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A novel approach for the prevention of ionizing radiation-induced bone loss using a designer multifunctional cerium oxide nanozyme

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Bioactive Materials 2023年第3期21卷 547-565页

作者： Fei Wei Craig J.Neal tamil Selvan Sakthivel Yifei Fu Mahmoud Omer Amitava Adhikary Samuel Ward khoa minh ta Samuel Moxon Marco Molinari Jackson Asiatico Michael Kinzel Sergey N.Yarmolenko Vee San Cheong Nina Orlovskaya Ranajay Ghosh Sudipta Seal Melanie Coathup Biionix Cluster Department of Internal MedicineCollege of MedicineUniversity of Central FloridaOrlandoFLUSA Advanced Materials Processing and Analysis Centre Nanoscience Technology Center(NSTC)Materials Science and EngineeringCollege of MedicineUniversity of Central FloridaOrlandoFLUSA CMC Materials 870 North CommonsDrAuroraILUSA Department of Chemistry Oakland UniversityRochesterMIMIUSA School of Applied Sciences Department of Chemical SciencesUniversity of HuddersfieldUK Department of Mechanical and Aerospace Engineering University of Central FloridaOrlandoFLUSA Engineering Research Center for Revolutionizing Biomaterials North Carolina A&T UniversityGreensboroNCUSA Department of Automatic Control and Systems Engineering Insigneo Institute for In Silico MedicineUniversity of SheffieldSheffieldS13JDUK

The disability,mortality and costs due to ionizing radiation(IR)-induced osteoporotic bone fractures are sub-stantial and no effective therapy *** radiation increases cellular oxidative damage,causing an imbalance in bone turnover that is primarily driven via heightened activity of the bone-resorbing *** demonstrate that rats exposed to sublethal levels of IR develop fragile,osteoporotic *** reactive surface sites,cerium ions have the ability to easily undergo redox cycling:drastically adjusting their electronic con-figurations and versatile catalytic *** properties make cerium oxide nanomaterials *** show that an engineered artificial nanozyme composed of cerium oxide,and designed to possess a higher fraction of trivalent(Ce^(3+))surface sites,mitigates the IR-induced loss in bone area,bone architecture,and *** investigations also demonstrate that our nanozyme furnishes several mechanistic avenues of protection and selectively targets highly damaging reactive oxygen species,protecting the rats against IR-induced DNA damage,cellular senescence,and elevated osteoclastic activity in vitro and in ***,we reveal that our nanozyme is a previously unreported key regulator of osteoclast formation derived from macrophages while also directly targeting bone progenitor cells,favoring new bone formation despite its exposure to harmful levels of IR in *** findings open a new approach for the specific prevention of IR-induced bone loss using synthesis-mediated designer multifunctional nanomaterials.

关键词： Ionizing radiation Osteoporosis Nanozyme Cerium oxide Bone strength Bone resorption

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Synthesis of cation exchange resin-supported iron and magnesium oxides/hydroxides composite for nitrate removal in water

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Chinese Journal of Chemical Engineering 2021年第4期34卷 378-384页

作者： Trung Thanh Nguyen Vu Anh khoa Tran Le Ba Tran Phuoc Toan Phan minh tan Nguyen Long Giang Bach Surapol Padungthon Cong Khiem ta Nhat Huy Nguyen Nanomaterial Laboratory An Giang University18 Ung Van Khiem St.Dong Xuyen DistLong Xuyen CityAn Giang ProvinceViet Nam Vietnam National University Ho Chi minh City Linh Trung WardThu Duc DistrictHo Chi Minh CityViet Nam Faculty of Natural Resources and Environment Ho Chi Minh City University of Technology(HCMUT)268 Ly Thuong Kiet St.Dist.10Ho Chi Minh CityViet Nam Faculty of Engineering-Technology-Environment An Giang University18 Ung Van Khiem StDong Xuyen DistLong Xuyen CityAn Giang ProvinceViet Nam Department of Scientific Research and International Relation Bac Lieu University178 Vo Thi Sau St.Ward 8Bac Lieu CityBac Lieu ProvinceViet Nam NTT Institute of High Technology Nguyen Tat Thanh University298-300A Nguyen Tat ThanhHo Chi Minh CityViet Nam Department of Environmental Engineering Khon Kaen University123 Moo 16 Mittraphap Rd.Nai-MuangMuang DistrictKhon Kaen 40002Thailand

In this study,we reported on the concept and practical use of cation exchange resin(CER)for removing anions in water via pretreating the CER with metal *** cation exchange resinsupported iron and magnesium oxides/hydroxides composite(FeMg/CER)was synthesized and introduced as a new and potential adsorbent for selective removal of nitrate ion in the water *** of FeMg/CER were determined by techniques such as Fouriertransform infrared spectroscopy,scanning electron microscopy,and Xray *** results showed that FeMg/CER material had a high nitrate adsorption capacity of 200 mg NO_(3)^()·g^(1)with a fast equilibrium adsorption time of 30 min at pH *** addition,it had good durability of at least 10 times of regeneration,which could be applied to practical water and wastewater treatment.

关键词： Iron oxide/hydroxide Magnesium oxide/hydroxide Cation exchange resin Adsorption Environment Nanomaterials

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LONG-TIME ASYMPTOTIC OF StaBLE DAWSON-WAtaNABE PROCESSES IN SUPERCRITICAL REGIMES

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Acta Mathematica Scientia 2019年第1期39卷 37-45页

作者： khoa Lê Department of Mathematical and Statistical Sciences University of Alberta Department of Mathematics South Kensington Campus Imperial College London

Let W =(W_t)_(t≥0) be a supercritical a-stable Dawson-Watanabe process(withα∈(0,2]) and f be a test function in the domain of-(-△)^(α/2) satisfying some integrability condition. Assuming the initial measure W_0 has a finite positive moment, we determine the long-time asymptotic of arbitrary order of W_t(f). In particular, it is shown that the local behavior of Wt in long-time is completely determined by the asymptotic of the total mass W_t(1), a global characteristic.

关键词： Dawson-Watanabe process α-stable process

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JOINT HOLDER CONTINUITY OF PARABOLIC ANDERSON MODEL

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Acta Mathematica Scientia 2019年第3期39卷 764-780页

作者： Yaozhong HU khoa Lê Department of Mathematical and Statistical Sciences University of Alberta Department of Mathematics South Kensington Campus Imperial College London

We obtain the H?lder continuity and joint H?lder continuity in space and time for the random field solution to the parabolic Anderson equation ■ in d-dimensional space, where ■ is a mean zero Gaussian noise with temporal covariance γ0 and spatial covariance given by a spectral density μ(ξ). We assume that ■ and ■ , where αi, i = 1, · · ·, d(or α) can take negative value.

关键词： Gaussian process stochastic heat equation parabolic Anderson model multiplicative noise chaos expansion hypercontractivity H?lder continuity joint Holder continuity

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Green synthesis of three-dimensional magnesium ferrite/titanium dioxide/reduced graphene from Garcinia mangostana extract for crystal violet photodegradation and antibacterial activity

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Journal of Semiconductors 2023年第12期44卷 111-124页

作者： Tong Hoang Lin Che Quang Cong Nguyen Thanh Hoai Nam Hoang An Nguyen Duy Hai Ton That Buu Thoi Le Nhat Binh Hoang Le minh Lam Thanh Ngan Hoang Thuy Kim Ngan Du Chi Vi ta Dang khoa Nguyen Huu Hieu VNU-HCM Key Laboratory of Chemical Engineering and Petroleum Processing(Key CEPP Lab)Ho Chi Minh City University of Technology(HCMUT)268 Ly Thuong Kiet StreetDistrict 10Ho Chi Minh CityVietnam Faculty of Chemical Engineering Ho Chi Minh City University of Technology(HCMUT)268 Ly Thuong Kiet StreetDistrict 10Ho Chi Minh CityVietnam Vietnam National University Ho Chi minh City(VNU-HCM) Linh Trung WardThu Duc CityVietnam

In this study,three-dimensional porous magnesium ferrite/titanium dioxide/reduced graphene oxide(Mg Fe_2O_(4)-GM/TiO_(2)/rGO(MGTG))was successfully synthesized via green and hydrothermal-supported co-precipitation methods using the extract of Garcinia mangostana(***)as a reducing *** characterization results indicate the successful formation of the nano/micro Mg Fe_(2)O_(4)(MFO)and TiO_(2) on the structure of the reduced graphene oxide(rGO),which can also act as efficient support,alleviating the agglomeration of the nano/micro MFO and TiO_(2).The synergic effects of the adsorption and photodegradation activity of the material were investigated according to the removal of crystal violet(CV)under ultraviolet *** effects of catalyst dosage,CV concentration,and p H on the CV removal efficiency of the MGTG were also *** to the results,the CV photodegradation of the MGTG-200 corresponded to the pseudo-first-order kinetic *** reusability of the material after 10 cycles also showed a removal efficiency of 92%.This happened because the materials can easily be recollected using external *** addition,according to the effects of different free radicals·O_(2)^(-),h^(+),and·OH on the photodegradation process,the photocatalysis mechanism of the MGTG was also thoroughly *** antibacterial efficiency of the MGTG was also evaluated according to the inhibition of the Gram-positive bacteria strain Staphylococcus aureus(***).Concurrently,the antibacterial mechanism of the fabricated material was also *** results confirm that the prepared material can be potentially employed in a wide range of applications,including wastewater treatment and antibacterial activity.

关键词： magnesium ferrite titanium dioxide reduced graphene oxide Garcinia mangostana photodegradation antibacterial

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Skin fold thickness at abdomen:a simple anthropometric measurement may compliment metabolic syndrome definition in patients with normal waist circumference

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Journal of Geriatric Cardiology 2006年第2期3卷 85-92页

作者： Toan C Nguyen Thai Q Ngo Son V Nguyen Hieu T Luong khoa ta Pham Cong D Nguyen Vietnam Military Medical University Ha ToyVietnam

Backgroud and Objectives Previous studies have reported that skin fold thickness (SF) strongly correlated with insulin resistance in the metabolic syndrome (MetS). In this study, we developed a MetS definition by SF at A8 point (SFA8) on Erdheim diagram(MetSSFA8) in essential hypertensive patients. Subjects and Methods Medical records of 268 essential hypertensive patients (126males and 122 females) were analyzed, including 210 non-diabetic patients (NDM group) and 58 patients with diabetes (DM group).The mean age was 61.4 ± 9.9 and 59.0 ± 11.0 years, respectively. The control group consisted of 90 non-diabetic, non-hypertensive patients with a mean age of 58.0 ± 11.3 years. The proposed MetSSFA8 definition included SFA8 specific values ( ≥30 mm in female and ≥27 mm in male) and at least two of the following: raised triglyceride levels ( ≥1.7 mmol/L), or specific treatment for this lipid abnormality; raised blood pressure (SBP≥130 mmHg and/or DBP≥85 mmHg), or treatment of previously diagnosed hypertension;reduced HDL-cholesterol (＜ 1.03 mmol/L in men, ＜1.29 mmol/L in women), or specific treatment for this lipid abnormality; raised fasting plasma glucose (≥5.6 mmol/l), or previously diagnosed DM. Metabolic Syndrome by the National Cholesterol Education Program and International Diabetes Federation definitions were determined with abdominal obesity defined by Asia-Pacific criteria for waist circumference (NCEPA and IDFA). Results The percentage of MetS as defined by NCEPA, IDFA and MetSSFA8 in NDM group was lower than that of NCEPA, IDFA and MetSSFA8 in DM group [OR=7.7 (95%CI, 2.9-20.2) and 2.5 (95%CI, 1.4-4.8) and 2.7(95%CI, 1.3-5.6), respectively] and higher than that of the control group [OR=53.3 (95%CI, 16.7-170.6), 5.8 (95%CI, 2.6-13.2) and18.8 (95%CI, 7.3-48.7), respectively]. The percentage of MetS by NCEPA, IDFA and MetSSFA8 in males in NDM group was lower than the percentage of MetS by NCEPA, IDFA and MetSSFA8 in females in NDM group (50.8% and 77.9%, P＜ 0.0

关键词： skin fold thickness metabolic syndrome hypertension

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A new formula for screening metabolic syndrome in Asians:skin fold thickness at A8 point on Erdheim diagram and waist circumference

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Journal of Geriatric Cardiology 2007年第1期4卷 32-41页

作者： Toan C Nguyen Thai Q Ngo khoa ta Pham Son V Nguyen Hieu T Luong Cong D Nguyen Vietnam Military Medical University Ha Dong Town Ha Tay Province Vietnam Department of Cardiology Hospital 103 Vietnam

Background and objectives Recent studies have shown that abdominal obesity is an important component for the diagnosis of metabolic syndrome (MS) and MS is a high risk factor for cardiovascular disease and diabetes mellitus. The aim of this study was to develop a new formula for screening and diagnosis of MS using the waist circumference (WC) and skin fold thickness at the point A8 (SFA8) on the Erdheim diagram. Methods A total of 358 essential hypertensive patients (189 male and 169 female) with a mean age of 59.0±9.7 years were included; 151 healthy people (79 male, 72 female) with a mean age of 57.3±12.1 years (similar to hypertensive patients) who were non-hypertensive and non-diabetic served as a control group. All subjects had no evidence of hepatic, renal, or endocrine disease as determined by history, physical examination and screening blood tests. Height, weight, WC, SFA8, blood pressure (BP), fasting plasma glucose, HDL-cholesterol and triglyceride levels were measured in all subjects. Abdominal obesity measured by WC using the Asia-Pacific criteria (IDFA) was applied for meeting the MS definition. The normal value of SFA8 was measured in the non- MS group. Relationships between SFA8 and systolic BP, diastolic BP, fasting plasma glucose, HDL-cholesterol and triglyceride levels were calculated in the control group. A new formula was developed according to high SFA8 and high WC. Results The normal value of SFA8 in non-MS group was 23.6±7.2 mm in male and 26.5±4.6 mm in female, respectively. The value of SFA8 in MS group was 36.7± 7.4 mm in male and 38.9 ± 8.1 mm in female, respectively. The value of WC in MS group and non-MS group were 92.5±3.0 cm and 79.4±6. 1 cm in male and 86.3±6.4 cm and 74.7±5.4 cm in female, respectively. There was a correlation between SFA8 and systolic BP, diastolic BP, fasting plasma glucose, HDL-cholesterol and triglyceride in control group (the correlation coefficients were 0.29, 0.23, 0.25, -0.31 and 0.46, respectively, P < 0.01)

关键词： waist circumference skin fold thickness metabolic syndrome

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Single-Layer Wideband Circularly Polarized Antenna Using Non-Uniform Metasurface for C-band Applications

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Computers, Materials & Continua 2021年第8期68卷 2487-2498页

作者： Huy Hung Tran khoa Nguyen-Dang Niamat Hussain Faculty of Electrical and Electronic Engineering PHENIKAA UniversityHanoi12116Vietnam PHENIKAA Research and Technology Institute(PRATI) A&A Green Phoenix Group JSCCau Giay11313HanoiVietnam Department of Computer and Communication Engineering Chungbuk National UniversityCheongju 28644Korea

A single-layer design of non-uniform metasurface(MS)based circularly polarized(CP)antenna with wideband operation characteristic is proposed and investigated in this *** antenna is excited by a truncated corner squared patch as a primary radiating CP ***,a non-uniform MS is placed in the same layer with the driven *** increasing the impedance bandwidth,the non-uniform MS also generates two additional CP bands in the high frequency band,leading to significantly increase the antenna’s overall *** use of non-uniform MS distinguishes our design from the other CP MS based antennas in literature,in which the MS is formed by multiple uniform unit cells and placed in different layer with the radiating *** validation,an antenna prototype,whose overall dimensions of 0.94λ_(o)×0.94λ_(o)×0.06λ_(o) at the center operating frequency,is fabricated and experimentally *** measured operating bandwidth with|S11|≤−10 dB and AR≤3 dB is 27.1%(5.1–6.7 GHz)and the broadside gain within this band is from 5.7 to 7.2 *** to the other related works,the proposed antenna has advantage of very wideband operation with single-layer design.

关键词： Circular polarization metasurface non-uniform patch antenna wideband

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Antibiotic usage in surgical sperm retrievals among IVF centers

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Asian Journal of Andrology 2022年第6期24卷 633-638页

作者： Le Dang khoa Ngo Dinh Trieu Vy Nguyen minh tai Loc Le Duc Thang Dang Tuan Anh Nguyen Phuc Hieu Giang Huynh Nhu Nguyen Dinh tao Le Hoang David J Handelsman IVFta Tam Anh General HospitalHo Chi Minh 700000Vietnam IVFta Tam Anh General HospitalHa Noi 100000Vietnam IVF Center 16A Ha Dong HospitalHa Noi 100000Vietnam ANZAC Research Institute University of Sydney and Concord Repatriation General HospitalHospital RoadConcordNSW 2139Australia

Surgical sperm retrieval(SSR)is currently one of the most common procedures in in vitro fertilization(IVF).However,a gap between the guidelines and routine clinical practice regarding antibiotic use in sSR,which might lead to antibiotic resistance,is a challenging problem worldwide.A cross-sectional survey was conducted from May 1,2021,to July 15,2021,to investigate antibiotic usage by medical professionals when performing SSR in IVF centers in *** confidential questionnaire comprised 12 items,including characteristics of the study population,awareness of antimicrobial resistance,attitude toward prescribing antibiotics,and current practice of prescribing antibiotics when performing *** were completed by 30 of 45 registered IVF centers(66.7%).Among 67 physicians working at those centers,the age and work-experience years(mean±standard deviation[s.d.])were 38.6±6.6 years and 11.2±7.0 years,*** 60%of them held a degree in Obstetrics and Gynecology,and over four-fifths were *** respondents"often/very often/always"raised awareness of antimicrobial resistance to their patients(83.3%),but only half of them"often/occasionally"prescribed antibiotics to patients with SSR in cases where the prescription would be *** one-tenth of respondents followed the recommendation from the American Urological Association using"prophylaxis only"for SSR *** more invasive SSR,physicians tended to prescribe more complicated and sometimes inappropriate *** conclusion,antibiotic usage in SSR was not always appropriate among IVF *** studies may define specific recommendations for regimens,intervention strategies,and programs to promote appropriate antibiotic use for SSR patients among IVF specialists.

关键词： antibiotic usage in vitro fertilization prophylaxis surgical sperm retrieval treatment

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Design response to rising sea levels in the Maldives:A study into aquatic architecture

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Frontiers of Architectural Research 2020年第3期9卷 623-640页

作者： Ahdha Moosa khoa Do Emil Jonescu School of Design and the BuiU Environment Curtin UniversityPerthAustralia

Climate change and rising sea levels present immediate threats to ***,the global catastrophe fails to generate sufficient *** to total submergence within 80 years,this study undertakes an iterative design process seeking sustainable adaptation strategies for the coastal island nation of the Maldives,specifically,Male,its capital,which exists under a"state of alert"by order of *** methods include literature reviews,site analysis,mapping,and iterative design processes to develop an implementation framework *** concepts are presented as speculative images with context-specific spatial relationships and *** do not intend to represent a conclusive prototype,rather,an ideation-a solution-based discourse among key audiences highlighting the need to act decisively and adaptively.

关键词： Architectural design Design practice Infrastructure design Rising sea levels Case study

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