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One-year clinical outcomes in invasive treatment strategies for acute ST-elevation myocardial infarction complicated by cardiogenic shock in eld-erly patients

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Journal of Geriatric Cardiology 2013年第3期10卷 235-241页

作者： Yeon Pyo Yoo ki-Woon Kang Hyeon Soo Yoon Jin Cheol Myung Yu jeong Choi Won Ho kim Sang Hyun Park Kyung Tae Jung Myung Ho jeong Division of Cardiology Hyosung General Hospital 162-90 Sandang dong Chungju 360-802 South Korea Division of Cardiology Eulji University Hospital Eulji University School of Medicine 1306 Dunsan dong Seogu Daejeon 302-120 South Korea Division of Cardiology Worker`s Compensation&Welfare Service Hospital 833 Gaejok-ro Daejeon 306-060 South Korea Division of Cardiology Chunman National University Hospital 42 Jaebong-ro Kwangju 501-757 South Korea

Objective To investigate the clinical outcomes of an invasive strategy for elderly (aged≥75 years) patients with acute ST-segment elevation myocardial infarction (STEMI) complicated by cardiogenic shock (CS). Methods Data on 366 of 409 elderly CS patients from a total of 6,132 acute STEMI cases enrolled in the Korea Acute Myocardial Infarction Registry between January 2008 and June 2011, were collected and analyzed. In-hospital deaths and the 1-month and 1-year survival rates free from major adverse cardiac events (MACE;defined as all cause death, myocardial infarction, and target vessel revascularization) were reported for the patients who had undergone invasive (n=310) and conservative (n=56) treatment strategies. Results The baseline clinical characteristics were not significantly different between the two groups. There were fewer in-hospital deaths in the invasive treatment strategy group (23.5%vs. 46.4%, P<0.001). In addition, the 1-year MACE-free survival rate after invasive treatment was significantly lower compared with the conservative treatment (51%vs. 66%, P=0.001). Conclusions In elderly patients with acute STEMI complicated by CS, the outcomes of invasive strategy are similar to those in younger patients at the 1-year follow-up.

关键词： Acute myocardial infarction Cardiogenic shock Elderly patients

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道家思想在现代服装设计手法上的应用研究

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广东轻工职业技术学院学报 2022年第1期21卷 76-80页

作者：张祥磊 jeong-ki Sung 广东轻工职业技术学院广东广州510300 启明大学韩国大邱42403

着重研究道家思想在现代服装设计上的应用,找寻道家思想在现代服装设计中的优点,将道家思想融入到我们现在生活生产的环境中,传承道家思想,汲取道家思想精神内涵,让道家思想在几千年后的今天重新焕发生机,为道家思想融入现代社会生产生... 详细信息

着重研究道家思想在现代服装设计上的应用,找寻道家思想在现代服装设计中的优点,将道家思想融入到我们现在生活生产的环境中,传承道家思想,汲取道家思想精神内涵,让道家思想在几千年后的今天重新焕发生机,为道家思想融入现代社会生产生活提供一个优秀的范例。

关键词：道家思想现代服装设计道法自然返璞归真

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高效液相色谱法—光散射检测器用于人参皂甙的测定

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药物分析杂志 1996年第6期16卷 412-414页

作者： Man ki Park jeong Hill Pard Sang Beom Han Young Geun shin Li Ho Park 汉城国立大学

高效液相色谱法—光散射检测器用于人参皂甙的测定ＭａｎＫｉＰａｒｋ，ＪｅｏｎｇＨｉｌＰａｒｄＳａｎｇＢｅｏｍＨａｎ，ＹｏｕｎｇＧｅｕｎｓｈｉｎ，ＬｉＨｏＰａｒｋ（汉城国立大学，药学院，１５１—７４２南朝鲜）人参（为五加... 详细信息

高效液相色谱法—光散射检测器用于人参皂甙的测定ＭａｎＫｉＰａｒｋ，ＪｅｏｎｇＨｉｌＰａｒｄＳａｎｇＢｅｏｍＨａｎ，ＹｏｕｎｇＧｅｕｎｓｈｉｎ，ＬｉＨｏＰａｒｋ（汉城国立大学，药学院，１５１—７４２南朝鲜）人参（为五加科植物人参Ｐａｎａｘｇｉｎｓｅｎｇ...

关键词：人参皂甙光散射检测器高效液相色谱法

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Gardenia jasminoides protects against cerulein-induced acute pancreatitis

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World Journal of Gastroenterology 2008年第40期14卷 6188-6194页

作者： Won-Seok Jung Young-Seok Chae Do-Yun kim Sang-Wan Seo Hee-Je Park Gi-Sang Bae Tae-Hyeon kim Hyo-jeong Oh ki-Jung Yun Rae-kil Park Jong-Suk kim Eun-Cheol kim Sung-Yeon Hwang Sung-Joo Park Ho-Joon Song Department of Biochemistry Institute of Medical ScienceChonbuk National University Medical School Department of Herbology School of Oriental MedicineWonkwang University Kohwang Medical Institute College of MedicineKyung Hee University Department of internal medicine College of MedicineWonkwng University Department of Pathology College of MedicineWonkwng University Vestibulocochlear Research Center & Department of Microbiology College of MedicineWonkwng University Department of Oral & Maxillofacial Pathology Dental CollegeWonkwang University

AIM： To investigate the effect of Garden/a fasm/noides （GJ） on cerulein-induced acute pancreatitis （AP） in mice. METHODS： C57BL/6 mice weighing 18-20 g were divided into three groups. （1） Normal salinetreated group, （2） treatment with GJ at a dose of 0.1 g/kg, （3） treatment with GJ at a dose of 1 g/kg. GJ was administered orally （n = 6 per group） for 1 wk. Three hours later, the mice were given anintraperitoneal injection of cerulein （50 μg/kg）, a stable cholecystokinin （CCK） analogue, every hour for a total of 6h as described previously. The mice were sacrificed at 6 h after completion of cerulein injections. Blood samples were obtained to determine serum amylase, lipase and cytokine levels. The pancreas was rapidly removed for morphologic examination and scoring. A portion of pancreas was stored at -70℃ and prepared for the measurement of tissue myeloperoxidase （MPO） activity, an indicator of neutrophil sequestration, and for reverse-transcriptase PCR （RT-PCR） and real-time PCR measurements. RESULTS： Treatment with G.1 decreased significantly the severity of pancreatitis and pancreatitis-associated lung injury. Treatment with G.1 attenuated the severity of AP compared with saline-treated mice, as shown by reduction in pancreatic edema, neutrophil infiltration, serum amylase and lipase levels, serum cytokine levels, and mRNA expression of multiple inflammatory mediators. CONCLUSION： These results suggest that GJ attenuated the severity of AP as well as pancreatitisassociated lung injury.

关键词： Gardenia Jasminoides Acute pancreatitis Cerulein

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Enhancement of Tumor Regression by Coulomb Nanoradiator Effect in Proton Treatment of Iron-Oxide Nanoparticle-Loaded Orthotopic Rat Glioma Model: Implication of Novel Particle Induced Radiation Therapy

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Journal of Cancer Therapy 2013年第11期4卷 25-32页

作者： Seung-Jun Seo Jae-Kun Jeon Eun-Ju jeong Won-Seok Chang Gi-Hwan Choi Jong-ki kim Department of Biomedical Engineering School of Medicine Catholic University of Daegu 3056-6 Taemyung 4 Dong Nam-Ku Daegu City South Korea Department of Diagnostic Imaging School of Medicine Catholic University of Daegu 3056-6 Taemyung 4 Dong Nam-Ku Daegu City South Korea Department of Neurosurgery School of Medicine Catholic University of Daegu 3056-6 Taemyung 4 Dong Nam-Ku Daegu City South Korea

Background: Proton-impact metallic nanoparticles, inducing low-energy electrons emission and characteristic X-rays termed as Coulomb nanoradiator effect (CNR), are known to produce therapeutic enhancement in proton treatment on experimental tumors. The purpose of this pilot study was to investigate the effect of CNR-based dose enhancement on tumor growth inhibition in an iron-oxide nanoparticle (FeONP)-loaded orthotopic rat glioma model. Methods: Proton-induced CNR was exploited to treat glioma-bearing SD rat loaded with FeONP by either fully-absorbed single pristine Bragg peak (APBP) or spread-out Bragg peak (SOBP) 45-MeV proton beam. A selected number of rats were examined by MRI before and after treatment to obtain the size and position information for adjusting irradiation field. Tumor regression assay was performed by histological analysis of residual tumor in the sacrificed rats 7 days after treatment. The results of CNR-treated groups were compared with the proton alone control. Results: Intravenous injection of FeONP (300 mg/kg) elevated the tumor concentration of iron up to 37 μg of Fe/g tissue, with a tumor-to-normal ratio of 5, 24 hours after injection. The group receiving FeONP and proton beam showed 65% - 79% smaller tumor volume dose-dependently compared with the proton alone group. The rats receiving FeONP and controlled irradiation field by MR imaging demonstrated more than 95% - 99% tumor regression compared with MRI-determined initial tumor size. Conclusions: Proton-impact FeONP produced therapeutic enhancement compared with proton alone in an orthotopic rat glioma model at a selected temporal point after treatment. Single BP proton beam could induce CNR- based dose enhancement and produce enhanced tumor regression that was comparable to SOBP treatment despite inhomogeneous tumor dose in the APBP-treated tumor. These results may suggest emergence of novel Particle Induced Radiation Therapy (PIRT) on malignant glioma.

关键词： Proton Therapy Iron Oxide Nanoparticles Coulomb Nanoradiator Malignant Glioma

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未来韩国将逐步减少化石燃料 002

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中国工业报

作者： Marn-ki jeong

由于全球变暖，韩国正在减少碳排放量。2015年的巴黎大会上，有200多个国家签署了减低碳排放的协议。为此，韩国的商业排放要减少到37%。未来韩国将很少使用化石燃料。在30～50年之内，化石燃料将彻底禁用，尤其要减少二氧化碳的排放，...

由于全球变暖，韩国正在减少碳排放量。2015年的巴黎大会上，有200多个国家签署了减低碳排放的协议。为此，韩国的商业排放要减少到37%。未来韩国将很少使用化石燃料。在30～50年之内，化石燃料将彻底禁用，尤其要减少二氧化碳的排放，所以汽车制造商必须要确保二氧化碳排

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Hepatitis B virus pre S1 deletion is related to viral replication increase and disease progression

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World Journal of Gastroenterology 2015年第16期21卷 5039-5048页

作者： Seoung-Ae Lee ki-jeong kim Hong kim Won-Hyuk Choi Yu-Sub Won Bum-Joon kim Department of Biomedical Sciences Microbiology and Immunologyand Liver Research InstituteSeoul National University College of Medicine Department of Microbiology School of MedicineChung-Ang University Department of Internal Medicine Konkuk University

AIM:To investigate the clinical implications of hepatitis B virus(HBV) pre S1 ***:We developed a fluorescence resonance energy transfer-based real-time polymerase chain reaction(RT-PCR) that can detect four genotypes(wild type, 15-bp, 18-bp and 21-bp deletion).The PCR method was used in two cohorts of Korean chronic HBV subjects with genotype C *** Ⅰ included 292 chronic HBV subjects randomly selected from Cheju National University Hospital(Jeju, South Korea) or Seoul National University Hospital(Seoul, South Korea), and cohort Ⅱ included 90 consecutive chronic HBV carriers recruited from Konkuk University Hospital(Seoul, South Korea); the cohort Ⅱ patients did not have hepatocellular carcinoma or liver ***:The method proposed in this study identified 341 of 382 samples(89.3%).Deletion variants were identified in 100(29.3%) of the 341 detected *** both cohorts, the subjects with deletions had a significantly higher Hepatitis B virus e antigen(HBe Ag)-positive seroprevalence [cohort Ⅰ, wild(51.0%) vs deletion(75.0%), P < 0.001; cohort Ⅱ, wild(69.2%) vs deletion(92.9%), P = 0.002] and higher HBV DNA levels [cohort Ⅰ, wild(797.7 pg/m L) vs deletion(1678.9 pg/m L), P = 0.013; cohort Ⅱ, wild(8.3 × 108 copies/m L) vs deletion(2.2 × 109 copies/m L), P = 0.049], compared to subjects with wild type ***:HBV genotype C pre S1 deletion may affect disease progression in chronic HBV subjects through an extended duration of HBe Ag seropositive status and increased HBV replications.

关键词： Hepatitis B virus PreS1 start codon deletion Hepatitis B virus e antigen Hepatocellular carcinoma Genotype C

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Simultaneous occurrence of malignant fibrous histiocytoma and hepatocellular carcinoma in cirrhotic liver: A case report

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World Journal of Hepatology 2011年第9期3卷 256-261页

作者： Hee Sang Hwang Nam Du Ha Yoong ki jeong Jae Hee Suh Hye jeong Choi Young Min kim Hee jeong Cha Department of Pathology University of Ulsan College of Medicine Asan Medical Center Department of Radiology University of Ulsan College of Medicine Ulsan University Hospital Department of Pathology University of Ulsan College of Medicine

Primary hepatic malignant fibrous histiocytoma (MFH) is rarely encountered. There have been no reports to date of hepatic MFH associated with liver cirrhosis. The presence of liver cirrhosis is considered an adjunctive feature favoring sarcomatoid hepatocellular carcinoma (HCC) in the diagnosis of spindle cell tumors in liver. We describe here a 59-year-old man with liver cirrhosis due to hepatitis B virus infection 20 years ago. On abdominal computed tomography scanning, two distinct hepatic masses were identified in the background of cirrhosis, which had different radiological features from conventional HCC. He underwent segmentectomy for removal of the tumors. The pathological examination of surgically resected specimen revealed the large malignant spindle cell tumor and small conventional HCC. Additional tissue sampling and immunohistochemical stainings demonstrated that the spindle cell tumor was consistent with MFH. On the post-operative follow-up for 21 mo, a round mass showing similar radiological findings for the previous MFH was appeared on the surface of resection margin, suggesting the recurrence. Despite its rarity, hepatic MFH should be considered during differential diagnosis, even in cirrhotic patients, and extensive tissue sampling and immunohistochemical analyses are necessary in the diagnosis of hepatic spindle cell tumors.

关键词： Liver neoplasm Malignant fibrous histiocytoma Hepatocellular carcinoma Liver cirrhosis

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Assessment of pathogens and risk factors associated with bloodstream infection in the year after pediatric liver transplantation

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World Journal of Gastroenterology 2022年第11期28卷 1159-1171页

作者： Yeong Eun kim Ho Jung Choi Hye-Jin Lee Hyun Ju Oh Mi Kyoung Ahn Seak Hee Oh Jung-Man Namgoong Dae Yeon kim Won Kyoung Jhang Seong Jong Park Dong-Hwan Jung deok Bog Moon Gi-Won Song Gil-Chun Park Tae-Yong Ha Chul-Soo Ahn ki-Hun kim Shin Hwang Sung Gyu Lee Kyung Mo kim Department of Pediatrics Asan Medical Center Children's HospitalUniversity of Ulsan College of MedicineSeoul 05505South Korea Division of Pediatric Surgery Department of SurgeryAsan Medical Center Children's HospitalUniversity of Ulsan College of MedicineSeoul 05505South Korea Division of Hepatobiliary Surgery and Liver Transplantation Department of SurgeryAsan Medical CenterUniversity of Ulsan College of MedicineSeoul 05505South Korea

BACKGROUND Bloodstream infection(BSI)is one of the most significantly adverse events that can occur after liver transplantation(LT)in *** To analyze the profile of BSI according to the postoperative periods and assess the risk factors after pediatric *** Clinical data,collected from medical charts of children(n=378)who underwent primary LT,were retrospectively *** primary outcome considered was BSI in the first year after *** and multivariate analyses were performed to identify risk factors for BSI and respective odds ratios(ORs).RESULTS Of the examined patients,106(28%)experienced 162 episodes of pathogen-confirmed BSI during the first year after *** were 1.53±0.95 episodes per children(mean±SD)among BSIcomplicated patients with a median onset of 0.4 mo *** most common pathogenic organisms identified were Coagulase-negative staphylococci,followed by Enterococcus *** Streptococcus *** half(53%)of the BSIs were of unknown *** analysis demonstrated that young age(≤1.3 year;OR=2.1,P=0.011),growth failure(OR=2.1,P=0.045),liver support system(OR=4.2,P=0.008),and hospital stay of>44 d(OR=2.3,P=0.002)were independently associated with BSI in the year after *** BSI was frequently observed in patients after pediatric LT,affecting survival *** profile of BSI may inform clinical treatment and management in high-risk children after LT.

关键词： Bloodstream infection Liver transplantation Children Pathogens

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Incremental age-related one-year MACCE after acute myocardial infarction in the drug-eluting stent era （from KAMIR-NIH registry）

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Journal of Geriatric Cardiology 2018年第9期15卷 574-584页

作者： Dae-Won kim Sung-Ho Her Ha Wook Park kiyuk Chang Wook Sung Chung ki Bae Seung Myung Ho jeong Hyo-Soo kim Hyeon Cheoi Gwon In Whan Seong Kyung Kuk Hwang Shung Chull Chae Kwon-Bae kim Young Jo kim Kwang Soo Cha Seok Kyu Oh Jei Keon Chae Ji-Hoon Jung Division of Cardiology Daejeon St. Mary's Hospital College of Medicine the Catholic University of Korea Seoul South Korea Division of Cardiology Seoul St. Mary's Hospital College of Medicine the Catholic University of Korea Seoul South Korea Chonnam National University Hospital Gwangju South Korea Seoul National University Hospital Seoul South Korea Sungkyunkwan Universtiy Samsung Medical Center Seoul South Korea Chungnam National University Hospital Daejeon South Korea Chungbuk National University Hospital Cheongju South Korea Kyungpook National University Hospital Daegu South Korea Keimyung University Dongsan Medical Center Daegu South Korea Yeungnam University Hospital Daegu South Korea Pusan National University Hospital Busan South Korea Wonkwang University Hospital Iksan South Korea Chonbuk National University Hospital Jeonju South Korea Statistical Manager Institute of Toxicology Daejeon South Korea

Objectives To evaluate the age-related one-year major adverse cardiocerebrovascular events （MACCE） after percutaneous coronary intervention （PCI） in acute myocardial infarction （AMI）. We analyzed the association between age and one-year MACCE after AMI. Methods A total of 13,104 AMI patients from Korea Acute Myocardial Infarction Registry-National Institue of Health （KAMIR-NIH） between November 2011 and December 2015 were classified into four groups according to age （Group I, 〈 60 years, n = 4199; Group II, 60-70 years, n = 2577; Group III; 70-80 years, n = 2774; Group IV, ≥ 80 years, n = 1018）. Patients were analyzed for one-year composite of MACCE （cardiac death, myocardial infarction, target vessel revascularization, cerebrovascular events） after AMI. Results The one-year MACCE in AMI were 3.5% （Group I）, 6.3% （Group II）, 9.6% （Group III） and 17.6% （Group IV）. After adjustment for confounding para- meters, the analysis results showed that patients with AMI had incremental risk of one-year MACCE [Group II, adjusted hazard ratios （aHR） = 1.224, 95% CI： 0.965-1.525, P = 0.096; Group III, aHR = 1.316, 95% CI： 1.037-1.671, P= 0.024; Group IV, aHR = 1.975, 95% CI： 1.500-62.601, P〈 0.001） compared to Group I. Especially, cardiac death in the composite of primary end point played a major role in this effect （Group II, aHR = 1.335, 95% CI： 0.941-1.895, P= 0.106; Group III, aHR = 1.575, 95% CI： 1.122-2.210, P= 0.009; Group IV, aHR = 2.803, 95% CI： 1.937-4.054, P 〈 0.001）. Conclusions Despite advanced techniques and medications for PCI in AMI, age still exerts a powerful influence in clinical outcomes. Careful approaches, even in the modem era of developed cardiology are needed for aged-population in AMI intervention.

关键词： Acute myocardial infarction Aged-population Major adverse cardiocerebrovascular events

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