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comparison between tocotrienol and omeprazole on gastric growth factors in stress-exposed rats

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World Journal of Gastroenterology 2017年第32期23卷 5887-5894页

作者： Mohd Fahami Nur Azlina hj Mohd Saad Qodriyah kien hui Chua Yusof Kamisah Department of Pharmacology Faculty of MedicineUniversiti Kebangsaan Malaysia Department of Physiology Faculty of MedicineUniversiti Kebangsaan Malaysia

AIM To investigate and compare the effects of tocotrienol and omeprazole on gastric growth factors in rats exposed to water-immersion restraint stress(WIRS).METhODS Twenty-eight male Wistar rats were randomly assigned to four groups of seven rats. The two control groups were administered vitamin-free palm oil(vehicle) and the two treatment groups were given omeprazole(20 mg/kg) or tocotrienol(60 mg/kg) by oral gavage. After 28 d of treatment, rats from one control group and both treated groups were subjected to WIRS one time for 3.5 h. Gastric lesions were measured and gastric tissues were obtained to measure vascular endothelial growth factor(VEGF), epidermal growth factor(EGF), basic fibroblast growth factor(b FGF), and transforming growth factor-alpha(TGF-α) m RNA expression. RESULTS Rats exposed to WIRS for 3.5 h demonstrated the presence of considerable ulcers in the form of gastric erosion. The lesion index in the stressed control(S) group was increased(P he tocotrienol treated and omeprazole treated groups. Stress led to a decrease in gastric VEGF(P hat was statistically significant compared to the nonstressed control group. Although both treatment agents exerted similar ulcer reducing ability, only treatment with tocotrienol led to increased expression of VEGF(P = 0.008), b FGF(P = 0.001) and TGF-α(P = 0.002) m *** Tocotrienol provides gastroprotective effects in WIRSinduced ulcers. Compared to omeprazole, tocotrienol exerts a similar protective effect, albeit through multiple mechanisms of protection, particularly through up-regulation of growth factors that assist in repair of gastric tissue injuries.

关键词： Tocotrienol Omeprazole Restraint-stress Gastric ulcers Growth factors

Cost-effective hybrid long-short read assembly delineates alternative GC-rich Streptomyces hosts for natural product discovery

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Synthetic and Systems Biotechnology 2023年第2期8卷 253-261页

作者： Elena heng Lee Ling Tan Dillon W.P.Tay Yee hwee lim Lay-kien Yang Deborah C.S.Seow Chung Yan Leong Veronica Ng Siew Bee Ng Yoganathan Kanagasundaram Fong Tian Wong Lokanand Koduru Molecular Engineering Laboratory Institute of Molecular and Cell Biology(IMCB)Agency for ScienceTechnology and Research(A*STAR)61 Biopolis Drive#07-06ProteosSingapore138673Singapore Green Chemistry and Biocatalysis Institute of Sustainability for ChemicalsEnergy and Environment(ISCE2)Agency for ScienceTechnology and Research(A*STAR)8 Biomedical GroveNeuros#07-01Singapore138665Singapore Singapore Institute of Food and Biotechnology Innovation(SIFBI) Agency for ScienceTechnology and Research(A*STAR)31 Biopolis WayLevel 2NanosSingapore138669Singapore

With the advent of rapid automated in silico identification of biosynthetic gene clusters(BGCs),genomics pre-sents vast opportunities to accelerate natural product(NP)***,prolific NP producers,Strepto-myces,are exceptionally GC-rich(>80%)and highly repetitive within *** pose challenges in sequencing and high-quality genome assembly which are currently circumvented via intensive ***,we outline a more cost-effective workflow using multiplex Illumina and Oxford Nanopore sequencing with hybrid long-short read assembly algorithms to generate high quality *** protocol involves subjecting long read-derived assemblies to up to 4 rounds of polishing with short reads to yield accurate BGC *** successfully sequenced and assembled 8 GC-rich Streptomyces genomes whose lengths range from 7.1 to 12.1 Mb with a median N50 of 8.2 *** analysis revealed previous misrepresentation among these strains and allowed us to propose a potentially new species,Streptomyces *** comprehensive characterization of their biosynthetic,pan-genomic and antibiotic resistance features especially for molecules derived from type I polyketide synthase(PKS)BGCs reflected their potential as alternative NP ***,the genome assemblies and insights presented here are envisioned to serve as gateway for the scientific community to expand their avenues in NP discovery.

关键词： Streptomyces GC-Rich hybrid assembly Biosynthetic gene cluster(BGC) Natural product(NP)chassis Type I polyketide Synthase(PKS)

Effect of Tannin in Green Tea By-Product in Combination with Bio-Char Supplemented into Basal Beef Cattle Diet on Nutrient Digestibility, Methane Production and Animal Performance

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Open Journal of Animal Sciences 2018年第3期8卷 206-214页

作者： M. A. Khoa N. h. Quang T. V. Thang T. V. Phung T. T. kien Thai Nguyen University Thai Nguyen City Vietnam University of Agriculture and Forestry-TNU Thai Nguyen City Vietnam Institute of Life Sciences-TNU Thai Nguyen City Vietnam

The experiment was conducted by using 20 bulls of Lai Sind cattle (a cross breed between Red Sindhi and local Vietnam yellow cattle) from 15 - 16 months of age, weighed approximately 154 - 156 kg, housed individually with provision of adequate feed trough and free access to water to evaluate the effect of tannin sourced from green tea by-product and addition of bio-char on methane production and animal performance. The experimental diets were formulated by replacing elephant grass in basal diet by bio-char and green tea by-product with the replacement of 0.5 - 1 bio-char and 3% - 5% green tea by-products, respectively to make the content of tannin in the diet of 7.3 g and 12.5 g tannin per kg dry matter. Results from this study revealed that bio-char and green tea by-product included into the diet with different levels had significantly affected on the feed intake, as the increasing level of tannin in the diet tended to increase the feed intake. The inclusion of green tea by-product in the diet which resulted in the content of tannin in the diet of 12.5 g/kg DM had significantly reduced methane emission without altering animal performance, thus the inclusion of 0.5% bio-char and 5% of green tea by-product can be applied in order to mitigate methane emission, thus contributed to environment protection.

关键词： Green Tea By-Product Bio-Char Tannin Methane Emission Animal Performance

Evaluation of Interaction between Surface Water and Groundwater in the South of hanoi City by Stable Isotope Technique

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Journal of Environmental Protection 2022年第11期13卷 870-880页

作者： Vo Thi Anh Tran Khanh Minh ha Lan Anh Mai Dinh kien Vu hoai Dang Duc Nhan Institute for Nuclear Science and Technology Hanoi Vietnam

The δ18O and δ2h stable isotope techniques for studying properties of groundwater and surface help us to understand more clearly about the distribution and movement of groundwater in the South of hanoi area. There were 68 water samples from the studying area and analyzed by a Liquid Water Isotope Analyzer (LWIA-24D). The stable isotope values of the groundwater from Pleistocene aquifers were range from -3.21‰ to -9.55‰ δ18O and -35.32‰ to -67.44‰ δ2h;rainwater from -8.18‰ to -4.13‰ δ18O and -61.19‰ to -17.93‰ δ2h;Red river water from -7.51‰ to -5.29‰ δ18O and -51.60‰ to -38.99‰ δ2h. Based on stable isotope characteristics, the results show that there was a relationship between surface water and groundwater in the South of hanoi city. It is that groundwater recharges for river water in the dry season with 74%, and in the rainfall season groundwater is recharged from river with 87%.

关键词： Stable Isotopes Groundwater Surface Water River Water Precipitation Recharge

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越南海防市近岸海洋水位变化特征分析

武汉大学学报（信息科学版） 2015年第4期40卷 552-557页

作者：团文征李建成裴氏坚贞武汉大学测绘学院湖北武汉430079 黎贵敦技术大学越南河内100803 水利大学越南河内100803

利用越南海防市沿海地区hONDAU验潮站52a的潮汐观测资料,采用基本统计方法和潮汐调和分析法研究该地区海洋水位变化特征。结果显示：该地区海平面、潮差均呈现上升趋势,年变化率分别是1.89mm/a、3.07mm/a;对采样间隔为1h的潮位连续观测... 详细信息

利用越南海防市沿海地区hONDAU验潮站52a的潮汐观测资料,采用基本统计方法和潮汐调和分析法研究该地区海洋水位变化特征。结果显示：该地区海平面、潮差均呈现上升趋势,年变化率分别是1.89mm/a、3.07mm/a;对采样间隔为1h的潮位连续观测数据作调和分析,得到调和常数的时间序列,分析显示各主要分潮的调和常数均为时变量,且与周期性（3～5a）El Nino和La Nina现象相关;余水位年上升率是1.76mm/a,平均增、减水位分别是12.48cm和-13.36cm。增、减水位持续时间小于24h的累积频率分别是95.5%和93.3%,增减水位持续时间大于48h的只占1%～2%。绝对余水位值小于50cm的占大多数,大约99%,增减水位绝对值大于100cm的只占0.1%左右。

关键词：越南海防海平面变化潮差变化潮汐调和常数余水位

颅骨测量数据揭示欧亚大陆东部史前人群扩散的"二层"模式

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南方文物 2020年第2期 226-241页

作者：松村博文洪晓纯 Charles higham 张弛山形真理子 Lan Cuong Nguyen 李珍范雪春 Truman Simanjuntak Adhi Agus Oktaviana 何嘉宁陈仲玉潘建国贺刚孙国平黄渭金李新伟魏兴涛 Kate Domett Sin halcrow Kim Dung Nguyen hoang hiep Trinh Chi hoang Bui Khanh Trung kien Nguyen Andreas Reinecke 邓婉文(译) 赵春光(译) 洪晓纯(校) 不详北京大学考古文博学院武汉大学历史学院考古学系澳大利亚国立大学考古与自然史学系

本文是基于考古发掘获取的人骨遗存在内的89组古代及现代的人群样本而做的颅骨形态测量研究,侧重说明解剖学意义上的现代人(anatomically modern humans)在欧亚大陆东部演化分布的“二层”模式。距今6.5万~5万年以前,“第一层”现代人... 详细信息

本文是基于考古发掘获取的人骨遗存在内的89组古代及现代的人群样本而做的颅骨形态测量研究,侧重说明解剖学意义上的现代人(anatomically modern humans)在欧亚大陆东部演化分布的“二层”模式。距今6.5万~5万年以前,“第一层”现代人经东南亚大陆向东、向南扩散,他们与现今安达曼人、澳大利亚人、巴布亚人的祖先以及日本绳纹时代人群最为接近。距今约九千年前,拥有东北亚血统的“第二层”现代人出现在中国中部地区,并于距今四千年前后向南扩张至东南亚地区,这些人群在颅骨形态上与西伯利亚人具有密切的亲缘关系。上述两大人群最初交流有限,在农业能够支撑增加人口密度的情境下,“第二层”现代人增长速度较快,人口数量较多。这两层人群显著的二重结构特征,表明了现代人在欧亚大陆南、北不同迁移路线间的历时性差异。

关键词：欧亚大陆澳大利亚人二重结构中国中部地区东南亚地区增长速度考古发掘绳纹时代