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The 8th International Congress on SLE

作者： Erwin K Chung Yee Ling Wu Stephanie Savelli Haikady N Nagaraja Maddie Hebert Karla Jones Kathryn Kitzmiller Carol A Blanchong NatalieJacobsen-Longman kim mcbride Gloria C Higgins Robert M Rennebohm Robert R Rice Kevin V Hackshaw Robert A Roubey Jennifer M Grossman Betty P Tsao Daniel J Birmingham Brad H Rovin Lee A Hebert C Yung Yu Columbus Children’s Research Institute College of Medicine and Public HealthThe Ohio State UniversityColumbusOhioUSA Division of Rheumatology Allergy and ImmunologyThe University of North Carolina at Chapel HillChapel Hill.NC.USA Department of Internal Medicine University of California.Los AngelesCaliforniaUSA

＜正＞Purpose:To determine the inter-individual gene copy number variation（GCNV）of complement C4 and its associated polymorphisms in gene size（long and short）and protein isotypes（C4A and C4B）in human SLE. Method...

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Annoyance and Health-Related Quality of Life: A Cross-Sectional Study Involving Two Noise Sources

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Journal of Environmental Protection 2014年第5期5卷 400-407页

作者： Daniel Shepherd David mcbride kim N. Dirks David Welch Department of Preventive and Social Medicine University of Otago Dunedin New Zealand School of Population Health The University of Auckland Auckland New Zealand School of Public Health AUT University Auckland New Zealand

Noise remains a potent degrader of health in many global contexts, capable of inducing severe annoyance and sleep disturbance. An epidemiological study was undertaken to compare noise annoyance and health-related quality of life of individuals residing close to a major international airport or wind turbine complex with those located in demographically matched areas. Results indicate that domains of health-related quality of life may be degraded in those living in areas more likely to induce noise annoyance. Furthermore, the addition of aviation noise to environments already encroached by road noise may induce further annoyance and degradations in health-related quality of life, indicating that one noise sources may not mask the impact of another.

关键词： Aviation Noise Wind Turbine Noise Noise Annoyance Health

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Next-generation resorbable polymer scaffolds with surface-precipitated calcium phosphate coatings

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Regenerative Biomaterials 2015年第1期2卷 1-8页

作者： Jinku kim Maria Hanshella R.Magno Ophir Ortiz Sean mcbride Aniq Darr Joachim Kohn Jeffrey O.Hollinger Bone Tissue Engineering Center Department of Biomedical EngineeringCarnegie Mellon UniversityPittsburghPA 15219USA Department of Bio and Chemical Engineering Hongik UniversitySejongKorea 339-701 Department of Chemistry and Chemical Biology and New Jersey Center for Biomaterials RutgersThe State University of New JerseyPiscatawayNJ 08854USA

Next-generation synthetic bone graft therapies will most likely be composed of resorbable polymers in combination with bioactive *** this article,we continue our exploration of E1001(1k),a tyrosine-derived polycarbonate,as an orthopedic implant ***,we use E1001(1k),which is degradable,nontoxic,and osteoconductive,to fabricate porous bone regeneration scaffolds that were enhanced by two different types of calcium phosphate(CP)coatings:in one case,pure dicalcium phosphate dihydrate was precipitated on the scaffold surface and throughout its porous structure(E1001(1k)+CP).In the other case,bone matrix minerals(BMM)such as zinc,manganese and fluoride were co-precipitated within the dicalcium phosphate dihydrate coating(E1001(1k)+BMM).These scaffold compositions were compared against each other and against ChronOS(Synthes USA,West Chester,PA,USA),a clinically used bone graft substitute(BGS),which served as the positive control in our experimental *** BGS is composed of poly(lactide co-e-caprolactone)and beta-tricalcium *** used the established rabbit calvaria critical-sized defect model to determine bone regeneration within the defect for each of the three scaffold *** bone formation was determined after 2,4,6,8 and 12 weeks by micro-computerized tomography(mCT)and *** experimental tyrosine-derived polycarbonate,enhanced with dicalcium phosphate dihydrate,E1001(1k)+CP,supported significant bone formation within the defects and was superior to the same scaffold containing a mix of BMM,E1001(1k)+*** comparison with the commercially available BGS was complicated by the large variability in bone formation observed for the laboratory preparations of E1001(1k)*** all time points,there was a trend for E1001(1k)+CP to be superior to the commercial ***,only at the 6-week time point did this trend reach statistical *** analysis of the μCT data suggested an increase in bone fo

关键词： tyrosine-derived polycarbonate dicalcium phosphate dihydrate calcium phosphate rabbit calvarial critical size defect model bone regeneration

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