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Hypothyroid effects on astrocytes and microglia in the adult rat hippocampus

Neural Regeneration Research 2009年第12期4卷 1078-1082页

作者： Choong Hyun Lee Jung Hoon Choi In Koo Hwang ki-yeon yoo Hyung-Cheul Shin Moo-Ho Won Department of Anatomy and Neurobiology and Institute of Neurodegeneration and NeuroregenerationCollege of MedicineHallym University South Korea Institute of Naturat Medicine Hallym University Department ofAnatomy and Cell Biology College of Veterinary Medicine and BK21 Program for Veterinary ScienceSeoul National Unlversity South Korea Institute of Natural Medicine Hallym University Department of Physiology College of MedicineHallym University

BACKGROUND： Thyroid hormones modulate proliferation of astrocytes and microglia depending on maturation stage and localization. Studies have demonstrated that triiodothyronine treatment or thyroidectomy during developmental stages results in morphological alterations and changes in the number of astrocytes and microglia. Little is known about the effects of hypothyroidism on astrocytes and microglia in adults. OBJECTIVE： To investigate the effects of hypothyroidism on morphology and number of astrocytes and microglia in the adult rat hippocampus. DESIGN, TIME AND SETTING： A randomized, controlled, neuroendocrinological, animal study was performed at the College of Medicine, Hallym University, South Korea between May 2008 and April 2009. MATERIALS： Methimazole, rabbit anti-glial fibrillary acidic protein （GFAP） antiserum, and rabbit anti-lba-1 antiserum were purchased from Sigma, USA. Rabbit anti-GFAP polyclonal antibody was provided by Chemicon, USA. Rabbit anti-lba-1 polyclonal antibody was purchased from Wako, Japan. Terminal deoxynucleotidyl transferase dUTP-biotin nick-end-labeling （TUNEL） kit was provided by Roche Molecular Biochemicals, Mannheim, Germany. METHODS： Hypothyroidism was induced in Wistar rats via methimazole administration （0.025%） in drinking water for 5 weeks, starting at 6 months of age. MAIN OUTCOME MEASURES： Following methimazole treatment, hippocampai neuronal death was determined using TUNEL staining. The morphology and number of GFAP and lba-1 immunoreactive cells were detected by immunohistochemistry. Hippocampal GFAP and lba-1 protein levels were detected by Western blot analysis. Serum-free triiodothyronine and thyroxine levels were quantified. RESULTS： TUNEL-positive neurons were not observed in the hippocampus of euthyroid and hypothyroid rats. Compared with the euthyroid rats, the number of GFAP immunoreactive astrocytes was decreased, and serum triiodothyronine and thyroxine levels were significantly decreased. In contrast, the numb

关键词： astrocytes hippocampus hypothyroidism microglia Wistar rats

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Time- and cell-type specific changes in iron, ferritin, and transferrin in the gerbil hippocampal CA1 region after transient forebrain ischemia

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Neural Regeneration Research 2016年第6期11卷 924-930页

作者： Dae Young yoo ki-yeon yoo Joon Ha Park Hyun Jung Kwon Hyo Young Jung Jong Whi kim Goang-Min Choi Seung Myung Moon Dae Won kim Yeo Sung yoon Moo-Ho Won In Koo Hwang Department of Anatomy and Cell Biology College of Veterinary Medicine and Research Institute for Veterinary Science Seoul National University Department of Oral Anatomy Research Institute of Oral Sciences College of Dentistry Gangneung-Wonju National University Department of Neurobiology School of Medicine Kangwon National University Department of Biochemistry and Molecular Biology Research Institute of Oral Sciences College of Dentistry Gangneung-Wonju National University Department of Thoracic and Cardiovascular Surgery Chuncheon Sacred Heart Hospital College of Medicine Hallym University Department of Neurosurgery Dongtan Sacred Heart Hospital College of Medicine Hallym University

In the present study, we used immunohistochemistry and western blot analysis to examine changes in the levels and cellular localization of iron, heavy chain ferritin（ferritin-H）, and transferrin in the gerbil hippocampal CA1 region from 30 minutes to 7 days following transient forebrain ischemia. Relative to sham controls, iron reactivity increased significantly in the stratum pyramidale and stratum oriens at 12 hours following ischemic insult, transiently decreased at 1–2 days and then increased once again within the CA1 region at 4–7 days after ischemia. One day after ischemia, ferritin-H immunoreactivity increased significantly in the stratum pyramidale and decreased at 2 days. At 4–7 days after ischemia, ferritin-H immunoreactivity in the glial components in the CA1 region was significantly increased. Transferrin immunoreactivity was increased significantly in the stratum pyramidale at 12 hours, peaked at 1 day, and then decreased significantly at 2 days after ischemia. Seven days after ischemia, Transferrin immunoreactivity in the glial cells of the stratum oriens and radiatum was significantly increased. Western blot analyses supported these results, demonstrating that compared to sham controls, ferritin H and transferrin protein levels in hippocampal homogenates significantly increased at 1 day after ischemia, peaked at 4 days and then decreased. These results suggest that iron overload-induced oxidative stress is most prominent at 12 hours after ischemia in the stratum pyramidale, suggesting that this time window may be the optimal period for therapeutic intervention to protect neurons from ischemia-induced death.

关键词： ferritin transferrin hippocampal stratum minutes glial Ferritin hippocampus rabbit reactivity

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Soybean isoflavones alter parvalbumin in hippocampus of mid-aged normal female,ovariectomized female,and normal male rats

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Acta Pharmacologica Sinica 2006年第1期27卷 59-65页

作者： In Koo HWANG yoon-bok LEE ki-yeon yoo Tae-cheon KANG Soon Sung LIM Sang Moo kiM Heon-soo SOHN Woo-jung kiM Hyun Kyung SHIN Moo Ho WON Department of Anatomy College of MedicineHallym UniversityChunchon 200-702Korea Department of Laboratory Animal Research.Central Research Institute Dr Chung's Food Co Ltd.Cheongju 361-782Korea Division of Life Science and Silver Biotechnology Research Center Korea Faculty of Marine Bioseience and Technology.Kangneung National University Kangneung 210-702Korea Faculty of Food Science and Technology College of Life SciencesSejong UniversitySejong 143-747Korea

Aim:To investigate the long-term effect of soybean isoflavones on changes inparvalbumin (PV) immunoreactivity in the hippocampus in normal female,ovariec-tomized (OVX) female and normal male ***:Ten-month-old rats wereassigned to one of 9 groups (n=7 in each group) based on body weight using arandomized complete-block *** groups were:control diet-treated females,OVX females,and males;0.3g/kg isoflavone-treated females,OVX females,andmales;and 1.2g/kg isoflavone-treated females,OVX females,and *** PVimmunostaining was conducted by using the standard avidin-biotin ***:PV immunoreactivity and the number of PV-immunoreactiveneurons in all the groups after isoflavone treatment were significantly changed inthe hippocampal CA1 region and in the dentate gyrus,but not in the hippocampalCA2/3 *** immunoreactivity and the number of PV-immunoreactive neu-rons in the control diet OVX females were similar to those in the control diet,andwere greater than those in the control diet normal *** immunoreactivityand the number of PV-immunoreactive neurons in all the isoflavone-treated groupsdecreased dose-dependently after isoflavone ***:Long-termadministration of isoflavones may induce a reduction of PV in interneurons in thehippocampal CA1 region and in the dentate *** reduction of PV in theseregions suggests that the long-term administration of isoflavones may cause achange in calcium homeostasis in the hippocampal CA1 region and in the dentategyrus.

关键词： isoflavones ovariectomy hippocampus immunohistochemistry

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Neuroprotective effects of roasted licorice,not raw form,on neuronal injury in gerbil hippocampus after transient forebrain ischemia

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Acta Pharmacologica Sinica 2006年第8期27卷 959-965页

作者： In-koo HWANG Soon-sung LIM Kyu-hyun CHOI ki-yeon yoo Hyun-kyung SHIN Eun-ji kiM Jung-han yooNPARK Tae-cheon KANG Young-sup kiM Dae-young KWON Dong-woo kiM Won-kook MOON Moo-ho WON Korea Central Research Institute.Natural F&P Co Ltd Chunchon 200-160Korea Silver Biotechnology Research Center Korea Silver Biotechnology Research Center Department of Food Science and Nutrition Hallym UniversityChunchon 200-702Korea Medical Science Division Korea Research Institute of Chemical TechnologyYuseong.Daejeon 305-343Korea Korea Central Research Institute.Natural F&P Co Ltd Chunchon 200-160Korea Korea Silver Biotechnology Research Center

Aim:To observe neuroprotective effects of raw and roasted licorice against hy-poxia and ischemic ***:When elucidating the protective effects ofraw and roasted licorice,we analyzed the lactate dehydrogenase (LDH) releaseusing PC12 cells after hypoxia in an in vitro study and after transient forebrainischemia in an in vivo study on Mongolian ***:Raw and roastedlicorice significantly reduced LDH release from PC12 cells exposed to an hypoxicchamber for *** the roasted licorice-treated group,the decrease of LDH releasewas more pronounced compared to that of the raw licorice-treated *** licorice-treated animals,approximately 66%-71% of CA1 pyramidal cellsin the ischemic hippocampus were stained with cresyl violet compared to thecontrol ***,in the raw licorice-treated animals,no significantneuroprotection against ischemic damage was *** addition,ischemic ani-mals in roasted licorice-treated group maintained the Cu,Zn-superoxide dismutase(SOD1) activity and protein levels compared to the control group,while in rawlicorice-treated group SOD1 activity and protein levels were reduced *** pressure liquid chromatography analysis showed that non-polar compoundscontaining glycyrrhizin-degraded products,such as glycyrrhetinic acid (GA) andglycyrrhetinic acid monoglucuronide (GM),were increased in roasted ***:Roasted licorice had neuroprotective effects against ischemic dam-age by maintaining the SOD1 *** addition,the difference in protectiveability between raw and roasted licorice may be associated with non-polarcompounds,such as GA and GM.

关键词： transient ischemic attack roasted licorice raw licorice neurons PC12 cells hippocampus pyramidal cells Gerbillinae superoxide dismutase

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Interworking between Modbus and internet of things platform for industrial services

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Digital Communications and Networks 2024年第2期10卷 461-471页

作者： Sherzod Elamanov Hyeonseo Son Bob Flynn Seong ki yoo Naqqash Dilshad JaeSeung Song Department of Convergence Engineering for Intelligent Drone Sejong UniversitySouth Korea SyncTechno Inc South Korea Exacta Global Smart Solutions USA Coventry University UK

In the era of rapid development of Internet of Things(IoT),numerous machine-to-machine technologies have been applied to the industrial *** to the divergence of IoT solutions,the industry is faced with a need to apply various technologies for automation and *** fact leads to a demand for an establishing interworking mechanism which would allow smooth interoperability between heterogeneous *** of the major protocols widely used today in industrial electronic devices is ***,data generated by Modbus devices cannot be understood by IoT applications using different protocols,so it should be applied in a couple with an IoT service layer ***2M,a global IoT standard,can play the role of interconnecting various protocols,as it provides flexible tools suitable for building an interworking framework for industrial ***,in this paper,we propose an interworking architecture between devices working on the Modbus protocol and an IoT platform implemented based on oneM2M *** the proposed architecture,we introduce the way to model Modbus data as oneM2M resources,rules to map them to each other,procedures required to establish interoperable communication,and optimization methods for this *** analyze our solution and provide an evaluation by implementing it based on a solar power management use *** results demonstrate that our model is feasible and can be applied to real case scenarios.

关键词： Internet of things Interoperability Interworking Modbus oneM2M

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Structural and electrochemical stabilization enabling high-energy P3-type Cr-based layered oxide cathode for K-ion batteries

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Carbon Energy 2024年第5期6卷 81-93页

作者： Wonseok Ko Seokjin Lee Hyunyoung Park Jungmin Kang Jinho Ahn Yongseok Lee Gwangeon Oh Jung-Keun yoo Jang-yeon Hwang Jongsoon kim Department of Energy Science Sungkyunkwan UniversitySuwonRepublic of Korea SKKU Institute of Energy Science and Technology(SIEST) Sungkyunkwan UniversitySuwonRepublic of Korea Department of Energy Engineering Hanyang UniversitySeoulRepublic of Korea Carbon Composites Department Korea Institute of Materials Science(KIMS)ChangwonRepublic of Korea Department of Battery Engineering Hanyang UniversitySeoulRepublic of Korea

Layered-type transition metal(TM)oxides are considered as one of the most promising cathodes for K-ion batteries because of the large theoretical gravimetric capacity by low molar ***,they suffer from severe structural change by de/intercalation and diffusion of K^(+)ions with large ionic size,which results in not only much lower reversible capacity than the theoretical capacity but also poor power ***,it is important to enhance the structural stability of the layered-type TM oxides for outstanding electrochemical behaviors under the K-ion battery ***,it is investigated that the substitution of the appropriate Ti^(4+)contents enables a highly enlarged reversible capacity of P3-type KxCrO_(2) using combined studies of first-principles calculation and various *** the pristine P3-type KxCrO_(2) just exhibits the reversible capacity of∼120 mAh g^(−1) in the voltage range of 1.5-4.0 V(vs.K^(+)/K),the∼0.61 mol K^(+)corresponding to∼150 mAh g^(−1) can be reversible de/intercalated at the structure of P3-type K0.71[Cr_(0.75)Ti_(0.25)]O_(2) under the same ***,even at the high current density of 788 mA g^(−1),the specific capacity of P3-type K0.71[Cr_(0.75)Ti_(0.25)]O_(2) is∼120 mAh g^(−1),which is∼81 times larger than that of the pristine P3-type KxCrO_(2).It is believed that this research can provide an effective strategy to improve the electrochemical performances of the cathode materials suffered by severe structural change that occurred during charge/discharge under not only K-ion battery system but also other rechargeable battery systems.

关键词： cathodes first-principles calculations layered-type oxide materials potassium-ion batteries structural stabilization

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Glehnia fittoralis Extract Promotes Neurogenesis in the Hippocampal Dentate Gyrus of the Adult Mouse through Increasing Expressions of Brain-Derived Neurotrophic Factor and Tropomyosin-Related kinase B

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Chinese Medical Journal 2018年第6期131卷 689-695页

作者： Joon Ha Park Bich Na Shin Ji Hyeon Ahn Jeong Hwi Cho Tae-Kyeong Lee Jae-Chul Lee Yong Hwan Jeon II Jun Kang ki-yeon yoo In Koo Hwang Choong Hyun Lee yoo Hun Noh Sung-Su kim Moo-Ho Won Jong Dai kim Department of Biomedical Science and Research Institute for Bioscience and Biotechnology Hallym University Chuncheon 24252 Korea Department of Neurobiology School of Medicine Kangwon National University Chuncheon 24341 Korea Department of Radiology School of Medicine Kangwon National University Chuncheon 24341 Korea Department of Food Science and Nutrition Hallym University Chuncheon 24252 Korea epartment of Oral Anatomy College of Dentistry and Research Institute of Oral Biology Gangneung-Wonju National University Gangneung 25457 Korea Department of Anatomy and Cell Biology College of Veterinary Medicine and Research Institute for Veterinary Science Seoul National University Seou108826 Korea Department of Pharmacy College of Pharmacy Dankook University Cheonan 31116 Korea Famenity Biomedical Research Center Famenity Inc. Gyeonggi 13837 Korea Division of Food Biotechnology School of Biotechnology Kangwon National University Chuncheon 24341 Korea

Background： Glehnia littoralis has been used for traditional Asian medicine, which has diverse therapeutic activities. However, studies regarding neurogenic effects of G. littoralis have not yet been considered. Therefore, in this study, we examined effects of G. littoralis extract on cell proliferation, neuroblast differentiation, and the maturation of newborn neurons in the hippocampus of adult mice. Methods： A total of 39 male ICR mice （12 weeks old） were randomly assigned to vehicle-treated and 100 and 200 mg/kg G. littoralis extract-treated groups （n = 13 in each group）. Vehicle and G. littoralis extract were orally administrated for 28 days. To examine neurogenic effects ofG. litmralis extract, we performed immunohistochemistry tbr 5-bromo-2-deoxyuridine （BrdU, an indicator for cell proliferation） and doublecortin （DCX, an immature neuronal marker） and double immunofluorescence staining for BrdU and neuronal nuclear antigen （NeuN, a mature neuronal marker）. In addition, we examined expressional changes of brain-derived neurotrophic factor （BDNF） and its major receptor tropomyosin-related kinase B （TrkB） using Western blotting analysis. Results： Treatment with 200 mg/kg, not 100 mg/kg, significantly increased number of BrdU-immunoreactive （＋） and DCX＋ cells （48.0 ±3.1and 72.0 ± 3.8 cells/section, respectively） in the subgranular zone （SGZ） of the dentate gyrus （DG） and BrdU＊/NeuN＋ cells （17.0 ±1.5 cells/section） in the granule cell layer as well as in the SGZ. In addition, protein levels of BDNF and YrkB （about 232% and 244% of the vehicle-treated group, respectively） were significantly increased in the DG of the mice treated with 200 mg/kg ofG. littoralis extract. Conclusion： G. littoralis extract promots cell proliferation, neuroblast differentiation, and neuronal maturation in the hippocampal DG, and neurogenic effects might be closely related to increases ofBDN F and TrkB proteins by G. littoralis extract treatment.

关键词： Brain-Derived Neurotrophic Factor CellProliferation Glehnia littoralis Neuroblast Differentiation Tropomyosin-Related kinase B

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Stoichiometric Ti3C2Tx Coating for Inhibiting Dendrite Growth in Anode-Free Lithium Metal Batteries

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Energy & Environmental Materials 2024年第4期7卷 153-162页

作者： Xiangrong Zeng Manmatha Mahato Woong Oh Hyunjoon yoo Van Hiep Nguyen Saewoong Oh Geetha Valurouthu Soon-ki Jeong Chi Won Ahn Yury Gogotsi Il-Kwon Oh National Creative Research Initiative for Functionally Antagonistic Nano-Engineering Department of Mechanical Engineering Korea Advanced Institute of Science and Technology (KAIST) Department of Materials Science & Engineering and A. J. Drexel Nanomaterials Institute Drexel University Department of Energy Engineering Soonchunhyang University National Nanofab Center (NNFC) Korea Advanced Institute of Science and Technology (KAIST)

Lithium metal batteries (LMBs) and anode-free LMBs (AFLMBs) present a solution to the need for batteries with a significantly superior theoretical energy ***,their adoption is hindered by low Coulombic efficiency (CE) and rapid capacity fading,primarily due to the formation of unstable solid electrolyte interphase (SEI) layer and Li dendrite growth as a result of uneven Li plating.

关键词： anode-free lithium metal batteries stoichiometric MXene solid electrolyte interphase surface terminations

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Oenanthe Javanica Extract Protects Against Experimentally Induced Ischemic Neuronal Damage via its Antioxidant Effects

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Chinese Medical Journal 2015年第21期128卷 2932-2937页

作者： Joon Ha Park Jeong Hwi Cho In Hye kim Ji Hyeon Ahn Jae-Chul Lee Bai Hui Chen Bich-Na Shin Hyun-Jin Tae ki-yeon yoo SeongKweon Hong II Jun Kang Moo-Ho Won Jong-Dai kim Department of Neurobiology School of Medicine Kangwon National University Chuncheon 200-701 South Korea Department of Physiology College of Medicine Hallym University Chuncheon 200-702 South Korea Department of Biomedical Science Research Institute of Bioscience and Biotechnology Hallym University Chuncheon 200-702 South Korea Department of Oral Anatomy College of Dentistry and Research Institute of Oral Science Gangneung-Wonju National University Gangneung 210-702 South Korea Department of Surgery School of Medicine Kangwon National University Chuncheon 200-701 South Korea Department of Food Science and Nutrition Hallym University Chuncheon 200-702 South Korea Division of Food Biotechnology School of Biotechnology Kangwon National University Chuncheon 200-701 South Korea

Background： Water dropwort （Oenanthejavanica） as a popular traditional medicine in Asia shows various biological properties including antioxidant activity. In this study, we firstly examined the neuroprotective effect of Oenanthejavanica extract （OJE） in the hippocampal comus ammonis 1 region （CA 1 region） of the gerbil subjected to transient cerebral ischemia. Methods： Gerbils were established by the occlusion of common carotid arteries for 5 min. The neuroprotective effect of OJE was estimated by cresyl violet staining. In addition, 4 antioxidants （copper, zinc superoxide dismutase [SOD], manganese SOD, catalase, and glutathione peroxidase） immunoreactivities were investigated by immunohistochemistry. Results： Pyramidal neurons in the CA1 region showed neuronal death at 5 days postischemia; at this point in time, all antioxidants immunoreactivities disappeared in CA1 pyramidal neurons and showed 100 mg/kg, OJE protected CA 1 pyramidal neurons from ischemic damage in many nonpyramidal cells. Treatment with 200 mg/kg, not In addition, 200 mg/kg OJE treatment increased or maintained antioxidants immunoreactivities. Especially, among the antioxidants, glutathione peroxidase immunoreactivity was effectively increased in the CA 1 pyramidal neurons of the OJE-treated sham-operated and ischemia-operated groups. Conclusion： Our present results indicate that treatment with OJE can protect neurons from transient ischemic damage and that the neuroprotective effect may be closely associated with increased or maintained intracellular antioxidant enzymes by OJE.

关键词： Antioxidant Enzymes Hippocampal Comus Ammonis 1 Region: Neuroprotection, Oenanthe Javanica Extract: TransientCerebral Ischemia

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Neuroprotection via maintenance or increase of antioxidants and neurotrophic factors in ischemic gerbil hippocampus treated with tanshinone I

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Chinese Medical Journal 2014年第19期127卷 3396-3405页

作者： Joon Ha Park Ok kyu Park Yah Bingchun Ji Hyeon Ahn In Hye kim Jae-Chul Lee Seung-Hae Kwon ki-yeon yoo Choong Hyun Lee In Koo Hwang Jung Hoon Choi Moo-Ho Won Jong-Dai kim Department of Neurobiology School ot Medicine Kangwon NationalUniversity Chuncheon 200-701 South Korea Division of Analytical Bio-Imaging Chuncheon Center Korea BasicScience Institute Chuneheon 200-701 South Korea Department of Integrative Traditional & Western Medicine MedicalCollege Yangzhou University Yangzhou Jiangsu 225001 China Department of Oral Anatomy College of Dentistry Gangneung-Woniu National University Gangneung 210-702 South Korea Department of Pharmacy College of Pharmacy Dankook UniversityCheonan 330-714 South Korea Department of Anatomy and Cell Biology College of VeterinaryMedicine and Research Institute for Veterinary Science SeoulNational University Seoul 151-742 South Korea Department of Anatomy College of Veterinary Medicine KangwonNational University Chuncheon 200-701 South Korea Division of Food Science and Biotechnology College of Agriculture and Life Sciences Kangwon National University Chuncheon 200- 701 South Korea

Background Danshen （Radix Salvia miltiorrhizae） has been used as a traditional medicine in Asia for treatment of various microcirculatory disturbance related diseases. Tanshinones are mainly hydrophobic active components, which have been isolated from Danshen and show various biological functions. In this study, we observed the neuroprotective effect of tanshinone I （Tsl） against ischemic damage in the gerbil hippocampal CA1 region （CA1） after transient cerebral ischemia and examined its neuroprotective mechanism. Methods The gerbils were divided into vehicle-treated-sham-group, vehicle-treated-ischemia-group, Tsl-treated-sham- group, and Tsl-treated-ischemia-group. Tsl was administrated intraperitoneally three times （once a day for three days） before ischemia-reperfusion. The neuroprotective affect of Tsl was examined using H＆E staining, neuronal nuclei （NeuN） immunohistochemistry and Fluoro-Jade B staining. To investigate the neuroprotective mechanism of Tsl after ischemia- reperfusion, immunohistochemical （IHC） and Western blotting analyses for Cu, Zn-superoxide dismutase （SOD1）, Mn- superoxide dismutase （SOD2）, brain-derived neurotrophic factor （BDNF） and insulin-like growth factor-I （IGF-I） were *** Treatment with Tsl protected pyramidal neurons from ischemia-induced neuronal death in the CA1 after ischemia-reperfusion. In addition, treatment with Tsl maintained the levels of SOD1 and SOD2 as determined by IHC and Western blotting in the CA1 after ischemia- reperfusion compared with the vehicle-ischemia-group. In addition, treatment with Tsl increased the levels of BDNF and IGF-I determined by IHC and Westem blotting in the Tsl-treated-sham-group compared with the vehicle-treated- sham-group, and their levels were maintained in the stratum pyramidale of the ischemic CA1 in the Tsl-treated- ischemia-group. Conclusion Treatment with Tsl protects pyramidal neurons of the CA1 from ischemic damage induced by transient cerebral ischemia via the maintena

关键词： transient cerebral ischemia ischemic damage tanshinone I neuroprotection antioxidants neurotrophic factors

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