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急性缺血性卒中血管内治疗质量改进的多学会共识

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国际脑血管病杂志 2013年第11期21卷 807-820页

作者： David Sacks Carl M. Black Christophe Cognard j.hn j. Connors Donald Frei Rishi Gupta Tudor G. j.vin Bryan Kluck Philip M. Meyers kieran j. murphy Stephen Ramee Daniel A. Rufenacht M.j. Bernadette Stallmeyer Dierk Vorwerk 皮燕(译) 张莉莉(译) 李敬诚(译) Department of Interventional Radiology Reading Hospital and Medical Center West Reading Center for Neuroendovascular Therapy University of Pittsburgh Medical Center Stroke Institute Pittsburgh The Heart Care Group Allentown Pennsylvania Department of Radiology Utah Valley Regional Medical Center Provo Utah Departments of Radiology Neurological Surgery and Neurology Vanderbilt University Medical Center Nashville Tennessee Department of Neurointerventional Surgery Radiology Imaging Associates and Swedish Medical Center Denver Colorado Department of Neurology Emory Clinic Atlanta Georgia Department of Neurological Surgery Columbia University College of Physicians and Surgeons New York New York Department of Interventional Cardiology Ochsner Medical Center New Orleans Louisiana Diagnostic and Therapeutic Neuroradiology Service Centre Hospitalier Universitaire de Toulouse Hopital Purpan Toulouse France Department of Medical Imaging University of Toronto Toronto Ontario Canada Neuroradiology Division Swiss Neurolnstitute Clinic Hirslanden Zurich Switzerland Institute for Diagnostic and Interventional Radiology Klinikum Ingolstadt Ingolstadt Germany 重庆第三军医大学第三附属医院野战外科研究所神经内科 400042

目的这份国际性多学科共识文件将对急性缺血性卒中诊治过程和临床转归的质量标准进行定义，并希望在质量保证程序中使用这些标准，从而评估和改善急性卒中血运重建的过程和转归。材料和方法写作组成员由美国神经放射学学会、加拿大介入... 详细信息

目的这份国际性多学科共识文件将对急性缺血性卒中诊治过程和临床转归的质量标准进行定义，并希望在质量保证程序中使用这些标准，从而评估和改善急性卒中血运重建的过程和转归。材料和方法写作组成员由美国神经放射学学会、加拿大介入放射学协会、欧洲心血管和介入放射学学会、心血管造影和介入学会、介入放射学学会、神经介入外科学会、欧洲微创神经病学治疗学会以及血管和介入神经病学学会认命。写作组回顾了1986年至2012年2月期间的相关文献，对急性缺血性卒中的诊疗过程和转归进行总结形成一份证据表，然后通过共识设立性能指标和阈值。本指南得到发起学会的批准，并计划在3年后进行全面更新。结果这份国际性多学科共识文件对诊治过程和临床转归的质量标准进行了定义，包括从入院到进行影像学检查、动脉穿刺和血运重建的时间间隔以及90d时的临床转归评估标准。结论本文件为急性缺血性卒中血管内血运重建程序提供了质量改进指南。

关键词：急性缺血性卒中血管内治疗质量改进学会介入放射学临床转归心血管造影质量标准

Predictors of the placebo response in a nutraceutical randomized controlled trial for depression

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j.urnal of Integrative Medicine 2024年第1期22卷 46-53页

作者： Rosemary Arnold j.nifer murphy-Smith Chee H.Ng David Mischoulon Gerard j.Byrne Chad A.Bousman Con Stough Michael Berk j.rome Sarris Professorial Unit the Melbourne ClinicDepartment of PsychiatryUniversity of MelbourneRichmond 3121Australia Depression Clinical and Research Program Department of PsychiatryMassachusetts General HospitalHarvard Medical SchoolBostonMA 02115USA Faculty of Medicine Discipline of PsychiatryCentre for Clinical ResearchRoyal Brisbane&Women’s HospitalHerstonthe University of QueenslandBrisbane 4006Australia Departments of Medical Genetics PsychiatryPhysiology&Pharmacology and Community Health SciencesUniversity of CalgaryCalgaryAB T2N 1N4Canada Department of Psychiatry the University of MelbourneMelbourne 3052Australia Centre for Human Psychopharmacology Swinburne UniversityMelbourne 3122Australia The Institute for Mental and Physical Health and Clinical Translation School of MedicineBarwon HealthDeakin UniversityGeelong 3220Australia The Centre of Excellence in Youth Mental Health the University of MelbourneParkville 3052Australia Florey Institute of Neuroscience and Mental Health the University of MelbourneParkville 3052Australia NICM Health Research Institute Western Sydney UniversityWestmeadNSW 2145Australia

Obj.ctive The placebo response in depression studies is the change in symptoms amongst those who receive an inactive *** well-designed randomized controlled trials(RCTs)of depression have a high proportion of placebo responders,with little understanding as to *** present study assesses characteristics associated with the placebo response in a nutraceutical trial with a large proportion of placebo *** This is a secondary analysis of a nutraceutical depression RCT which identified no overall treatment benefit relative to placebo(n=69 in placebo group).We investigated participant characteristics such as socio-demographics,clinical features,and recruitment methods,and their association with the placebo *** genetic polymorphisms were also *** response was measured based on change in Montgomery-Asberg Depression Rating Scale *** association of these hypothesis-driven variables of interest and the placebo response was examined using linear mixed effects *** Greater levels of education,particularly pursuing post-high school education,better self-reported general health,marriage/de facto,greater improvement in the first trial week,and more failed antidepressant therapies in the current depressive episode were associated with greater placebo *** increased placebo response was not found in those recruited via social media nor in those with concomitant antidepressant *** nucleotide polymorphisms from the tryptophan hydroxylase 1(TPH1)gene(A779C and A218C)were weakly associated with greater placebo response,although the evidence was attenuated after accounting for multiple *** This is,to our knowledge,the first study within nutraceutical research for depression to assess the association between participant characteristics and variation in the placebo *** variables appeared to predict the placebo *** findings may encourage future trial design

关键词： Randomized controlled trial Placebo Depression Nutraceutical Psychiatry

Editorial for the Special Issue on Emerging Technology and Advanced Application of Nondestructive Detection for Power Equipment

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Chinese j.urnal of Electrical Engineering 2024年第1期10卷 1-2页

作者： Li j. Mei H. Li S. Tianj.n University China Tsinghua Shenzhen International Graduate School China Lanzhou j.aotong University China

The rapid development of clean and renewable energy technologies represented by wind and solar energy,as well as the continuous growth of load demand,have put forward higher requirements for the safe operation of the power *** performance of power equipment based on traditional dielectric materials is often limited by various defects generated during molding,transportation,assembly,and operation,which cannot meet the reliability requirements of power systems in the new *** detection is an essential technical method in industrial development,which can detect and evaluate the defect and damage status of in-service equipment,key components,and materials without damaging the obj.ct.

关键词： service Application operation

The secondary inj.ry cascade after spinal cord inj.ry:an analysis of local cytokine/chemokine regulation

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Neural Regeneration Research 2024年第6期19卷 1308-1317页

作者： Daniel j.Hellenbrand Charles M.Quinn Zachariah j.Piper Ryan T.Elder Raveena R.Mishra Taylor L.Marti Phoebe M.Omuro Rylie M.Roddick j.e Sung Lee William L.murphy Amgad S.Hanna Department of Neurosurgery University of Wisconsin-Madison School of Medicine and Public HealthMadisonWIUSA Department of Biomedical Engineering University of Wisconsin-MadisonMadisonWIUSA Department of Orthopedics and Rehabilitation University of Wisconsin-MadisonMadisonWIUSA Department of Materials Science and Engineering University of Wisconsin-MadisonMadisonWIUSA Forward BIO Institute University of Wisconsin-MadisonMadisonWIUSA

After spinal cord inj.ry,there is an extensive infiltration of immune cells,which exacerbates the inj.ry and leads to further neural ***,a maj.r aim of current research involves targeting the immune response as a treatment for spinal cord *** much research has been performed analyzing the complex inflammatory process following spinal cord inj.ry,there remain maj.r discrepancies within previous literature regarding the timeline of local cytokine *** obj.ctives of this study were to establish an overview of the timeline of cytokine regulation for 2 weeks after spinal cord inj.ry,identify sexual dimorphisms in terms of cytokine levels,and determine local cytokines that significantly change based on the severity of spinal cord *** were inflicted with either a mild contusion,moderate contusion,severe contusion,or complete transection,7 mm of spinal cord centered on the inj.ry was harvested at varying times post-inj.ry,and tissue homogenates were analyzed with a Cytokine/Chemokine 27-Plex *** demonstrated pro-inflammatory cytokines including tumor necrosis factorα,interleukin-1β,and interleukin-6 were all upregulated after spinal cord inj.ry,but returned to uninj.red levels within approximately 24 hours post-inj.ry,while chemokines including monocyte chemoattractant protein-1 remained upregulated for days *** contrast,several anti-inflammatory cytokines and growth factors including interleukin-10 and vascular endothelial growth factor were downregulated by 7 days *** spinal cord inj.ry,tissue inhibitor of metalloproteinase-1,which specifically affects astrocytes involved in glial scar development,increased more than all other cytokines tested,reaching 26.9-fold higher than uninj.red *** a mild inj.ry,11 cytokines demonstrated sexual dimorphisms;however,after a severe contusion only leptin levels were different between female and male *** conclusion,pro-inflammatory cytokines in

关键词： astrocytes chemokines cytokines inflammation macrophages microglia secondary damage spinal cord inj.ry

Error field penetration in j.TEXT tokamak based on two-fluid drift-MHD model

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Chinese Physics B 2024年第4期33卷 545-551页

作者：王文徐涛张仪 the j.TEXT team State Key Laboratory of Advanced Electromagnetic Technology International Joint Research Laboratory of Magnetic Confinement Fusion and Plasma PhysicsSchool of Electrical and Electronic EngineeringHuazhong University of Science and TechnologyWuhan 430074China

An externally generated resonant magnetic perturbation can induce complex non-ideal MHD responses in their resonant *** have studied the plasma responses using Fitzpatrick's improved two-fluid model and program *** calculated the error field penetration threshold for *** addition,we find that the island width increases slightly as the error field amplitude increases when the error field amplitude is below the critical penetration ***,the island width suddenly j.mps to a large value because the shielding effect of the plasma against the error field disappears after the *** scanning the natural mode frequency,we find that the shielding effect of the plasma decreases as the natural mode frequency ***,we obtain the m/n=2/1 penetration threshold scaling on density and temperature.

关键词： plasma responses drift-MHD model error field penetration

Evaluating the Effects of Graviton Redshift upon Spiral Galaxy Rotation Curves, Surface Brightness Magnitudes and Gravitational Lensing

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j.urnal of High Energy Physics, Gravitation and Cosmology 2024年第3期10卷 967-985页

作者： Firmin j. Oliveira East Asian Observatory James Clerk Maxwell Submillimetre Telescope Hilo USA

The effects of the gravitational redshift of gravitons upon spiral galaxy rotation energy are compared to the standard mass to light analyses in obtaining rotation curves. The derivation of the total baryonic matter compares well with the standard theory and the rotation velocity is matched to a high precision. The stellar mass distributions obtained from the fit with graviton energy loss are used to derive the surface brightness magnitudes for the galaxies, which agree well with the observed measurements. In a new field of investigation, the graviton theory is applied to the observations of gravitational lenses. The results of these applications of the theory suggest that it can augment the standard methods and may eliminate the need for dark matter.

关键词： Gravitons Gravitational Redshift Surface Brightness Gravitational Lens Lens Mass

The Regional Economic Impacts of Coal Mining: A Case Study of Signal Peak Energy

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Natural Resources 2024年第8期15卷 211-223页

作者： Timothy j. Considine School of Energy Resources University of Wyoming Laramie USA

This paper quantifies the regional economic contributions of coal exports from the US using a case study of Signal Peak Energy in Montana. Two methods of estimating economic contributions are compared, contribution and impact analysis. The latter is adopted because the industry impact analysis is more accurate, especially since it is based upon accounting records from Signal Peak. Our estimates of regional economic and fiscal impacts do not vary significantly with the price of coal because we explicitly account for swings in royalty income. Our analysis finds that Signal Peak Energy supports 678 j.bs, over $55 million in tax revenues, more than $90 million in royalties, $111.7 million in value added, and $62.3 million in labor income. Curtailing or halting Signal Peak’s coal production for environmental reasons as some environmental groups have argued would eliminate these economic contributions.

关键词： Coal Regional Economic Exports Fiscal

Fresnel Equations Derived Using a Non-Local Hidden-Variable Particle Theory

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j.urnal of Modern Physics 2024年第6期15卷 950-984页

作者： Dirk j. Pons Department of Mechanical Engineering University of Canterbury Christchurch New Zealand

Problem: The Fresnel equations describe the proportions of reflected and transmitted light from a surface, and are conventionally derived from wave theory continuum mechanics. Particle-based derivations of the Fresnel equations appear not to exist. Approach: The obj.ctive of this work was to derive the basic optical laws from first principles from a particle basis. The particle model used was the Cordus theory, a type of non-local hidden-variable (NLHV) theory that predicts specific substructures to the photon and other particles. Findings: The theory explains the origin of the orthogonal electrostatic and magnetic fields, and re-derives the refraction and reflection laws including Snell’s law and critical angle, and the Fresnel equations for s and p-polarisation. These formulations are identical to those produced by electromagnetic wave theory. Contribution: The work provides a comprehensive derivation and physical explanation of the basic optical laws, which appears not to have previously been shown from a particle basis. Implications: The primary implications are for suggesting routes for the theoretical advancement of fundamental physics. The Cordus NLHV particle theory explains optical phenomena, yet it also explains other physical phenomena including some otherwise only accessible through quantum mechanics (such as the electron spin g-factor) and general relativity (including the Lorentz and relativistic Doppler). It also provides solutions for phenomena of unknown causation, such as asymmetrical baryogenesis, unification of the interactions, and reasons for nuclide stability/instability. Consequently, the implication is that NLHV theories have the potential to represent a deeper physics that may underpin and unify quantum mechanics, general relativity, and wave theory.

关键词： Wave-Particle Duality Optical Law Fresnel Equation Non-Local Hidden-Variable

An Analysis of Specific Categories of Birth Defects and Developmental Disabilities for Children of Participants of the Air Force Health Study

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Open j.urnal of Epidemiology 2024年第2期14卷 312-330页

作者： George j. Knafl School of Nursing University of North Carolina at Chapel Hill Chapel Hill NC USA

Background: The Air Force Health Study collected reproductive outcomes for live-born children of male Air Force veterans of the Vietnam War. Methods: Dioxin values for participants were obtained from blood samples. Analyses were conducted of occurrence of 16 specific categories of birth defects and developmental disabilities. Children were categorized as conceived before and after the start of participants’ Vietnam War service. Children conceived before the start of Vietnam War service were treated as being conceived when their fathers had unquantifiable dioxin values. Children conceived after the start of Vietnam War service for participants with missing dioxin values were excluded from primary analyses, but were used to assess the impact of their exclusion on conclusions. Correlation between values for specific categories for multiple children fathered by the same participant was accounted for. The dose-response relationship was treated as a step function increasing for dioxin values larger than adaptively identified individual thresholds changing with the specific category. Results: For 15 of 16 specific categories, the probability of occurrence increased substantially for a sufficiently high dioxin level above identified thresholds. Exclusion of children due to missing dioxin likely did not affect these results. Conclusions: Results supported the conclusion of substantial adverse effects on a wide variety of specific categories of birth defects and developmental disabilities due to sufficiently high exposures to dioxin, a toxic contaminant of Agent Orange used for herbicide spraying in the Vietnam War. Results may hold more generally, but might also have been affected by a variety of limitations.

关键词： Agent Orange Air Force Health Study Birth Defects Developmental Disabilities Dioxin Dose-Response Relationship Vietnam War