检索结果-南通市图书馆

Phosphorylated p70S6K in urothelial carcinoma of the tumor recurrence noninvasive low-grade bladder： correlation with

引用

Asian Journal of Andrology 2014年第4期16卷 611-617页

作者： Soon-Ja kim Jung hoon kim Hui Seok Jung Tae-Jin Lee Kyung Mee Lee In Ho Chang Department of Convergence Medicine and Pharmaceutical Biosciences Chung-Ang University Graduate School Seoul Department of Urology Department of Pathology Chung-Ang University College of Medicine Seoul Korea.

We investigated whether inhibiting phosphorylated p70S6K （p-p70S6K） suppresses the proliferation and growth of noninvasive low-grade urothelial carcinoma （LG-URCa） in vitro and whether p-p70S6K can serve as a predictive biomarker for the recurrence of noninvasive LG-URCa of the bladder in patients. We constructed a tissue microarray （TMA） for 95 LG-URCa and 35 benign urothelium samples and performed immunohistochemical staining for p-p70S6K and p-4E-BP1. A Cox regression model was used to investigate the predictive factors for recurrence of LG-URCa. We investigated the dose-dependent antiproliferative effect of rapamycin, its antiproliferative effect and the growth-inhibition effect of p70S6K siRNA transfection in RT4 and 253J cell lines. The pT1 staged group （P 〈 0.05; hazard ratio （HR）, 2.415） and the high p-p70S6K staining group （P 〈 0.05; HR, 2.249） were independent factors for predicting recurrence. Rapamycin inhibited RT4 and 253J cell proliferation in a dose-dependent manner （r = -0.850, P 〈 0.001 in RT4 cells; r = -0.835, P 〈 0.001 in 253J cells）. RT4 and 253J cell proliferation and growth were inhibited by the transfection of p70S6K siRNA and rapamycin, respectively （P 〈 0.05）. Transfection of p70S6K siRNA resulted in inhibitory effects on cell proliferation and growth that were similar to those of rapamycin. Our results suggest that inhibiting p70S6K phosphorylation is important to prevent recurrence and that p70S6K phosphorylation can be used as a molecular biomarker to predict recurrence of certain LG-URCa of the bladder.

关键词： bladder cancer p7OS6K

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Effects of ocean acidifi cation driven by elevated CO_2 on larval shell growth and abnormal rates of the venerid clam, Mactra veneriformis

引用

Chinese Journal of Oceanology and Limnology 2016年第6期34卷 1191-1198页

作者： Jee-hoon kim Ok Hwan YU Eun Jin YANG Sung-Ho KANG Won kim Eun Jung CHOY Division of Polar Ocean Environment Research Korea Polar Research Institute Korea Institute of Ocean Science and Technology School of Biological Sciences Seoul National University Marine Ecosystem Research Division Korea Institute of Ocean Science and Technology

A bstract The venerid clam(M actra veneriformis Reeve 1854) is one of the main cultured bivalve species in intertidal and shallow subtidal ecosystems along the west coast of Korea. To understand the effects of ocean acidifi cation on the early life stages of Korean clams, we investigated shell growth and abnormality rates and types in the D-shaped, umbonate veliger, and pediveliger stages of the venerid clam M. veneriformis during exposure to elevated seawater pCO_2. In particular, we examined abnormal types of larval shell morphology categorized as shell deformations, shell distortions, and shell fi ssures. Specimens were incubated in seawater equilibrated with bubbled CO_2-enriched air at(400±25)×10^(-6)(ambient control),(800±25)×10^(-6)(high pCO_2), or(1 200±28)×10^(-6)(extremely high pCO_2), the atmospheric CO_2 concentrations predicted for the years 2014, 2084, and 2154(70-year intervals; two human generations), respectively, in the Representative Concentration Pathway(RCP) 8.5 scenario. The mean shell lengths of larvae were signifi cantly decreased in the high and extremely high pCO_2 groups compared with the ambient control groups. Furthermore, under high and extremely high pCO_2 conditions, the cultures exhibited signifi cantly increased abundances of abnormal larvae and increased severity of abnormalities compared with the ambient control. In the umbonate veliger stage of the experimental larvae, the most common abnormalities were shell deformations, distortions, and fi ssures; on the other hand, convex hinges and mantle protuberances were absent. These results suggest that elevated CO_2 exerts an additional burden on the health of M. veneriformis larvae by impairing early development.

关键词： abnormality larval shell growth Mactra veneriformis ocean acidifi cation pCO2

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Successful treatment of intracardiac air embolism using intracardiac catheter aspiration

引用

Journal of Geriatric Cardiology 2017年第2期14卷 151-154页

作者： Ae-Young Her Yong hoon kim Da Hye Moon Ji Hyun kim Jae hoon Jeong Sung-Hyun Park Jin Seon Jeong Division of Cardiology Department of Internal Medicine Kangwon National University School of Medicine Chuncheon South Korea Department of Internal Medicine Kangwon National University Hospital Chuncheon South Korea

Intracardic air embolism is uncommon, however it is a serious condition which frequently leads to catastrophic complications during or after invasive procedures resulting in significant morbidity and mortality. For a successful re- suscitation of patients with intracardiac air embolism, hy- perbaric oxygen therapy is critical.~~2~ Still, due to a hyper- baric chamber＇s unavailability at many hospitals and con- cerns about patient movement resulting in further embolism during transport, such treatment method is gradually dimin- ishing.

关键词： Aspiration Catheter Intracardiac air embolism

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Transarterial chemoembolization in Barcelona Clinic Liver Cancer Stage 0/A hepatocellular carcinoma

引用

World Journal of Gastroenterology 2014年第3期20卷 745-754页

作者： Heung Cheol kim Ki Tae Suk Dong Joon kim Jai hoon Yoon Yeon Soo kim Gwang Ho Baik Jin Bong kim Chang hoon kim Hotaik Sung Jong Young Choi Kwang Hyub Han Seung Ha Park Department of Radiology Hallym University College of Medicine Department of Internal Medicine Hallym University College of Medicine College of Medicine Upstate Medical UniversityState University of New York Department of Biology Stanford University Department of Internal Medicine Catholic University College of Medicine Liver Cirrhosis Clinical Research Center Yonsei University College of Medicine Department of Internal Medicine Inje University College of Medicine

AIM: To evaluate the clinical characteristics of patients with Barcelona Clinic Liver Cancer (BCLC) stage 0 and A hepatocellular carcinoma (HCC) after transarterial chemoembolization (TACE).

关键词： Carcinoma Hepatocellular Chemoembolization Therapeutic Survival Stage Efficacy

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Nontarget screening using passive air and water sampling with a level Ⅱ fugacity model to identify unregulated environmental contaminants

引用

Journal of Environmental Sciences 2017年第12期29卷 84-91页

作者： In-Young Chung Yu-Mi Park Hyun-Jeoung Lee Hyuk kim Dong-hoon kim Il-Gyu kim Sang-Min kim Young-Sun Do Kwang-Seol Seok Jung-Hwan Kwon Chemical Research Division Environmental Health Research Department National Institute of Environmental ResearchIncheon Division of Environmental Science and Ecological Engineering Korea University

It is thought that there are many unregulated anthropogenic chemicals in the *** risk assessment of chemicals, it is essential to estimate the predicted environmental concentrations. As an effort of identifying residual organic contaminants in air and water in Korea, nontarget screening using two-dimensional gas chromatography time-of-flight mass spectrometry（GC × GC-TOFMS） was conducted at 10 sites using polyurethane foam passive air sampler and at 6 sites using polydimethyl siloxane（PDMS） passive water sampler in three different seasons in 2014. More than 600 chemical peaks were identified satisfying the identification criteria in air and water samples, respectively, providing a list for further investigation. Chemical substances with reported national emission rates in2014（n = 149） were also screened for potential existence in the environment using a level Ⅱ fugacity model. Most of chemical substances classified as not detectable were not identified with detection frequency greater than 20% by nontarget screening, indicating that a simple equilibrium model has a strong potential to be used to exclude chemicals that are not likely to remain in the environment after emissions from targeted monitoring.

关键词： Nontarget screening GC × GC-TOFMS Passive sampling Pollutant release and transfer register(PRTR) Fugacity model

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Modulation of signal transduction pathways by natural compounds in cancer

引用

Chinese Journal of Natural Medicines 2015年第10期13卷 730-742页

作者： Alok Ranjan Neel M.Fofaria Sung-hoon kim Sanjay K.Srivastava Department of Biomedical Sciences and Cancer Biology Center Texas Tech University Health Sciences Center Cancer Preventive Material Development Research Center College of Korean Medicine Department of Pathology Kyunghee University

Cancer is generally regarded as the result of abnormal growth of cells. According to World Health Organization, cancer is the leading cause of mortality worldwide. Mother nature provides a large source of bioactive compounds with excellent therapeutic efficacy. Numerous phytochemicals from nature have been investigated for anticancer properties. In this review article, we discuss several natural compounds, which have shown anti-cancer activity. Natural compounds induce cell cycle arrest, activate intrinsic and extrinsic apoptosis pathways, generate Reactive Oxygen Species(ROS), and down-regulate activated signaling pathways, resulting in inhibition of cell proliferation, progression and metastasis of cancer. Several preclinical studies have suggested that natural compounds can also increase the sensitivity of resistant cancers to available chemotherapy agents. Furthermore, combining FDA approved anti-cancer drugs with natural compounds results in improved efficacy. On the basis of these exciting outcomes of natural compounds against several cancer types, several agents have already advanced to clinical trials. In conclusion, preclinical results and clinical outcomes against cancer suggest promising anticancer efficacy of agents from natural sources.

关键词： Natural compounds Capsaicin Curcumin Diindolylmethane(DIM) Isothiocyanate Piperine Deguelin Cucurbitacin B Cancer

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Association between preoperative high sensitive troponin I levels and cardiovascular events after hip fracture surgery in the elderly

引用

Journal of Geriatric Cardiology 2018年第3期15卷 215-221页

作者： Bum Sung kim Tae-hoon kim Jeong-Hwan Oh Chang Hee Kwon Sung Hea kim Hyun-Joong kim Heung Kon Hwang Sang-Man Chung in-gu Seoul Republic of Korea Department of Orthopedic surgery Konkuk University Medical Center 120-1 Neungdong-ro Hwayang-dong Gwangjin-guSeoulRepublic of Korea

Objective Cardiovascular complications contribute to postoperative morbidity and mortality in elderly hip fracture patients. Limited data are available regarding which preoperative risk factors predict cardiovascular course following hip fracture surgery （HFS）. We used high sensitive troponin I （hs-TnI） assays and clinical parameters to identify preoperative risk factors associated with major adverse cardiac events （MACE） in elderly hip frac^u＇e patients. Method From August 2014 to November 2016, 575 patients with hip fracture were enrolled in a retrospective, single-center registry. A total of 262 of these patients underwent HFS and hs-TnI assays. MACE was defined as postoperative all-cause deaths, heart failure （HF）, new-onset atrial fibrillation （AF）, myocardial infarction （MI） and cardiovascular re-hospitalization that occurred within 90 days postoperative. Results Of 262 HFS patients, MACE developed following HFS in 65 （24.8%）. Patients with MACE were older and had higher rates of renal insufficiency, coronary artery disease, prior HF, low left ventricular ejection fraction and use of beta blockers; higher levels of hs-Tnl and N-terminal pro-brain natriuretic peptide （NT-proBNP） and higher revised cardiac risk index. A preoperative hs-TnI≥ 6.5 ng/L was associated with high risk of postoperative HF, new-onset AF and MACE. In multivariable analysis, pre-operative independent predictors for MACE were age 〉 80 years [adjusted hazard ratio （HR）： 1.79, 95% confident interval （CI）： 1.03-3.13, P = 0.04], left ventricular ejection fraction （LVEF）〈 50% （adjusted HR： 3.17, 95% CI： 1.47-5.82, P 〈 0.01） and hs-TnI 〉 6.5 ng/L （adjusted HR： 3.75, 95% CI： 2.09~5.17, P 〈 0.01）. Conclusion In elderly patients with hip fracture who undergo HFS, a preoperative assessment of hs-TnI may help the risk refinement of cardiovascular complications.

关键词： Cardiovascular complication High sensitive troponin I Hip fracture surgery

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Residual U-Network for Breast Tumor Segmentation from Magnetic Resonance Images

引用

Computers, Materials & Continua 2021年第6期67卷 3107-3127页

作者： Ishu Anand Himani Negi Deepika Kumar Mamta Mittal Tai-hoon kim Sudipta Roy Department of Computer Science&Engineering Bharati Vidyapeeth’s College of EngineeringNew Delhi110063India Department of Computer Science&Engineering G B Pant Govt.College of EngineeringNew Delhi110020India Glocal Campus Konkuk UniversityChungju-si Chungcheongbuk-do27478Korea Washington University in St.Louis MO63110USA

Breast cancer positions as the most well-known threat and the main source of malignant growth-related morbidity and mortality throughout the *** is apical of all new cancer incidences analyzed among *** features substantially inuence the classication accuracy of malignancy and benignity in automated cancer *** are the precision of tumor segmentation and appropriateness of extracted attributes required for the *** this research,the authors have proposed a ResU-Net(Residual U-Network)model for breast tumor *** proposed methodology renders augmented,and precise identication of tumor regions and produces accurate breast tumor segmentation in contrast-enhanced MR ***,the proposed framework also encompasses the residual network technique,which subsequently enhances the performance and displays the improved training *** and above,the performance of ResU-Net has experimentally been analyzed with conventional U-Net,FCN8,*** performance is evaluated in the form of dice coefcient and MIoU(Mean Intersection of Union),accuracy,loss,sensitivity,specicity,*** results show that ResU-Net achieved validation accuracy&dice coefcient value of 73.22%&85.32%respectively on the Rider Breast MRI dataset and outperformed as compared to the other algorithms used in experimentation.

关键词： UNet segmentation residual network breast cancer dice coefcient MRI

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Pretransplant absolute monocyte count in peripheral blood predicts posttransplant tumor prognosis in patients undergoing liver transplantation for hepatocellular carcinoma

引用

Hepatobiliary & Pancreatic Diseases International 2014年第3期13卷 250-258页

作者： Young-Kyu kim Seong hoon kim Seung-Duk Lee Soon-ae Lee Sang-Jae Park Center for Liver Cancer National Cancer Center323 Ilsan-ro Ilsandong-gu Goyang-si Gyeonggi-do Republic of Korea Department of Surgery College of Medicine Kangwon National University 1 Kangwondaehak-gilChuncheon-si Gangwon-do 200-701 Republic of Korea

BACKGROUND: Preoperative absolute monocyte count in peripheral blood(AMCPB) is closely associated with prognoses in not only various malignancies but also hepatocellular carcinoma(HCC). The purpose of this study was to evaluate whether pretransplant AMCPB predicts posttransplant outcomes in patients with HCC undergoing liver transplantation(LT).METHOD: We retrospectively analyzed relationships between clinicopathologic factors involving pretransplant AMCPB and tumor recurrence or survival in 256 patients who had undergone LT for HCC between January 2005 and April ***: ROC curve analysis showed that AMCPB >200/mm3was a risk factor for tumor recurrence; 43 patients showed higher AMCPB(>200/mm3), whereas 213 showed lower AMCPB(≤200/mm3) at the time of LT. On multivariate analysis,pretransplant high AMCPB, positive findings in pretransplant18F-FDG PET/CT, pathological maximal tumor size >5 cm,intrahepatic metastasis, moderately or poorly differentiated tumor and microvascular invasion were independent factors affecting recurrence-free survival. When we performed subgroup analysis based on the Milan criteria, high AMCPB was an independent factor for predicting HCC recurrence in patients with tumor beyond the Milan criteria(P=0.004), and not for patients within the ***: This study demonstrated that pretransplant AMCPB could predict tumor recurrence after LT for HCC,especially in patients with tumor beyond the Milan criteria.

关键词： liver transplantation hepatocellular carcinoma recurrence survival monocyte count

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Graft-to-recipient weight ratio lower to 0.7% is safe without portal pressure modulation in right-lobe living donor liver transplantation with favorable conditions

引用

Hepatobiliary & Pancreatic Diseases International 2014年第1期13卷 18-24页

作者： Seung Duk Lee Seong hoon kim Young-Kyu kim Soon-Ae Lee Sang-Jae Park Center for Liver Cancer National Cancer Center

BACKGROUND: The low graft-to-recipient weight ratio(GRWR) in adult-to-adult living donor liver transplantation(LDLT) is one of the major risk factors affecting graft survival. The goal of this study was to evaluate whether the lower limit of the GRWR can be safely reduced without portal pressure modulation in right-lobe LDLT. METHODS: From 2005 to 2011, 317 consecutive patients from a single institute underwent LDLT with right-lobe grafts without portal pressure modulation. Of these, 23 had a GRWR of less than 0.7%(group A), 27 had a GRWR of ≥0.7%, <0.8%(group B), and 267 had a GRWR of more than and equal to 0.8%(group C). Medical records, including recipient, donor, operation factors, laboratory findings and complications were reviewed retrospectively. RESULTS: The baseline demographics showed low model for end-stage liver disease score(mean 16.3±8.9) and high percentage of hepatocellular carcinoma(231 patients, 72.9%). Three groups by GRWR demonstrated similar characteristics except recipient body mass index and donor gender. For smallforsize syndrome, there were 3(13.0%) in group A, 1(3.7%) in group B, and 2 patients(0.7%) in group C(P<0.001). Hepatic artery thrombosis was more frequently observed in group A than in groups B and C(8.7% vs 3.7% vs 1.9%, P=0.047). However, among the three groups, graft survival rates at 1 year(100% vs 96.3% vs 93.6%) and 3 years(91.7% vs 73.2% vs 88.1%) were not different(P=0.539). In laboratory measurements,there was no group difference in total bilirubin and albumin. However, prothrombin time was longer in group A within postoperative 1 week and platelet count was lower in groups A and B within postoperative 1 month. CONCLUSION: A GRWR lower to 0.7% is safe and does not need to modulate portal pressure in adult-to-adult LDLT using the right-lobe in favorable conditions including low model for end-stage liver disease score.

关键词： graft-to-recipient weight ratio living donor liver transplantation small-for-size graft small-for-size syndrome

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：