检索结果-南通市图书馆

Piezo1 expression in chondrocytes controls endochondral ossification and osteoarthritis development

Bone Research 2024年第1期12卷 199-214页

作者： Laura J.Brylka Assil-Ramin Alimy Miriam E.A.Tschaffon-Müller Shan Jiang Tobias Malte Ballhause Anke Baranowsky Simon von Kroge Julian Delsmann Eva Pawlus kian eghbalian Klaus Püschel Astrid Schoppa Melanie Haffner-Luntzer David J.Beech Frank Timo Beil Michael Amling Johannes Keller Anita Ignatius Timur A.Yorgan Tim Rolvien Thorsten Schinke Department of Osteology and Biomechanics University Medical Center Hamburg-Eppendorf20246 HamburgGermany Department of Trauma and Orthopedic Surgery University Medical Center Hamburg-Eppendorf20246 HamburgGermany Institute of Orthopedic Research and Biomechanics University Medical Center UlmBadenWürttemberg89081 UlmGermany Department Legal Medicine University Medical Center Hamburg-Eppendorf20246 HamburgGermany Leeds Institute of Cardiovascular and Metabolic Medicine School of MedicineUniversity of LeedsLS29JT LeedsUK

Piezo proteins are mechanically activated ion channels,which are required for mechanosensing functions in a variety of cell *** we and others have previously demonstrated that the expression of Piezo1 in osteoblast lineage cells is essential for boneanabolic processes,there was only suggestive evidence indicating a role of Piezo1 and/or Piezo2 in *** we addressed the question if and how chondrocyte expression of the mechanosensitive proteins Piezo1 or Piezo2 controls physiological endochondral ossification and pathological osteoarthritis(OA)*** with chondrocyte-specific inactivation of Piezo1(Piezo1^(Col2a1Cre)),but not of Piezo2,developed a near absence of trabecular bone below the chondrogenic growth plate ***,all Piezo1^(Col2a1Cre) animals displayed multiple fractures of rib bones at 7 days of age,which were located close to the growth *** skeletal growth was only mildly affected in these mice,OA pathologies were markedly less pronounced compared to littermate controls at 60 weeks of ***,when OA was induced by anterior cruciate ligament transection,only the chondrocyte inactivation of Piezo1,not of Piezo2,resulted in attenuated articular cartilage ***,osteophyte formation and maturation were also reduced in Piezo1^(Col2a1Cre) *** further observed increased Piezo1 protein abundance in cartilaginous zones of human ***,we identified Ptgs2 and Ccn2 as potentially relevant Piezo1 downstream genes in ***,our data do not only demonstrate that Piezo1 is a critical regulator of physiological and pathological endochondral ossification processes,but also suggest that Piezo1 antagonists may be established as a novel approach to limit osteophyte formation in OA.

关键词： Piezo1 markedly ossification

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Amphiphilic amino-acid derivatives promote gram-scale single-crystal COFs synthesis

引用

Science China Chemistry 2024年第2期67卷 415-416页

作者： Yijia Yuan kian Ping Loh Department of Chemistry National University of SingaporeSingapore117543Singapore

Covalent organic frameworks(COFs) are crystalline organic compounds synthesized from covalently linked building blocks that extend in space to form a framework structure with periodic pores. The covalent linkages used... 详细信息

关键词： synthesis correction reversible

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Bilayer separator enabling dendrite-free zinc anode with ultralong lifespan >5000 h

引用

Green Energy & Environment 2024年第4期9卷 771-776页

作者： Lu Wang Feifei Wang Zhe Ding Yingxin Liu Ziyi Zhang Chunpeng Yang kian Ping Loh Quan-Hong Yang Joint School of National University of Singapore and Tianjin University International Campus of Tianjin UniversityFuzhou350207China Nanoyang Group State Key Laboratory of Chemical EngineeringSchool of Chemical Engineering and TechnologyTianjin UniversityCollaborative Innovation Center of Chemical Science and Engineering(Tianjin)Tianjin300072China Haihe Laboratory of Sustainable Chemical Transformations Tianjin300192China Department of Chemistry National University of Singapore117543Singapore Institute of Process Engineering Chinese Academy of SciencesBeijing100190China

Aqueous zinc(Zn)batteries with Zn metal anodes are promising clean energy storage devices with intrinsic safety and low ***,Zn dendrite growth severely restricts the use of Zn *** effectively suppress Zn dendrite growth,we propose a bilayer separator consisting of commercial butter paper and glassfiber *** dense cellulose-based butter paper(BP)with low zincophilicity and high mechanical properties prevents the pore-filling behavior of deposited Zn and related separator piercing,effectively suppressing the Zn dendrite *** a result,the bilayer separators endow the ZnjjZn symmetrical batteries with a superlong cycling life of Zn anodes(over 5000 h)at 0.5 mA cm^(-2) and the full batteries enhanced capacity retention,demonstrating the advancement of the bilayer separator to afford excellent cyclability of aqueous metal batteries.

关键词： Zn battery Bilayer separator Butter paper Zn metal anode Zn dendrite

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Guest Editorial:Special issue on advances in representation learning for computer vision

引用

CAAI Transactions on Intelligence Technology 2024年第1期9卷 1-3页

作者： Andrew Beng Jin Teoh Thian Song Ong kian Ming Lim Chin Poo Lee Electrical and Electronic Engineering Department Yonsei UniversitySeoulSouth Korea Faculty of Information Science and Technology Multimedia UniversityMelakaMalaysia

Deep learning has been a catalyst for a transformative revo-lution in machine learning and computer vision in the past *** these research domains,methods grounded in deep learning have exhibited exceptional performance across a spectrum of *** success of deep learning methods can be attributed to their capability to derive potent representations from data,integral for a myriad of downstream *** representations encapsulate the intrinsic structure,fea-tures,or latent variables characterising the underlying statistics of visual *** these achievements,the challenge per-sists in effectively conducting representation learning of visual data with deep models,particularly when confronted with vast and noisy *** special issue is a dedicated platform for researchers worldwide to disseminate their latest,high-quality articles,aiming to enhance readers'comprehension of the principles,limitations,and diverse applications of repre-sentation learning in computer vision.

关键词： spite computer representation

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Developing a Clang Libtooling-Based Refactoring Tool for CUDA GPU Programming

引用

Journal of Software Engineering and Applications 2024年第2期17卷 89-108页

作者： kian Nejadfard Janche Sang Champ Titles Inc. Cleveland USA Department of Computer Science Cleveland State University Cleveland USA

Refactoring tools, whether fully automated or semi-automated, are essential components of the software development life cycle. As software libraries and frameworks evolve over time, it’s crucial for programs utilizing them to also evolve to remain compatible with modern advancements. Take, for example, NVIDIA CUDA’s platform for general-purpose GPU programming. Embracing the more contemporary unified memory architecture offers several benefits, such as simplifying program source code, reducing bugs stemming from manual memory management between host and device memory, and optimizing memory transfer through automated memory handling. This paper describes our development of a refactoring tool based on Clang’s Libtooling to facilitate this transition automatically, thereby relieving developers from the burden and risks associated with manually refactoring large code bases.

关键词： Refactoring CUDA Unified Memory Clang Libtooling

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Tribology of self-lubricating high performance ATSP,PI,and PEEK-based polymer composites up to 300℃

引用

Friction 2023年第1期11卷 141-153页

作者： kian BASHANDEH Pixiang LAN Andreas A.POLYCARPOU Department of Mechanical Engineering Texas A&M UniversityCollege StationTexas 77843USA ATSP Innovations Inc.Texas 77055USA

High-performance polymers(HPPs)are increasingly used in different industrial machinery components,particularly for rubbing parts that demand reliable and durable operation at extreme sliding conditions such as elevated temperature environments,where the use of conventional lubricants is not *** current study investigates the role of environmental temperature on the tribological properties of three advanced HPPs,namely aromatic thermosetting copolyester(ATSP),polyimide(PI),and polyether ether ketone(PEEK)based polymer *** experiments were carried out at different environmental temperatures from room temperature up to 300℃,and under dry sliding *** attention was given to the role of temperature on the development of transfer films and its subsequent effect on the tribological *** ATSP composite was recommended as the best performing material,based on the overall tribological performance at all examined operating temperatures.

关键词： aromatic thermosetting copolyester(ATSP) polyimide(PI) polyether ether ketone(PEEK) high temperature tribology transfer film

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Prenatal risk factors and genetic causes of ADHD in children

引用

World Journal of Pediatrics 2022年第5期18卷 308-319页

作者： Naghmeh kian Noosha Samieefar Nima Rezaei Student Research Committee School of MedicineShahid Beheshti University of Medical SciencesTehranIran Network of Interdisciplinarity in Neonates and Infants(NINI) Universal Scientific Education and Research Network(USERN)TehranIran USERN Office School of Advanced Technologies in MedicineShahid Beheshti University of Medical SciencesTehranIran Research Center for Immunodeficiencies Pediatrics Center of ExcellenceChildren's Medical CenterTehran University of Medical SciencesTehranIran

Background Attention deficit/hyperactivity disorder(ADHD)is a common disease among children;it affected 5-7% of the population in *** is a multifactorial disease,and its etiology is still not clearly *** Sources This narrative review has been done by searching the PubMed and Embase databases using attention deficit/hyperactivity disorder,ADHD,risk factors;genetics;pediatrics;psychiatrics as *** ADHD is considered to be a hereditary disorder in which genes play the fundamental role in the pathogenesis;however,findings from genetic-environmental studies support the hypothesis that genetic factors can exert effects on an indi-viduaFs condition by determining his/her responses to environmental exposures,especially those during the prenatal *** ADHD is considered as a hereditary disorder in which genes and prenatal risk factors play fundamental roles in the pathogenesis.

关键词： Attention deficit/hyperactivity disorder genetics Risk factors Pediatrics Psychiatrics

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Ultrahigh Loading Copper Single Atom Catalyst for Palladium-free Wacker Oxidation

引用

Chemical Research in Chinese Universities 2022年第5期38卷 1239-1242页

作者： SONG Jingting LIU Jia LOH kian Ping CHEN Zhongxin Department of Chemistry National University of SingaporeSingapore 117543Singapore Joint School of National University of Singapore and Tianjin University International Campus of Tianjin UniversityFuzhou 350207P.R.China

Wacker oxidation is an industry-adopted process to transform olefins into value-added epoxides and ***,traditional Wacker oxidation involves the use of homogeneous palladium and copper catalysts for the olefin addition and reductive ***,we demonstrated an ultrahigh loading Cu single atom catalyst(14%Cu,mass fraction)for the palladium-free Wacker oxidation of 4-vinylanisole into the corresponding ketone with N-methylhydroxylamine hydrochloride as an additive under mild *** studies by ^(18)O and deuterium isotope labelling revealed a hydrogen shift mechanism in this palladium-free process using N-methylhydroxylamine hydrochloride as the oxygen *** reaction scope can be further extended to Kucherov *** study paves the way to replace noble metal catalysts in the traditional homogeneous processes with single atom catalysts.

关键词： Single atom catalyst Wacker oxidation Ultrahigh loading High valued chemical Organic catalysis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Small bowel adenocarcinoma in neoterminal ileum in setting of stricturing Crohn’s disease:A case report and review of literature

引用

World Journal of Clinical Cases 2023年第9期11卷 2021-2028页

作者： Shruthi Karthikeyan Jeanne Shen kian Keyashian John Gubatan Department of Medicine Division of Gastroenterology and HepatologyStanford University School of MedicineStanfordCA 94306United States Department of Pathology Stanford University School of MedicineStanfordCA 94306United States

BACKGROUND Small bowel adenocarcinomas(SBA) are rare malignancies with exceedingly low survival rates, with different presentation in Crohn’s disease(CD). CD-induced SBA poses diagnostic challenges given overlapping presentation with stricturing CD and lack of diagnostics for early detection. Moreover, guidance is lacking on the impact of recently approved therapeutics in CD on SBA management. Here, we aim to highlight the future of CD-induced SBA management and discuss the potential merit of balloon enteroscopy and genetic testing for earlier *** SUMMARY We report the case of a 60-year-old female with longstanding Crohn’s ileitis, presenting with acute obstructive symptoms attributed to stricturing phenotype. Her obstructive symptoms were refractory to intravenous(Ⅳ) steroids, with further investigation via computed tomography enterography not providing additional diagnostic yield. Ultimately, surgical resection revealed SBA in the neoterminal ileum, with oncologic therapy plan created. However, this therapy plan could not be initiated due to continued obstructive symptoms attributed to active CD. Ultimately, infused biologic therapy was initiated, but her obstructive symptoms continued to remain dependent on Ⅳ corticosteroids. Review of diagnostics by a multidisciplinary care team suggested metastatic disease in the peritoneum, lending to a shift in the goals of care to *** With the diagnostic and therapeutic challenges of concurrent SBA and CD, multidisciplinary care and algorithmic management can optimize outcomes.

关键词： Crohn’s disease Small bowel adenocarcinoma Management Diagnosis Case report

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chiral self-assembly of terminal alkyne and selenium clusters organic–inorganic hybrid

引用

Nano Research 2022年第3期15卷 2741-2745页

作者： Zhi Chen Tao Lin Haohan Li Mingzi Sun Chenliang Su Bolong Huang kian Ping Loh SZU-NUS Collaborative Innovation Center for Optoelectronic Science&Technology International Collaborative Laboratory of 2D Materials for Optoelectronics Science and Technology of Ministry of EducationInstitute of Microscale OptoelectronicsCollege of Chemistry and Environmental EngineeringShenzhen UniversityShenzhen 518060China Department of Chemistry Centre for Advanced 2D Materials(CA2DM)National University of Singapore3 Science Drive 3Singapore 117543Singapore College of New Materials and New Energies Shenzhen Technology UniversityShenzhen 518118China Department of Applied Biology and Chemical Technology The Hong Kong Polytechnic UniversityHung HomKowloonHong Kong SARChina

The on-surface self-assembly of inorganic atomic clusters and organic molecules offers significant opportunities to design novel hybrid materials with tailored *** adopting the advantages from both inorganic and organic components,the hybrid self-assembly molecules have shown great potential in future optoelectrical ***,we report the co-deposition of 4,8-diethynylbenzo[1,2-d-4,5-d0]bisoxazole(DEBBA)and Se atoms to produce a motif-adjustable organic–inorganic hybrid self-assembly system via the non-covalent *** controlling the coverage of Se atoms,various chiral molecular networks containing Se,Se_(6),Se_(8),and terminal alkynes evolved on the Ag(111)*** particular,with the highest coverage of Se atoms,phase segregation into alternating one-dimensional chains of non-covalently bonded Se_(8) clusters and organic ligands has been *** atom-coverage dependent evolution of self-assembly structures reflects the remarkable structural adaptability of Se clusters as building blocks based on the spontaneous resize to reach the maximum non-covalent *** work has significantly extended the possibilities of flexible control in self-assembly nanostructures to enable more potential functions for broad applications.

关键词： self-assembly inorganic–organic hybrid chiral Se cluster concentration-dependent

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：