生殖激素卵泡发育

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川黄柏幼龄林有效成分盐酸小檗碱的累积及光合特性

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应用与环境生物学报 2023年第5期29卷 1234-1240页

作者：孙志鹏罗建勋蒲尚饶宋鹏武华卫王刚四川省林业科学研究院森林和湿地生态恢复与保育四川省重点实验室成都610081 四川农业大学林学院成都611130 四川农业大学风景园林学院成都611130

为探究川黄柏幼龄林有效成分盐酸小檗碱累积、光合及叶绿素荧光参数变化规律,以1-3年生川黄柏为材料,测定分析不同月份不同树龄地上和地下部位盐酸小檗碱含量、生长量和生物量,以及不同树龄叶片光合参数和叶绿素荧光参数.结果表明:(1)1-... 详细信息

为探究川黄柏幼龄林有效成分盐酸小檗碱累积、光合及叶绿素荧光参数变化规律,以1-3年生川黄柏为材料,测定分析不同月份不同树龄地上和地下部位盐酸小檗碱含量、生长量和生物量,以及不同树龄叶片光合参数和叶绿素荧光参数.结果表明:(1)1-3年生苗木各部位盐酸小檗碱含量年均值分别达2%、3%和5%,以6月较高,且各生长时期均以地下部位较高;(2)苗高、地径和生物量在1年中的增长变化基本一致,表现为迅速增加→缓慢增加,生长量(苗高、地径)增加峰值为4-6月,生物量增加峰值为6-8月,占年增长量的42%以上;(3)不同月份、树龄盐酸小檗碱累积量具有显著差异(P2年可适当开发利用,最佳采收月份是10月;结果可为川黄柏幼龄林合理开发利用提供一定的指导.

关键词：川黄柏盐酸小檗碱累积量光合作用叶绿素荧光参数 PCA

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Elastic organic crystals with ultralong phosphorescence for flexible anti-counterfeiting

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npj Flexible Electronics 2021年第1期5卷 169-174页

作者： Kaiwei Huang Lulu Song Kun Liu Anqi Lv Manjeet Singh Kang Shen Jing Shen Jiamin Wang Hongchen Wang Huifang Shi Huili Ma Mingxing Gu Gengzhi sun Wei Yao Zhongfu An Wei Huang Key Laboratory of Flexible Electronics(KLOFE)&Institute of Advanced Materials(IAM) Nanjing Tech University(NanjingTech)NanjingPeople’s Republic of China Frontiers Science Center for Flexible Electronics(FSCFE) Shaanxi Institute of Flexible Electronics(SIFE)&Shaanxi Institute of Biomedical Materials and Engineering(SIBME)Northwestern Polytechnical University(NPU)Xi’anChina

Ultralong organic phosphorescence(UOP)crystals have attracted increased attention due to the distinct photophysical property of a long-lived ***,organic crystals are generally brittle,leading to a serious problem for their application in flexible ***,we report three types of elastic organic crystals(EOCs)with ultralong phosphorescence via introducing halogen atoms(Cl,Br,I)intoπ-conjugated phosphorescent ***,the crystal containing iodine atoms displayed both excellent elasticity(ε=3.01%)and high phosphorescent efficiency(Φ_(Ph)=19.1%)owing to the strong halogen *** advantage of its highly efficient UOP and excellent elasticity,we successfully used a DCz4I crystal for anti-counterfeiting *** findings may provide guidance for the development of elastic crystals with afterglow and expand the scope of potential applications on flexible materials.

关键词： materials elasticity crystal

Application of the Prague C and M criteria for endoscopic description of columnar-lined esophagus in South Korea

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World Journal of Gastrointestinal Endoscopy 2016年第8期8卷 357-361页

作者： Jung Wan Choe young Choon kim Moon Kyung Joo Hyo Jung kim Beom Jae Lee Ji Hoon kim Jong Eun Yeon Jong-Jae Park Jae Seon kim Kwan Soo Byun young-Tae Bak Department of Gastroenterology Korea University Guro Hospital

AIM:To ascertain whether the Prague circumferential(C) length and maximal(M) length criteria for grading the extent of Barrett's esophagus can be applied prior to its widespread application in South ***:Two hundred and thirteen consecutive cases with endoscopic columnar-lined esophagus(CLE) were included and classified according to the Prague C and M ***:Of 213 cases with CLE, the distribution of maximum CLE lengths was: 0.5-0.9 cm in 99 cases(46.5%); 1.0-1.4 cm in 63 cases(29.6%); 1.5-1.9 cm in 15 cases(7.0%); 2.0-2.4 cm in 14 cases(6.6%); 2.5-2.9 cm in 1 case(0.5%); and 7.0 cm in 1 case(0.5%). Twenty cases(9.4%) had columnar islands alone. Two hundred and eight cases(97.7%) lacked the circumferential CLE component(C0Mx). Columnar islands were found in 70 cases(32.9%), of which 20 cases(9.4%) had columnar islands ***:In regions where most CLE patients display short or ultrashort tongue-like appearance, more detailed descriptions of CLE's in < 1.0 cm lengths and columnar islands, as well as avoidance of repeating the prefix "C0" need to be considered in parallel with the widespread application of the Prague system in South Korea.

关键词： Barrett’s esophagus Endoscopy Columnarlined esophagus Prague criteria

运动对老年大鼠骨质疏松及骨髓间充质干细胞自噬的影响

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中国康复医学杂志 2023年第1期38卷 16-21,34页

作者：廖阳屈萌艰孙光华刘静杨璐王金玲周君黄夏荣南华大学附属第一医院康复医学中心湖南省衡阳市421001 南华大学附属第一医院康复医学科南华大学附属第一医院康复医学实验室湖南师范大学体育学院体适能与运动康复湖南省重点实验室

目的:观察运动对老年大鼠骨髓间充质干细胞自噬及其骨微结构的影响。方法:6只6月龄大鼠为青年组,饲养6月后取材;12只27月龄大鼠分为运动组、老年组,运动组大鼠给予运动跑台干预8周。干预结束后,ELISA检测血清骨代谢标志物NTX、PINP、BLA... 详细信息

目的:观察运动对老年大鼠骨髓间充质干细胞自噬及其骨微结构的影响。方法:6只6月龄大鼠为青年组,饲养6月后取材;12只27月龄大鼠分为运动组、老年组,运动组大鼠给予运动跑台干预8周。干预结束后,ELISA检测血清骨代谢标志物NTX、PINP、BLAP、TRCAP水平;双能X线骨密度仪检测骨密度;骨显微CT检测骨微结构;RT-PCR、Western Blot检测Beclin1、LC3-Ⅱ、p62 m RNA及蛋白表达情况。结果:与青年组相比,老年组血清骨形成标志物PINP、BALP水平均降低(P0.05)。结论:通过运动提高骨髓间充质干细胞自噬水平,促进骨髓间充质干细胞向成骨细胞分化,改善老年大鼠骨量、骨微结构,减轻骨质疏松症。

关键词：运动骨质疏松骨髓间充质干细胞细胞自噬

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L1 scheme on graded mesh for the linearized time fractional KdV equation with initial singularity

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International Journal of Modeling, Simulation, and Scientific Computing 2019年第1期10卷 77-94页

作者： Hu Chen Xiaohan Hu Jincheng Ren Tao sun Yifa Tang Applied and Computational Mathematics Division Beijing Computational Science Research Center Beijing 100194 P.R.China School of Mathematical Sciences University of Chinese Academy of Sciences Beijing 100049 P.R.China College of Mathematics and Information Science Henan University of Economics and Law Zhengzhou 450045 P.R.China School of Statistics and Mathematics Shanghai Lixin University of Accounting and Finance Shanghai 201209 P.R.China LSEC ICMSECAcademy of Mathematics and Systems Science Chinese Academy of SciencesBeijing 100190P.R.China School of Mathematical Sciences University of Chinese Academy of Sciences Beijing 100049P.R.China

Numerical approximation for a linearized time fractional KdV equation with initial singularity using L1 scheme on graded mesh is *** is proved that the L1 scheme can attain order 2−αconvergence rate with appropriate choice of the grading parameter,whereα(0<α<1)is the order of temporal Caputo fractional derivative.A fully discrete spectral scheme is constructed combing a Petrov-Galerkin spectral method for the spatial discretization,and its stability and convergence are theoretically *** numerical results are provided to verify the theoretical analysis and demonstrated the sharpness of the error analysis.

关键词： Fractional KdV equation initial singularity L1 scheme graded mesh

Research Progress on Harmless Treatment of Dead Livestock and Poultry with Alkaline Hydrolysis in China

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Animal Husbandry and Feed Science 2017年第6期9卷 346-348,354页

作者： Zhang Zhenling Xu Haifei sun Peng Zhao Bingkai Dong Shuhong Department of Animal Engineering Xuzhou Vocational College of Bioengineering COFCO-JOYCOME (Yancheng) Ltd.

China＇s animal husbandry industry has developed rapidly and the inventory of swine, poultry, and sheep has been in the first place in the world of late years. For several consecutive years, the annual slaughter swine has reached to more than 700 million head, 70 million head of carcasses, about 2 million tons. The number will be even more if cattle, sheep and poultry had been considered. If handled improperly, the large number of carcasses of livestock and poultry will seriously pollute environment and even bring food safety issues and harm to public health security. More and more concern has been attracted on harmless disposal of dead animals. Of all the harmless disposal methods on carcasses of livestock and poultry, the application and research of alkalizalion hydrolysisar （ AH ） are less and only restricted in the higher-level security laboratory field in China. The method of alkalization hydrolysis has the advantages of completely inactivating pathogenic microorganisms （including prions）, no harmful gas, simple operation, low cost, etc, which has the value of research and application. This paper summarized the characteristics and the sterilization effect of alkaline hydrolysis, and discussed the processing and application of AH products of animal carcasses ,meanwhile, introduced the types, research and application state of AH in China, finally, briefly discussed the application prospect of AH in China.

关键词： Carcasses of livestock and poultry Alkalization hydrolysis Harmless disposal technology Prions

CP-25 reverses prostaglandin E4 receptor desensitization-induced fibroblast-like synoviocyte dysfunction via the G protein-coupled receptor kinase 2 in autoimmune arthritis

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Acta Pharmacologica Sinica 2019年第8期40卷 1029-1039页

作者： Xiao-yi Jia Yan Chang Fang Wei Xing Dai Yu-jing Wu Xiao-jing sun Shu Xu Hua-xun Wu Chun Wang Xue-zhi Yang Wei Wei Institute of Clinical Pharmacology Anhui Medical University Key Laboratory of Anti-inflammatory and Immune Medicine Ministry of Education Anhui Collaborative Innovation Center of Anti-inflammatory and Immune Medicine School of Pharmacy Anhui University of Chinese Medicine

Paeoniflorin-6’-O-benzene sulfonate(CP-25)is a novel compound derived from paeoniflorin that has been demonstrated to have therapeutic effects in a rat model of rheumatoid arthritis(RA).However,the underlying mechanism has not been elucidated to *** explored this mechanism in the present study by treating rats with adjuvant arthritis(AA)with *** found that the membrane EP4 protein level was downregulated;whereas,GRK2 was upregulated,in fibroblast-like synoviocyte(FLS)s of AA ***(PGE)2 stimulated FLS proliferation and enhanced the membrane EP4 receptor protein level;the latter was reversed by the administration of an EP4 receptor agonist,whereas the membrane GRK2 protein level gradually *** changes in the EP4 receptor and GRK2 expression were enhanced by TNF-α,and the former was accompanied by an alteration in the cyclic(c)AMP *** EP4 receptor agonist stimulation increased the association between GRK2 and the EP4 ***2 knockdown abrogated the abnormalities in FLS *** CP-25 treatment(100 mg/kg)suppressed joint inflammation with an efficacy that was similar to that of *** finding was associated with EP4 upregulation and GRK2 downregulation in ***,GRK2 plays an important role in the abnormal FLS proliferation observed in AA possibly by promoting EP4 receptor desensitization and decreasing the cAMP *** results demonstrate that CP-25 has therapeutic potential for the treatment of human RA via GRK2 regulation.

关键词： adjuvant-induced arthritis paeoniflorin-6’-O-benzene sulfonate fibroblast-like synoviocytes G protein-coupled receptor kinase 2 prostaglandin E2

Fuzzy tracking control design for hypersonic vehicles via T-S model

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Science China(Information Sciences) 2011年第3期54卷 521-528页

作者： GAO DaoXiang 1 & sun ZengQi 2 1 School of Technology, Beijing Forestry University, Beijing 100083, China 2 State Key Laboratory of Intelligent Technology and System, Department of Computer Science and Technology, Tsinghua University, Beijing 100084, China School of Technology Beijing Forestry University Beijing China State Key Laboratory of Intelligent Technology and System Department of Computer Science and Technology Tsinghua University Beijing China

The main focus of this paper is on designing a T-S fuzzy controller for the hypersonic vehicle. The longitudinal dynamics of the vehicle are studied using time-scale decomposition to reduce the complexity of T-S modeling. The dynamic inversion with PI control technique is applied for the slow dynamics to derive the flight path angle command and throttle setting by taking the pilot altitude and velocity command as its inputs. The T-S fuzzy controller is designed for the fast dynamics to derive the elevator deflection to track the flight path angle command. The discrepancy between the T-S model and real vehicle model is considered by using sliding mode control for the system stability. Simulation results are included to show the effectiveness of the controller.

关键词： fuzzy control T-S model sliding mode control hypersonic vehicle