检索结果-南通市图书馆

Rare Metals 2006年第Z2期25卷 118-123页

作者： LEE Dock-Young KANG Suk-Won CHO Duck-Ho kim ki-bae Division of Materials Korea Institute of Science and Technology P.O. Box 131 Cheongryang Seoul 130-650 Korea Department of Applied Materials Engineering Hanbat National University Daejeon 305-719 Korea

Recently, a semi-solid metal processing has been acknowledged as a cost-effective technique to be able to manufacture high quality product for the transportation industry. In this study a hypo-eutectic Al alloy was fabricated by means of an electromagnetic stirrer in continuous casting process and the microstructural change during solidification due to a fluid flow by electromagnetic stirring was examined. Due to the forced fluid flow during solidification a dendritic phase of primary α phase of Al alloy was turned into a globular phase, which can make the Al alloy get a thixotropic behavior in the semi-solid region. In order to establish the quantitative relationship between microstructure and the process parameters, the morphology shape, a silicon distribution and a size of primary α phase were observed according to casting speed in continuous casting machine. The primary α phase was turned into the degenerate dendrites approaching a spherical configuration with increasing casting speed. The fine-grained and equiaxed microstructure appeared at higher casting speed. A segregation behavior of Si element was declined with increasing casting speed and a very uniform distribution of Si element was observed on the billet at a casting speed of 600 mm·min-1. A thickness of the solidifying shell of the billet was shortened with increasing the casting speed.

关键词： semi-solid slurry electromagnetic stirring casting speed segregation Al alloy

Negative Stiffness Mechanism on An Asymmetric Wave Energy Converter by Using A Weakly Nonlinear Potential Model

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

China Ocean Engineering 2024年第4期38卷 689-700页

作者： Sunny Kumar POGULURI Dongeun kim Yoon Hyeok bae Department of Ocean Engineering IIT MadrasChennaiIndia Multidisciplinary Graduate School Program for Wind Energy Jeju National UniversityJejuRepublic of Korea Mechanical and System Design Engineering Hongik UniversitySeoulRepublic of Korea

Salter's duck,an asymmetrical wave energy converter(WEC)device,showed high efficiency in extracting energy from 2D regular waves in the past;yet,challenges remain for fluctuating wave *** can potentially be addressed by adopting a negative stiffness mechanism(NSM)in WEC devices to enhance system efficiency,even in highly nonlinear and steep 3D waves.A weakly nonlinear model was developed which incorporated a nonlinear restoring moment and NSM into the linear formulations and was applied to an asymmetric WEC using a time domain potential flow *** model was initially validated by comparing it with published experimental and numerical computational fluid dynamics *** current results were in good agreement with the published *** was found that the energy extraction increased in the range of 6%to 17%during the evaluation of the effectiveness of the NSM in regular *** irregular wave conditions,specifically at the design wave conditions for the selected test site,the energy extraction increased by 2.4%,with annual energy production increments of approximately *** findings highlight the potential of NSM in enhancing the performance of asymmetric WEC devices,indicating more efficient energy extraction under various wave conditions.

关键词： asymmetric wave energy converter negative stiffness mechanism weakly nonlinear potential flow power

Hydrangea serrata extract exerts tumor inhibitory activity against hepatocellular carcinoma HepG2 cells via inducing p27/CDK2-mediated cell cycle arrest and apoptosis

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Asian Pacific Journal of Tropical Biomedicine 2024年第2期14卷 65-72,I0002-I0005页

作者： Ye-eun kim Jeonghye Hwang ki-Young kim Graduate School of Biotechnology Kyung Hee UniversitySeocheonGiheungYonginGyeonggi-do 446-701Republic of Korea Department of Genetics and Biotechnology College of Life SciencesKyung Hee UniversitySeocheonGiheungYonginGyeonggi-do 446-701Republic of Korea

Objective:To examine the inhibitory effect of Hydrangea serrata extract against hepatocellular carcinoma HepG2 cells and its underlying ***:The effects of Hydrangea serrata extract on growth inhibition of tumor cells and spheroids were assessed using MTT and 3D culture *** real-time PCR and Western blot analyses were employed to investigate the changes in mRNA and protein expression levels of molecules related to cell cycle and ***:Hydrangea serrata extract effectively inhibited the growth of both tumor cells and *** extract also significantly upregulated p27 mRNA expression and downregulated CDK2 mRNA expression,leading to cell cycle ***,increased BAX/Bcl-2 ratio as well as caspase-9 and-3 were observed after treatment with Hydrangea serrata extract,indicating the induction of tumor cell ***:Hydrangea serrata extract has the potential to alleviate tumors by effectively modulating cell-cycle-related gene expressions and inducing apoptosis,thereby inhibiting tumor growth.

关键词： Hydrangea serrata Hepatocellular carcinoma Liver cancer Anticancer Cell cycle arrest Apoptosis

Real-world utility of serological tests in patients with suspected scrub typhus in the Republic of Korea:A single-center,retrospective,observational study

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Asian Pacific Journal of Tropical Medicine 2024年第6期17卷 273-280,I0004,I0005页

作者： Seulki kim A Reum kim Seungjin Lim Su Jin Lee Moonsuk bae Division of Infectious Diseases Department of Internal MedicinePusan National University Yangsan HospitalYangsanRepublic of Korea Research Institute for Convergence of Biomedical Science and Technology Pusan National University Yangsan HospitalYangsanRepublic of Korea Department of Internal Medicine Pusan National University School of MedicineBusanRepublic of Korea

Objective:Serological tests are widely used for scrub typhus diagnosis;however,their limitations are *** study aims to assess their practical value in clinical ***:We analyzed the data of adult patients with suspected scrub typhus who visited a tertiary care hospital in the Republic of Korea from September to December from 2019 to *** included patients had an acute fever and at least one of the following ten secondary findings:myalgia,skin rash,eschar,headache,thrombocytopenia,increased liver enzyme levels,lymphadenopathy,hepatomegaly,splenomegaly,and pleural *** diagnoses were grouped as scrub typhus or other diseases by two infectious disease ***:Among 136 patients who met the eligibility criteria,109 had scrub typhus and 27 had different *** and paired total antibodies using immunofluorescence assay(IFA),and total antibodies using immunochromatography-based rapid diagnostic testing(ICT)were measured in 98%,22%,and 75%of all patients,*** using paired samples for scrub typhus was established at a median of 11[interquartile range(IQR)10-16]days following the first *** the 82 admitted patients,the median admission time was 9(IQR 7-13)*** to IFA,58(55%)patients with scrub typhus had total immunoglobulin titers≥1:320,while 23(85%)patients with other disease had titersking in clinical practice.

关键词： Scrub typhus Serological test Immunofluorescence assay Immunochromatography Rapid detecting test

Microstructural evolution in lithium plating process and its effect on the calendar storage life

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Nano Research 2024年第10期17卷 8834-8841页

作者： ki Hwan Koh Dong Ju Lee Anthony Mu Kangwoon kim Taehee kim Zheng Chen Department of Chemical and Nano Engineering University of California San DiegoLa JollaCA 92093USA Program of Materials Science and Engineering University of California San DiegoLa JollaCA 92093USA Sustainable Power and Energy Center University of California San DiegoLa JollaCA 92093USA

The growing demand for electric vehicles highlights the need for energy storage solutions with higher densities,spotlighting Li metal anodes as potential successors to traditional Li-ion batteries(LIBs).Achieving longer calendar aging life for Li metal anodes is crucial for their practical use,given their propensity for corrosion due to a low redox potential,which leads to compromised cycling stability and significant capacity loss during *** research investigated that this susceptibility is mainly dependent on the surface area of Li metal anode and the properties of the solid electrolyte interphase(SEI),particularly its stability and growth *** research adds to this understanding by demonstrating that the amount of Li plating is a key factor in its corrosion during open-circuit storage,as assessed across various *** discovered that increasing the Li plating amount effectively reduces Coulombic efficiency(C.E.)loss during aging,due to a lower surface area-to-Li *** implies that the choice of electrolyte for optimal storage life should consider the amount of Li plating,with higher capacities promoting better storage characteristics.

关键词： lithium metal batteries anode-free batteries calendar life of batteries lithium anode corrosion

Modification strategies improving the electrochemical and structural stability of high-Ni cathode materials

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Energy Chemistry 2024年第9期96卷 185-205页

作者： Yoon Bo Sim Hami Lee Junyoung Mun ki Jae kim Department of Energy Science Sungkyunkwan UniversitySuwon 16419Republic of Korea School of Advanced Materials Science and Engineering Sungkyunkwan UniversitySuwon 16419Republic of Korea SKKU Institute of Energy Science and Technology(SIEST) Sungkyunkwan UniversitySuwon 16419Republic of Korea

With the increasing spotlight in electric vehicles,there is a growing demand for high-energy-density batteries to enhance driving ***,several studies have been conducted on high-energy-density LiNi_(x)Co_(y)Mn_(z)O_(2)***,there is a limit to permanent performance deterioration because of side reactions caused by moisture in the atmosphere and continuous microcracks during cycling as the Ni content to express high energy increases and the content of Mn and Co that maintain structural and electrochemical stabilization *** direct modification of the surface and bulk regions aims to enhance the capacity and long-term performance of high-Ni cathode ***,an efficient modification requires a study based on a thorough understanding of the degradation mechanisms in the surface and bulk *** this review,a comprehensive analysis of various modifications,including doping,coating,concentration gradient,and single crystals,is conducted to solve degradation issues along with an analysis of the overall degradation mechanism occurring in high-Ni cathode *** also summarizes recent research developments related to the following modifications,aims to provide notable points and directions for post-studies,and provides valuable references for the commercialization of stable high-energy-density cathode materials.

关键词： High energy density High-Ni cathode materials Degradation Structural stability Lithium-ion battery

Nuclear receptor coactivator 6 is a critical regulator of NLRP3 inflammasome activation and gouty arthritis

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Cellular & Molecular Immunology 2024年第3期21卷 227-244页

作者： Kang-Gu Lee Bong-ki Hong Saseong Lee Naeun Lee Seung-Whan kim Donghyun kim Wan-Uk kim Center for Integrative Rheumatoid Transcriptomics and Dynamics The Catholic University of KoreaSeoul 06591Republic of Korea Department of Biomedicine&Health Sciences The Catholic University of KoreaSeoul 06591Republic of Korea Department of Pharmacology Asan Medical CenterUniversity of Ulsan College of MedicineSeoul 05505Republic of Korea Bio-Medical Institute of Technology University of UlsanSeoul 05505Republic of Korea Department of Microbiology and Immunology Seoul National University College of MedicineSeoul 03080Republic of Korea Institute of Infectious Diseases Seoul National University College of MedicineSeoul 03080Republic of Korea Division of Rheumatology Department of Internal MedicineThe Catholic University of KoreaSeoul 06591Republic of Korea

Transcriptional coactivators regulate the rate of gene expression in the *** receptor coactivator 6(NCOA6),a coactivator,has been implicated in embryonic development,metabolism,and cancer pathogenesis,but its role in innate immunity and inflammatory diseases remains ***,we demonstrated that NCOA6 was expressed in monocytes and macrophages and that its level was increased under proinflammatory ***,nuclear NCOA6 was found to translocate to the cytoplasm in activated monocytes and then become incorporated into the inflammasome with NLRP3 and ASC,forming cytoplasmic ***,NCOA6 associated with the ATP hydrolysis motifs in the NACHT domain of NLRP3,promoting the oligomerization of NLRP3 and ASC and thereby instigating the production of IL-1βand active *** note,Ncoa6 deficiency markedly inhibited NLRP3 hyperactivation caused by the Nlrp3^(R258W) gain-of-function mutation in *** ablation of Ncoa6 substantially attenuated the severity of two NLRP3-dependent diseases,folic-induced acute tubular necrosis and crystal-induced arthritis,in *** with these findings,NCOA6 was highly expressed in macrophages derived from gout patients,and NCOA6-positive macrophages were significantly enriched in gout macrophages according to the transcriptome profiling ***,NCOA6 is a critical regulator of NLRP3 inflammasome activation and is therefore a promising target for NLRP3-dependent diseases,including gout.

关键词： Nuclear receptor coactivator 6 Nuclear-to-cytoplasmic translocation NLRP3 inflammasome NACHT domain Gouty arthritis

CD200Rhigghh neutrophils with dysfunctional autophagy establish systemic immunosuppression by increasing regulatory T cells

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Cellular & Molecular Immunology 2024年第4期21卷 349-361页

作者： Ye Seon kim Yu Sun Jeong Geon Ho bae Ji Hyeon Kang Mingyu Lee Brian A.Zabel Yoe-Sik bae Department of Biological Sciences Sungkyunkwan UniversitySuwon16419Republic of Korea Department of Health Science and Technology SAIHSTSungkyunkwan UniversitySeoul06351Republic of Korea Palo Alto Veterans Institute for Research Veterans Affairs HospitalPalo AltoCA94304USA

Distinct neutrophil populations arise during certain pathological *** generation of dysfunctional neutrophils during sepsis and their contribution to septicemia-related systemic immune suppression remain *** this study,using an experimental sepsis model that features immunosuppression,we identified a novel population of pathogenic CD200R^(high) neutrophils that are generated during the initial stages of sepsis and contribute to systemic immune suppression by enhancing regulatory T(T_(reg))*** to their CD200R^(low)counterparts,sepsis-generated CD200Rhigh neutrophils exhibit impaired autophagy and dysfunction,with reduced chemotactic migration,superoxide anion production,and TNF-α*** soluble CD200 blocks autophagy and neutrophil maturation in the bone marrow during experimental sepsis,and recombinant CD200 treatment in vitro can induce neutrophil dysfunction similar to that observed in CD200R^(high) *** administration of anα-CD200R antibody effectively reversed neutrophil dysfunction by enhancing autophagy and protecting against a secondary infection challenge,leading to increased *** analysis revealed that CD200R^(high) neutrophils expressed high levels of Igf1,which elicits the generation of Treg cells,while the administration of anα-CD200R antibody inhibited Treg cell generation in a secondary infection *** together,our findings revealed a novel CD200R^(high) neutrophil population that mediates the pathogenesis of sepsis-induced systemic immunosuppression by generating Treg cells.

关键词： Sepsis Neutrophils CD200R Autophagy IGF-1 Regulatory T cells

A Traffic-Aware and Cluster-Based Energy Efficient Routing Protocol for IoT-Assisted WSNs

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Computers, Materials & Continua 2024年第8期80卷 1831-1850页

作者： Hina Gul Sana Ullah ki-Il kim Farman Ali Department of Computer and Software Technology University of SwatMingora19130Pakistan Department of Computer Science and Engineering Chungnam National UniversityDaejeon34134Republic of Korea Department of Applied AI Sungkyunkwan UniversitySeoul03063Republic of Korea

The seamless integration of intelligent Internet of Things devices with conventional wireless sensor networks has revolutionized data communication for different applications,such as remote health monitoring,industrial monitoring,transportation,and smart *** and reliable data routing is one of the major challenges in the Internet of Things network due to the heterogeneity of *** paper presents a traffic-aware,cluster-based,and energy-efficient routing protocol that employs traffic-aware and cluster-based techniques to improve the data delivery in such *** proposed protocol divides the network into clusters where optimal cluster heads are selected among super and normal nodes based on their residual *** protocol considers multi-criteria attributes,i.e.,energy,traffic load,and distance parameters to select the next hop for data delivery towards the base *** performance of the proposed protocol is evaluated through the network simulator *** different traffic rates,number of nodes,and different packet sizes,the proposed protocol outperformed LoRaWAN in terms of end-to-end packet delivery ratio,energy consumption,end-to-end delay,and network *** 100 nodes,the proposed protocol achieved a 13%improvement in packet delivery ratio,10 ms improvement in delay,and 10 mJ improvement in average energy consumption over LoRaWAN.

关键词： Internet of Things wireless sensor networks traffic load clustering routing energy efficiency

Pedicled abdominal flap using deep inferior epigastric artery perforators for forearm reconstruction: A case report

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Clinical Cases 2024年第4期12卷 828-834页

作者： Jae Hyung Jeon Kyung Wook kim Hong bae Jeon Department of Plastic and Reconstructive Surgery Dankook University HospitalCheonan 31116ChungnamSouth Korea Department of Orthopaedic Surgery Dankook University HospitalDankook University College of MedicineCheonan 31116ChungnamSouth Korea Department of Plastic and Reconstructive Surgery Dankook University HospitalDankook University College of MedicineCheonan 31116ChungnamSouth Korea

BACKGROUND Pedicled abdominal flaps are a widely used surgical technique for forearm reconstruction in patients with soft tissue ***,some drawbacks include restricted flap size,partial flap loss,and donor-site *** address these concerns,we present a case of a pedicled abdominal flap using the deep inferior epigastric artery perforators(DIEP)for forearm reconstruction in a patient with a large soft tissue *** SUMMARY A 46-year-old male patient was admitted to our hospital with forearm injury caused by a pressing machine.A 15 cm×10 cm soft tissue defect with complete rupture of the ulnar side structures of the forearm was *** week after orthopedic management of the neurovascular injury and fractures using the first stage of Masquelet technique,the patient was referred to the plastic and recon-structive surgery department for wound *** debridement and negative-pressure wound therapy revealed a 20 cm×15 cm soft tissue defect.A pedicle abdominal flap with the DIEP was used to cover the *** weeks later,the flap was detached from the abdomen,and the abdominal defect was directly ***,the second stage of Masquelet technique was performed at the fracture site at week ***,all donor and recipient sites healed without complications,such as flap dehiscence,infection,hematoma,or *** site osteosynthesis was achieved without *** Pedicled abdominal flap using the DIEP provides a reliable option for forearm reconstruction in patients with large soft tissue defects.

关键词： Forearm injury Open fracture reduction Perforator flap Deep inferior epigastric artery perforators Case report