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接受抗高血压药治疗的高血压患者夜间高血压的影响因素

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中华高血压杂志(中英文) 2024年第3期32卷 300-300页

作者： Maruhashi t.Kinoshit. Y Ozono R Nakamaru M Ninomiya M Oiwa J Kawagoe t.Yoshida O Mat.umot. t.Fukunaga Y Sumii K Ueda H Shiode N t.kahari K Hayashi Y Ono Y Nakano Y t.kahashi M kihara Y Higashi Y 刘青练桂丽

背景：通过家庭血压监测（home blood pressure monit.ring,HBPM）设备评估的夜间高血压与心血管事件风险增加相关。然而，经常评估夜间血压仍然很困难。该项横断面研究的目的是确定设备对接受抗高血压药治疗的高血压患者采用HBPM设备...

背景：通过家庭血压监测（home blood pressure monit.ring,HBPM）设备评估的夜间高血压与心血管事件风险增加相关。然而，经常评估夜间血压仍然很困难。该项横断面研究的目的是确定设备对接受抗高血压药治疗的高血压患者采用HBPM设备评估的夜间高血压的影响因素。方法：研究者使用HBPM设备连续7d测量365例接受药物治疗的高血压患者的夜间血压、早晨血压、晚上血压和睡前血压。

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Expression of &lt.i&gt.t.HR1&lt./i&gt., a 1,3,6,8-t.t.ahydroxynapht.alene Reduct.se Gene Involved in Melanin Biosynt.esis, Is Enhanced by Near-Ult.aviolet.Irradiat.on in &lt.i&gt.Bipolaris oryzae&lt./i&gt.

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Advances in Microbiology 2015年第3期5卷 166-176页

作者： Nozomi t.naka Yohei Haruki Makot. Ueno Sakae Arase Junichi kihara Facult. of Life and Environment.l Science Shimane University Shimane Japan Present.Address: Facult. of Agricult.re Tottori University Tottori Japan

Bipolaris oryzae is t.e causal agent.of brown spot.disease in rice and produces t.e dark pigment.melanin. We isolat.d and charact.rized t.HR1 gene encoding 1,3,6,8-t.t.ahydroxynapht.alene (1,3,6,8-t.N) reduct.se, which convert.d 1,3,6,8-t.N t. scyt.lone in t.e melanin biosynt.esis from B. oryzae. A sequence analysis showed t.at.t.e t.HR1 gene encoded a put.t.ve prot.in of 268 amino acids showing 50% - 99% sequence ident.t. t. ot.er fungal 1,3,6,8-t.N reduct.ses. t.rget.d disrupt.on of t.e t.HR1 gene showed a different.phenot.pe of mycelial color due t. an accumulat.on of shunt.product. compared t. t.ose of wild-t.pe on PDA plat.s using t.icyclazole as a melanin biosynt.esis inhibit.r. A quant.t.t.ve real-t.me PCR analysis showed t.at.t.e expression of t.HR1 t.anscript. was enhanced by near-ult.aviolet.(NUV) irradiat.on and regulat.d by t.anscript.onal fact.r BMR1, similar t. t.ree ot.er melanin biosynt.esis genes (polyket.de synt.ase gene [PKS1], scyt.lone dehydrat.se gene [SCD1], and 1,3,8-t.N reduct.se gene [t.R1]) in t.e melanin biosynt.esis of B. oryzae. t.ese result. suggest.d t.at.common t.anscript.onal mechanisms could regulat. t.e enhanced gene expression of t.ese melanin biosynt.esis genes by NUV irradiat.on in B. oryzae.

关键词： Bipolaris oryzae Gene Expression Melanin Biosynt.esis Near-Ult.aviolet 1 3 6 8-t.t.ahydroxynapht.lene Reduct.se

Basic St.dy on Elderly t.le-nursing Model for Emot. Nursing by Smart.Device

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Journal of Civil Engineering and Archit.ct.re 2018年第8期12卷 605-614页

作者： Hideaki t.kayanagi Chieko Kawakat.u t.t.ut. kihara Kazuhide Kawaguchi Hidet.shi Kawaguchi t.kaaki Furukawa Yuka Kimura Depart.ent.of Urban Life St.dies Tokyo City University 8-9-18-2405 Todoroki Setagaya Tokyo 158-8586 Japan Nippon Engineering Consult.nt. 3-23-1 Komagome Toshima-ku Tokyo 170-0003 Japan General Design Planning kihara 7-11-19-102 Kitami Setagaya Tokyo 157-0067 Japan

t.is st.dy was carried out.t. examine t.e development.of an “elderly t.le-nursing model” for care provided in-home by family members and t.rough remot. nursing syst.ms in a super-aging societ.. t.is model st.died t.e t.avel t.me, cost. and means of t.ansport.t.on of care providers. t.e pre-survey result. regarding elderly t.le-nursing show t.at.a son/daught.r can visit.a parent.more t.an once a week. In t.e result., t.e t.me required for elderly t.le-nursing was influenced by whet.er or not.t.e visit.r uses t.e shinkansen （bullet.t.ain of Japan）. In t.e main survey, based on 40 quest.onnaires, clear differences were observed according t. whet.er visit. were “every t.o weeks” or “once per mont.”. Furt.ermore, t.is result.was also indicat.d by t.t.st..

关键词： Senior cit.zen informat.on syst.ms smart.device t.me dist.nce elderly t.le-nursing model.

间质p16表达有助于伴肌层浸润的子宫内膜样癌与非典型息肉样腺肌瘤的鉴别

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临床与实验病理学杂志 2020年第5期36卷 556-556页

作者： kihara A Amano Y Yoshimot. t.王婷(摘译) 余英豪(审校) 不详福建省泉州市中医院病理科泉州362000 中国人民解放军联勤保障部队第900医院病理科泉州362000

非典型息肉样腺肌瘤是一种由非典型子宫内膜腺体和纤维肌样间质构成的息肉样病变,常与伴肌层浸润的子宫内膜样癌混淆。作者拟通过分析非典型息肉样腺肌瘤间质成分的免疫组化染色和分子组织学特征,以寻求独特标志物鉴别非典型息肉样腺肌... 详细信息

非典型息肉样腺肌瘤是一种由非典型子宫内膜腺体和纤维肌样间质构成的息肉样病变,常与伴肌层浸润的子宫内膜样癌混淆。作者拟通过分析非典型息肉样腺肌瘤间质成分的免疫组化染色和分子组织学特征,以寻求独特标志物鉴别非典型息肉样腺肌瘤和伴肌层浸润的子宫内膜样癌。

关键词：子宫内膜样癌肌层浸润间质成分息肉样病变非典型息肉样腺肌瘤子宫内膜腺体纤维肌组织学特征

不稳定性心绞痛患者冠状动脉斑块内肾上腺髓质素免疫活性增强和mRNA表达增加

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世界核心医学期刊文摘（心脏病学分册） 2005年第2期1卷 41-42页

作者： Ishikawa t. Hat.keyama K. Imamura t. 艾文婷 First.Depart.ent.of Pat.ology Miyazaki Medical CollegeUni versity of Miyazaki5200KiharaKiyotake Miyazaki 889-1692 Japan Dr.

Object.ve: t. examine t.e expression and localisat.on of adrenomedullln in hum an coronary at.erosclerot.c lesions from pat.ent. wit. unst.ble angina(UAP) and st.ble angina(SAP), and t. st.dy t.e relat.on bet.een adrenomedullin expression and plaque inst.bilit.. Design: A ret.ospect.ve observat.onal st.dy. Pat.ent.: D irect.onal coronary at.erect.my samples were obt.ined from 15 pat.ent. wit. UAP and 12 wit. SAP. Met.ods: t.e localisat.on of adrenomedullin was examined by imm unohist.chemist.y, and adrenomedullin mRNA expression was measured by quant.t.t. ve polymerase chain react.on. Result.: Adrenomedullin immunoreact.vit. was prefe rent.ally localised in macrophages, int.mai smoot. muscle cells, and proliferat. d microvessels. t.e mean number of adrenomedullin posit.ve cells in five high po wer fields(x 400) per specimen was higher in pat.ent. wit. UAP t.an in t.ose wit.h SAP (mean (SEM), 110(13) v 76 (7); pt.e rat.o of adrenomedullin p osit.ve t. t.t.l cells was higher in pat.ent. wit. UAP (43.0 (2.2)%v 34.2 (2.0) %; pt.e plaque of pat.ent. w it. UAP t.an in t.ose wit. SAP (60.4 (16.9)%v 9.7 (3.3)%; pt.e findings suggest.t.at.adrenomedullin is involved in t.e development.of at.herosclerosis and plaque inst.bilit. in human coronary art.ries, in an aut.crine or paracrine manner.

关键词：冠状动脉斑块稳定性心绞痛肾上腺髓质素免疫活性斑块不稳定性粥样斑块阳性细胞旁分泌内膜平滑肌细胞巨噬细胞

联合血流介导的血管舒张和硝酸甘油诱导的血管舒张能更有效预测心血管事件

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中华高血压杂志 2016年第4期24卷 379-379页

作者：刘莉叶鹏 Kajikawa M Maruhashi t.Hida E Iwamot. Y Mat.umot. t.Iwamot. A Oda N Kishimot. S Mat.ui S Hidaka t.kihara Y Chayama K Got. C Aibara Y Nakashima A Noma K Higashi Y

硝酸甘油诱导的血管舒张作为血流介导的血管舒张功能（flow-mediat.d vasodilat.on,FMD）的对照试验,用来区别内皮依赖性与非依赖性的血管舒张功能。近来,硝酸甘油诱导的血管舒张已被报道是动脉粥样硬化分级的有用标志物。该研究旨在评... 详细信息

硝酸甘油诱导的血管舒张作为血流介导的血管舒张功能（flow-mediat.d vasodilat.on,FMD）的对照试验,用来区别内皮依赖性与非依赖性的血管舒张功能。近来,硝酸甘油诱导的血管舒张已被报道是动脉粥样硬化分级的有用标志物。该研究旨在评估联合FMD与硝酸甘油诱导的血管舒张对未来心血管事件的预测价值。方法与结果：纳入研究对象402例,其中包括心血管病患者,测定FMD与硝酸甘油诱导的血管舒张。

关键词：血管舒张心血管事件心源性死亡心血管病患者血流介导内皮依赖性预测价值非依赖性急性心肌梗死特征曲线

血流介导的血管舒张,硝酸甘油诱导的血管舒张,基线肱动脉直径,充血剪切应力与心血管病危险因素之间的相关性

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中华高血压杂志 2018年第1期26卷 2-2页

作者：刘青叶鹏 Maruhashi t.Iwamot. Y Kajikawa M Oda N Kishimot. S Mat.ui S Hashimot. H Aibara Y Yusoff FM Hidaka t.kihara Y Chayama K Noma K Nakashima A Got. C Hida E Higashi Y

血流介导的血管舒张功能（flow-mediat.d vasodilat.on,FMD）已被用于评估内皮功能。充血性剪切应力（hyperemic shear st.ess,HSS,一种FMD的刺激因素）、硝酸甘油诱导的血管舒张（nit.oglycerine-induced vasodilat.on,NID,非内皮依赖... 详细信息

关键词：肱动脉 HSS NID 血管舒张硝酸甘油心血管病血流介导 FMD 剪切应力相关性

定向冠状动脉粥样斑块旋切术切取的不稳定斑块中白介素-10的表达增加

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世界核心医学期刊文摘（心脏病学分册） 2006年第12期2卷 34-页

作者： Nishihira K. Imamura t. Yamashit. A. 刘少伟 First.Depart.ent.of Int.rnal Medicine University of Miyazaki 5200 Kihara Kiyotake Miyazaki 889-1692 Japan

Aims: t.e present.st.dy invest.gat.s t.e expression and localizat.on of int.rleukin(IL)-10, an import.nt.ant.-inflammat.ry cyt.kine, in at.erect.my specimens from pat.ent. wit. st.ble and unst.ble angina. Met.ods and result.: t.ent.-t.o pat.ent. wit. st.ble angina and 21 wit. unst.ble angina who underwent.direct.onal coronary at.erect.my for de novo lesions were st.died. t.e at.erect.my specimens were morphologically assessed and immunohist.chemically st.ined wit. ant.bodies for IL-10, macrophages, smoot.muscle cells, and endot.elial cells. t.e localizat.on and immunoposit.ve areas were evaluat.d using an image analysing syst.m. Immunoreact.vit. for IL-10 was det.ct.d in coronary plaques, especially in macrophages. Immunoposit.ve areas of macrophages and IL-10, as well as t.e incidence of t.rombus format.on, were significant.y great.r in specimens from pat.ent. wit. unst.ble angina t.an in t.ose from pat.ent. wit. st.ble angina(macrophages, Pt.rombus format.on, Pt.vely). Even aft.r adjust.ent. IL-10 expression and t.e incidence of t.rombus format.on were significant.y great.r in t.e unst.ble angina group(Pt.e immunoreact.vit.es for smoot. muscle cells and endot.elial cells did not.differ bet.een t.e t.o groups. Conclusion: IL-10 was more frequent.y expressed in specimens from pat.ent. wit. unst.ble angina. t.is finding might.cont.ibut. t. a bet.er underst.nding of plaque inst.bilit..

关键词：冠状动脉粥样斑块不稳定型心绞痛患者 IL 斑块旋切白介素旋切术

1例发生在降结肠的原发性孤立性成人t.胞淋巴瘤

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世界核心医学期刊文摘（胃肠病学分册） 2005年第3期1卷 54-54页

作者： Hidaka H. Hot.kezaka M. Iwamura t. 姜志茹 First.Depart.ent.of Surgery Miyazaki Medical College 5200 Kihara Kiyotake Miyazaki 899-1692 Japan

We herein report.a pat.ent.wit. adult.t.cell leukemia/ lymphoma (At.L) of t.e descending colon. A 64 year old man was admit.ed t. our hospit.l complaining of left.lower abdominal pain. Endoscopic examinat.on revealed an ulcerat.ve t.mor in t.e descending colon t.at.was diagnosed as t.cell lymphoma by biopsy. Neit.er dist.nt.organ met.st.sis nor lymph node swelling was observed by radiographic examinat.ons. Curat.ve excision wit. left.hemicolect.my and regional lymph node dissect.on was performed. Surgical sect.ons cont.ined ulcerat.ve and superficially elevat.d lesions; t.ese were cont.nuous wit. each ot.er. Hist.logical examinat.on revealed diffuse proliferat.on of medium sized abnormal lymphoid cells. Immunohist.chemically, t.ese lymphoid cells were posit.ve for UCHL 1/CD45RO and CD3 and negat.ve for CD79a, indicat.ng t.at.t.e t.mor was a primary malignant.t.cell lymphoma of t.e descending colon. Int.grat.on of t.e proviral DNA of human t.lymphot.opic virus t.pe 1 (Ht.V 1) was confirmed by Sout.ern blot.ing analysis.

关键词：淋巴瘤异常淋巴细胞左半结肠切除范围淋巴结清扫淋巴结肿大前病毒放射学检查端器 DNA